Displaying publications 401 - 420 of 55997 in total

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  1. Nova et Vetera: Latah and amok
    Abraham JJ
    Br Med J, 1912;1:438-446.
    Matched MeSH terms: Humans
  2. Malaria in the Federated Malay States [duplicate title2]
    Br Med J, 1923;2:1125-1126.
    Matched MeSH terms: Humans
  3. Fulltext Potential role of Manilkara Zapota L in treating bacterial infection
    Febriza A, Usman F, Rasyid AUM, Idrus HH, Mokhtar MH
    PeerJ, 2024;12:e17890.
    PMID: 39148677 DOI: 10.7717/peerj.17890
    The increasing problem of antibiotic resistance in bacteria leads to an urgent need for new antimicrobial agents. Alternative treatments for bacterial infections need to be explored to tackle this issue. Plant-based substances are emerging as promising options. Manilkara zapota L. contains compounds with antibiotic activities, and anti-inflammatory, antitumor, antipyretic, and antioxidant properties. It has medicinal properties and contains bioactive compounds, like tannins, flavonoids, and triterpenoids. This review aimed to comprehensively evaluate the existing literature on the potential medicinal and therapeutic benefits of M. zapota in bacterial infections by utilizing data from in vivo and in vitro studies. M. zapota has the potential to be a nutritional source of antimicrobial food. Numerous preclinical studies have demonstrated the antibacterial activities of M. zapota and its components. The antibacterial mechanisms of this fruit could interact with bacterial cell structures such as cell walls or membranes.
    Matched MeSH terms: Humans
  4. Immunogenicity of monoclonal antibody: Causes, consequences, and control strategies
    Asmani AZA, Zainuddin AFF, Azmi Murad NA, Mohd Darwis NH, Suhaimi NS, Zaini E, et al.
    Pathol Res Pract, 2024 Nov;263:155627.
    PMID: 39357185 DOI: 10.1016/j.prp.2024.155627
    Antibody-based treatment was first used in 1891 for the treatment of diphtheria. Since then, monoclonal antibodies (mAbs) have been developed to treat many diseases such as cancer and act as vaccines. However, murine-derived therapeutic mAbs were found to be highly immunogenic, and caused anti-drug antibodies (ADAs) reaction, reducing their efficacy and causing severe infusion reactions. Fully human, humanised, and chimeric antibodies were then introduced for better therapeutic efficacy. With the introduction of immune response associated with mAbs immunogenicity. This review explores the immunogenicity of mAbs, its mechanism, contributing factors, and its impact on therapeutic efficacy. It also discusses immunogenicity assessment for preclinical studies and strategies for minimising immunogenicity for effective therapeutic treatment in various diseases. Finally, predicting immunogenicity in drug development is essential for selecting top drug candidates. A lot of methods can be implemented by the researchers and developers to reduce the development of ADAs while simultaneously minimising the immunogenicity reaction of mAbs.
    Matched MeSH terms: Humans
  5. Fulltext The undeclared use of third-party service providers in academic publishing is unethical: an epistemic reflection and scoping review
    Teixeira da Silva JA, Daly T, Türp JC, Sabel BA, Kendall G
    Naunyn Schmiedebergs Arch Pharmacol, 2024 Dec;397(12):9435-9447.
    PMID: 38990307 DOI: 10.1007/s00210-024-03177-6
    There is a substantial body of scientific literature on the use of third-party services (TPS) by academics to assist as "publication consultants" in scholarly publishing. TPS provide a wide range of scholarly services to research teams that lack the equipment, skills, motivation, or time to produce a paper without external assistance. While services such as language editing, statistical support, or graphic design are common and often legitimate, some TPS also provide illegitimate services and send unsolicited e-mails (spam) to academics offering these services. Such illegitimate types of TPS have the potential to threaten the integrity of the peer-reviewed scientific literature. In extreme cases, for-profit agencies known as "paper mills" even offer fake scientific publications or authorship slots for sale. The use of such illegitimate services as well as the failure to acknowledge their use is an ethical violation in academic publishing, while the failure to declare support for a TPS can be considered a form of contract fraud. We discuss some literature on TPS, highlight services currently offered by ten of the largest commercial publishers and expect authors to be transparent about the use of these services in their publications. From an ethical/moral (i.e., non-commercial) point of view, it is the responsibility of editors, journals, and publishers, and it should be in their best interest to ensure that illegitimate TPS are identified and prohibited, while publisher-employed TPS should be properly disclosed in their publications.
