Displaying publications 561 - 580 of 1359 in total

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  1. Fulltext Experimental dataset on the dispersion stability of natural polymer non-covalently functionalized graphene nanoplatelets in high salinity brines
    Hamdi SS, Al-Kayiem HH, Muhsan AS, Magaril E
    Data Brief, 2020 Aug;31:105702.
    PMID: 32462067 DOI: 10.1016/j.dib.2020.105702
    The data in this article present the effective parameters of experimental ultrasonication process on the dispersion stability of graphene nanoplatelets (GNPs) grafted with a natural polymer of Gum Arabic (GA). These datasets are supporting the article "Natural Polymer Non-Covalently Grafted Graphene Nanoplatelets for Improved Oil Recovery Process: A Micromodel Evaluation" [1]. The datasets were gained during experiments conducted at various dwell time (30, 60, 90 and 120 min) at constant power amplitude (60%) of sonication for preparing the stable GA-GNP/brine solutions aiming cost-effective and green agent solution for chemical enhanced oil recovery (C-EOR). The GA-GNPs dispersion data was verified using particle size analyser and UV-Vis measurements. The optimized time and power amplitude parameters of the sonication process were utilized for preparing stabilized samples of GA grafted GNPs in regarding to research work on Natural Polymer Non-Covalently Grafted Graphene Nanoplatelets for EOR. The dispersion stability of GA-GNPs nanofluids at reservoir conditions of high salinity and high temperatures (HSHT) was further demonstrated in the measured data through the sedimentation of nanoparticles.
    Matched MeSH terms: Nanoparticles
  2. Fulltext Physical, mechanical, chemical and biological properties data of gellan gum incorporating titanium dioxide nanoparticles biofilm
    Razali MH, Ismail NA, Amin KAM
    Data Brief, 2020 Jun;30:105478.
    PMID: 32346560 DOI: 10.1016/j.dib.2020.105478
    Gellan gum incorporating titanium dioxide nanoparticles biofilm was synthesized and characterized using UV, FTIR and XRD to study their physical and chemical properties. The mechanical properties were measured using universal mechanical testing. Meanwhile, the biological properties were investigated towards for antibacterial and cell proliferation. This comprehensive data are relevant with the research article entitled "Gellan gum incorporating titanium dioxide nanoparticles biofilm as wound dressing: Physicochemical, mechanical, antibacterial properties and wound healing studies" [1].
    Matched MeSH terms: Nanoparticles
  3. Coordination polymer-derived cobalt-embedded and N/S-doped carbon nanosheet with a hexagonal core-shell nanostructure as an efficient catalyst for activation of oxone in water
    Tuan DD, Oh WD, Ghanbari F, Lisak G, Tong S, Andrew Lin KY
    J Colloid Interface Sci, 2020 Nov 01;579:109-118.
    PMID: 32574728 DOI: 10.1016/j.jcis.2020.05.033
    As sulfate-radical (SR)-based advanced oxidation processes are increasingly implemented, Oxone has been frequently-used for generation of SR. While Co3O4 nanoparticle (NP) has been widely-accepted as a promising catalyst for activating Oxone, Co3O4 NPs tend to aggregate in water, losing their reactivity. Thus, many attempts have immobilized Co3O4 NPs on supports, especially carbonaceous substrates, because combination of Co NPs with carbon substrates offers synergistic effects for boosting catalytic activities. Moreover, carbon substrates doped with hetero-atoms (N and S) further increase electron transfer and reactivity. Therefore, it is even promising to immobilize Co NPs onto N/S-doped carbon (NSC) to form Co-embedded NSC (denoted as CoNSC) for enhancing Oxone activation. In this study, a convenient and facile technique is proposed to prepare such a CoNSC via a simple carbonization treatment of a coordination polymer of Co and trithiocyanuric acid (TTCA). The resulting CoNSC exhibits the sheet-like hexagonal morphology with the core-shell configuration, and Co NPs are well-embedded into the N/S-doped carbonaceous matrix, making it an advantageous heterogeneous catalyst for Oxone activation. As Azorubine S (ARS) decolorization is employed as a model reaction of Oxone activation, CoNSC exhibits a higher catalytic activity than pristine Co3O4 and NSC for Oxone activation to decolorize ARS. In comparison to the other reported catalysts, CoNSC also possesses a much lower Ea for ARS decolorization. CoNSC can be also reusable and stable for Oxone activation over multiple cycles without loss of catalytic activity. These features validate that CoNSC is a promising and useful Co-based catalyst for Oxone activation.
