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Fulltext Evaluation of Indonesian mangrove Xylocarpus granatum leaves ethyl acetate extract as potential anticancer drug

Darmadi J, Batubara RR, Himawan S, Azizah NN, Audah HK, Arsianti A, et al.

Sci Rep, 2021 Mar 16;11(1):6080.
PMID: 33727582 DOI: 10.1038/s41598-021-85383-3

Local Xylocarpus granatum leaves were extracted by ethyl acetate solvent and characterized by TLC fingerprinting and 2D 1H NMR spectroscopy to contain phenolic compounds as well as several organic and amino acids as metabolic byproducts, such as succinic acid and acetic acid. Traces of flavonoids and other non-categorized phenolic compounds exhibited intermediate antioxidant activity (antioxidant IC50 84.93 ppm) as well as anticancer activity against HeLa, T47D, and HT-29 cell lines; which the latter being most effective against HT-29 with Fraction 5 contained the strongest activity (anticancer IC50 23.12 ppm). Extracts also behaved as a natural growth factor and nonlethal towards brine shrimps as well as human adipose-derived stem cell hADSC due to antioxidative properties. A stability test was performed to examine how storage conditions factored in bioactivity and phytochemical structure. Extracts were compared with several studies about X. granatum leaves extracts to evaluate how ethnogeography and ecosystem factored on biologically active compounds. Further research on anticancer or antioxidant mechanism on cancer cells is needed to determine whether the extract is suitable as a candidate for an anticancer drug.

Matched MeSH terms: Adipose Tissue/metabolism
Fulltext Vitamin D status among postmenopausal Malaysian women

Rahman SA, Chee WS, Yassin Z, Chan SP

Asia Pac J Clin Nutr, 2004;13(3):255-60.
PMID: 15331337

Serum levels of 25-hydroxyvitamin D (25 (OH) D) were determined in 276 (103 Malays and 173 Chinese) postmenopausal women, aged 50 to 65 years. The level of 25 (OH) D was significantly lower in the postmenopausal Malay women (44.4 +/-10.6 nmol/L) compared to the Chinese women (68.8 +/- 15.7 nmol/L) (P<0.05). There were 27% Malay women with serum 25 (OH) D in the range of 50 - 100 nmol/L (defined as lowered vitamin D status, or hypovitaminosis D) and 71% with levels in the range of 25 - 50 nmol/L (defined as vitamin D insufficiency) compared to 87% and 11% Chinese women respectively. Serum 25 (OH) D was found to significantly correlate with BMI, fat mass and PTH level. Multivariate analyses showed that race has a strong association with vitamin D status. The high prevalence of inadequate levels of serum vitamin D found in our study may have important public health consequences and warrants the development of a strategy to correct this problem in the older adult Malaysian population.

Matched MeSH terms: Adipose Tissue/metabolism
Association of parental body mass index before pregnancy on infant growth and body composition: Evidence from a pregnancy cohort study in Malaysia

Zalbahar N, Jan Mohamed HJ, Loy SL, Najman J, McIntyre HD, Mamun A

Obes Res Clin Pract, 2016 09;10 Suppl 1:S35-S47.
PMID: 26321098 DOI: 10.1016/j.orcp.2015.08.002

BACKGROUND AND OBJECTIVES: Parental body mass index (BMI) is strongly linked with the development of offspring overweight and obesity. However, there are a limited number of studies focusing on the association of parental body mass index before pregnancy on offspring growth and body composition in early life, particularly in developing countries.
METHODS: Data from the University Sains Malaysia (USM) Pregnancy Cohort which consists of 153 mother-offspring pairs were used. Data were collected using interview-administered questionnaires and anthropometric measurements were also obtained. Multiple linear regression and generalised equation estimation (GEE) were used to examine the direction and impact of the association between parental BMI and child growth and body composition (weight for age, height for age, body mass index for age, weight for height and fat mass at age 2m, 6m, and 12m). Potential confounders, including validated measures of maternal diets and physical activity during pregnancy, were considered.
RESULTS: Of 153 parents, one-quarter of the mothers and 42.2% of the fathers, respectively, were overweight or obese before pregnancy. A significant association was found between maternal BMI and child's weight for height z-score (WHZ) and body mass index for age z-score (BAZ).
CONCLUSIONS: Having high pre-pregnancy BMI may increase BMI and WAZ of offspring in early life. Findings from this study emphasise the importance of monitoring maternal weight status, particularly before and during pregnancy and early life of offspring among Malaysians.

