MyMedR

Fulltext Screw Migration into Colon after Anterior Cervical Plating - An Unusual Complication: A Case Report

Sath S

Malays Orthop J, 2020 Nov;14(3):184-187.

PMID: 33403084 DOI: 10.5704/MOJ.2011.031

Complications in the form of esophageal injury, tracheal injury, injury to carotids, implant failure, loosening of screws, etc do occur after anterior cervical surgeries. Although intra-operative esophageal injuries are as such rare, there have been few reports of delayed esophageal perforation as well after anterior cervical surgeries. We report a very rare case of migration of missing screw from anterior cervical plate after anterior cervical corpectomy and plating, which had ultimately migrated down to colon and had to be removed via colonoscopy. Along with removal of migrated screw from colon, revision of failed anterior cervical surgery was done wherein plate and screws were removed with mesh cage left in-situ as it was snug-fit while pharyngeophageal perforation was explored and was found to be spontaneously healing, with addition of posterior Bohlman's interspinous wiring for added stability. Migration of screw from the anterior cervical plate into the colon although very rare, should be always kept in mind and its potentially serious complications. We also conclude that particular attention should be given to elderly people with poor bony quality who have high chances of implant failure, along with attention to proper cage size, screw position and proper locking of the screw to further lessen the chances of implant failure.

Matched MeSH terms: Colon; Colonoscopy

Fulltext The neorectum reservoirs

Wong M.P.K

IIUM Medical Journal Malaysia, 2020;19(1):33-37.

MyJurnal

The incidence of rectal dissection is increasing with the rise of rectal cancer all over the world. This
technique has been used regularly to provide a reasonable quality of life for patients. The concern raised
was the functions of these neorectum to replace the original rectum. Several configurations have been
suggested namely the straight end-to-end coloanal anastomosis, side-to-end coloanal anastomosis, colonic Jpouch and the transverse coloplasty to suit the anatomy of the deep pelvis. Apparently, there was no
difference in terms of functional outcome among all these four types of reconstructions. However, these
configurations have seen the emergence of anterior resection syndrome or a pragmatic defaecatory
dysfunction as their complications. Furthermore, the neorectum functions are affected by many other
factors such as preoperative chemoradiotherapy, septic complications, and others more.

Matched MeSH terms: Colon

Fulltext Capsule endoscopy in inflammatory bowel disease: when and how

Hilmi I, Kobayashi T

Intest Res, 2020 Jul;18(3):265-274.

PMID: 32623876 DOI: 10.5217/ir.2019.09165

Capsule endoscopy (CE) is emerging as an important investigation in inflammatory bowel disease (IBD); common types include the standard small bowel CE and colon CE. More recently, the pan-enteric CE was developed to assess the large and small bowel in patients with Crohn's disease (CD). Emerging indications include noninvasive assessment for mucosal healing (both in the small bowel and the colon) and detection of postoperative recurrence in patients with CD. Given the increasing adoption, several CE scoring systems have been specifically developed for IBD. The greatest concern with performing CE, particularly in CD, is capsule retention, but this can be overcome by performing cross-sectional imaging such as magnetic resonance enterography and using patency capsules before performing the procedure. The development of software for automated detection of mucosal abnormalities typically seen in IBD may further increase its adoption.

Matched MeSH terms: Colon; Colonoscopy

Fulltext Design of polysaccharidic nano-in-micro soft agglomerates as primary oral drug delivery vehicle for colon-specific targeting

Musa N, Wong TW

Carbohydr Polym, 2020 Nov 01;247:116673.