    Matched MeSH terms: Nanoparticles
  4. Fulltext Biogenic silver nanoparticles using Rhinacanthus nasutus leaf extract: synthesis, spectral analysis, and antimicrobial studies
    Pasupuleti VR, Prasad TN, Shiekh RA, Balam SK, Narasimhulu G, Reddy CS, et al.
    Int J Nanomedicine, 2013;8:3355-64.
    PMID: 24039419 DOI: 10.2147/IJN.S49000
    Nanotechnology is gaining momentum due to its ability to transform metals into nanoparticles. The synthesis, characterization, and applications of biologically synthesized nanomaterials have become an important branch of nanotechnology. Plant extracts are a cost-effective, ecologically friendly, and efficient alternative for the large-scale synthesis of nanoparticles. In this study, silver nanoparticles (AgNps) were synthesized using Rhinacanthus nasutus leaf extract. After exposing the silver ions to the leaf extract, the rapid reduction of silver ions led to the formation of AgNps in solution. The synthesis was confirmed by ultraviolet-visible spectroscopy, Fourier transform infrared spectroscopy, and transmission electron microscopy. The in vitro antimicrobial activity of the AgNps synthesized using R. nasutus leaf extract was investigated against Bacillus subtilis, Staphylococcus aureus, Pseudomonas aeruginosa, Klebsiella pneumonia, Escherichia coli, Aspergillus niger, and Aspergillus flavus using a disc diffusion method. The AgNps showed potential activity against all of the bacterial strains and fungal colonies, indicating that R. nasutus has the potential to be used in the development of value-added products in the biomedical and nanotechnology-based industries.
    Matched MeSH terms: Metal Nanoparticles/administration & dosage*; Metal Nanoparticles/ultrastructure; Metal Nanoparticles/chemistry*
  5. Size-Controlled and Optical Properties of Platinum Nanoparticles by Gamma Radiolytic Synthesis
    Gharibshahi E, Saion E, Ashraf A, Gharibshahi L
    Appl Radiat Isot, 2017 Dec;130:211-217.
    PMID: 29028581 DOI: 10.1016/j.apradiso.2017.09.012
    Gamma radiolytic synthesis was used to produce size-controlled spherical platinum nanoparticles from an aqueous solution containing platinum tetraammine and polyvinyl pyrrolidone. The structural characterizations were performed using X-ray diffraction, and transmission electron microscopy. The transmission electron microscopy was used to determine the average particle diameter, which decreased from 4.4nm at 80kGy to 2.8nm at 120kGy. The UV-visible absorption spectrum was measured and found that platinum nanoparticles exhibit two steady absorption maxima in UV regions due to plasmonic excitation of conduction electrons, which blue shifted to lower wavelengths with a decrease in particle size. We consider the conduction electrons of platinum nanoparticles to follow Thomas-Fermi-Dirac-Weizsacker atomic model that they are not entirely free but weakly bounded to particles at lower-energy states {n = 5, l = 2 or 5d} and {n = 6, l = 0 or 6s}, which upon receiving UV photon energy the electrons make intra-band quantum excitations to higher-energy states allowed by the principles of quantum number that results the absorption maxima. We found an excellent agreement between the experimental and theoretical results, which suggest that the optical absorption of metal nanoparticles could be fundamentally described by a quantum mechanical interpretation, which could be more relevant to photo-catalysis and heterogeneous catalysis.
    Matched MeSH terms: Metal Nanoparticles
  6. Effect of Milling Time on the Microstructure, Physical and Mechanical Properties of Al-Al₂O₃ Nanocomposite Synthesized by Ball Milling and Powder Metallurgy
    Toozandehjani M, Matori KA, Ostovan F, Abdul Aziz S, Mamat MS
    Materials (Basel), 2017 Oct 26;10(11).