Matched MeSH terms: Adipose Tissue
Fulltext Treatment of spinal cord injury with mesenchymal stem cells

Liau LL, Looi QH, Chia WC, Subramaniam T, Ng MH, Law JX

Cell Biosci, 2020;10:112.
PMID: 32983406 DOI: 10.1186/s13578-020-00475-3

Background: Spinal cord injury (SCI) is the damage to the spinal cord that can lead to temporary or permanent loss of function due to injury to the nerve. The SCI patients are often associated with poor quality of life.
Results: This review discusses the current status of mesenchymal stem cell (MSC) therapy for SCI, criteria to considering for the application of MSC therapy and novel biological therapies that can be applied together with MSCs to enhance its efficacy. Bone marrow-derived MSCs (BMSCs), umbilical cord-derived MSCs (UC-MSCs) and adipose tissue-derived MSCs (ADSCs) have been trialed for the treatment of SCI. Application of MSCs may minimize secondary injury to the spinal cord and protect the neural elements that survived the initial mechanical insult by suppressing the inflammation. Additionally, MSCs have been shown to differentiate into neuron-like cells and stimulate neural stem cell proliferation to rebuild the damaged nerve tissue.
Conclusion: These characteristics are crucial for the restoration of spinal cord function upon SCI as damaged cord has limited regenerative capacity and it is also something that cannot be achieved by pharmacological and physiotherapy interventions. New biological therapies including stem cell secretome therapy, immunotherapy and scaffolds can be combined with MSC therapy to enhance its therapeutic effects.

Matched MeSH terms: Adipose Tissue
Fulltext The Potential of Mesenchymal Stromal Cell as Therapy in Neonatal Diseases

Liau LL, Al-Masawa ME, Koh B, Looi QH, Foo JB, Lee SH, et al.

Front Pediatr, 2020;8:591693.
PMID: 33251167 DOI: 10.3389/fped.2020.591693

Mesenchymal stromal cells (MSCs) can be derived from various tissue sources, such as the bone marrow (BMSCs), adipose tissue (ADSCs), umbilical cord (UC-MSCs) and umbilical cord blood (UCB-MSCs). Clinical trials have been conducted to investigate the potential of MSCs in ameliorating neonatal diseases, including bronchopulmonary dysplasia (BPD), intraventricular hemorrhage (IVH) and necrotizing enterocolitis (NEC). In preclinical studies, MSC therapy has been tested for the treatment of various neonatal diseases affecting the heart, eye, gut, and brain as well as sepsis. Up to date, the number of clinical trials using MSCs to treat neonatal diseases is still limited. The data reported thus far positioned MSC therapy as safe with positive outcomes. However, most of these trials are still preliminary and generally smaller in scale. Larger trials with more appropriate controls and a longer follow-up period need to be conducted to prove the safety and efficacy of the therapy more conclusively. This review discusses the current application of MSCs in treating neonatal diseases, its mechanism of action and future direction of this novel therapy, including the potential of using MSC-derived extracellular vesicles instead of the cells to treat various clinical conditions in the newborn.

Matched MeSH terms: Adipose Tissue
Fulltext Aqua zumba versus aqua jogging: comparative effects on health parameters among obese middle aged women

Sarina Md. Yusof, Maisarah Shari, Zulkifli Kadir, Aishah Adam, Teh, Lay Kek, Suhana Aiman, et al.

