MyMedR

Fulltext The Potential Use of Mesenchymal Stem Cells and Their Derived Exosomes for Orthopedic Diseases Treatment

Malekpour K, Hazrati A, Zahar M, Markov A, Zekiy AO, Navashenaq JG, et al.

Stem Cell Rev Rep, 2022 Mar;18(3):933-951.

PMID: 34169411 DOI: 10.1007/s12015-021-10185-z

Musculoskeletal disorders (MSDs) are conditions that can affect muscles, bones, and joints. These disorders are very painful and severely limit patients' mobility and are more common in the elderly. MSCs are multipotent stem cells isolated from embryonic (such as the umbilical cord) and mature sources (such as adipose tissue and bone marrow). These cells can differentiate into various cells such as osteoblasts, adipocytes, chondrocytes, NP-like cells, Etc. Due to MSC characteristics such as immunomodulatory properties, ability to migrate to the site of injury, recruitment of cells involved in repair, production of growth factors, and large amount production of extracellular vesicles, these cells have been used in many regenerative-related medicine studies. Also, MSCs produce different types of EVs, such as exosomes, to the extracellular environment. Exosomes reflect MSCs' characteristics and do not have cell therapy-associated problems because they are cell-free. These vesicles carry proteins, nucleic acids, and lipids to the host cell and change their function. This review focuses on MSCs and MSCs exosomes' role in repairing dense connective tissues such as tendons, cartilage, invertebrate disc, bone fracture, and osteoporosis treatment.

Matched MeSH terms: Regenerative Medicine

Obituary: Wu Lien-Teh, M.D., Sc.D., Litt.D., LL.D., M.P.H

Nixon WCW

Br Med J, 1960;1:655.

Matched MeSH terms: History of Medicine

Fulltext Malaysian Journal of Medical Sciences: a step forward towards an international journal

Ghazli NF, Che Annual N, Abdullah JM

Malays J Med Sci, 2015 Nov;22(6):1-4.

PMID: 28223878

In 1986, the Malaysian Journal of Medical Sciences (MJMS) began as the small and newly established journal Diagnosa, established by the Universiti Sains Malaysia School of Medicine. After 28 years in the publishing industry, we have received the honor of a listing as a local journal in the Emerging Sources Citation Index (ESCI) created by Thomson Reuters (TR) to spotlight emerging high-quality scientific publications. The editorial team of MJMS looks forward to the next step in the march of progress toward the status of an international journal.

Matched MeSH terms: Medicine

Fulltext Identifying the Core Content of a Dermatology Module for Malaysian Medical Undergraduate Curriculum Using a Modified Delphi Method

Jamil A, Muthupalaniappen L, Md Nor N, Siraj HH, Salam A

Malays J Med Sci, 2016 May;23(3):78-85.

PMID: 27418873 MyJurnal

Dermatology is a minor module in internal medicine undergraduate curriculum. Limited time is allocated for its teaching. Most graduates are inadequately prepared to diagnose and manage skin diseases. We aimed to identify the core content of a more effective dermatology module.

Matched MeSH terms: Internal Medicine

Fulltext Malaysian Journal of Medical Sciences' Performance Status in 2017 and the Challenges

Zulkapli NA, Abdullah JM

Malays J Med Sci, 2018 Nov;25(6):1-5.

PMID: 30914874 DOI: 10.21315/mjms2018.25.6.1

This report presents a review of the Malaysian Journal of Medical Sciences' (MJMS) performance status throughout 2017, which covers the submission pattern of original manuscripts by month, the geographical distribution of submitting authors, the types of manuscripts and overall acceptance/rejection rates. As the years progress, MJMS continues to receive an escalating number of manuscript submissions. This contributes to an ever-increasing workload, which makes administrative tasks continually more challenging. Although the manuscript submission platform seeks to minimise the pre-publication workload of the journal administrator, it is still a time-consuming task, particularly when authors seek exclusive attention for their submitted manuscripts.

Matched MeSH terms: Medicine

Fulltext A traditional Malay myth leading to unintentional self intoxication with kecubung fruit

Mohamad N, Baharuddin KA, Ahmad R

Southeast Asian J Trop Med Public Health, 2009 Nov;40(6):1331-4.

PMID: 20578469

Traditional Malay herbal medicine is still used in Malaysia especially in rural areas, instead of using modern medicine. Datura or "kecubung" has been used to treat allergic rhinitis in certain places. Inaccurate doses can potentially cause severe or fatal neurologic anti-cholinergic toxidromes. A good knowledge of toxidromes with optimization of supportive care can prevent fatal complications and lead to a more speedy recovery. We present a case of kecubung poisoning.