    PMID: 29072632 DOI: 10.3390/ma10111232
    The effect of milling time on the morphology, microstructure, physical and mechanical properties of pure Al-5 wt % Al₂O₃ (Al-5Al₂O₃) has been investigated. Al-5Al₂O₃ nanocomposites were fabricated using ball milling in a powder metallurgy route. The increase in the milling time resulted in the homogenous dispersion of 5 wt % Al₂O₃ nanoparticles, the reduction of particle clustering, and the reduction of distances between the composite particles. The significant grain refining during milling was revealed which showed as a reduction of particle size resulting from longer milling time. X-Ray diffraction (XRD) analysis of the nanocomposite powders also showed that designated ball milling contributes to the crystalline refining and accumulation of internal stress due to induced severe plastic deformation of the particles. It can be argued that these morphological and microstructural variations of nanocomposite powders induced by designated ball milling time was found to contribute to an improvement in the density, densification, micro-hardness (HV), nano-hardness (HN), and Young's modulus (E) of Al-5Al₂O₃ nanocomposites. HV, HN, and E values of nanocomposites were increased by ~48%, 46%, and 40%, after 12 h of milling, respectively.
    Matched MeSH terms: Nanoparticles
  7. Fulltext A Printed Xi-Shaped Left-Handed Metamaterial on Low-Cost Flexible Photo Paper
    Ashraf FB, Alam T, Islam MT
    Materials (Basel), 2017 Jul 05;10(7).
    PMID: 28773113 DOI: 10.3390/ma10070752
    A Xi-shaped meta structure, has been introduced in this paper. A modified split-ring resonator (MSRR) and a capacitive loaded strip (CLS) were used to achieve the left-handed property of the metamaterial. The structure was printed using silver metallic nanoparticle ink, using a very low-cost photo paper as a substrate material. Resonators were inkjet-printed using silver nanoparticle metallic ink on paper to make this metamaterial flexible. It is also free from any kind of chemical waste, which makes it eco-friendly. A double negative region from 8.72 GHz to 10.91 GHz (bandwidth of 2.19 GHz) in the X-band microwave spectra was been found. Figure of merit was also obtained to measure any loss in the double negative region. The simulated result was verified by the performance of the fabricated prototype. The total dimensions of the proposed structure were 0.29 λ × 0.29 λ × 0.007 λ. It is a promising unit cell because of its simplicity, cost-effectiveness, and easy fabrication process.
    Matched MeSH terms: Metal Nanoparticles
  8. Fulltext Biosynthesis of Silver Nanoparticles Using Brown Marine Macroalga, Sargassum Muticum Aqueous Extract
    Azizi S, Namvar F, Mahdavi M, Ahmad MB, Mohamad R
    Materials (Basel), 2013 Dec 18;6(12):5942-5950.
    PMID: 28788431 DOI: 10.3390/ma6125942
    Biological synthesis of nanoparticles is a relatively new emerging field of nanotechnology which has economic and eco-friendly benefits over chemical and physical processes of synthesis. In the present work, for the first time, the brown marine algae Sargassum muticum (S. muticum) aqueous extract was used as a reducing agent for the synthesis of nanostructure silver particles (Ag-NPs). Structural, morphological and optical properties of the synthesized nanoparticles have been characterized systematically by using FTIR, XRD, TEM and UV-Vis spectroscopy. The formation of Ag-NPs was confirmed through the presence of an intense absorption peak at 420 nm using a UV-visible spectrophotometer. A TEM image showed that the particles are spherical in shape with size ranging from 5 to 15 nm. The nanoparticles were crystalline in nature. This was confirmed by the XRD pattern. From the FTIR results, it can be seen that the reduction has mostly been carried out by sulphated polysaccharides present in S. muticum.
    Matched MeSH terms: Nanoparticles
  9. Brain-Eating Amoebae: Silver Nanoparticle Conjugation Enhanced Efficacy of Anti-Amoebic Drugs against Naegleria fowleri
    Rajendran K, Anwar A, Khan NA, Siddiqui R
    ACS Chem Neurosci, 2017 12 20;8(12):2626-2630.
    PMID: 29206032 DOI: 10.1021/acschemneuro.7b00430
    The overall aim of this study was to determine whether conjugation with silver nanoparticles enhances effects of available drugs against primary amoebic meningoencephalitis due to Naegleria fowleri. Amphotericin B, Nystatin, and Fluconazole were conjugated with silver nanoparticles, and synthesis was confirmed using UV-visible spectrophotometry. Atomic force microscopy determined their size in range of 20-100 nm. To determine amoebicidal effects, N. fowleri were incubated with drugs-conjugated silver nanoparticles, silver nanoparticles alone, and drugs alone. The findings revealed that silver nanoparticles conjugation significantly enhanced antiamoebic effects of Nystatin and Amphotericin B but not Fluconazole at micromolar concentrations, compared with the drugs alone. For the first time, our findings showed that silver nanoparticle conjugation enhances efficacy of antiamoebic drugs against N. fowleri. Given the rarity of the disease and challenges in developing new drugs, it is hoped that modifying existing drugs to enhance their antiamoebic effects is a useful avenue that holds promise in improving the treatment of brain-eating amoebae infection due to N. fowleri.