Movement Health & Exercise, 2018;7(2):11-21.
MyJurnal

Background: Obesity is major contributor to diseases and mortality. Constant weight loss significantly reverses diseases related to obesity and helps prolong human life expectancy. To date, there has been limited scientific evidence comparing the effectiveness of the Aqua Zumba® Fitness program and conventional aqua jog among obese women. Thus, the purpose of this study is to compare the effects between 12 weeks of Aqua Zumba® Fitness and aqua jog on health parameters among middle-age women. Methods: A total of sixty sedentary obese women (BMI >30 kg/m2), aged 40-59 years old were randomized to either Aqua Zumba® Fitness (AZ, n=20), aqua jog (AJ, n=20) or control group (C, n=20). Exercise groups were involved in different 12-week aqua exercise programs, 3 times per week, 60 minutes per session, with an intensity of 50-75% of maximum heart rate. Body mass (BM), skeletal muscle mass (SMM), body fat percentage (BF%), waist circumference (WC), upper and lower body strength (UBS and LBS), cardiorespiratory fitness (CRF), and flexibility were measured at baseline (week-0) and post-exercise intervention (week-13). Result: The AZ group demonstrated significant changes (p

Matched MeSH terms: Adipose Tissue
Comparison of the effectiveness of online and face-to-face weight-loss interventations in the workplace: evidence from Malaysia

Roszanadia Rusali, Zahara Abdul Manaf, Suzana Shahar, Fatin Hanani Mazri, Norhayati Ibrahim, Arimi Fitri Mat Ludin, et al.

Sains Malaysiana, 2018;47:2437-2445.

A structured weight management programme at a workplace may help in reducing the prevalence of overweight and obesity.
Therefore, this intervention study was to determine the effectiveness of weight loss programmes including face-to-face,
online and control group at workplace among employees who are overweight and obese. A total of 108 overweight and
obese adults were recruited and randomly divided into three groups (face-to-face group (FT), n=38; online group (OG),
n=31; control group (CG), n=39). In the FT group, the participants took part in health talks, interactive activities and
counselling; the OG group was given access to an online weight management program and the CG group was provided
with educational booklets on weight loss. All information given was related to nutrition, physical activity and motivation
to reduce weight. Body weight, body mass index (BMI), waist circumference (WC), body fat percentage, dietary intake,
fasting lipid profile and glucose levels were assessed at baseline and 4 months. The FT group showed greater reduction
in body weight (-5.80 kg) compared to OG (-1.12 kg) and CG (-1.82 kg). Significant interaction effects were found for BMI,
WC, fasting serum triglycerides, HDL-cholesterol and total cholesterol/HDL-cholesterol ratio (all p<0.05), with the FT
group showing the biggest improvements, compared to the other groups. The face-to-face weight management program
offered in the workplace showed to be the most effective at improving anthropometric profile, fasting serum triglycerides,
HDL-C, total cholesterol/HDL-C ratio, and dietary intake among overweight and obese employees.

Matched MeSH terms: Adipose Tissue
Fulltext Ultra-processed food consumption in relation to BMI and body fat percentage of adults in Terengganu

Asma’ Ali, Nurul Atiqah Khasbullah, Fauziah Tufail Ahmad, Hayati Mohd Yusof

Malaysian Journal of Medicine and Health Sciences, 2020;16(1):37-43.
MyJurnal

Introduction: There is an emergent increase of ultra-processed food consumption in developing countries including Malaysia which carries a likelihood towards the increase of obesity. However, few studies have been done in relating between ultra-processed consumption and obesity, especially in Malaysia. Therefore, this study aims to determine the consumption of ultra-processed foods and its relationship with BMI and body fat percentage among university committee in Kuala Nerus, Terengganu. Methods: A cross-sectional study was performed among 167 individuals aged 18 to 59 years old in Kuala Nerus. Data were collected using a researcher-administered questionnaire which consisted of three different sections: socio-demographic profile, two days 24-hour dietary recall, and nutritional status assessment on BMI and body fat percentage. Consumption of ultra-processed foods were determined by classifying two days 24-hour dietary recall based on ultra-processed food classification. Data were analyzed using SPSS version 21.0 with p

Matched MeSH terms: Adipose Tissue
Fulltext Leptin: a pleitropic factor in physiology

Fayez A Almabhouh, Faizatul Isyraqiah Ahmad Muhammad, Hisham Ibrahim, Harbindarjeet Singh

