MyMedR

Birthweight and early neonatal health: Bangladesh perspective

Ullah A, Barman A, Haque J, Khanum M, Bari I

Paediatr Perinat Epidemiol, 2009 Nov;23(6):542-7.

PMID: 19840290 DOI: 10.1111/j.1365-3016.2009.01063.x

It has been suggested that a birthweight limit of 2.5 kg should not be regarded as valid for all populations as the cut-off point of low-weight births because of demographic, genetic and environmental differences. Countries often choose alternative cut-off values for low birthweight for clinical purposes. Bangladesh also needs to choose a convenient cut-off value for low birthweight. A total of 770 live singleton full-term normal newborns were included in this study by stratified sampling; birthweight was measured using the Detecto-type baby weight machine. Newborns were followed up to the end of their first week of life. For data collection a pretested structured questionnaire and an Apgar Score estimating checklist were used. Chi-square test was applied to assess the association of different birthweight strata and neonatal health outcomes. Multiple logistic regression analyses were carried out to identify the independent effects of different levels of birthweight on early neonatal health. The neonates having birthweight < or = 2 kg had a significantly higher risk of early neonatal mortality and morbidity than the higher level birthweight group. Birth asphyxia was the commonest cause of early neonatal mortality and morbidity. Borderline birthweight (>2 to <2.5 kg) neonates experienced the same mortality and morbidity rates as the normal birthweight neonates during their early neonatal life. Birthweight < or = 2 kg may be one of the criteria for admission to a neonatal intensive care unit whereas more than 2 kg may not require admission unless otherwise necessary.

Matched MeSH terms: Infant, Newborn; Infant, Newborn, Diseases/mortality*

Fulltext Neonatal group B beta-haemolytic streptococcal infection in Kuala Lumpur

Minhaj AA, Jamal F, Mohamed R

Med J Malaysia, 1980 Dec;35(2):117-21.

PMID: 7022149

First six cases of neonatal group B beta-haemolytic streptococcal sepsis in GHKL & Maternity Hospital K.L. were reported and in one third, it was fatal. Five of the cases were 'early - onset' type and one was 'late - onset' type. While maternal infant transmission of the disease is important in the 'early - onset' type, environmental sources of infection are also significant. No gestational age or birthweight is spared from the disease. Finally, there are cases of 'early - onset' GBS sepsis presenting like hyaline membrane disease of the newborn and it is important to find ways to distinguish them which so far has not been satisfactory.

Matched MeSH terms: Infant, Newborn; Infant, Newborn, Diseases/diagnosis*

Fulltext Timing of antenatal tetanus immunization for effective protection of the neonate

Chen ST, Edsall G, Peel MM, Sinnathuray TA

Bull World Health Organ, 1983;61(1):159-65.

PMID: 6601539

The relationship between the timing of maternal tetanus toxoid immunization and the presence of protective antitoxin in placental cord blood was investigated among women admitted to the obstetrical service of the University Hospital in Kuala Lumpur, Malaysia. The 1st dose was given between 13-39 weeks of gestation, with a median of 29 weeks. The 2nd dose was given an average of 4 weeks later. Protection was conferred on 80% or more of newborns whose mothers received their 1st tetanus toxoid injection 60 days or more before delivery. Protective levels were seen in all cord blood samples from infants whose mothers had received their 1st injection 90 days before delivery. Similarly,protective titers were found in 100% of cord blood samples when the 2nd maternal injection was give 60 days or more before delivery. There was no significant degree of protection when immunization was carried out less than 20 days before delivery. A single-dose schedule provided no protection when less than 70 days before delivery. Cord and maternal antiotoxin titers differed by no more than 1 2-fold dilution for almost all of the individual paired sera. A cord: maternal antitoxin ratio of 2 was more likely to occur with increasing time between the 2nd injection and delivery. Overall, these findings indicate that the 1st injection of a 2-dose maternal tetanus toxoid schedule should be given at least 60 days and preferably 90 days before delivery.

Matched MeSH terms: Infant, Newborn; Infant, Newborn, Diseases/prevention & control*

Fulltext A case of neonatal meningitis caused by Acinetobacter calcoaceticus var anitratus

Lim VKE, Talib S

Med J Malaysia, 1982 Mar;37(1):11-3.