PMID: 32829801 DOI: 10.1016/j.carbpol.2020.116673

Microencapsulation of polysaccharidic nanoparticles is met with nanoscale and biological performance changes. This study designs soft agglomerates as nanoparticle vehicle without nanoparticles undergoing physical processes that alter their geometry. The nanoparticles were made of high molecular weight chitosan/pectin with covalent 5-fluorouracil/folate. Nanoparticle aggregation vehicle was prepared from low molecular weight chitosan. The nanoparticles and aggregation vehicle were blended in specific weight ratios to produce soft agglomerates. Nanoparticles alone are unable to agglomerate. Adding aggregation vehicle (< 2 μm) promoted soft agglomeration with nanoparticles deposited onto its surfaces with minimal binary coalescence. The large and rough-surfaced aggregation vehicle promoted nanoparticles deposition and agglomeration. A rounder vehicle allowed assembly of nanoparticles-on-aggregation vehicle into agglomerates through interspersing smaller between larger populations. Soft agglomeration reduced early drug release, and was responsive to intracapsular sodium alginate coat to further sustain drug release. The soft agglomerates can serve as a primary oral colon-specific vehicle.

Matched MeSH terms: Colon

Lipid-based Nanocarriers for Cancer and Tumor Treatment

Ansari MT, Ramlan TA, Jamaluddin NN, Zamri N, Salfi R, Khan A, et al.

Curr Pharm Des, 2020;26(34):4272-4276.

PMID: 32693760 DOI: 10.2174/1381612826666200720235752

Cancer and tumor have been major reasons for numerous deaths in this century across the world. Many strategies have been designed to treat, diagnose, or prevent cancer. The success of chemotherapy largely depends on drug targeting. The advent of nanotechnology has vastly improved drug delivery for targeting and diagnosis. Nevertheless, the accuracy of drug targeting with polymeric nanoparticles has always been questionable. The polymeric nanoparticles synthesized from varieties of lipid-based compounds or combined with vectors, such as liposomes, ethosomes, and transfersomes, may allow the drug to overcome the issue of resistance to drug absorption in biological membranes. The combined effects of lipid-based nanocarriers are known to improve the efficacy and accuracy of polymeric nanoparticles. The present review explores the application of lipid based nanocarriers in the treatment and diagnosis of cancer A special focus is given to the use of lipid-based nanocarriers in the treatment, diagnosis, and mitigation of cancer located in blood, brain, lung, and colon. The treatment of these cancers has always been questionable as the chances of relapse are very high. The review encompasses the use of lipid-based nanocarriers in targeting tissue-specific cancer cells.

Matched MeSH terms: Colon

Fulltext The uncharted danger of living in the tropics: a needlefish impalement of the sigmoid colon

Assikin Muhamad, Aishath Azna Ali, Firdaus Hayati, Andee Dzulkarnaen Zakaria

Malaysian Journal of Medicine and Health Sciences, 2020;16(3):337-339.

MyJurnal

Penetrating injury to the abdominal viscera is not uncommon unless when it is caused by marine life. We present a 39-year-old fisherman from a tropical country who had sustained a penetrating injury from a stab wound to the abdomen due to needlefish impalement. He sustained a small perforation of the sigmoid colon during exploratory laparotomy and primary repair was done. Although this incident is rare, there are cases involving seawater activities either for leisure, sport or diving for fishing. We highlight this rare incident and discuss the management plan.

Matched MeSH terms: Colon, Sigmoid

Fabrication, Evaluation, In Vivo Pharmacokinetic and Toxicological Analysis of pH-Sensitive Eudragit S-100-Coated Hydrogel Beads: a Promising Strategy for Colon Targeting

Rehman S, Ranjha NM, Shoukat H, Madni A, Ahmad F, Raza MR, et al.

AAPS PharmSciTech, 2021 Jul 26;22(6):209.

PMID: 34312763 DOI: 10.1208/s12249-021-02082-y

The aim of present research aims to fabricate a system of enteric coating of hydrogel beads with pH-sensitive polymer, which shows solubility at pH > 7, and explore their potential to target the colon for drug delivery. Hydrogel beads were fabricated through the extrusion-dripping technique followed by ion gelation crosslinking. Moreover, freeze-thaw cycle was implemented for crosslinking of polyvinyl alcohol (PVA)/Ca-alginate blend beads. The oil-in-oil solvent evaporation method was adopted for the Eudragit coating of hydrogel beads using different coat: core ratios (4:1 or 8:1). Coated and uncoated hydrogel beads were evaluated by in vitro physicochemical properties, swelling and drug release behaviours, and in vivo pharmacokinetics, swelling, and toxicity evaluation. Diclofenac sodium was loaded as an experimental drug. Drug entrapment efficiency for the PVA/Ca-alginate beads was calculated as 98%, and for Ca-alginate beads, it came out to a maximum of 74%. Drug release study at various pH suggested that, unlike uncoated hydrogel beads, the coated beads delay the release of diclofenac sodium in low pH of the gastric and intestinal environment, thus targeting the colon for the drug release. It was concluded that Eudragit S-100-coated hydrogel beads could serve as a more promising and reliable way to target the colon for drug delivery.Graphical abstract.