Journal of Clinical and Health Sciences, 2019;4(2):31-57.
MyJurnal

Leptin, a 16 kDa protein and a product of the ob/ob gene, has a tertiary structure similar to that
of a cytokine. It is primarily secreted by white adipose tissue and its levels in the blood correlate
positively with percentage body fat. Leptin was first identified in 1994 as a major factor that
regulated food intake and energy balance. Leptin in the circulation exists either as a free
monomeric hormone or bound to its soluble receptor. Its serum levels usually range from 0.5 to
37.7 ng/ml in males and 2.0 to 45.2 ng/ml in females. The half-life of leptin is between 20 - 30
minutes and it is eliminated mainly by the kidneys. However, research over the last 25 years
has revealed numerous other physiological roles for leptin, including roles in inflammation,
immune function, neuro-endocrine function, bone metabolism, blood pressure regulation and
sexual maturation. Most of these roles have been identified from studies on leptin deficient
rodents. Apart from energy balance and sexual maturation, where its role is direct and obvious,
its actions on the rest of the other systems are permissive. Actions of leptin are both centrally
and peripherally mediated involving receptors that are widely distributed in the body. Six leptin
receptor isoforms, belonging to the class 1 cytokine receptor family, have been identified.
These receptors are products of the OBR gene. The cellular actions of leptin are mediated
through any one of five different signalling pathways that include the JAK-STAT, PI3K, MAPK,
AMPK, and the mTOR signalling pathways.

Matched MeSH terms: Adipose Tissue, White
Fulltext Prevalence of overweight and obesity among primary healthcare workers in Perak, Malaysia

Low, Pei Kit, Hazizi Abu Saad, Rosita Jamaluddin, Chee, Huei Phing

IIUM Medical Journal Malaysia, 2020;19(1):23-30.
MyJurnal

Introduction: Overweight and obesity has been emerging as one of the most common and preventable
nutritional problems worldwide. In 2016, 39% and 13% of the adult population worldwide was classified as
overweight and obese, respectively. Materials and Methods: We conducted a cross-sectional study at 12
selected health clinics in Perak, Malaysia, and we used multi-stage cluster random sampling to determine the
prevalence of overweight and obesity among the primary healthcare workers and the associate factors of
obesity indices. Each respondent was required to complete a self-administered questionnaire on their sociodemographic characteristics. In addition, we took anthropometric measurements, including height, weight,
BMI, waist circumference, and body fat percentage, of the participants. Results: We recruited 261 primary
healthcare workers. Overall, 49.9% of the healthcare workers were overweight or obese, 51.0% were at risk
of having abdominal obesity, and 79.6% had a high body fat percentages. Age and self-reported health status
were significantly associated with all the obesity indices. Educational level showed significant association
with BMI and waist circumference, while occupational status showed an association only with BMI. Older age
and professionals were predictors for high obesity indices. Conclusion: The prevalence of obesity among the
primary healthcare workers was higher than among the general population. An immediate intervention
programme is needed to reduce the prevalence of overweight and obesity among primary healthcare
workers.

Matched MeSH terms: Adipose Tissue
Fulltext Infrapatellar fat pad resection or preservation during total knee arthroplasty: a meta-analysis of randomized controlled trials

Sun C, Zhang X, Lee WG, Tu Y, Li H, Cai X, et al.

J Orthop Surg Res, 2020 Aug 05;15(1):297.
PMID: 32758250 DOI: 10.1186/s13018-020-01823-2