Matched MeSH terms: Medicine, East Asian Traditional*; Herbal Medicine*

Significance of herbal medicine in removing excessive iron content in human

Wbin-Wan-Ibrahim WA, Mirza EH, Akbar Ali SF

Pak J Pharm Sci, 2013 Jul;26(4):823-6.

PMID: 23811465

Heavy metals in cigarette tobacco such as iron may cause a serious damage on human health. Surveys showed that the accumulation of certain toxic heavy metals like cadmium, mercury, iron is very often due to the effect of smoking. This work involved 15 volunteers in two randomly divided groups having the habit of cigarette smoking over 15 cigarettes / day. Concentration level of iron in blood and urine before and after treatment using the herbal medicine, widely used in Europe, is analyzed. Determination of Iron concentration in blood and urine was calculated by Inductively Coupled Plasma-Atomic Emission Spectrometry (ICP-AES) according to the procedure DIN EN ISO 11885 ("E22" from April 1998). The analysis shows that the concentration of iron in blood and urine samples in both groups increased in some volunteers instead of decrease. The independent T-test shows that the mean of iron concentration in the group A and group B had no significant difference (p>0.05). The results suggested that the herbal medicine under test does not have significant influence on reduction of iron concentration levels.

Matched MeSH terms: Herbal Medicine*

Making it real: a hands-on approach to teaching research

Birks M

Int Nurs Rev, 2011 Jun;58(2):270-2.

PMID: 21554303 DOI: 10.1111/j.1466-7657.2011.00894.x

The purpose of this paper was to report on the delivery of a series of seminars in Sarawak, East Malaysia using a unique hands-on approach to the teaching of skills in research and evidence-based health care. These seminars proved to be a meaningful and memorable experience for both the facilitators and participants.

Matched MeSH terms: Evidence-Based Medicine/education*

Fulltext Clinical oncology in Malaysia: 1914 to present

Lim GCC

Biomed Imaging Interv J, 2006 Jan;2(1):e18.

PMID: 21614216 MyJurnal DOI: 10.2349/biij.2.1.e18

A narration of the development of staff, infrastructure and buildings in the various parts of the country is given in this paper. The role of universities and other institutions of learning, public health, palliative care, nuclear medicine and cancer registries is described together with the networking that has been developed between the government, non-governmental organisations and private hospitals. The training of skilled manpower and the commencement of the Master of Clinical Oncology in the University of Malaya is highlighted. Efforts taken to improve the various aspects of cancer control which includes prevention of cancer, early detection, treatment and palliative care are covered. It is vital to ensure that cancer care services must be accessible and affordable throughout the entire health system, from the primary care level up to the centres for tertiary care, throughout the whole country.

Matched MeSH terms: History of Medicine*

Fulltext Exploring Ayurvedic Knowledge on Food and Health for Providing Innovative Solutions to Contemporary Healthcare

Payyappallimana U, Venkatasubramanian P

Front Public Health, 2016;4:57.

PMID: 27066472 DOI: 10.3389/fpubh.2016.00057

Ayurveda, a traditional system of medicine that originated over three millennia ago in the South Asian region, offers extensive insights about food and health based on certain unique conceptual as well as theoretical positions. Health is defined as a state of equilibrium with one's self (svasthya) but which is inextricably linked to the environment. Ayurvedic principles, such as the tridosa (three humors) theory, provide the relationship between the microcosm and the macrocosm that can be applied in day-to-day practice. Classical Ayurveda texts cover an array of themes on food ranging from diversity of natural sources, their properties in relation to seasons and places and to their specific function both in physiological and pathological states. The epistemic perspective on health and nutrition in Ayurveda is very different from that of biomedicine and modern nutrition. However, contemporary knowledge is reinventing and advancing several of these concepts in an era of systems biology, personalized medicine, and the broader context of a more holistic transition in sciences in general. Trans-disciplinary research could be important not only for pushing the boundaries of food and health sciences but also for providing practical solutions for contemporary health conditions. This article briefly reviews the parallels in Ayurveda and biomedicine and draws attention to the need for a deeper engagement with traditional knowledge systems, such as Ayurveda. It points out that recreation of the methodologies that enabled the holistic view point about health in Ayurveda may unravel some of the complex connections with Nature.

Matched MeSH terms: Medicine, Ayurvedic; Precision Medicine

Emerging problems of antibiotic resistance in community medicine

Parasakthi N

Malays J Pathol, 1996 Jun;18(1):9-13.

PMID: 10879217

Emergence of antimicrobial resistance in bacteria associated with community acquired infections has made the choice of empirical therapy more difficult and more expensive. The problems due to possible spread of MRSA to the community, emergence of penicillin resistance in S. pneumoniae, ampicillin resistance in H. influenzae, and multiresistance among common enteric pathogens are highlighted. Bacteria have a remarkable ability to develop resistance to many of the newly synthesized antimicrobial agents but the appropriate use of antibiotics will delay and in many cases prevent the emergence of resistance.

