Displaying publications 301 - 320 of 1340 in total

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  1. Jegasothy R, Sengupta P, Dutta S, Jeganathan R
    J Basic Clin Physiol Pharmacol, 2020 Dec 14;32(5):911-924.
    PMID: 33580644 DOI: 10.1515/jbcpp-2020-0236
    Climate change is an incessant global phenomenon and has turned contentious in the present century. Malaysia, a developing Asian country, has also undergone significant vicissitudes in climate, which has been projected with significant deviations in forthcoming decades. As per the available studies, climate changes may impact on the fertility, either via direct effects on the gonadal functions and neuroendocrine regulations or via several indirect effects on health, socioeconomic status, demeaning the quality of food and water. Malaysia is already observing a declining trend in the Total fertility rate (TFR) over the past few decades and is currently recorded below the replacement level of 2.1 which is insufficient to replace the present population. Moreover, climate changes reportedly play a role in the emergence and cessation of various infectious diseases. Besides its immediate effects, the long-term effects on health and fertility await to be unveiled. Despite the huge magnitude of the repercussion of climate changes in Malaysia, research that can explain the exact cause of the present reduction in fertility parameters in Malaysia or any measures to preserve the national population is surprisingly very scarce. Thus, the present review aims to elucidate the possible missing links by which climate changes are impairing fertility status in Malaysia.
    Matched MeSH terms: Developing Countries
  2. Tewari D, Mocan A, Parvanov ED, Sah AN, Nabavi SM, Huminiecki L, et al.
    Front Pharmacol, 2017;8:519.
    PMID: 28848436 DOI: 10.3389/fphar.2017.00519
    In many developing countries, jaundice is the common symptom of hepatic diseases which are a major cause of mortality. The use of natural product-based therapies is very popular for such hepatic disorders. A great number of medicinal plants have been utilized for this purpose and some facilitated the discovery of active compounds which helped the development of new synthetic drugs against jaundice. However, more epidemiological studies and clinical trials are required for the practical implementation of the plant pharmacotherapy of jaundice. The focus of this second part of our review is on several of the most prominent plants used against jaundice identified in the analysis performed in the first part of the review viz. Andrographis paniculata (Burm.f.) Nees, Silybum marianum (L.) Gaertn., Terminalia chebula Retz., Glycyrrhiza glabra L. and some species of genus Phyllanthus. Furthermore, we discuss their physiological effects, biologically active ingredients, and the potential mechanisms of action. Some of the most important active ingredients were silybin (also recommended by German commission), phyllanthin and andrographolide, whose action leads to bilirubin reduction and normalization of the levels of relevant serum enzymes indicative for the pathophysiological status of the liver.
    Matched MeSH terms: Developing Countries
  3. Myo, Thura Zaw, Ahmad Faris Abdullah, Naing, Oo Tha, Zainal Arifin Mustapha, Nor Amalina Emran, Zaw, Lin
    MyJurnal
    Emergence of multidrug resistant tuberculosis (MDR-TB) and extensively drug resistant tuberculosis (XDR-TB) is one of the reasons why tuberculosis (TB) continues to cause great mortality and morbidity in less-developed countries. The development of rapid diagnostic methods targeting genetic mutations associated with resistance to the anti-tuberculous drugs is essential to fight this deadly pathogen. Isoniazid (INH) has been included in the multidrug regimens for the treatment of drug-susceptible TB for the decades. In the worldwide setting, isoniazid resistance was highly prevalent and was observed in one of every seven TB cases. Since katG315 mutation is highly prevalent, the common mutation in the enzyme essential for the activation of the INH concerned with the mechanism of drug resistance and associated with high level resistance to INH, katG315 mutation was necessary to be identified by molecular method as a molecular determinant of INH resistant Mycobacterium tuberculosis. The prevalence of katG315 mutation in various countries was discussed in this report and a new molecular method for the detection of the mutation was proposed.