    Matched MeSH terms: Humans
  6. Fulltext Multi-perspectives systematic review on the applications of sentiment analysis for vaccine hesitancy
    Alamoodi AH, Zaidan BB, Al-Masawa M, Taresh SM, Noman S, Ahmaro IYY, et al.
    Comput Biol Med, 2021 Dec;139:104957.
    PMID: 34735945 DOI: 10.1016/j.compbiomed.2021.104957
    A substantial impediment to widespread Coronavirus disease (COVID-19) vaccination is vaccine hesitancy. Many researchers across scientific disciplines have presented countless studies in favor of COVID-19 vaccination, but misinformation on social media could hinder vaccination efforts and increase vaccine hesitancy. Nevertheless, studying people's perceptions on social media to understand their sentiment presents a powerful medium for researchers to identify the causes of vaccine hesitancy and therefore develop appropriate public health messages and interventions. To the best of the authors' knowledge, previous studies have presented vaccine hesitancy in specific cases or within one scientific discipline (i.e., social, medical, and technological). No previous study has presented findings via sentiment analysis for multiple scientific disciplines as follows: (1) social, (2) medical, public health, and (3) technology sciences. Therefore, this research aimed to review and analyze articles related to different vaccine hesitancy cases in the last 11 years and understand the application of sentiment analysis on the most important literature findings. Articles were systematically searched in Web of Science, Scopus, PubMed, IEEEXplore, ScienceDirect, and Ovid from January 1, 2010, to July 2021. A total of 30 articles were selected on the basis of inclusion and exclusion criteria. These articles were formed into a taxonomy of literature, along with challenges, motivations, and recommendations for social, medical, and public health and technology sciences. Significant patterns were identified, and opportunities were promoted towards the understanding of this phenomenon.
    Matched MeSH terms: Humans
  7. Establishing a Lancet Oncology Commission on the humanitarian crisis of cancer
    Rodin G, Skelton M, Bhoo-Pathy N, Dewachi O, Li M, Trapani D, et al.
    Lancet Oncol, 2023 Aug;24(8):835-837.
    PMID: 37541269 DOI: 10.1016/S1470-2045(23)00346-7
    Matched MeSH terms: Humans
  8. Recurrent pericardial effusion: a treatable cause not to be overlooked
    Teoh VWY, Kamarulata IL, Loch A
    Heart, 2023 Jul 27;109(16):1215-1262.
    PMID: 37500180 DOI: 10.1136/heartjnl-2023-322843
    Matched MeSH terms: Humans
  9. African care for congenital central nervous system disorders: Falling far short of global management standards?
    Wireko AA, Ohenewaa Tenkorang P, Fosuah Debrah A, Akin-Olugbemi T, Yarlagadda R, Mehta A, et al.
    Int J Surg, 2023 Mar 01;109(3):534-535.
    PMID: 36928287 DOI: 10.1097/JS9.0000000000000011
    Matched MeSH terms: Humans
  10. Chronic Painless, Multiple Papulo-Nodular Skin Lesion at Foot Resembles Mycetoma Infection (Madura Foot): A Case Report
    Bahar Moni AS, Hoque MM
    Int J Low Extrem Wounds, 2023 Sep;22(3):616-619.
    PMID: 34223771 DOI: 10.1177/15347346211030753
    Madura foot is a chronic, progressively destructive bacterial or fungal infection of the subcutaneous tissues, which may affect skin, muscle, and bone. It is endemic in tropical and subtropical areas known as the "Mycetoma belt" between latitude 30°N and 15°S. Mycetoma is prevalent in the poor population living in remote areas of developing countries that lack proper reporting system and management. The World Health Organization recognized mycetoma as a neglected tropical disease back in 2016. Though the diagnosis is challenging, early detection and proper treatment can reduce morbidity and provide a promising outcome. We report a case of chronic painless, multiple papulo-nodular skin lesions at the foot that resembles mycetoma infection which was detected early and recovered with a satisfactory outcome with proper treatment.