Matched MeSH terms: Colon

Fulltext The illustration of a rat large intestine: a model for the effect of Carcinogens

Khodijah Zulkiflee, Zunariah Buyong, Asmah Hanim Hamdan

International Medical Journal Malaysia, 2017;16(11):28-28.

MyJurnal

Rat large intestine is an established model to study the effect of
carcinogens. There are several distinctive features among mammalian gastrointestinal
tracts in gross anatomy but they share some basic similar structures. The variety in
digestive system relies on its physiology. Rats rarely eat high fatty diets, thus the
function of gall bladder become less significant in their digestive system and this is
justified by the fact that rats have none. Rats have large caecum designated for their
fermentation chamber to digest cellulose. Another notable difference is the size and
length of colon itself, in which human colon is significantly bigger and longer. We aimed
to demonstrate the gross anatomy and histology of rat digestive system particularly the
large intestine. (Copied from article).

Matched MeSH terms: Colon

Fulltext Distribution of 5-HT3, 5-HT4, and 5-HT7 Receptors Along the Human Colon

Yaakob NS, Chinkwo KA, Chetty N, Coupar IM, Irving HR

J Neurogastroenterol Motil, 2015 Jul 30;21(3):361-9.

PMID: 26130632 DOI: 10.5056/jnm14157

Several disorders of the gastrointestinal tract are associated with abnormal serotonin (5-HT) signaling or metabolism where the 5-HT3 and 5-HT4 receptors are clinically relevant. The aim was to examine the distribution of 5-HT3, 5-HT4, and 5-HT7 receptors in the normal human colon and how this is associated with receptor interacting chaperone 3, G protein coupled receptor kin-ases, and protein LIN-7 homologs to extend previous observations limited to the sigmoid colon or the upper intestine.

Matched MeSH terms: Colon, Sigmoid

Fulltext Images in clinical medicine: Melanosis coli

Kew ST, Chakravarthi S

N Engl J Med, 2013 Jun 13;368(24):2303.

PMID: 23758235 DOI: 10.1056/NEJMicm1204882

Matched MeSH terms: Colon/pathology*; Colonic Diseases/chemically induced; Colonic Diseases/pathology*

Fulltext Low prevalence of 'classical' microscopic colitis but evidence of microscopic inflammation in Asian irritable bowel syndrome patients with diarrhoea

Hilmi I, Hartono JL, Pailoor J, Mahadeva S, Goh KL

BMC Gastroenterol, 2013;13:80.

PMID: 23651739 DOI: 10.1186/1471-230X-13-80

There is increasing evidence for the role of microscopic inflammation in patients with IBS. We aimed to examine the prevalence of microscopic colitis and inflammation in Malaysian IBS patients with diarrhoea (IBS-D).

Matched MeSH terms: Colon/pathology*; Colonoscopy

Fulminant amoebic colitis causing a colonic mucosal tube

Kyaw K

Aust N Z J Surg, 1994 Jan;64(1):67-9.

PMID: 8267547

Matched MeSH terms: Colon/pathology; Megacolon, Toxic/etiology*; Megacolon, Toxic/pathology; Megacolon, Toxic/surgery

Fulltext Antegrade intraoperative colonic lavage

Ng PE

Med J Malaysia, 1993 Jun;48(2):217-21.

