MyMedR

Fulltext Neuropsychological profile at three months post injury in patients with traumatic brain injury

Ali R, Wahab S, Abdul Rahman AH

Sains Malaysiana, 2013;42(3):403-408.

This study looked into the rate and pattern of neuropsychological impairment in patients with traumatic brain injury patients at three months post injury. Forty patients attending the neurosurgery outpatient clinic were included in the study. Benton visual retention test (BVRT), rey auditory verbal learning test (RAVLT), digit span test, trail making test (TMT) and mini mental state examination (MMSE) were used for assessment. Forty five percent (n=18) sustained moderate to severe head injury. Twenty five percent (n=10) have abnormal MMSE result. Forty two and a half percent (n=17) have abnormal BVRT result. Seventy five percent (n=30) have abnormal RAVLT result while 35% (n=14) have abnormal digit span test result. Seventy seven and a half percent (n=31) have at least one neurological deficit. There was significant association between severity of head injury (GCS score) and neuropsychological deficit. This study highlights the point that in post head injury patients, there are high occurrences of cognitive dysfunction. MMSE and GCS play a significant and important role in assessing cognitive dysfunction. Severity of head injury as determined by GCS scores also influence the outcome in patients with head injury

Polymorphism of the serotonin transporter gene (5-HTTLPR) in major depressive disorder patients in Malaysia

Mohamed Saini S, Muhamad Radzi A, Abdul Rahman AH

Asia Pac Psychiatry, 2012 Jun;4(2):126-30.

PMID: 26767356 DOI: 10.1111/j.1758-5872.2012.00190.x

The serotonin transporter promoter (5-HTTLPR) is a potential susceptibility locus in the pathogenesis of major depressive disorder. However, data from Malaysia is lacking. The present study aimed to determine the association between the homozygous short variant of the serotonin transporter promoter gene (5-HTTLPR) with major depressive disorder.

Malignant catatonia secondary to viral meningoencephalitis in a young man with bipolar disorder

Saini SM, Eu CL, Wan Yahya WN, Abdul Rahman AH

Asia Pac Psychiatry, 2013 Apr;5 Suppl 1:55-8.

PMID: 23857838 DOI: 10.1111/appy.12045

Serotonin transporter gene polymorphism and its association with bipolar disorder across different ethnic groups in Malaysia

Mohamed Saini S, Nik Jaafar NR, Sidi H, Midin M, Mohd Radzi A, Abdul Rahman AH

Compr Psychiatry, 2014 Jan;55 Suppl 1:S76-81.

PMID: 23410635 DOI: 10.1016/j.comppsych.2012.12.005

The risk variants have been shown to vary substantially across populations and a genetic study in a heterogeneous population might shed a new light in the disease mechanism. This preliminary study aims to determine the frequency of the serotonin transporter gene polymorphism (5-HTTLPR) in the three main ethnic groups in Malaysia and its association with bipolar disorder.

Fulltext The Hyperactivity of Efferent Auditory System in Patients with Schizophrenia: A Transient Evoked Otoacoustic Emissions Study

Abdul Wahab NA, Wahab S, Abdul Rahman AH, Sidek D, Zakaria MN

Psychiatry Investig, 2016 Jan;13(1):82-8.

PMID: 26766950 DOI: 10.4306/pi.2016.13.1.82

Electrophysiological studies, which are mostly focused on afferent pathway, have proven that auditory processing deficits exist in patients with schizophrenia. Nevertheless, reports on the suppressive effect of efferent auditory pathway on cochlear outer hair cells among schizophrenia patients are limited. The present, case-control, study examined the contralateral suppression of transient evoked otoacoustic emissions (TEOAEs) in patients with schizophrenia.

Evaluation of auditory hallucinations in patients with schizophrenia: A validation study of the Malay version of Psychotic Symptom Rating Scales (PSYRATS)

Wahab S, Zakaria MN, Sidek D, Abdul Rahman AH, Shah SA, Abdul Wahab NA

Psychiatry Res, 2015 Aug 30;228(3):462-7.

PMID: 26142835 DOI: 10.1016/j.psychres.2015.06.014

The Psychotic Symptom Rating Scales (PSYRATS) is the most widely used validated scale to measure the specific symptoms of auditory hallucination and delusion. The aim of this study was to validate and to examine the psychometric properties of the auditory hallucination component of the Malay PSYRATS (MyPSYRATS). The research was done in the Universiti Kebangsaan Malaysia Medical Center (UKMMC) among 51 schizophrenia inpatients and outpatients who had experienced or reported verbal auditory hallucination. The psychometric properties of MyPSYRATS (auditory hallucination) were studied and a comparison was made between the psychometric properties obtained and the Positive and Negative Syndrome Scale (PANSS). The internal consistency of MyPSYRATS was good as revealed by Cronbach's alpha value. Factor analysis replicated three components (emotional, cognitive, and physical) similar to the factorial structure of the original auditory hallucination scale. However, two items were regrouped under the emotional component. Spearman's rank-order correlation showed a significant positive relationship between the total score of auditory hallucinations and PANSS auditory hallucinations item (P3). In conclusion, the auditory hallucination domain of MyPSYRATS is a reliable and valid assessment tool for further clinical applications.

Study site: Pusat Perubatan Universiti Kebangsaan Malaysia (PPUKM)

Fulltext Listening to Sentences in Noise: Revealing Binaural Hearing Challenges in Patients with Schizophrenia

Abdul Wahab NA, Zakaria MN, Abdul Rahman AH, Sidek D, Wahab S

Psychiatry Investig, 2017 Nov;14(6):786-794.

PMID: 29209382 DOI: 10.4306/pi.2017.14.6.786

Objective: The present, case-control, study investigates binaural hearing performance in schizophrenia patients towards sentences presented in quiet and noise.

Methods: Participants were twenty-one healthy controls and sixteen schizophrenia patients with normal peripheral auditory functions. The binaural hearing was examined in four listening conditions by using the Malay version of hearing in noise test. The syntactically and semantically correct sentences were presented via headphones to the randomly selected subjects. In each condition, the adaptively obtained reception thresholds for speech (RTS) were used to determine RTS noise composite and spatial release from masking.

Results: Schizophrenia patients demonstrated significantly higher mean RTS value relative to healthy controls (p=0.018). The large effect size found in three listening conditions, i.e., in quiet (d=1.07), noise right (d=0.88) and noise composite (d=0.90) indicates statistically significant difference between the groups. However, noise front and noise left conditions show medium (d=0.61) and small (d=0.50) effect size respectively. No statistical difference between groups was noted in regards to spatial release from masking on right (p=0.305) and left (p=0.970) ear.

Conclusion: The present findings suggest an abnormal unilateral auditory processing in central auditory pathway in schizophrenia patients. Future studies to explore the role of binaural and spatial auditory processing were recommended.

Association between cognitive reserve with cognitive impairment, social and occupational functioning, and quality of life in schizophrenia: A preliminary study in the Malaysian population

Sharip S, Zairani MI, Ing LP, Baharom NN, Asarapoo NS, Rahman NA, et al.

Asian J Psychiatr, 2020 Oct;53:102230.

PMID: 32585635 DOI: 10.1016/j.ajp.2020.102230

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