MyMedR

Fulltext Clinical presentation of patients with nasopharyngeal carcinoma

Suzina SAH, Hamzah M

Med J Malaysia, 2003 Oct;58(4):539-45.

PMID: 15190630

The poor prognosis for patients with nasopharyngeal carcinoma is principally due to its advanced stage at the time of diagnosis. The symptoms and clinical findings at presentation of 56 patients with confirmed nasopharyngeal carcinoma is described and analysed. Recognising the common modes of presentation is essential to diagnose the disease at an early stage.

Matched MeSH terms: Carcinoma/diagnosis; Carcinoma/ethnology; Carcinoma/pathology*

The early detection of unsuspected carcinoma of cervix in Malaysia by exfoliative cytological screening

Sinnathuray TA, Lau KS

Med J Malaysia, 1973 Dec;28(2):70-4.

PMID: 4276263

Matched MeSH terms: Carcinoma in Situ/diagnosis*; Carcinoma, Squamous Cell/diagnosis*

p16 gene expression in basal cell carcinoma

Eshkoor SA, Ismail P, Rahman SA, Oshkour SA

Arch Med Res, 2008 Oct;39(7):668-73.

PMID: 18760195 DOI: 10.1016/j.arcmed.2008.06.003

Basal cell carcinoma (BCC) develops predominantly in sun-exposed skin in fair-skinned individuals prone to sunburn. BCC typically occurs in adults. High exposure to ultraviolet (UV) radiation increases rate of developing BCC, a slowly growing tumor that occurs in hair-growing squamous epithelium and rarely metastasizes. In genetic studies, BCC patients have cell-cycle abnormalities of different parts of the signaling pathway. Retinoblastoma regulatory pathway is important in cell cycle arrest. In this pathway, p16INK4a, an inhibitor of Rb pathway, binds to CDK4 and CDK6 competitively with cyclin D1 to prevent phosphorylation of tumor suppressor pRB gene. Alteration of this pathway contributes to development of human cancers and also is effective in skin cancers. In this study, we analyzed mRNA expression using in situ RT-PCR and the role of immunohistochemical expression of p16INK4a in BCC.

Matched MeSH terms: Carcinoma, Basal Cell/genetics*; Carcinoma, Basal Cell/metabolism; Carcinoma, Basal Cell/pathology

Incidence of esophageal carcinoma among Malays in North-Eastern Peninsular Malaysia: an area with an exceptionally low prevalence of Helicobacter pylori infection

Lee YY, Raj SM, Sharif SE, Salleh R, Ayub MC, Graham DY

Dig Dis Sci, 2011 May;56(5):1438-43.

PMID: 21082350 DOI: 10.1007/s10620-010-1473-1

Obesity, gastroesophageal reflux, and Barrett's esophagus have all been linked to esophageal adenocarcinoma. In addition, the decline in Helicobacter pylori (H. pylori) infection in affluent societies has also been suggested to be a major factor in the recent rise in the incidence of esophageal adenocarcinoma. If H. pylori infection has a protective role, populations with a naturally low prevalence of H. pylori infection such as the ethnic Malays of Northeastern Peninsular Malaysia should have high rates of esophageal adenocarcinoma.

Matched MeSH terms: Carcinoma/complications; Carcinoma/ethnology; Carcinoma/epidemiology*

Invasive squamous cell carcinoma arising from chromoblastomycosis

Jamil A, Lee YY, Thevarajah S

Med Mycol, 2012 Jan;50(1):99-102.

PMID: 21449695 DOI: 10.3109/13693786.2011.571295

Chromoblastomycosis is a chronic subcutaneous mycosis seen mainly in tropical regions. While malignant transformation rarely occurs, the present report describes a 69-year-old man with a 21-year history of chromoblastomycosis complicated by invasive squamous cell carcinoma requiring amputation of the affected limb. A review of previous reported cases shows malignancy arising after 20-30 years of infection in ≥60-year-old males who have received inadequate treatment of chromoblastomycosis and have had relapses. An immunocompromised state is not an associated feature of such cases. The extremities are commonly affected as carcinomas occur from the most chronic lesions which are generally found on these limbs.

Matched MeSH terms: Carcinoma, Squamous Cell/diagnosis*; Carcinoma, Squamous Cell/pathology*; Carcinoma, Squamous Cell/surgery

Fulltext Diagnostic implications of miRNAs in Liquid Biopsy for Oral Squamous Cell Carcinoma (OSCC): Clinical validity and interpretation

Jayaraj R, Kumaraswamy C, Raymond G, Ravishankar Ram M, Govind SK, Chandramoorthy HC, et al.