    Matched MeSH terms: Humans
  11. Fulltext Letter from Malaysia
    Ban AY, Ng BH, Nik Abeed NN
    Respirology, 2023 Sep;28(9):890-891.
    PMID: 37451809 DOI: 10.1111/resp.14554
    Matched MeSH terms: Humans
  12. An automated malaria cells detection from thin blood smear images using deep learning
    Sukumarran D, Hasikin K, Mohd Khairuddin AS, Ngui R, Wan Sulaiman WY, Vythilingam I, et al.
    Trop Biomed, 2023 Jun 01;40(2):208-219.
    PMID: 37650409 DOI: 10.47665/tb.40.2.013
    Timely and rapid diagnosis is crucial for faster and proper malaria treatment planning. Microscopic examination is the gold standard for malaria diagnosis, where hundreds of millions of blood films are examined annually. However, this method's effectiveness depends on the trained microscopist's skills. With the increasing interest in applying deep learning in malaria diagnosis, this study aims to determine the most suitable deep-learning object detection architecture and their applicability to detect and distinguish red blood cells as either malaria-infected or non-infected cells. The object detectors Yolov4, Faster R-CNN, and SSD 300 are trained with images infected by all five malaria parasites and from four stages of infection with 80/20 train and test data partition. The performance of object detectors is evaluated, and hyperparameters are optimized to select the best-performing model. The best-performing model was also assessed with an independent dataset to verify the models' ability to generalize in different domains. The results show that upon training, the Yolov4 model achieves a precision of 83%, recall of 95%, F1-score of 89%, and mean average precision of 93.87% at a threshold of 0.5. Conclusively, Yolov4 can act as an alternative in detecting the infected cells from whole thin blood smear images. Object detectors can complement a deep learning classification model in detecting infected cells since they eliminate the need to train on single-cell images and have been demonstrated to be more feasible for a different target domain.
    Matched MeSH terms: Humans
  13. Abstracts of the 13th Asia-Pacific International Academy of Pathology Congress 2023 held 16th to 18th June 2023
    Malays J Pathol, 2023 Aug;45(2):299-313.
    PMID: 37658541
    No abstract available.
    Matched MeSH terms: Humans
  14. Fulltext Neurological Applications of Celery (Apium graveolens): A Scoping Review
    Tan TYC, Lim XY, Norahmad NA, Chanthira Kumar H, Teh BP, Lai NM, et al.
    Molecules, 2023 Aug 02;28(15).
    PMID: 37570794 DOI: 10.3390/molecules28155824
    Apium graveolens is an indigenous plant in the family Apiaceae, or Umbelliferae, that contains many active compounds. It has been used traditionally to treat arthritic conditions, gout, and urinary infections. The authors conducted a scoping review to assess the quality of available evidence on the overall effects of celery when treating neurological disorders. A systematic search was performed using predetermined keywords in selected electronic databases. The 26 articles included upon screening consisted of 19 in vivo studies, 1 published clinical trial, 4 in vitro studies and 2 studies comprising both in vivo and in vitro methods. A. graveolens and its bioactive phytoconstituent, 3-n-butylphthalide (NBP), have demonstrated their effect on neurological disorders such as Alzheimer's disease, Parkinson's disease, stroke-related neurological complications, depression, diabetes-related neurological complications, and epilepsy. The safety findings were minimal, showing that NBP is safe for up to 18 weeks at 15 mg/kg in animal studies, while there were adverse effects (7%) reported when consuming NBP for 24 weeks at 600 mg daily in human trials. In conclusion, the safety of A. graveolens extract and NBP can be further investigated clinically on different neurological disorders based on their potential role in different targeted pathways.
    Matched MeSH terms: Humans
  15. Systematic review on the contents and parameters of self-management education programs in older adults with knee osteoarthritis
    Salwana Kamsan S, Kaur Ajit Singh D, Pin Tan M, Kumar S
    Australas J Ageing, 2021 Mar;40(1):e1-e12.
    PMID: 32881241 DOI: 10.1111/ajag.12844
    OBJECTIVE: The aim of this review was to determine the contents and parameters of self-management education programs (SMEPs) for older adults with knee osteoarthritis (KOA).

