MyMedR

Oral carcinoma. A review of the etiological factors and a preventive programme

Omar-Ahmad U, Ramanathan K

Med J Malaya, 1968 Mar;22(3):172-81.

PMID: 4234351

Matched MeSH terms: Mouth Neoplasms/etiology*; Mouth Neoplasms/epidemiology; Mouth Neoplasms/prevention & control*

The distinctive features of the tumours of the salivary glands in Malaya

MARSDEN AT

Br. J. Cancer, 1951 Dec;5(4):375-81.

PMID: 14904833

Matched MeSH terms: Neoplasms*; Salivary Gland Neoplasms*

CHORIOCARCINOMA

KIM CK

Med J Malaysia, 1964 Dec;19:140-4.

PMID: 14279237

Matched MeSH terms: Liver Neoplasms*; Neoplasms/diagnosis*

Malays J Pathol, 2018 Apr;40(1):79-82.

PMID: 29704389

No abstract available.

Matched MeSH terms: Intestinal Neoplasms/classification*; Intestinal Neoplasms/pathology*; Pancreatic Neoplasms/classification*; Pancreatic Neoplasms/pathology*; Stomach Neoplasms/classification*; Stomach Neoplasms/pathology*

Gastric Metastasis from Hepatocellular Carcinoma: A Rare Manifestation

Abdul Hakim MS, Azmi AN, Jayalakshmi P, Mahadeva S

J Gastrointest Cancer, 2018 Sep;49(3):346-348.

PMID: 28066868 DOI: 10.1007/s12029-016-9913-6

Matched MeSH terms: Liver Neoplasms/pathology*; Stomach Neoplasms/secondary*

Fulltext Cancer Control Opportunities in Low- and Middle-Income Countries

ISBN: 978-0-309-10384-8

Citation: Institute of Medicine (US). Committee on Cancer Control in Low- and Middle-Income Countries, Frank A. Sloan, Hellen Gelband (Eds.). Cancer Control Opportunities in Low- and Middle-Income Countries. Washington DC: Institute of Medicine, National Academies Press, 2007

Full text contains Malaysian data:
Appendix A. Cancer Control in Malaysia and Tanzania. page 305

Matched MeSH terms: Neoplasms

A case of benign tumour of the lung

Ess BJ

Malayan Medical Journal, 1936;11:183.

Matched MeSH terms: Neoplasms

Hodgkin's disease

Webster JS

Journal of the Malaya Branch of the British Medical Association, 1938;2:12-8.

Matched MeSH terms: Neoplasms

Tumours of upper respiratory and alimentary tracts. Leucoplakia buccalis

Mekie DEC

Journal of the Malaya Branch of the British Medical Association, 1937;1:97-112.

Matched MeSH terms: Neoplasms

Bootstrap intervals in the presence of left-truncation, censoring and covariates with a parametric distribution

Thirunanthini Manoharan, Jayanthi Arasan, Habshah Midi, Mohd Bakri Adam

Sains Malaysiana, 2017;46:2529-2539.

Left-truncated and censored survival data are commonly encountered in medical studies. However, traditional inferential methods that heavily rely on normality assumptions often fail when lifetimes of observations in a study are both truncated and censored. Thus, it is important to develop alternative inferential procedures that ease the assumptions of normality and unconventionally relies on the distribution of data in hand. In this research, a three parameter log-normal parametric survival model was extended to incorporate left-truncated and right censored medical data with covariates. Following that, bootstrap inferential procedures using non-parametric and parametric bootstrap samples were applied to the parameters of this model. The performance of the parameter estimates was assessed at various combinations of truncation and censoring levels via a simulation study. The recommended bootstrap intervals were applied to a lung cancer survival data.

Matched MeSH terms: Lung Neoplasms

Fulltext Sclerosing odontogenic carcinoma - review of all published cases: is it a justifiable addition as a malignancy?