Oral Oncol, 2020 10;109:104634.

PMID: 32171663 DOI: 10.1016/j.oraloncology.2020.104634

Matched MeSH terms: Carcinoma, Squamous Cell/blood; Carcinoma, Squamous Cell/diagnosis*; Carcinoma, Squamous Cell/genetics*

A systematic review and meta-analysis of immunohistochemical biomarkers that differentiate chromophobe renal cell carcinoma from renal oncocytoma

Ng KL, Morais C, Bernard A, Saunders N, Samaratunga H, Gobe G, et al.

J Clin Pathol, 2016 Aug;69(8):661-71.

PMID: 26951082 DOI: 10.1136/jclinpath-2015-203585

Numerous immunohistochemical (IHC) biomarkers have been employed to aid in the difficult differentiation between chromophobe renal cell carcinoma (chRCC) and renal oncocytoma (RO). A systematic review and meta-analysis of the published literature was carried out to summarise and analyse the evidence for discriminatory IHC biomarkers to differentiate the two entities.

Matched MeSH terms: Carcinoma, Renal Cell/diagnosis*; Carcinoma, Renal Cell/metabolism; Carcinoma, Renal Cell/pathology

Fulltext Inferior vena cava tumour thrombectomy by novel endovascular approach

Shahril, K., Reynu, R., Kosai, N.R., Bong, J.J., Rozman, Z., Yazmin, Y., et al.

Medicine & Health, 2015;10(2):151-155.

MyJurnal

The presence of thrombus within the inferior vena cava (IVC) is often a sign of advance hepatocellular carcinoma (HCC). Various treatment methods have been described with variable and inconclusive results. Now, the advancement of endovascular approach offers new possibility as a potential treatment modality. We discuss the removal of tumour thrombus with catheter directed mechanical thrombectomy. IVC tumour secondary HCC was removed by AngioJet® rheolytic system (Possis Medical, Minneapolis, MN, USA) with good result. Further work should be encouraged to explore the prospect of this technique with other treatment modalities.

Matched MeSH terms: Carcinoma, Hepatocellular

HBAg-positive chronic liver disease associated with cirrhosis and hepatocellular carcinoma in the Senoi

Sumithran E, Prathap K

Cancer, 1977 Oct;40(4):1618-20.

PMID: 198100

Necropsy and clinical data show that primary hepatocellular carcinoma (PHC) is the commonest cancer among the Senoi (a Malaysian aboringine group). The other aboringine tribes do not appear to have this high predilection for liver cancer. In the necropsy series, PHS was present in 10 out of 22 Senoi patients with cirrhosis. All the 22 livers contained hepatocytes that stained with Shikata's orcein stain and specific immunoperoxidase and immunofluorescent stains for hepatitis B antigen (HBAg). This observation raises the strong possibility that hepatitis B may be an important etiologic factor in the development of cirrhosis and PHC in the Senoi. The reason for the high susceptibility of the Senoi for HB virus infection is not clear, and the role of aflatoxin in the pathogenesis of PHC in the Senoi has yet to be determined. That the Senoi are a numerically small community, maintaining their own unique dietary and social customs and living in readily accessible areas in the Malaysian jungle, makes them an ideal population for the study of factors in the etiology of liver cancer.

Matched MeSH terms: Carcinoma, Hepatocellular/complications*; Carcinoma, Hepatocellular/immunology; Carcinoma, Hepatocellular/epidemiology

Fulltext Imaging and histopathology correlation of solid papillary carcinoma of the breast : a review of four cases.

Sharifah, M.I.A.

International Medical Journal Malaysia, 2015;14(1):93-97.

MyJurnal

Solid papillary breast carcinoma is a rare type of breast carcinoma. We present four cases which highlight the radiological and histological findings of solid papillary carcinoma. Mammogram supplemented with ultrasound played an important role in detecting solid papillary carcinomas which usually presents as intraductal lesions or intracystic mass with Doppler signal. Excision biopsy is a better option than core biopsy as the latter modality may not be representative and the diagnosis of solid papillary breast carcinoma may be missed.

Matched MeSH terms: Carcinoma, Papillary

Fulltext Prolonged survival of metastatic hepatocellular carcinoma: a case report

Zainal N, Hasbullah HH

J Gastrointest Oncol, 2018 Apr;9(2):E6-E8.