    Matched MeSH terms: Metal Nanoparticles/administration & dosage*; Metal Nanoparticles/ultrastructure; Metal Nanoparticles/chemistry
  10. Nanotechnology based approaches for anti-diabetic drugs delivery
    Kesharwani P, Gorain B, Low SY, Tan SA, Ling ECS, Lim YK, et al.
    Diabetes Res Clin Pract, 2018 Feb;136:52-77.
    PMID: 29196152 DOI: 10.1016/j.diabres.2017.11.018
    Nanotechnology science has been diverged its application in several fields with the advantages to operate with nanometric range of objects. Emerging field of nanotechnology has been also being approached and applied in medical biology for improved efficacy and safety. Increased success in therapeutic field has focused several approaches in the treatment of the common metabolic disorder, diabetes. The development of nanocarriers for improved delivery of different oral hypoglycemic agents compared to conventional therapies includes nanoparticles (NPs), liposomes, dendrimer, niosomes and micelles, which produces great control over the increased blood glucose level and thus becoming an eye catching and most promising technology now-a-days. Besides, embellishment of nanocarriers with several ligands makes it more targeted delivery with the protection of entrapped hypoglycaemic agents against degradation, thereby optimizing prolonged blood glucose lowering effect. Thus, nanocarriers of hypoglycemic agents provide the aim towards improved diabetes management with minimized risk of acute and chronic complications. In this review, we provide an overview on distinctive features of each nano-based drug delivery system for diabetic treatment and current NPs applications in diabetes management.
    Matched MeSH terms: Nanoparticles
  11. Design and tuning of a cell-penetrating albumin derivative as a versatile nanovehicle for intracellular drug delivery
    Ichimizu S, Watanabe H, Maeda H, Hamasaki K, Nakamura Y, Chuang VTG, et al.
    J Control Release, 2018 05 10;277:23-34.
    PMID: 29530390 DOI: 10.1016/j.jconrel.2018.02.037
    Human serum albumin (HSA) is a superior carrier for delivering extracellular drugs. However, the development of a cell-penetrating HSA remains a great challenge due to its low membrane permeability. We report herein on the design of a series of palmitoyl-poly-arginine peptides (CPPs) and an evaluation of their cell-penetrating effects after forming a complex with HSA for use in intracellular drug delivery. The palmitoyl CPPs forms a stable complex with HSA by anchoring itself to the high affinity palmitate binding sites of HSA. Among the CPPs evaluated, a cyclic polypeptide composed of D-dodecaarginines, palmitoyl-cyclic-(D-Arg)12 was the most effective for facilitating the cellular uptake of HSA by HeLa cells. Such a superior cell-penetrating capability is primarily mediated by macropinocytosis. The effect of the CPP on pharmacological activity was examined using three drugs loaded in HSA via three different methods: a) an HSA-paclitaxel complex, b) an HSA-doxorubicin covalent conjugate and c) an HSA-thioredoxin fusion protein. The results showed that cell-penetrating efficiency was increased with a corresponding and significant enhancement in pharmacological activity. In conclusion, palmitoyl-cyclic-(D-Arg)12/HSA is a versatile cell-penetrating drug delivery system with great potential for use as a nano-carrier for a wide diversity of pharmaceutical applications.
    Matched MeSH terms: Nanoparticles/administration & dosage*; Nanoparticles/metabolism; Nanoparticles/chemistry
  12. Photo-irradiation coupled biosynthesis of magnesium oxide nanoparticles for antibacterial application
    Siaw YM, Jeevanandam J, Hii YS, Chan YS
    Naunyn Schmiedebergs Arch Pharmacol, 2020 Dec;393(12):2253-2264.