Lim D, Tan CC, Tilakaratne WM, Goh YC

Braz J Otorhinolaryngol, 2021 02 27;88(1):118-129.

PMID: 33715971 DOI: 10.1016/j.bjorl.2021.01.007

INTRODUCTION: Sclerosing odontogenic carcinoma was a new addition to the list of head and neck tumors by World Health Organization in 2017. This lesion has scarcely been reported and a lack of pathognomonic markers for diagnosis exists.

OBJECTIVE: The aim of the study was to summarize findings from the available literature to provide up-to-date information on sclerosing odontogenic carcinoma and to analyse clinical, radiological, and histopathological features to obtain information for and against as an odontogenic malignancy.

METHODS: We conducted a comprehensive review of literature by searching Pubmed, EBSCO and Web of Science databases, according to PRISMA guidelines. All the cases reported as sclerosing odontogenic carcinoma in English were included. Data retrieved from the articles were gender, age, clinical features, site, relevant medical history, radiographical findings, histopathological findings, immunohistochemical findings, treatments provided and prognosis.

RESULTS: Mean age at diagnosis of sclerosing odontogenic carcinoma was 54.4 years with a very slight female predilection. Sclerosing odontogenic carcinoma was commonly reported in the mandible as an expansile swelling which can be asymptomatic or associated with pain or paraesthesia. They appeared radiolucent with cortical resorption in radiograph evaluation. Histologically, sclerosing odontogenic carcinoma was composed of epithelioid cells in dense, fibrous, or sclerotic stroma with equivocal perineural invasion. Mild cellular atypia and inconspicuous mitotic activity were observed. There is no specific immunohistochemical marker for sclerosing odontogenic carcinoma. AE1/AE3, CK 5/6, CK 14, CK19, p63 and E-cadherin were the widely expressed markers for sclerosing odontogenic carcinoma. Surgical resection was the main treatment provided with no recurrence in most cases. No cases of metastasis were reported.

CONCLUSION: From the literature available, sclerosing odontogenic carcinoma is justifiable as a malignant tumor with no or unknown metastatic potential which can be adequately treated with surgical resection. However, there is insufficient evidence for histological grading or degree of malignancy of this tumor.

Matched MeSH terms: Head and Neck Neoplasms*; Mouth Neoplasms*

Fulltext An enhanced topologically significant directed random walk in cancer classification using gene expression datasets

Seah CS, Kasim S, Fudzee MFM, Law Tze Ping JM, Mohamad MS, Saedudin RR, et al.

Saudi J Biol Sci, 2017 Dec;24(8):1828-1841.

PMID: 29551932 DOI: 10.1016/j.sjbs.2017.11.024

Microarray technology has become one of the elementary tools for researchers to study the genome of organisms. As the complexity and heterogeneity of cancer is being increasingly appreciated through genomic analysis, cancerous classification is an emerging important trend. Significant directed random walk is proposed as one of the cancerous classification approach which have higher sensitivity of risk gene prediction and higher accuracy of cancer classification. In this paper, the methodology and material used for the experiment are presented. Tuning parameter selection method and weight as parameter are applied in proposed approach. Gene expression dataset is used as the input datasets while pathway dataset is used to build a directed graph, as reference datasets, to complete the bias process in random walk approach. In addition, we demonstrate that our approach can improve sensitive predictions with higher accuracy and biological meaningful classification result. Comparison result takes place between significant directed random walk and directed random walk to show the improvement in term of sensitivity of prediction and accuracy of cancer classification.

Matched MeSH terms: Neoplasms

Fulltext Quality of Life of Family Caregivers of Cancer Patients in a Developing Nation

Gan GG, Tey KWF, Mat S, Saad M, Bee PC, Abdul Malik R, et al.

Asian Pac J Cancer Prev, 2022 Nov 01;23(11):3905-3914.