BACKGROUND: The infrapatellar fat pad (IPFP) or Hoffa's fat pad is often resected during total knee arthroplasty in order to improve visibility. However, the management of the IPFP during total knee arthroplasty (TKA) is the subject of an ongoing debate that has no clear consensus. The purpose of this review was to appraise if resection of the IPFP affects clinical outcomes.
METHODS: We conducted a meta-analysis to identify relevant randomized controlled trials involving infrapatellar fat pad resection and infrapatellar fat pad preservation during total knee arthroplasty in electronic databases, including Web of Science, Embase, PubMed, Cochrane Controlled Trials Register, Cochrane Library, Highwire, CBM, CNKI, VIP, and Wanfang database, up to March 2020.
RESULTS: Nine randomized controlled trials, involving 783 TKAs (722 patients), were included in the systematic review. Outcome measures included patellar tendon length (PTL), Insall-Salvati ratio (ISR), rate of anterior knee pain, Knee Society Scores (KSS), and knee range of motion. The meta-analysis identified a trend toward the shortening of the patellar tendon with IPFP resection at 6 months (P = 0.0001) and 1 year (P = 0.001). We found no statistical difference in ISR (P = 0.87), rate of anterior knee pain within 6 months (p = 0.45) and 1 year (p = 0.38), KSS at 1 year (p = 0.77), and knee range of motion within 6 months (p = 0.61) and 1 year (0.46).
CONCLUSION: Based on the available level I evidence, we were unable to conclude that one surgical technique of IPFP can definitively be considered superior over the other. More adequately powered and better-designed randomized controlled trial (RCT) studies with long-term follow-up are required to produce evidence-based guidelines regarding IPFP resection.

Matched MeSH terms: Adipose Tissue
Fulltext Determinants of metabolic syndrome among Malaysian government employees

Chee, Huei Phing, Hazizi Abu Saad, Barakatun Nisak Mohd Yusof, Mohd Nasir Mohd Taib

International Medical Journal Malaysia, 2018;17(1):87-92.
MyJurnal

Introduction: The metabolic syndrome comprises a collection of cardiovascular disease risks, which has been demonstrated to predict type 2 diabetes mellitus and cardiovascular disease. Metabolic syndrome is a crucial health concern in Malaysia, with a prevalence of about 42.5% in the general population based on the ‘Harmonized’ definition. The aim of this study was to ascertain the association between socioeconomic status among Malaysian government employees with metabolic syndrome, compared with those without metabolic syndrome. Furthermore, this study also aimed to ascertain the associated obesity indicators for metabolic syndrome among employees—explicitly body mass index, waist circumference, waist-to-hip ratio, body fat percentage, fat mass index, and waist-to-height ratio. Methods: This cross-sectional study was
undertaken at government agencies in Putrajaya, Malaysia, via multi-stage random sampling. A total of 675 government employees were randomly sampled from a list of 3,173 government employees working in five government agencies under five geographical areas. Data on socioeconomic status, anthropometric, biochemical, and clinical assessments were collected. Results: Employees who were males had higher metabolic syndrome prevalence compared to their counterparts (p=0.019). In addition, employees aged between 20 to younger than 30 years had lowest metabolic syndrome prevalence (p=0.002). The risk of having metabolic syndrome was almost 10 times more likely in men with a waist-to-hip ratio of ≥0.90 compared to men with a waist-to-hip ratio of

Matched MeSH terms: Adipose Tissue
Celastrol attenuates inflammatory responses in adipose tissues and improves skeletal muscle mitochondrial functions in high fat diet-induced obese rats via upregulation of AMPK/SIRT1 signaling pathways

Abu Bakar MH, Shariff KA, Tan JS, Lee LK

Eur J Pharmacol, 2020 Sep 15;883:173371.
PMID: 32712089 DOI: 10.1016/j.ejphar.2020.173371

Accumulating evidence indicates that adipose tissue inflammation and mitochondrial dysfunction in skeletal muscle are inextricably linked to obesity and insulin resistance. Celastrol, a bioactive compound derived from the root of Tripterygium wilfordii exhibits a number of attributive properties to attenuate metabolic dysfunction in various cellular and animal disease models. However, the underlying therapeutic mechanisms of celastrol in the obesogenic environment in vivo remain elusive. Therefore, the current study investigated the metabolic effects of celastrol on insulin sensitivity, inflammatory response in adipose tissue and mitochondrial functions in skeletal muscle of the high fat diet (HFD)-induced obese rats. Our study revealed that celastrol supplementation at 3 mg/kg/day for 8 weeks significantly reduced the final body weight and enhanced insulin sensitivity of the HFD-fed rats. Celastrol noticeably improved insulin-stimulated glucose uptake activity and increased expression of plasma membrane GLUT4 protein in skeletal muscle. Moreover, celastrol-treated HFD-fed rats showed attenuated inflammatory responses via decreased NF-κB activity and diminished mRNA expression responsible for classically activated macrophage (M1) polarization in adipose tissues. Significant improvement of muscle mitochondrial functions and enhanced antioxidant defense machinery via restoration of mitochondrial complexes I + III linked activity were effectively exhibited by celastrol treatment. Mechanistically, celastrol stimulated mitochondrial biogenesis attributed by upregulation of the adenosine monophosphate-activated protein kinase (AMPK) and sirtuin 1 (SIRT1) signaling pathways. Together, these results further demonstrate heretofore the conceivable therapeutic mechanisms of celastrol in vivo against HFD-induced obesity mediated through attenuation of inflammatory response in adipose tissue and enhanced mitochondrial functions in skeletal muscle.