    Matched MeSH terms: Developing Countries
  4. Narwani Hussin, Hafizah Jumat, Mabelle Wong, Liau Siow Yen, Jeremy Robert Jinuin Jimin, Beh Boon Cong, et al.
    Int J Public Health Res, 2017;7(1):757-764.
    MyJurnal
    Rheumatic heart disease is still endemic in developing countries and among the indigenous population in developed countries. However, there is no comprehensive data on rheumatic heart disease patients in Malaysia. The Cardiology Department of Queen Elizabeth ll Hospital (QEH ll), Sabah started this hospital-based registry in 2010. The objective of this analysis was to report the demographic profile, severity of disease, types of valve involvement and the practice of secondary prophylaxis among these patients.
    Matched MeSH terms: Developing Countries
  5. Nguyen TA, Hassali MAA, McLachlan A
    WHO South East Asia J Public Health, 2013 Jan-Mar;2(1):72-74.
    PMID: 28612828 DOI: 10.4103/2224-3151.115849
    Generic medicines are a key strategy used by governments and third-party payers to contain medicines costs and improve the access to essential medicines. This strategy represents an important opportunity provided by the global intellectual property regimes to discover and develop copies of original products marketed by innovator companies once the patent protection term is over. While there is an extensive experience regarding generic medicines policies in developed countries, this evidence may not translate to developing countries. The generic medicines policies workshop at the Asia Pacific Conference on National Medicines Policies 2012 provided an important opportunity to discuss and document country-specific initiatives for improving access to and the rational of use of generic medicines in the Asia Pacific region. Based on the identified barriers and enablers to implementation of generic medicines policies in the region, a set of future action plans and recommendations has been made.
    Matched MeSH terms: Developing Countries
  6. Nuzul Azam Haron, Raja Putri Zarifh Ana Raja Soh, Aizul Nahar Harun
    MyJurnal
    This paper seeks to clarify Building Information Modelling (BIM) and its implementation in Malaysia.
    Most developed countries that have implemented BIM in the construction industry have found it effective. This paper reviews existing literature on the implementation of BIM and examines the implementation strategies that have been developed. The review highlights numerous advantages of BIM in construction, which include, among others, reducing cost, time, carbon burden and capital cost. BIM can also help increase broader efficiencies and improve coordination and communication between each party. However, implementing BIM is complicated and requires efforts from both the government and the private sector. While the implementation of BIM may reduce costs in developed countries, it may not do so in developing countries; in Malaysia, for instance, costs act as an initial barrier. Other obstacles to implementing BIM in Malaysia include application system requirements and lack of knowledge and readiness to change. To facilitate its implementation in the construction industry, the Malaysian government needs to hold seminars to promote a better understanding of BIM. They may also introduce a properly structured BIM course by preparing a standard code of practices and guidelines for BIM in the education sector.
    Matched MeSH terms: Developing Countries
  7. Quar TK, Rashid MFN, Rosdi MYM, Ishak WS, Chong FY
    Am J Audiol, 2023 Mar;32(1):59-69.
    PMID: 36446036 DOI: 10.1044/2022_AJA-22-00033
    OBJECTIVE: This study aimed to determine the challenges faced by individuals with hearing loss at a time when many nations were attempting to move from the COVID-19 pandemic to endemic.