PMID: 29755781 DOI: 10.21037/jgo.2018.01.04

Management of hepatocellular carcinoma (HCC) generally follows EASL-EORTC clinical practise guideline. We report a case of a 50-year-old man who had multinodular HCC with lung metastases, whose management had deviated from the standard guideline but still survive 5 years after initial diagnosis.

Matched MeSH terms: Carcinoma, Hepatocellular

Fulltext Colonic metastasis from an invasive lobular carcinoma of the breast

Norfaidhi Akram, M.N., Samuel, T., Norly, S., Ros’aini, P.

Journal of Surgical Academia, 2017;7(2):37-38.

MyJurnal

Breast carcinoma to the colon and rectum is rare type of metastatic spread. We report a case of colonic metastasis
from a lobular carcinoma of the breast twelve years after the initial diagnosis. Accurate diagnosis and early treatment
of systemic therapy can be done if awareness is increased.

Matched MeSH terms: Carcinoma, Lobular

Fulltext Pedunculated hepatocellular carcinoma: distinguishing features from conventional hepatocellular carcinoma

Norzila, A.B., Wong, M.P.K.

International Medical Journal Malaysia, 2016;15(1):110-113.

MyJurnal

Malignant pedunculated (exophytic) hepatocellular carcinoma (P-HCC) is a rare entity of hepatocellular
carcinoma. Due to its unique characteristics, it gives a different spectrum of clinical findings, radiological
presentation and different management approach with reported better outcome to the patients. We
present a case report of a lady diagnosed with malignant pedunculated hepatocellular carcinoma.

Matched MeSH terms: Carcinoma, Hepatocellular

Synchronous papillary thyroid carcinoma and medullary thyroid carcinoma - a pitfall waiting to happen

Tang PY, Khor LY, Takano A

Malays J Pathol, 2017 Aug;39(2):171-174.

PMID: 28866700

Papillary thyroid carcinoma (PTC) is the most common thyroid carcinoma and is derived from thyroid follicular cells. In contrast, medullary thyroid carcinoma (MTC) is rare and originates from the parafollicular C-cells. Synchronous occurrence of these two carcinomas is uncommon and occurs as either discrete lesions or as a mixed lesion. The current case report describes a 50-year-old woman with synchronous multiple discrete MTC and PTC with lymph nodes metastasis. Pathologists and treating physicians should be aware of the synchronous coexistence of these entities to avoid possible misdiagnosis.

Matched MeSH terms: Carcinoma, Papillary/pathology*; Carcinoma, Neuroendocrine/pathology*

Fulltext Delayed surgery for localised and metastatic renal cell carcinoma: a systematic review and meta-analysis for the COVID-19 pandemic

Chan VW, Tan WS, Leow JJ, Tan WP, Ong WLK, Chiu PK, et al.

World J Urol, 2021 Dec;39(12):4295-4303.

PMID: 34031748 DOI: 10.1007/s00345-021-03734-1

PURPOSE: The COVID-19 pandemic has led to the cancellation or deferment of many elective cancer surgeries. We performed a systematic review on the oncological effects of delayed surgery for patients with localised or metastatic renal cell carcinoma (RCC) in the targeted therapy (TT) era.

METHOD: The protocol of this review is registered on PROSPERO(CRD42020190882). A comprehensive literature search was performed on Medline, Embase and Cochrane CENTRAL using MeSH terms and keywords for randomised controlled trials and observational studies on the topic. Risks of biases were assessed using the Cochrane RoB tool and the Newcastle-Ottawa Scale. For localised RCC, immediate surgery [including partial nephrectomy (PN) and radical nephrectomy (RN)] and delayed surgery [including active surveillance (AS) and delayed intervention (DI)] were compared. For metastatic RCC, upfront versus deferred cytoreductive nephrectomy (CN) were compared.

RESULTS: Eleven studies were included for quantitative analysis. Delayed surgery was significantly associated with worse cancer-specific survival (HR 1.67, 95% CI 1.23-2.27, p

Matched MeSH terms: Carcinoma, Renal Cell/mortality*; Carcinoma, Renal Cell/pathology; Carcinoma, Renal Cell/surgery*

Fulltext Metaplastic breast carcinoma with upper limb gangrene

Rajan R, Abdullah N, Abdullah NMA, Mohd Kassim AY

Breast Cancer (Dove Med Press), 2017;9:297-299.

PMID: 28496362 DOI: 10.2147/BCTT.S126909

Metaplastic breast carcinomas (MBCs) are rapidly growing tumors with histological heterogeneity, and triple negative receptor status. The aim of this case report is to highlight a case of advanced MBC with axillary artery infiltration leading to gangrene of the ipsilateral upper limb, in a young woman.