    METHODS: A systematic electronic literature search (Scopus, MEDLINE, ProQuest, CINAHL, Cochrane and a grey literature specific site through Google Scholar) was undertaken between March and May 2018 (search updated in June 2019). Studies were selected based on predetermined criteria. Data relating to the contents and parameters of the SMEP were extracted and collated.

    RESULTS: A total of 11 experimental studies met the inclusion criteria. Overall quality of the selected studies was good. The contents used for SMEP in older adults with KOA were information and management of KOA, healthy lifestyle and additional management strategies for KOA. The parameters used were face-to-face sessions led by health professionals and were chiefly group-based.

    CONCLUSION: This review comprehensively summarises the structure of multifaceted SMEP for people with KOA, which could be used to inform clinical practice and future research.

    Matched MeSH terms: Humans
  16. Pyloric Stenosis of Infancy(PS): Discovering the Cause
    Rogers IM
    J Pediatr Surg, 2023 Oct;58(10):2066-2067.
    PMID: 36907772 DOI: 10.1016/j.jpedsurg.2023.01.064
    Matched MeSH terms: Humans
  17. Comparative genomic and phenotypic analyses of pathogenic fungi Neoscytalidium dimidiatum and Bipolaris papendorfii isolated from human skin scraping
    Kuan CS, Ng KP, Yew SM, Umar Meleh H, Seow HF, How KN, et al.
    Braz J Microbiol, 2023 Sep;54(3):1351-1372.
    PMID: 37351789 DOI: 10.1007/s42770-023-01032-z
    Neoscytalidium dimidiatum and Bipolaris species are fungal plant pathogens that have been reported to cause human diseases. Recently, we have isolated numerous N. dimidiatum and Bipolaris species from the skin scrapings and nails of different patients. In this work, we have sequenced the genome of one strain of N. dimidiatum. The sequenced genome was compared to that of a previously reported Bipolaris papendorfii genome for a better understanding of their complex lifestyle and broad host-range pathogenicity. Both N. dimidiatum UM 880 (~ 43 Mb) and B. papendorfii UM 226 (~ 33 Mb) genomes include 11,015-12,320 putative coding DNA sequences, of which 0.51-2.49% are predicted transposable elements. Analysis of secondary metabolism gene clusters revealed several genes involved in melanin biosynthesis and iron uptake. The arsenal of CAZymes related to plants pathogenicity is comparable between the species, including genes involved in hemicellulose and pectin decomposition. Several important gene encoding keratinolytic peptidases were identified in N. dimidiatum and B. papendorfii, reflecting their potential pathogenic role in causing skin and nail infections. In this study, additional information on the metabolic features of these two species, such as nutritional profiling, pH tolerance, and osmotolerant, are revealed. The genomic characterization of N. dimidiatum and B. papendorfii provides the basis for the future functional studies to gain further insights as to what makes these fungi persist in plants and why they are pathogenic to humans.
    Matched MeSH terms: Humans
  18. Child with global developmental delay presenting with autistic features
    Masiran R, Ilias MNA
    BMJ Case Rep, 2023 Sep 20;16(9).
    PMID: 37730421 DOI: 10.1136/bcr-2023-257293
    Matched MeSH terms: Humans
  19. The multi-societal European consensus on the terminology, diagnosis and management of patients with synchronous colorectal cancer and liver metastases: an E-AHPBA consensus in partnership with ESSO, ESCP, ESGAR, and CIRSE
    Siriwardena AK, Serrablo A, Fretland ÅA, Wigmore SJ, Ramia-Angel JM, Malik HZ, et al.
    HPB (Oxford), 2023 Sep;25(9):985-999.
    PMID: 37471055 DOI: 10.1016/j.hpb.2023.05.360
    BACKGROUND: Contemporary management of patients with synchronous colorectal cancer and liver metastases is complex. The aim of this project was to provide a practical framework for care of patients with synchronous colorectal cancer and liver metastases with a focus on terminology, diagnosis and management.

    METHODS: This project was a multi-organisational, multidisciplinary consensus. The consensus group produced statements which focused on terminology, diagnosis and management. Statements were refined during an online Delphi process and those with 70% agreement or above were reviewed at a final meeting. Iterations of the report were shared by electronic mail to arrive at a final agreed document comprising twelve key statements.

    RESULTS: Synchronous liver metastases are those detected at the time of presentation of the primary tumour. The term "early metachronous metastases" applies to those absent at presentation but detected within 12 months of diagnosis of the primary tumour with "late metachronous metastases" applied to those detected after 12 months. Disappearing metastases applies to lesions which are no longer detectable on MR scan after systemic chemotherapy. Guidance was provided on the recommended composition of tumour boards and clinical assessment in emergency and elective settings. The consensus focused on treatment pathways including systemic chemotherapy, synchronous surgery and the staged approach with either colorectal or liver-directed surgery as first step. Management of pulmonary metastases and the role of minimally invasive surgery was discussed.

    CONCLUSIONS: The recommendations of this contemporary consensus provide information of practical value to clinicians managing patients with synchronous colorectal cancer and liver metastases.

    Matched MeSH terms: Humans
  20. Fulltext Prerequisite for COVID-19 Prediction: A Review on Factors Affecting the Infection Rate
    Tang SGH, Hadi MHH, Arsad SR, Ker PJ, Ramanathan S, Afandi NAM, et al.
    Int J Environ Res Public Health, 2022 Oct 11;19(20).
    PMID: 36293576 DOI: 10.3390/ijerph192012997
    Since the year 2020, coronavirus disease 2019 (COVID-19) has emerged as the dominant topic of discussion in the public and research domains. Intensive research has been carried out on several aspects of COVID-19, including vaccines, its transmission mechanism, detection of COVID-19 infection, and its infection rate and factors. The awareness of the public related to the COVID-19 infection factors enables the public to adhere to the standard operating procedures, while a full elucidation on the correlation of different factors to the infection rate facilitates effective measures to minimize the risk of COVID-19 infection by policy makers and enforcers. Hence, this paper aims to provide a comprehensive and analytical review of different factors affecting the COVID-19 infection rate. Furthermore, this review analyses factors which directly and indirectly affect the COVID-19 infection risk, such as physical distance, ventilation, face masks, meteorological factor, socioeconomic factor, vaccination, host factor, SARS-CoV-2 variants, and the availability of COVID-19 testing. Critical analysis was performed for the different factors by providing quantitative and qualitative studies. Lastly, the challenges of correlating each infection risk factor to the predicted risk of COVID-19 infection are discussed, and recommendations for further research works and interventions are outlined.
    Matched MeSH terms: Humans
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