    DESIGN: A cross-sectional survey was conducted on Malaysian adults with hearing loss to determine the impact of the COVID-19 crisis on hearing aid management, communication difficulties, psychosocial challenges, and access to audiological services.

    STUDY SAMPLE: One hundred forty-six individuals aged 18 years old and above with hearing loss were recruited from hearing health care centers to participate in the survey.

    RESULTS: Many of the participants (54.2%) reported significant difficulties communicating with people wearing face masks. For hearing aid management, repairing (36.3%) and fine-tuning devices (30.2%) were considered more challenging than obtaining a battery (21.3%). The COVID-19 pandemic had a serious psychosocial impact on a small portion of the individuals surveyed. Remote services were rarely offered by the audiologists, and most participants preferred in-person treatment. However, the majority perceived that creating awareness and training on telehealth was important.

    CONCLUSIONS: Effective management for people with hearing loss needs to consider the challenges faced by them, as the world prepares to live with the coronavirus. Clinical protocols should consider providing a service that is helpful for the clients as well as safe and sustainable in future pandemics.

    Matched MeSH terms: Developing Countries
  8. Gan GG, Tey KWF, Mat S, Saad M, Bee PC, Abdul Malik R, et al.
    Asian Pac J Cancer Prev, 2022 Nov 01;23(11):3905-3914.
    PMID: 36444604 DOI: 10.31557/APJCP.2022.23.11.3905
    BACKGROUND: Quality of life (QOL) of family caregivers of cancer patients is usually affected due to increase in caregiver burden. Their QOL has not garnered much attention by many including the health professionals and community. This study aims to explore the QOL of family caregivers of cancer patients in a multi-ethnic country in Asia and to investigate its associate factors.

    METHODS: This is a cross-sectional study where family caregivers and patients who were diagnosed of cancers within 12 months were recruited. QOL of caregivers were measured using The Caregiver Quality of Life Index-Cancer (CQOLC). Psychological distress was measured using Hospital anxiety and depressive scale. Logistic regression analysis was performed to determine the related factors of QOL of caregivers.

    RESULTS: A total of 458 patients/caregiver pairs were included. Symptoms of anxiety and depression reported by caregivers were 24.9% and 24.2% respectively. Caregivers of patients with solid tumors have better CQOLC score compared to those who cared for patients with hematological cancers (91.25 vs 86.75). Caregivers of non-Malay ethnicity, those caring for patients with advanced stage cancer and with hematological cancers had significantly poorer QOL. QOL of caregivers are also significantly affected when patients demonstrated anxiety symptoms.

    CONCLUSION: This study provides detailed evaluation of the QOL of caregivers of cancer patients in Malaysia. The significant psychological distress and low caregiver QOL indicate the urgent need for comprehensive supports for caregivers with cancer patients, especially those caring for patients with haematological cancers.