PMID: 6981750

A case of neonatal meningitis caused by an unusual organism, Acinetobacter calcoaceticus var anitratus is reported. The source of the meningitis is probably a scalp abscess caused by the same organism. This patient was successfully treated with cotrimoxazole. Infections caused by Acinetobacter are rare and are briefly reviewed in this article

Matched MeSH terms: Infant, Newborn; Infant, Newborn, Diseases/diagnosis*

Fulltext An unsuspected danger in oxygen administration

Kuhan N, Abidin Z, Koh KH

Med J Malaysia, 1981 Mar;36(1):37-8.

PMID: 7321936

Matched MeSH terms: Infant, Newborn; Infant, Newborn, Diseases/therapy*

Overview of the problems of the small birth weight baby in Singapore

Wong HB

J Singapore Paediatr Soc, 1986;28(1-2):104-11.

PMID: 3762069

Matched MeSH terms: Infant, Newborn; Infant, Newborn, Diseases/epidemiology

The traditional birth attendant and neonatal tetanus: the Malaysian experience

Chen PC

J Trop Pediatr Environ Child Health, 1976 Dec;22(6):263-4.

PMID: 1051832

Matched MeSH terms: Infant, Newborn; Infant, Newborn, Diseases/etiology*

Group B streptococci in a maternity unit

Jamal F, Mohamed R, Zainal Z, Arshat H

Med J Malaysia, 1979 Jun;33(4):349-51.

PMID: 574917

Matched MeSH terms: Infant, Newborn; Infant, Newborn, Diseases/microbiology*

Neonatal hyperbilirubinaemia

Sinniah D

Med J Malaya, 1971 Mar;25(3):211-4.

PMID: 4253249

Matched MeSH terms: Infant, Newborn; Infant, Newborn, Diseases/epidemiology*

Spontaneous bowel perforation after exchange transfusion

Ong HT, Kamath KR

Med J Malaysia, 1973 Sep;28(1):32-4.

PMID: 4273780

Matched MeSH terms: Infant, Newborn; Infant, Newborn, Diseases/etiology*

Oxygen therapy and pulmonary fibroplasia: a review and case reports

Chew DT, Yin AL

Med J Malaya, 1971 Dec;26(2):122-8.

PMID: 4260858

Matched MeSH terms: Infant, Newborn; Infant, Newborn, Diseases/therapy*

Fulltext Effectiveness of a simple heated water-filled mattress for the prevention and treatment of neonatal hypothermia in the labour room

Boo NY, Selvarani S

Singapore Med J, 2005 Aug;46(8):387-91.

PMID: 16049607

This study aimed to determine the proportions of normothermic infants who remained normothermic, and hypothermic infants who became normothermic following the use of a heated water-filled mattress (HWM) in the labour room.

Matched MeSH terms: Infant, Newborn; Infant, Newborn, Diseases/prevention & control*

Fulltext C-reactive protein/albumin ratio is a prognostic indicator for predicting surgical intervention and mortality in neonates with necrotizing enterocolitis

Mohd Amin AT, Zaki RA, Friedmacher F, Sharif SP

Pediatr Surg Int, 2021 Jul;37(7):881-886.

PMID: 33779823 DOI: 10.1007/s00383-021-04879-1

PURPOSE: The role of hypoalbuminemia and raised C-reactive protein (CRP) levels in predicting critical prognosis has been described extensively in adult literature. However, there are limited studies in pediatrics, particularly neonates. The CRP/albumin (CRP/ALB) ratio is often associated with higher mortality, organ failure and prolonged hospital stay. We hypothesized that the serum CRP/ALB ratio has a prognostic value in predicting surgery and mortality in neonates with necrotizing enterocolitis (NEC).

METHODS: Retrospective review of all neonates with clinical and radiological evidence of non-perforated NEC that were treated in a tertiary-level referral hospital between 2009 and 2018. General patient demographics, laboratory parameters and outcomes were recorded. Receiver operating characteristics analysis was performed to evaluated optimal cut-offs and area under the curve (AUC) with 95% confidence intervals (CI).

RESULTS: A total of 191 neonates were identified. Of these, 103 (53.9%) were born at ≤ 28 weeks of gestation and 101 (52.9%) had a birth weight of ≤ 1000 g. Eighty-four (44.0%) patients underwent surgical intervention for NEC. The overall survival rate was 161/191 (84.3%). A CRP/ALB ratio of ≥ 3 on day 2 of NEC diagnosis was associated with a statistically significant higher likelihood for surgery [AUC 0.71 (95% CI 0.63-0.79); p

Matched MeSH terms: Infant, Newborn; Infant, Newborn, Diseases/blood*; Infant, Newborn, Diseases/mortality; Infant, Newborn, Diseases/surgery

Fulltext Neonatal intrahepatic cholestasis caused by citrin deficiency (NICCD) in three Malay children

Ngu HL, Zabedah MY, Kobayashi K

Malays J Pathol, 2010 Jun;32(1):53-7.