PMID: 8350799

Emergency left-sided colonic resections have traditionally been dealt with by employing staged resections due to the dangers of an anastomosis in unprepared bowel. A small series of 6 patients with left-sided colonic obstruction is presented in which a single stage primary anastomosis was done after an antegrade intraoperative colonic lavage. There were no deaths, infective complications or anastomotic leaks. Major series in the last decade using intraoperative colonic lavage are reviewed as well, to confirm that the method is safe, effective and warrants wider usage locally.

Matched MeSH terms: Colon*; Colonic Diseases/surgery*

Fulltext Per rectal extrusion of a ventriculo peritoneal shunt catheter. A case report

Ali J, Cheah FKC

Med J Malaysia, 1987 Sep;42(3):201-3.

PMID: 3333537

A rare complication of per rectal extrusion of a ventricule peritoneal shunt catheter occuring in a four-month old Chinese baby boy with hydrocephalus is described. Perforation of the bowel by the shunt occurred without any peritonitis or retrograde infection of the shunt system. Its pathogenesis and diagnosis are discussed.

Matched MeSH terms: Colon/radiography*

Fulltext Massage-related perforation of the sigmoid colon in Kelantan

Gohar Rahman MN, McAll G, Koh GC

Med J Malaysia, 1987 Mar;42(1):56-7.

PMID: 3431504

Perforation of the sigmoid colon is an occasional complication of blunt injury to the abdomen. We report three cases following abdominal massage (urut) by traditional healers (bomohs) in which no other underlying pathology was found.

Matched MeSH terms: Colon, Sigmoid/injuries*

Detection rate of colonic polyp among patients who had undergone colonoscopy at gastroenterology unit of Serdang Hospital, Malaysia

Tan YJ, Wendy T, Chieng JY

Med J Malaysia, 2019 02;74(1):20-24.

PMID: 30846657

OBJECTIVE: The aim of this study was to evaluate the demography, and to determine the detection rate of polyps, and detection rate of adenoma at a Malaysian tertiary hospital.

METHODS: This is a retrospective study of all the patients who had undergone colonoscopy at Gastroenterology endoscopy unit, Serdang Hospital from 1st January 2010 to 31st December 2016. Patients who had a history of colorectal cancer, polyp or inflammatory bowel disease were excluded. Data collected which included patients' demography, indication for colonoscopy, colonoscopy finding, and histopathology results. Data was analysed with SPSS version 16.

RESULTS: Among the 559 patients who had fulfilled the inclusion criteria (68 males, 44 females), 112 patients were found to have at least one polyp giving the polyp detection rate (PDR) of 20% and 168 polypectomies were performed. The PDR among male patients was higher than that of females (22.5% vs 17.1%, p<0.05). The detection rate of polyp was nearly equal in Malays, Chinese, Indians, and Others. The polyps were more common in those of age 40 years old and above (p<0.05), with the mean age of 63.0±1.5 years. The commonest morphology of polyp in our patients was sessile (58%) and majority was medium size (5-9mm). Otherwise, the polyps were commonly found in the distal colon those that in proximal colon (55.3% vs 38.7%, p<0.05). The adenoma detection rate (ADR) was 19.1% (107/559).

CONCLUSION: The detection rate of colonic polyp from colonoscopy is 20% in our centre.

Matched MeSH terms: Colon/pathology; Colonic Polyps/diagnosis*; Colonic Polyps/epidemiology; Colonic Polyps/pathology

Caffeic acid phenethyl ester (CAPE) reverses fibrosis caused by chronic colon inflammation in murine model of colitis

Tambuwala MM, Kesharwani P, Shukla R, Thompson PD, McCarron PA

Pathol Res Pract, 2018 Nov;214(11):1909-1911.