    PMID: 32632566 DOI: 10.1007/s00210-020-01934-x
    In recent times, magnesium oxide (MgO) nanoparticles are proven to be an excellent antibacterial agent which inhibits the growth of bacteria by generating reactive oxygen species (ROS). Release of ROS by nanoparticles will damage the cell membrane of bacteria and leads to the leakage of bacterial internal components and cell death. However, chemically synthesized MgO nanoparticles may possess toxic functional groups which may inhibit healthy human cells along with bacterial cells. Thus, the aim of the present study is to synthesize MgO nanoparticles using leaf extracts of Amaranthus tricolor and photo-irradiation of visible light as a catalyst, without addition of any chemicals. Optimization was performed using Box-Behnken design (BBD) to obtain the optimum condition required to synthesize smallest nanoparticles. The parameters such as time of reaction, the concentration of precursor, and light intensity have been identified to affect the size of biosynthesized nanoparticles and was optimized. The experiment performed with optimized conditions such as 0.001 M concentration of magnesium acetate as precursor, 5 cm distance of light (intensity), and 15 min of reaction time (light exposure) has led to the formation of 74.6 nm sized MgO nanoparticles. The antibacterial activities of MgO nanoparticles formed via photo-irradiation and conventional biosynthesis approach were investigated and compared. The lethal dosage of E. coli for photo-irradiated and conventional biosynthesis MgO nanoparticles was 0.6 ml and 0.4 ml, respectively. Likewise, the lethal dosage of S. aureus for both biosynthesis approaches was found to be 0.4 ml. The results revealed that the antibacterial activity of MgO nanoparticles from both biosynthesis approaches was similar. Thus, photo-irradiated MgO nanoparticles were beneficial over heat-mediated conventional method due to the reduced synthesis duration.
    Matched MeSH terms: Nanoparticles/administration & dosage; Nanoparticles/radiation effects; Nanoparticles/chemistry*
  13. Fulltext The Photocatalytic Effects of Modified Hydrothermal Nanotitania Extraction on the Skin and Behavior of Sprague-Dawley Rats
    Harun AM, Awang H, Noor NFM, Makhatar NM, Yusoff ME, Affandi NDN, et al.
    Biomed Res Int, 2021;2021:6173143.
    PMID: 34859102 DOI: 10.1155/2021/6173143
    BACKGROUND: Potential antibacterial substances, such as titanium dioxide (TiO2), are being extensively studied throughout the research world. A modified hydrothermal nanotitania extraction was shown to inhibit Staphylococcus aureus growth in the laboratory. However, the toxicity effect of the extract on rats is unknown. In this study, we observed the effects of a modified hydrothermal nanotitania extraction on the skin and behavior of Sprague-Dawley rats.

    METHODS: Sprague-Dawley (Rattus norvegicus) rats were used as the experimental animals. The skin around the dorsum of the tested animals was shaved and pasted with 0.1 mg and 0.5 mg of the nanotitania extraction. The color and condition of the pasted area and the behavior of the animals were observed.

    RESULTS: 0.1 mg nanotitania extraction application on the dorsum of the rat produced no skin color changes at day 1, day 3, day 5, or day 7 postapplication. There were no changes in their behavior up to day 7 with no skin rashes or skin scratches seen or fur changes. However, 0.5 mg of nanotitania extraction resulted in redness and less fur regrowth at day 7.

    CONCLUSIONS: A 0.1 mg modified nanotitania extraction was observed to have no effect on the skin of Sprague-Dawley rats.

    Matched MeSH terms: Metal Nanoparticles/administration & dosage; Metal Nanoparticles/toxicity; Metal Nanoparticles/chemistry
  14. Fulltext Synthesis, characterization, controlled release, and antibacterial studies of a novel streptomycin chitosan magnetic nanoantibiotic
    Hussein-Al-Ali SH, El Zowalaty ME, Hussein MZ, Ismail M, Webster TJ
    Int J Nanomedicine, 2014;9:549-57.
    PMID: 24549109 DOI: 10.2147/IJN.S53079
    This study describes the preparation, characterization, and controlled release of a streptomycin-chitosan-magnetic nanoparticle-based antibiotic in an effort to improve the treatment of bacterial infections. Specifically, chitosan-magnetic nanoparticles were synthesized by an incorporation method and were characterized by Fourier transform infrared spectroscopy, X-ray diffraction, thermogravimetric analysis, and vibrating sample magnetometry. Streptomycin was incorporated into the nanoparticles to form a streptomycin-coated chitosan-magnetic nanoparticle (Strep-CS-MNP) nanocomposite. The release profiles showed an initially fast release, which became slower as time progressed. The percentage of drug released after 350 minutes was around 100%, and the best fit mathematical model for drug release was the pseudo-second order model. The Strep-CS-MNP nanocomposite showed enhanced antibacterial activity against methicillin-resistant Staphylococcus aureus. This study forms a significant basis for further investigation of the Strep-CS-MNP nanocomposite in the treatment of various bacterial infections.