Matched MeSH terms: Community Medicine/trends*

Fulltext Identification from dental characteristics

Phrabhakaran N

Med J Malaysia, 1994 Dec;49(4):406-8.

PMID: 7674977

Law enforcing authorities need to provide a scientific basis for the identification of any unknown individual. In recent years, dental records comparison has developed into one such credible method of confirming the identity of a deceased. This method is however restricted as dentists are not making and maintaining adequate records of their patients. Fortunately the advent of inexpensive cameras and print processing procedures has enabled the availability of ample antemortem photographs. Photographs in which a person expresses his/her teeth 'gleefully' has provided a sound scientific basis for the identification by comparing dental characteristics of the deceased.

Matched MeSH terms: Forensic Medicine/methods*

Training and education of occupational health and safety personnel in a developing country

Lim Heng Huat

J R Soc Health, 1983 Dec;103(6):246-8.

PMID: 6644735

Matched MeSH terms: Occupational Medicine/education*

Obtaining a reliable travel history from III returned travellers

Gately R, Economos H, Fleming C, Flaherty G

Travel Med Infect Dis, 2015 Jul-Aug;13(4):342-3.

PMID: 26005161 DOI: 10.1016/j.tmaid.2015.05.003

Matched MeSH terms: Travel Medicine/methods*

Radionuclide concentrations in medicinal florae and committed effective dose through Ayurvedic medicines

Monica S, Jojo PJ, Khandaker MU

Int J Radiat Biol, 2020 08;96(8):1028-1037.

PMID: 32394771 DOI: 10.1080/09553002.2020.1767816

Purpose: Ayurveda is one of the oldest systems of medicines in the world being practiced widely in the Indian subcontinent for more than 3000 years, and still remains as one of the important traditional health care systems. The Ayurvedic drugs are derived primarily from various parts of the plants, like root, leaf, flower, fruit or plant as a whole. Plants uptake minerals and other nutrients from the soil through their root system. Along with other minerals radionuclides present in the growing media also reach to the plant parts following the same pathway. Realizing the probable health hazards via the intake of Ayurvedic drugs, it is important to assess the concentration of natural radionuclides in commonly used medicinal plants.Materials and methods: NaI(Tl) scintillator-based gamma-ray spectrometry has been used to determine the activity concentrations of primordial radionuclides (226Ra, 232Th and 40K) in the most commonly used medicinal plant parts as ingredients of Ayurvedic medicines in India.Results and discussion: The average specific activity (Bqkg-1) of 226Ra, 232Th and 40K was found to be 43 ± 18, 36 ± 15[Formula: see text] and 230 ± 46, respectively. The estimated annual committed effective doses due to the intake of common Ayurvedic medicines at prescribed dosage was found to be 39 ± 16 µSv y-1,[Formula: see text] which is quite low as compared with the radiation dose limit of 1 mSvy-1 from all natural sources, reported by the International Commission on Radiological Protection (ICRP-60).Conclusions: It is found categorically that intake of Ayurvedic medicines at normal dosage poses no radiological hazard to the individual. Present results are significant in the wake of myths that many hazardous materials including radioisotopes are present at higher levels. Obtained results also serve as a reference information for the distribution of radionuclides in medicinal plant species.

Matched MeSH terms: Medicine, Ayurvedic*

The Integration and Harmonisation of Secular and Islamic Ethical Principles in Formulating Acceptable Ethical Guidelines for Modern Biotechnology in Malaysia

Hasim NA, Amin L, Mahadi Z, Yusof NAM, Ngah AC, Yaacob M, et al.

Sci Eng Ethics, 2020 06;26(3):1797-1825.

PMID: 32266581 DOI: 10.1007/s11948-020-00214-4

The Malaysian government recognises the potential contribution of biotechnology to the national economy. However, ongoing controversy persists regarding its ethical status and no specific ethical guidelines have been published relating to its use. In developing such guidelines, it is important to identify the underlying principles that are acceptable to Malaysian society. This paper discusses the process of determining relevant secular and Islamic ethical principles and establishing their similarities before harmonising them. To achieve this, a series of focus group discussions were conducted with 23 knowledge experts representing various stakeholders in the biotechnology community. Notably, several principles between the secular and Islamic perspectives are indirectly or directly similar. All the experts agreed with the predominant six ethical principles of secular and Islamic philosophy and their importance and relevance in modern biotechnology. These are beneficence and non-maleficence as the main or overarching principles, the preservation of religious and moral values, the preservation of the intellect and the mind, the protection of human safety, the protection of future generations, and protection of the environment and biological diversity. Several adjustments were made to the terminologies and definitions of these six principles to formulate acceptable guiding principles for the ethics of modern biotechnology in Malaysia. These can then be adopted as core values to underpin future national guidelines on modern biotechnology ethics. These principles will be particularly important in guiding the policy makers, enforcers, industries and researchers to streamline their activities. In so doing, modern biotechnology and its products can be properly managed without jeopardising the interests of the Muslim community as well as the general public. Importantly, they are expansive and inclusive enough to embrace the religious sensitivity of diverse quarters of Malaysia.