Matched MeSH terms: Carcinoma, Ductal, Breast

Fulltext Verrucous carcinoma of maxillary antrum

Indudharan R, Das PK, Thida T

Singapore Med J, 1996 Oct;37(5):559-61.

PMID: 9046219

Verrucous carcinoma of the paranasal sinuses is a rare malignant tumour. It occurs most frequently in the oral cavity and larynx. We present a case of extensive verrucous carcinoma of the maxillary sinus. This paper discusses the clinical and histological features and modes of treatment. All previous reports of verrucous carcinoma cases of paranasal sinuses are reviewed.

Matched MeSH terms: Carcinoma, Verrucous/diagnosis*; Carcinoma, Verrucous/pathology; Carcinoma, Verrucous/therapy

Fulltext Association of ABCG2 Polymorphisms on Triple Negative Breast Cancer (TNBC) Susceptibility Risk

Hao Ing Y, Md Salleh MS, Yahya MM, Ankathil R, Abdul Aziz AA

Asian Pac J Cancer Prev, 2023 Nov 01;24(11):3891-3897.

PMID: 38019248 DOI: 10.31557/APJCP.2023.24.11.3891

OBJECTIVE: The aim of this study was to elucidate the association of ATP-binding cassette super-family G member 2 (ABCG2) gene polymorphisms with individual susceptibility to Triple Negative Breast Cancer (TNBC) as well as clinicopathological variables in TNBC patients. Two common polymorphisms in Asian population, ABCG2 34 G>A and 421 C>A was selected in this study.

METHODS: Blood samples were collected from 75 TNBC patients and 83 controls. Genomic DNA was extracted from blood samples and the SNP genotyping was performed by using PCR-RFLP technique. The genotypes were characterized and grouped into homozygous wildtype, heterozygote and homozygous variant based on the band size. The result was subjected to statistical analysis.

RESULTS: The A allele and AA genotype of ABCG2 421 C>A had OR of 3.011 (p=0.003, 95% CI: 1.417-6.398) and 9.042 (p=0.011, 95% CI: 1.640-49.837), to develop advanced staging carcinoma respectively. The AA genotype of ABCG2 421 C>A polymorphism was also associated with metaplastic and medullary carcinoma with an OR of 6.429 (p=0.018, 95% CI: 1.373-30.109). A significant association was also found in haplotype 34G/421A of ABCG2 with advanced cancer staging as well as metaplastic and medullary carcinoma with OR of 2.347 (p=0.032, 95% CI: 1.010-5.560) and 2.546 (p=0.008, 95% CI: 1.005-6.447), respectively. Conclusion: The present study suggests that ABCG2 421 C>A polymorphism was associated with metaplastic and medullary histology and advanced cancer staging in TNBC patients.

Matched MeSH terms: Carcinoma, Medullary*; Carcinoma, Neuroendocrine*

Fulltext Multiple metastatic deposits in the head and neck region from a renal cell carcinoma

Ishak AI, Md Pauzi SH, Masir N, Goh BS

Malays J Med Sci, 2010 Oct;17(4):71-4.

PMID: 22135565 MyJurnal

Metastatic renal cell carcinoma (RCC) presenting with multiple deposits in the head and neck region is unusual. It is not uncommon for a RCC to metastasise to a distant site after years of a tumour-free period, but most of it would be expected to have a single site of deposit. We report a rare case of a patient who had a nephrectomy 10 years earlier for RCC and presented with tumours in the frontal sinus and posterior pharyngeal wall. Radiological imaging and histology confirmed metastatic RCC at both sites.

Matched MeSH terms: Carcinoma, Renal Cell

Fulltext Paraneoplastic neurological disorder in nasopharyngeal carcinoma

Ng SY, Kongg MH, Yunus MR

Malays J Med Sci, 2017 Mar;24(1):113-116.

PMID: 28381934 DOI: 10.21315/mjms2017.24.1.12

Paraneoplastic neurological disorder (PND) is a condition due to immune cross-reactivity between the tumour cells and the normal tissue, whereby the "onconeural" antibodies attack the normal host nervous system. It can present within weeks to months before or after the diagnosis of malignancies. Nasopharyngeal carcinoma is associated with paraneoplastic syndrome, for example, dermatomyositis, and rarely with a neurological disorder. We report on a case of nasopharyngeal carcinoma with probable PND. Otolaryngologists, oncologists and neurologists need to be aware of this condition in order to make an accurate diagnosis and to provide prompt treatment.

Matched MeSH terms: Carcinoma

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