    Matched MeSH terms: Magnetite Nanoparticles/administration & dosage*; Magnetite Nanoparticles/ultrastructure; Magnetite Nanoparticles/chemistry*
  15. Solid Lipid Nanoparticles of Atovaquone Based on 2(4) Full-Factorial Design
    Mohtar N, A K Khan N, Darwis Y
    Iran J Pharm Res, 2015;14(4):989-1000.
    PMID: 26664366
    Solid lipid nanoparticles of atovaquone (ATQ-SLN) were prepared by high shear homogenization method using tripalmitin, trilaurin, and Compritol 888 ATO as the lipid matrices and Phospholipon 90H, Tween 80, and poloxamer 188 as the surfactants. Optimization of the formulations was conducted using 6 sets of 2(4) full-factorial design based on four independent variables that were the number of homogenizing cycles, concentration of the lipid, concentration of the co-surfactant, and concentration of the main surfactant. The dependent variables were particle size and polydispersity index (PdI). The homogenizing cycles showed a negative influence on the dependent variables which reduced both the particle size and the PdI value. Moreover, a combination of certain percentages of the main surfactant and co-surfactant also showed a negative influence that reduced both the particle size and PdI value. Selected formulations from each design were further characterized for the entrapment efficiency and yield. The optimised formulation of ATQ-SLN consisted of trilaurin, Phospholipon 90H and Tween 80 with a particle size of 89.4 ± 0.2 nm and entrapment efficiency of 83.0 ± 1.7%. The in-vitro release evaluation of the formulation showed a complete and immediate release of ATQ from the SLN that could be a solution to improve the poor aqueous solubility and hence poor bioavailability of the drug.
    Matched MeSH terms: Nanoparticles
  16. Applications and advancements of nanoparticle-based drug delivery in alleviating lung cancer and chronic obstructive pulmonary disease
    De Rubis G, Paudel KR, Corrie L, Mehndiratta S, Patel VK, Kumbhar PS, et al.
    Naunyn Schmiedebergs Arch Pharmacol, 2024 May;397(5):2793-2833.
    PMID: 37991539 DOI: 10.1007/s00210-023-02830-w
    Lung cancer (LC) and chronic obstructive pulmonary disease (COPD) are among the leading causes of mortality worldwide. Cigarette smoking is among the main aetiologic factors for both ailments. These diseases share common pathogenetic mechanisms including inflammation, oxidative stress, and tissue remodelling. Current therapeutic approaches are limited by low efficacy and adverse effects. Consequentially, LC has a 5-year survival of < 20%, while COPD is incurable, underlining the necessity for innovative treatment strategies. Two promising emerging classes of therapy against these diseases include plant-derived molecules (phytoceuticals) and nucleic acid-based therapies. The clinical application of both is limited by issues including poor solubility, poor permeability, and, in the case of nucleic acids, susceptibility to enzymatic degradation, large size, and electrostatic charge density. Nanoparticle-based advanced drug delivery systems are currently being explored as flexible systems allowing to overcome these limitations. In this review, an updated summary of the most recent studies using nanoparticle-based advanced drug delivery systems to improve the delivery of nucleic acids and phytoceuticals for the treatment of LC and COPD is provided. This review highlights the enormous relevance of these delivery systems as tools that are set to facilitate the clinical application of novel categories of therapeutics with poor pharmacokinetic properties.
    Matched MeSH terms: Nanoparticles
  17. The current understanding of the interactions between nanoparticles and cytochrome P450 enzymes - a literature-based review
    Pan Y, Ong CE, Pung YF, Chieng JY
    Xenobiotica, 2019 Jul;49(7):863-876.
    PMID: 30028220 DOI: 10.1080/00498254.2018.1503360
    Nanoparticles (NPs) have wide spectrum applications in the areas of industry and biomedicine. However, concerns about their toxic and negative impacts on the environments as well as human health have been raised. Cytochrome P450s (CYPs) are involved in endogenous and exogenous metabolism. Modulations of CYP can adversely damage drug metabolism, detoxification of xenobiotics and animal physiology functions. This article focused on NPs-CYP interactions for humans and animals available in the literature. It was found that different NPs process specific inhibitory potencies against CYPs involved in drug metabolism. Moreover, NPs were able to modify the expression of CYPs genes or protein in humans and other animals, which highlighted their detoxification functions. Nonetheless, changes of CYPs responsible for hormone synthesis and metabolism resulted in endocrine disturbances. Hence, there is a need to screen newly developed NPs to evaluate their interactions with CYPs. The future studies should further strategize the in vitro approaches to reveal the molecular mechanisms behind interactions by taking full considerations of the interference of co-factors, buffers, substrates and metabolites with NPs. Moreover, in vivo studies should compare the influences of NPs via different administration routes and different duration of treatments to reveal the physiological significance.