Matched MeSH terms: Adipose Tissue/drug effects*; Adipose Tissue/enzymology; Adipose Tissue/physiopathology
Molecular mechanism of down-regulating adipogenic transcription factors in 3T3-L1 adipocyte cells by bioactive anti-adipogenic compounds

Guru A, Issac PK, Velayutham M, Saraswathi NT, Arshad A, Arockiaraj J

Mol Biol Rep, 2021 Jan;48(1):743-761.
PMID: 33275195 DOI: 10.1007/s11033-020-06036-8

Obesity is growing at an alarming rate, which is characterized by increased adipose tissue. It increases the probability of many health complications, such as diabetes, arthritis, cardiac disease, and cancer. In modern society, with a growing population of obese patients, several individuals have increased insulin resistance. Herbal medicines are known as the oldest method of health care treatment for obesity-related secondary health issues. Several traditional medicinal plants and their effective phytoconstituents have shown anti-diabetic and anti-adipogenic activity. Adipose tissue is a major site for lipid accumulation as well as the whole-body insulin sensitivity region. 3T3-L1 cell line model can achieve adipogenesis. Adipocyte characteristics features such as expression of adipocyte markers and aggregation of lipids are chemically induced in the 3T3-L1 fibroblast cell line. Differentiation of 3T3-L1 is an efficient and convenient way to obtain adipocyte like cells in experimental studies. Peroxisome proliferation activated receptor γ (PPARγ) and Cytosine-Cytosine-Adenosine-Adenosine-Thymidine/Enhancer-binding protein α (CCAAT/Enhancer-binding protein α or C/EBPα) are considered to be regulating adipogenesis at the early stage, while adiponectin and fatty acid synthase (FAS) is responsible for the mature adipocyte formation. Excess accumulation of these adipose tissues and lipids leads to obesity. Thus, investigating adipose tissue development and the underlying molecular mechanism is important in the therapeutical approach. This review describes the cellular mechanism of 3T3-L1 fibroblast cells on potential anti-adipogenic herbal bioactive compounds.

Matched MeSH terms: Adipose Tissue/drug effects; Adipose Tissue/metabolism; Adipose Tissue/pathology
The interaction between energy intake, physical activity and UCP2 -866G/A gene variation on weight gain and changes in adiposity: an Indonesian Nutrigenetic Cohort (INDOGENIC)

Muhammad HFL, Sulistyoningrum DC, Huriyati E, Lee YY, Muda WAMW

Br J Nutr, 2021 03 28;125(6):611-617.
PMID: 32746947 DOI: 10.1017/S0007114520003104

The present study aimed to investigate an interaction between energy intake, physical activity and UCP2 gene variation on weight gain and adiposity changes in Indonesian adults. This is a prospective cohort study conducted in 323 healthy adults living in the city of Yogyakarta, Indonesia. Energy intake, physical activity, body weight, BMI, percentage body fat and waist:hip ratio (WHR) were measured at baseline and after 2 years while UCP2 -866G/A gene variation was determined at baseline. We reported that after 2 years subjects had a significant increment in body weight, BMI, body fat and reduction in WHR (all P < 0·05). In all subjects, total energy intake was significantly correlated with changes in body weight (β = 0·128, P = 0·023) and body fat (β = 0·123, P = 0·030). Among subjects with the GG genotype, changes in energy intake were positively correlated with changes in body weight (β = 0·232, P = 0·016) and body fat (β = 0·201, P = 0·034). These correlations were insignificant among those with AA + GA genotypes (all P > 0·05). In summary, we show that UCP2 gene variation might influence the adiposity response towards changes in energy intake. Subjects with the GG genotype of UCP2 -866G/A gene were more responsive to energy intake, thus more prone to weight gain due to overeating.