PMID: 30170869 DOI: 10.1016/j.prp.2018.08.020

Fibrosis is known to be the hallmarks of chronic inflammation of the bowel. Epithelial damage due to inflammation compromises the barrier function of the gastrointestinal tract. This barrier dysfunction leads to further spread of inflammation resulting in a chronic state of inflammation. This chronic inflammation leads to development of fibrosis, which has very limited therapeutic options and usually requires surgical removal of the affected tissue. Our previous work has shown that Caffeic acid phenethyl ester (CAPE) is a naturally occurring anti-inflammatory agent, found in propolis, has been found to be protective in experimental colitis via enhancement of epithelial barrier function. However, the impact of CAPE on resolution of fibrosis in the long-term is unknown. The aim of this follow up study was to investigate the effect of CAPE on colon fibrosis in a chronic model of Dextran sulphate sodium induced colitis in mice. Dextran sulphate sodium (DSS) 2.5% w/v was administered in drinking water to induce colitis in C57/BL6 mice for 5 days on the 6th day DSS was stopped and test group mice were treated with intraperitoneal administration of CAPE (30 mg kg-1 day-1) for a further 7 days. Disease activity index (DAI) score, colon length and tissue histology and level of tissue fibrosis was observed. CAPE-treated mice had significantly lower levels of DAI, tissue inflammation scores and fibrosis as compared with control group. Our results show that CAPE is effective in resolving colon fibrosis in chronic inflammation. Thus, we can conclude CAPE could be a potential therapeutic agent for further clinical investigations for treatment of fibrosis in inflammatory bowel diseases in humans.

Matched MeSH terms: Colon/drug effects*

Analysis of differentially expressed proteins in cancerous and normal colonic tissues

Gam LH, Leow CH, Man CN, Gooi BH, Singh M

World J Gastroenterol, 2006 Aug 21;12(31):4973-80.

PMID: 16937492

AIM: To identify and analyze the differentially expressed proteins in normal and cancerous tissues of four patients suffering from colon cancer.

METHODS: Colon tissues (normal and cancerous) were homogenized and the proteins were extracted using three protein extraction buffers. The extraction buffers were used in an orderly sequence of increasing extraction strength for proteins with hydrophobic properties. The protein extracts were separated using the SDS-PAGE method and the images were captured and analyzed using Quantity One software. The target protein bands were subjected to in-gel digestion with trypsin and finally analyzed using an ESI-ion trap mass spectrometer.

RESULTS: A total of 50 differentially expressed proteins in colonic cancerous and normal tissues were identified.

CONCLUSION: Many of the identified proteins have been reported to be involved in the progression of similar or other types of cancers. However, some of the identified proteins have not been reported before. In addition, a number of hypothetical proteins were also identified.

Matched MeSH terms: Colon/metabolism*; Colonic Neoplasms/metabolism*

Responses of large and small intestine of the rat to cesium, 5-hydroxytryptamine ouabain and acetyl choline

Thevathasan OI, Archdeacon JW

Med J Malaya, 1966 Jun;20(4):306-15.

PMID: 4224339

Matched MeSH terms: Colon/drug effects*

In vitro catabolism of 3',4'-dihydroxycinnamic acid by human colonic microbiota

Hasyima Omar M, González Barrio R, Pereira-Caro G, Almutairi TM, Crozier A

Int J Food Sci Nutr, 2021 Jun;72(4):511-517.

PMID: 33238790 DOI: 10.1080/09637486.2020.1850650

3',4'-Dihydroxycinnamic acid (aka caffeic acid) is a common dietary component found in a variety of plant-derived food products either in a free form or esterified as in chlorogenic acids such as 5-O-caffeoylquinic acid. The dihydroxycinnamate is produced principally by hydrolysis in the colon of 5-O-caffeoylquinic acid and other caffeoylquinic acid esters, and is catabolised by the resident microbiota prior to absorption. In the present study 3',4'-dihydroxycinnamic acid was incubated in vitro, with or without glucose, under anaerobic conditions with faecal slurries obtained from five volunteers. The main resultant catabolites to accumulate were 3-(3',4'-dihydroxyphenyl)propanoic acid (aka dihydrocaffeic acid), 3-(3'-hydroxyphenyl)propanoic acid and phenylacetic acid. Both the rate of degradation of the hydroxycinnamate substrate and the catabolite profile varied between the faecal samples from the individual volunteers. Overall there was no clear cut effect when glucose was added to incubation medium.

Matched MeSH terms: Colon/metabolism*

Displaying publications 41 - 60 of 129 in total