    Matched MeSH terms: Nanoparticles
  18. A new mechanism of thermal sensitivity for rapid drug release and low systemic toxicity in hyperthermia and thermal ablation temperature ranges
    Dabbagh A, Abdullah BJ, Abu Kasim NH, Abdullah H, Hamdi M
    Int J Hyperthermia, 2015 Jun;31(4):375-85.
    PMID: 25716769 DOI: 10.3109/02656736.2015.1006268
    The aim of this paper was to introduce a new mechanism of thermal sensitivity in nanocarriers that results in a relatively low drug release at physiological temperature and rapid release of the encapsulated drug at hyperthermia and thermal ablation temperature range (40-60 °C).
    Matched MeSH terms: Nanoparticles/chemistry*
  19. Fulltext A gastrointestinal transit study on amphotericin B-loaded solid lipid nanoparticles in rats
    Amekyeh H, Billa N, Yuen KH, Chin SL
    AAPS PharmSciTech, 2015 Aug;16(4):871-7.
    PMID: 25588365 DOI: 10.1208/s12249-014-0279-4
    The gastrointestinal (GI) transit behavior of and absorption from an amphotericin B (AmB) solid lipid nanoformulation (SLN) in rats was investigated. We aimed to estimate the gastric emptying time (GET) and cecal arrival time (CAT) of AmB SLN in rats as animal models. From these two parameters, an insight on the absorption window of AmB was ascertained. Three types of SLNs, AmB, paracetamol (PAR), and sulfasalazine (SSZ), were similarly formulated using beeswax/theobroma oil composite as the lipid matrix and characterized with regard to size, viscosity, density, migration propensity within agarose gel, in vitro drug release, morphology, gastrointestinal transit, and in vivo absorption. The GET and CAT were estimated indirectly using marker drugs: PAR and sulfapyridine (SP). All three types of SLNs exhibited identical properties with regard to z-average, viscosity, relative density, and propensity to migrate. PAR was absorbed rapidly from the small intestine following emptying of the SLNs giving the T50E (time for 50% absorption of PAR) to be 1.6 h. SP was absorbed after release and microbial degradation of SSZ from SLN in the colon with a lag time of 2 h post-administration, serving as the estimated cecal arrival time of the SLNs. AmB within SLN was favorably absorbed from the small intestine, albeit slowly.
    Matched MeSH terms: Nanoparticles*
  20. Application of response surface methodology in optimization of electrospinning process to fabricate (ferrofluid/polyvinyl alcohol) magnetic nanofibers
    Ahmadipourroudposht M, Fallahiarezoudar E, Yusof NM, Idris A
    Mater Sci Eng C Mater Biol Appl, 2015 May;50:234-41.
    PMID: 25746266 DOI: 10.1016/j.msec.2015.02.008
    Magnetic nanofibers are composed of good dispersion of magnetic nanoparticles along an organic material. Magnetic nanofibers are potentially useful for composite reinforcement, bio-medical and tissue engineering. Nanofibers with the thinner diameter have to result in higher rigidity and tensile strength due to better alignments of lamellae along the fiber axis. In this study, the performance of electrospinning process was explained using response surface methodology (RSM) during fabrication of magnetic nanofibers using polyvinyl alcohol (PVA) as a shelter for (γ-Fe2O3) nanoparticles where the parameters investigated were flow rate, applied voltage, distance between needle and collector and collector rotating speed. The response variable was diameter distribution. The two parameters flow rate and applied voltage in primary evaluation were distinguished as significant factors. Central composite design was applied to optimize the variable of diameter distribution. Quadratic estimated model developed for diameter distribution indicated the optimum conditions to be flow rate of 0.25 ml/h at voltage of 45 kV while the distance and rotating speed are at 8 cm and 1500 rps respectively. The obtained model was verified successfully by the confirmation experiments.
    Matched MeSH terms: Nanoparticles/chemistry*
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