Matched MeSH terms: Adipose Tissue
Fulltext A Study on the Nutritional Status of Physically Active Men in Kota Bharu

Malays J Nutr, 2003;9(2):-.
MyJurnal

A cross-sectional comparative study was conducted to determine the nutritional status among physically active groups in Kota Bharu. The study population comprised 83 adult male athletes from 8 different types of sports (athlete group), 80 active men who exercised a minimum of 30 min per day for at least 3 times per week (exercise group), and 80 inactive men (sedentary group). All the respondents were aged between 18 to 44 years. Measurements taken from the respondents were anthropometric measurements, systolic (SBP) and diastolic (DBP) blood pressure, and serum total cholesterol (TC). The results showed that the combined prevalence of pre-obese (BMI 25.0-29.9) and obese (BMI Â¡Ã30.0) was 21.7% in athletes, 29.9% in exercise group, and 47.5% in sedentary group. The mean (Â± SD) percentage of body fat in athletes was 15.7 Â± 5.4%, which was lower compared to the exercise (18.9 Â± 5.5%) and sedentary (20.6 Â± 5.8%) groups. The incidence of waist-to-hip ratio above 0.9 in athlete, exercise and sedentary groups was 9.6%, 18.7% and 31.3%, respectively. The incidence of hypertension (SBP Â¡Ã140 and/or DBP Â¡Ã90 mmHg) was 13.2% in athletes, 17.5% in exercise group and 42.5% in the sedentary group. The TC values showed that the prevalence of â€œhigh riskâ€ individuals (TC Â¡Ã6.20 mmol/l) was also lower in athletes (20.5%), compared to the exercise (36.2%) and sedentary (47.5%) groups. The study revealed that individuals who are actively involved in physical activity, particularly in sport activities have better nutritional status compared to sedentary people. However, the nutritional status in the athlete and exercise groups was still unsatisfactory. The incidence of poor health status related to over nutrition in the active groups was rather high and needs attention from health professionals. Further studies are needed to determine nutritional practices among physically active groups.

Matched MeSH terms: Adipose Tissue
Fulltext A randomised controlled trial of a facebook-based physical activity intervention for government employees with metabolic syndrome

Chee, H.P., Hazizi, A.S., Barakatun Nisak, M.Y., Mohd Nasir, M.T.

Malays J Nutr, 2014;20(2):165-181.
MyJurnal

Introduction: This study aimed to ascertain the effects of a Facebook-based physical activity intervention on improvements in step counts and metabolic syndrome. Methods: Government employees with metabolic syndrome were randomly assigned by cluster to the Facebook group (n = 44) or the control group (n = 103). All participants were asked to complete self-administered questionnaires at baseline, after the first and second phases. Data from anthropometric (weight, body mass index, fat mass, body fat percentage, waist circumference, hip circumference and waist-to-hip ratio), biochemical (total cholesterol, HDL cholesterol, LDL cholesterol, triglycerides and fasting glucose) and clinical examinations (systolic blood pressure and diastolic blood pressure) were collected. The number of steps per day was determined by a Lifecorder e- STEP accelerometer. Results: A significant difference in the number of steps per day between the baseline and the first phase (p

Matched MeSH terms: Adipose Tissue
Fulltext Body fat percentage distribution of an orang asli group (aborigines) in Cameron Highlands, Malaysia

Azuwani, A.R., Noor Khairiah, K., Cheong, Y.Z., Kok, C.C., Aw, N.S.L., Nadiah Mhd, S., et al.