PMID: 20614727 MyJurnal

Citrin deficiency is an autosomal recessive disorder caused by mutation in the SLC25AJ3 gene. It has two major phenotypes: adult-onset type II citrullinemia (CTLN2) and neonatal intrahepatic cholestatic caused by citrin deficiency (NICCD). NICCD is characterized by neonatal/infantile-onset cholestatic hepatitis syndrome associated with multiple amino acidemia and hypergalactosemia. NICCD is self-limiting in most patients. However, some patients may develop CTLN2 years later, which manifests as fatal hyperammonemia coma. We report three unrelated Malay children with genetically confirmed NICCD characterised by an insertion mutation IVS16ins3kb in SLC25A13 gene. All 3 patients presented with prolonged neonatal jaundice which resolved without specific treatment between 5 to 10 months. Of note was the manifestation of a peculiar dislike of sweet foods and drinks. Elevated plasma citrulline was an important biochemical marker. NICCD should be considered in the differential diagnosis of cholestatic jaundice in Malaysian infants regardless of ethnic origin.

Matched MeSH terms: Infant, Newborn; Infant, Newborn, Diseases/genetics

Rickettsia tsutsugamushi antibody in mother/cord pairs of sera

Shirai A, Brown GW, Gan E, Huxsoll DL, Groves MG

Jpn. J. Med. Sci. Biol., 1981 Feb;34(1):37-9.

PMID: 6790744

Matched MeSH terms: Infant, Newborn; Infant, Newborn, Diseases/epidemiology

Tetanus neonatorum in West Malaysia

Chen ST

J Trop Med Hyg, 1974 Sep;77(9):204-7.

PMID: 4416077

Matched MeSH terms: Infant, Newborn; Infant, Newborn, Diseases/epidemiology*

Smallpox vaccination: complications and present role

Balasundram R

Med J Malaya, 1972 Dec;27(2):89-94.

PMID: 4145716

Matched MeSH terms: Infant, Newborn; Infant, Newborn, Diseases/etiology

To breast feed or not?

Nutr Rev, 1972 May;30(5):112-4.

PMID: 4554312

Matched MeSH terms: Infant, Newborn; Infant, Newborn, Diseases/etiology

Recurrent candidaemia in a neonate with Hirschsprung's disease: fluconazole resistance and genetic relatedness of eight Candida tropicalis isolates

Chong PP, Chieng DC, Low LY, Hafeez A, Shamsudin MN, Seow HF, et al.

J Med Microbiol, 2006 Apr;55(Pt 4):423-428.

PMID: 16533990 DOI: 10.1099/jmm.0.46045-0

The incidence of candidaemia among immunocompromised patients in Malaysia is increasing at an alarming rate. Isolation of clinical strains that are resistant to fluconazole has also risen markedly. We report here the repeated isolation of Candida tropicalis from the blood of a neonatal patient with Hirschsprung's disease. In vitro fluconazole susceptibility tests of the eight isolates obtained at different time points showed that seven of the isolates were resistant and one isolate was scored as susceptible dose-dependent. Random amplification of polymorphic DNA fingerprinting of the isolates using three primers and subsequent phylogenetic analysis revealed that these isolates were highly similar strains having minor genetic divergence, with a mean pairwise similarity coefficient of 0.893+/-0.041. The source of the infectious agent was thought to be the central venous catheter, as culture of its tip produced fluconazole-resistant C. tropicalis. This study demonstrates the utility of applying molecular epidemiology techniques to complement traditional mycological culture and drug susceptibility tests for accurate and appropriate management of recurrent candidaemia and highlights the need for newer antifungals that can combat the emergence of fluconazole-resistant C. tropicalis strains.

Matched MeSH terms: Infant, Newborn; Infant, Newborn, Diseases/microbiology*

Metabolic acidosis and renal solute load in relation to the protein intake of low birth weight Malaysian neonates

Johnson RO, Johnson BH, Raman A, Lee EL, Lam KL

Aust Paediatr J, 1979 Jun;15(2):101-6.

PMID: 485988

Matched MeSH terms: Infant, Newborn; Infant, Newborn, Diseases/etiology*

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