PMID: 36444604 DOI: 10.31557/APJCP.2022.23.11.3905

BACKGROUND: Quality of life (QOL) of family caregivers of cancer patients is usually affected due to increase in caregiver burden. Their QOL has not garnered much attention by many including the health professionals and community. This study aims to explore the QOL of family caregivers of cancer patients in a multi-ethnic country in Asia and to investigate its associate factors.

METHODS: This is a cross-sectional study where family caregivers and patients who were diagnosed of cancers within 12 months were recruited. QOL of caregivers were measured using The Caregiver Quality of Life Index-Cancer (CQOLC). Psychological distress was measured using Hospital anxiety and depressive scale. Logistic regression analysis was performed to determine the related factors of QOL of caregivers.

RESULTS: A total of 458 patients/caregiver pairs were included. Symptoms of anxiety and depression reported by caregivers were 24.9% and 24.2% respectively. Caregivers of patients with solid tumors have better CQOLC score compared to those who cared for patients with hematological cancers (91.25 vs 86.75). Caregivers of non-Malay ethnicity, those caring for patients with advanced stage cancer and with hematological cancers had significantly poorer QOL. QOL of caregivers are also significantly affected when patients demonstrated anxiety symptoms.

CONCLUSION: This study provides detailed evaluation of the QOL of caregivers of cancer patients in Malaysia. The significant psychological distress and low caregiver QOL indicate the urgent need for comprehensive supports for caregivers with cancer patients, especially those caring for patients with haematological cancers.

Matched MeSH terms: Neoplasms*; Hematologic Neoplasms*

Fulltext Association of Microbiome with Oral Squamous Cell Carcinoma: A Systematic Review of the Metagenomic Studies

Su Mun L, Wye Lum S, Kong Yuiin Sze G, Hock Yoong C, Ching Yung K, Kah Lok L, et al.

Int J Environ Res Public Health, 2021 Jul 06;18(14).

PMID: 34299675 DOI: 10.3390/ijerph18147224

The past decade has witnessed a surge in epidemiological studies that have explored the relationship between the oral microbiome and oral cancer. Owing to the diversity of the published data, a comprehensive systematic overview of the currently available evidence is critical. This review summarises the current evidence on the metagenomic studies on the oral microbiome in oral cancer. A systematic search was conducted in Medline and Embase databases to identify original studies examining the differences in the oral microbiome of oral cancer cases and controls. A total of twenty-six studies were identified that reported differences in microbial abundance between oral squamous cell carcinoma (OSCC) and controls. Although almost all the studies identified microbial dysbiosis to be associated with oral cancer, the detailed qualitative analysis did not reveal the presence/abundance of any individual bacteria or a consortium to be consistently enriched in OSCC samples across the studies. Interestingly, few studies reported a surge of periodontopathogenic taxa, especially Fusobacteria, whereas others demonstrated a depletion of commensal taxa Streptococci. Considerable heterogeneity could be identified in the parameters used for designing the studies as well as reporting the microbial data. If microbiome data needs to be translated in the future, to complement the clinical parameters for diagnosis and prognosis of oral cancer, further studies with the integration of clinical variables, adequate statistical power, reproducible methods, and models are required.

Matched MeSH terms: Head and Neck Neoplasms*; Mouth Neoplasms*

Fulltext Comparison of Image Quality Criteria between Digital Storage Phosphor Plate in Mammography and Full-Field Digital Mammography in the Detection of Breast Cancer

Thevi Rajendran P, Krishnapillai V, Tamanang S, Kumari Chelliah K

Malays J Med Sci, 2012 Jan;19(1):52-9.

PMID: 22977375 MyJurnal

Digital mammography is slowly replacing screen film mammography. In digital mammography, 2 methods are available in acquiring images: digital storage phosphor plate and full-field digital mammography. The aim of this study was to compare the image quality acquired from the 2 methods of digital mammography in the detection of breast cancer.