Malays J Nutr, 2013;19(2):205-214.
MyJurnal

Background: Although body fat percentage (BFP) is a widely accepted indicator of total body fat, it has not been extensively used in studies conducted among the Orang Asli in Peninsular Malaysia. Objective: This study was undertaken to determine the BFP distribution in a group of Orang Asli adults living in Cameron Highlands, Malaysia. Methods: Kampung Sungai Ruil, one of the Orang Asli settlements in Cameron Highlands, was conveniently selected for this crosssectional study. A total of 138 respondents aged 18 years and above were assessed. Skinfold thickness was measured using the Slim Guide skinfold caliper to calculate BFP. Waist circumference, BMI, blood pressure and random plasma glucose were also measured. Results: The mean BFP of the females (29.7%) was higher than the males (18.9%) and the respondents with abdominal obesity (36.2%) had higher mean BFP compared to those with normal waist circumference (23.7%) Those in the age group of 18-28 years old (22.1%) had lower BFP than
respondents in the age groups 29-39 years old (27.3%) and 40-50 years old (29.1%) (p=

Matched MeSH terms: Adipose Tissue
Fulltext The effect of increased consumption of edible palm oil on the nutritional status, lipid profiles and lipid peroxidation among Malaysian aborigines

Iskandar Zulkarnain Alias, Zaleha Md. Isa, Osman Ali, Khalid Abdul Kadir

Malays J Nutr, 2002;8(2):137-156.
MyJurnal

This study was conducted to determine the effects of increased edible palm oil consumption on community health status in the aboriginal communities in Tual Post (treatment group) and Sinderut Post (control group), Kuala Lipis, Pahang. Nutritional status, blood pressure, lipid profiles, fasting blood glucose (FBG), vitamin E (alpha-tocopherol) levels and lipid peroxidation product (malonaldehyde) levels were taken as indicators of health status. This is a pre-and post-controlled community trial in which similar variables were measured in each group. Every family of 2–6 household members was given 2–5 kg cooking palm oil per month for a period of 18 months. All subjects were measured for height (cm), weight (kg) and waist-hip ratio (WHR). For calorie intake measurement, house-to-house interviews were conducted using 24-hour dietary recall method. Blood pressure, percent body fat, lipid profiles, namely total cholesterol, high density lipoprotein cholesterol, triglyceride and fasting blood glucose (FBG) were also measured. Vitamin E (alpha-tocopherol) levels and lipid peroxidation products (MDA) were also determined. There was a significant increase (p

Matched MeSH terms: Adipose Tissue
Fulltext Association between anthropometric status, dietary intake and physical activity with bone health status among premenopausal Chinese women in the Klang Valley, Malaysia

Yee, Y.S.S., Zaitun, Y., Chan, Y.M., Norhaizan, M.E.

Malays J Nutr, 2013;19(3):293-302.
MyJurnal

Introduction: There is a lack of information on bone health status of premenopausal women in Malaysia. This study investigated the bone health status of premenopausal women and its associations with anthropometric, dietary and physical activity. Methods: Bone mineral density (BMD) was measured using dual X-ray absorptiometry (DEXA) at the lumbar spine, femoral neck, total hip and total body. Serum osteocalcin, parathyroid hormone (PTH), beta-crosslaps were also determined. Results: A total of 73 Chinese premenopausal women were recruited in the study with a mean age of 39.3 ± 5.0 years. Average BMI, body fat percentage and lean body mass were 22.2 ± 3.4 kg/m2, 33.9 ± 4.6% and 34.5 ± 4.4 kg, respectively. Mean BMD at the spine, total hip, femoral neck, and total body were 1.025 ± 0.118 g/cm2, 0.876 ± 0.109 g/cm2, 0.739 ± 0.110 g/cm2, and 1.061 ± 0.755 g/cm2, respectively. Their serum beta-crosslaps and PTH were within normal range, but serum osteocalcin (8.5 ± 4.2 ng/ ml) was low. On average, calorie intake (1506 ± 427 kcal/ day) was below the Malaysian Recommended Nutrient Intake (RNI) while their calcium intake achieved only 67% of RNI. Their mean metabolic equivalent score (MET) was 771.4 ± 926.1 min/week. Body weight and related indices (BMI, lean mass, fat mass) were significantly positively correlated with BMD at all skeletal sites. Conclusion: The study revealed that Chinese premenopausal women in the Klang Valley have low calcium intake and low level of physical activity.

Matched MeSH terms: Adipose Tissue

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