Matched MeSH terms: Religion and Medicine*

Fulltext Tungsten-based material as promising new lead-free gamma radiation shielding material in nuclear medicine

Jamal AbuAlRoos N, Azman MN, Baharul Amin NA, Zainon R

Phys Med, 2020 Oct;78:48-57.

PMID: 32942196 DOI: 10.1016/j.ejmp.2020.08.017

PURPOSE: The main objective of this study was to evaluate the efficacy of tungsten carbide as new lead-free radiation shielding material in nuclear medicine by evaluating the attenuation properties.

MATERIALS AND METHODS: The elemental composition of tungsten carbide was analysed using Field-Emission Scanning Electron Microscopy (FESEM) with energy dispersive X-ray (EDX). The purity of tungsten carbide was 99.9%, APS: 40-50 µm. Three discs of tungsten carbide was fabricated with thickness of 0.1 cm, 0.5 cm and 1.0 cm. Three lead discs with similar thickness were used to compare the attenuation properties with tungsten carbide discs. Energy calibration of gamma spectroscopy was performed by using 123I, 133Ba, 152Eu, and 137Cs. Gamma radiation from these sources were irradiated on both materials at energies ranging from 0.160 MeV to 0.779 MeV. The experimental attenuation coefficients of lead and tungsten carbide were compared with theoretical attenuation coefficients of both materials from NIST database. The half value layer and mean free path of both materials were also evaluated in this study.

RESULTS: This study found that the peaks obtained from gamma spectroscopy have linear relationship with all energies used in this study. The relative differences between the measured and theoretical mass attenuation coefficients are within 0.19-5.11% for both materials. Tungsten carbide has low half value layer and mean free path compared to lead for all thickness at different energies.

CONCLUSION: This study shows that tungsten carbide has high potential to replace lead as new lead-free radiation shielding material in nuclear medicine.

Matched MeSH terms: Nuclear Medicine*

Infantile seborrheic dermatitis: a pediatric Siddha medicine treatise

Thambyayah M, Amuthan A

Clin Dermatol, 2015 May-Jun;33(3):355-61.

PMID: 25889138 DOI: 10.1016/j.clindermatol.2014.12.013

Siddha medicine is one of the oldest (5000 years old) well-documented Indian traditional medicines, compared with Ayurveda, Unani, and traditional Chinese medicine, by way of keen observation and experimentation. It mentions 108 diseases that occur in childhood, which are further classified and described into various subtypes based on the clinical features and different stages of a particular disease. The authors translate the elegant and detailed description of one neonatal disorder, infantile seborrheic dermatitis (cradle cap), called kabaala kuttam (KK), described in 17 stanzas of four lines for each stanza from Tamil language script into English. There are five different types of cradle cap, including white type, dark black type, red type, weeping type, and toxic type. Four polyherbal formulations are described for external and oral administration, in which there is mention of 39 herbals and pure sulfur as ingredients. The safety and efficacy of these herbal products varies and has not been fully explored in infants, but may represent options for clinical development.

Matched MeSH terms: Medicine, Ayurvedic*

Medical Humanities in the Nepalese context

Shankar PR

J Nepal Health Res Counc, 2021 Sep 06;19(2):439-440.

PMID: 34601549 DOI: 10.33314/jnhrc.v19i2.3339

Medical humanities use the creative and intellectual strengths of the arts for specific purposes in medical education. The author read with great interest the Medical humanities program at the Patan Academy of Health Sciences and has been associated with Medical humanities since 2007. There are several factors favouring the development of Medical humanities in Nepal but the major challenge is there is no specific faculty and/or department involved and the discipline may be relegated to the background in the face of other pressing priorities. In the west humanities faculty had played an important role in popularizing Medical humanities. Clinical teachers can incorporate Medical humanities into their clinical teaching. Large student sizes and lesser number of faculty may be challenges in moving the discipline forward. Keywords: Medical humanities, medical schools, Nepal, undergraduate medical.

Matched MeSH terms: Medicine*

Mystic practices and their effects on modern society

Danaraj AG

Nurs J Singapore, 1977 Nov;17(2):51-3, 57.

PMID: 247345

Matched MeSH terms: Medicine, Traditional*

Displaying publications 161 - 180 of 1443 in total