Matched MeSH terms: Breast Neoplasms

Fulltext Correlation of Nuclear Morphometry and AgNOR Score with Radiation Response in Squamous Cell Cancers of the Head and Neck: A Preliminary Study

Biswal BM, Othman NH

Malays J Med Sci, 2010 Jul;17(3):19-26.

PMID: 22135545 MyJurnal

Prediction of radiation response before the completion of the radiotherapy schedule is challenging. Information about radiation response could help oncologist to choose the appropriate combination and sequence of therapies in the multidisciplinary management of cancer.

Matched MeSH terms: Neoplasms

Fulltext Diffuse neonatal haemangiomatosis: a rare cause of haemorrhagic shock and refractory coagulopathy in the newborn

Rohana J, Boo NY, Hayati AR, Baizura J

Med J Malaysia, 2002 Sep;57(3):364-7.

PMID: 12440278

A term newborn infant developed hypovolaemic shock shortly after birth. She was pale with gross hepatomegaly. She required multiple boluses of intravenous fluids, blood products as well as inotropic support. Blood investigations showed persistent thrombocytopenia, anaemia and disseminated intravascular coagulopathy (DIC). She also developed heart failure. She finally succumbed on the eleventh day of life. Autopsy revealed haemangiomatosis involving the liver, lungs, gastrointestinal tract, kidneys and adrenals.

Matched MeSH terms: Adrenal Gland Neoplasms/complications*; Adrenal Gland Neoplasms/congenital*; Gastrointestinal Neoplasms/complications*; Gastrointestinal Neoplasms/congenital*; Kidney Neoplasms/complications*; Kidney Neoplasms/congenital*; Liver Neoplasms/complications*; Liver Neoplasms/congenital*; Lung Neoplasms/complications*; Lung Neoplasms/congenital*

Malignant melanoma of the choroid in a naevus of Ota

Singh M, Kaur B, Annuar NM

Br J Ophthalmol, 1988 Feb;72(2):131-3.

PMID: 3349013

A rare case of choroidal malignant melanoma in a naevus of Ota is described. This is the first reported case from Asia outside the Japanese population. This case illustrates the need for close observation of all pigmented lesions of the eye.

Matched MeSH terms: Choroid Neoplasms/diagnosis; Choroid Neoplasms/pathology*; Eye Neoplasms/pathology; Liver Neoplasms/secondary; Neoplasms, Multiple Primary/pathology*; Skin Neoplasms/pathology*

Fulltext Outcomes Following Surgery for Distal Rectal Cancers: A Comparison between Laparoscopic and Open Abdomino-Perineal Resection

Tan KK, Chong CS, Tsang CB, Koh DC

Med J Malaysia, 2013 Aug;68(4):348-52.

PMID: 24145265

Oncologic outcomes following laparoscopic abdomino-perineal resection (APR) for distal rectal cancer are infrequently reported. This study aims to compare the long term outcomes between laparoscopic and open APR in distal rectal cancers.

Matched MeSH terms: Rectal Neoplasms*

Fulltext Blastic plasmacytoid dendritic cell neoplasm in an elderly woman

Foong HBB, Chong M, Taylor EM, Carlson JA, Petrella T

Med J Malaysia, 2013 Apr;68(2):161-3.

PMID: 23629565 MyJurnal

Blastic plasmacytoid dendritic cell neoplasm (a.k.a. NK cell lymphoma, CD4+CD56+ haematodermic neoplasm) is a rare aggressive tumour that arises from plasmacytoid dendritic cell precursors. We report the first case from Malaysia of a 79-year-old Chinese woman who presented with purpuric plaques and nodules produced by pleomorphic CD4+, CD56+, CD68+, CD123+ and CD303+, but CD2APmononuclear cell infiltrates. Leukemic dissemination occurred and she succumbed to disease without treatment 4 weeks after diagnosis and 9 months after onset of cutaneous disease.

Matched MeSH terms: Hematologic Neoplasms*

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