    Matched MeSH terms: Developing Countries
  9. Solarin SA, Al-Mulali U
    PMID: 29931634 DOI: 10.1007/s11356-018-2562-5
    This study aims to contribute to the existing literature by looking at the influence of foreign direct investment on carbon dioxide emissions, carbon footprint, and ecological footprint. In order to realize the aim of this study, we have utilized the augmented mean group estimator, which is supported by common correlated effect mean group estimator in the analysis for 20 countries. The panel results reveal that foreign direct investment has no effect on environmental degradation indicators. The panel results further reveal that gross domestic product, energy consumption, and urbanization are the main contributors to environmental degradation. The results at country level show that foreign direct investment and urbanization increase pollution in the developing countries while they mitigate pollution in the developed countries. Moreover, gross domestic product and energy consumption increase pollution for both developed and developing countries, which includes China and the USA. The negative impact of foreign direct investment on environmental degradation in the developed countries can be explained on the basis that these countries have strong environmental regulations, which makes it almost impossible for dirty foreign industries to invest therein. From the output of this research, several policy recommendations are enumerated for the investigated countries.
    Matched MeSH terms: Developing Countries
  10. Wu B, Liu S, Wang J, Tahir S, Patwary AK
    Environ Sci Pollut Res Int, 2021 Aug;28(30):40858-40870.
    PMID: 33772472 DOI: 10.1007/s11356-021-13605-2
    This work aims to assess multidimensional energy poverty and energy efficiency for environmental policy measures using data envelopment analysis (DEA), a DEA-Like mathematical composite indicator applied on a dataset based on multiple sets of variables from South Asian economies. The multidimensional energy poverty index (MEPI) is computed to analyze the combining effects and energy poverty in these countries. Simultaneously, South Asia's metropolitan areas' population rose by 130 million between 2001 and 2011 and is projected to expand by approximately 250 million by 2030. The findings reveal that endogenous increasing population shocks account for about 72% of energy use. In contrast, the long-term effects of remittance revenue, economic growth, and urbanization on energy use are approximately 20%, 8.25%, and 0.03%, respectively. This work advocates more coordinated and innovative policies to eliminate energy poverty. It can act as a base for policymakers and government officials to make efficient policies and enforce them properly in the regional power sector. Policies should be designed around a smarter use of biomass for cooking, alternate sources for domestic energy production, increased programs for biomass-based cookstoves, and periodic regional-level energy database development.
    Matched MeSH terms: Developing Countries
  11. Sohag K, Al Mamun M, Uddin GS, Ahmed AM
    Environ Sci Pollut Res Int, 2017 Apr;24(10):9754-9764.
    PMID: 28251538 DOI: 10.1007/s11356-017-8599-z
    Middle-income countries are currently undergoing massive structural changes towards more industrialized economies. In this paper, we carefully examine the impact of these transformations on the environmental quality of middle-income countries. Specifically, we examine the role of sector value addition to GDP on CO2 emission nexus for middle-income economies controlling for the effects of population growth, energy use, and trade openness. Using recently developed panel methods that consider cross-sectional dependence and allow for heterogeneous slope coefficients, we show that energy use and growth of industrial and service sectors positively explain CO2 emissions in middle-income economies. We also find that population growth is insignificantly associated with CO2 emission. Hence, our paper provides a solid ground for developing a sustainable and pro-growth policy for middle-income countries.
    Matched MeSH terms: Developing Countries
  12. Azam M, Khan AQ
    Environ Sci Pollut Res Int, 2017 Jul;24(19):16407-16417.
    PMID: 28550635 DOI: 10.1007/s11356-017-9299-4
    This study examines the impact of economic growth, corruption, health, and poverty on environmental degradation for three countries from ASEAN, namely Indonesia, Malaysia, and Thailand using annual data over the period of 1994-2014. The relationship between environmental degradation (pollution) by carbon dioxide (CO2) emissions and economic growth is examined along with some other variables, namely health expenditure, poverty, agriculture value added growth, industrial value added growth, and corruption. The ordinary least squares (OLS) method is applied as an analytical technique for parameter estimation. The empirical results reveal that almost all variables are statistically significant at the 5% level of significance, whereby test rejects the null hypotheses of non-cointegration, indicating that all variables play an important role in affecting the environment across countries. Empirical results also indicate that economic growth has significant positive impact, while health expenditures show significantly negative impact on the environment. Corruption has significant positive effect on environment in the case of Malaysia; while in the case of Indonesia and Thailand, it has insignificant results. However, for the individual analysis across countries, the regression estimate suggests that economic growth has a significant positive relationship with environment for Indonesia, while it is found insignificantly negative and positive in the case of Malaysia and Thailand, respectively, during the period under the study. Empirical findings of the study suggest that policy-makers require to make technological-friendly environment sequentially to surmount unregulated pollution, steady population transfers from rural areas to urban areas are also important, and poverty alleviation and better health provision can also help to improve the environment.
    Matched MeSH terms: Developing Countries
  13. Nwameme A, Dako-Gyeke P, Asampong E, Allotey P, Reidpath DD, Certain E, et al.
    PLoS Negl Trop Dis, 2023 Mar;17(3):e0011139.
    PMID: 36961830 DOI: 10.1371/journal.pntd.0011139
    The Special Programme for Research and Training in Tropical Diseases developed a massive open online course (MOOC) on implementation research with a focus on infectious diseases of poverty (IDPs) to reinforce the explanation of implementation research concepts through real case studies. The target MOOC participant group included public health officers, researchers and students. By reshaping institutions and building resilience in communities and systems, implementation research will allow progress towards universal health coverage and sustainable development goals. This study evaluates learners' knowledge in implementation research after completing the MOOC using anonymous exit survey responses. Of the almost 4000 enrolled in the two sessions of the MOOC in 2018, about 30% completed all five modules and the assessments, and were awarded certificates. The majority of the participants were early to mid-career professionals, under the age of 40, and from low- and middle-income countries. They were slightly more likely to be men (56%) with a Bachelor or a Master's degree. Participants were public health researchers (45%), public health officers (11%) or students (11%). On completion of the course, an exit survey revealed that 80.9% of respondents indicated significant improvement to strong and very strong implementation research knowledge. This evaluation clearly shows the usefulness of the MOOC on implementation research for reaching out to field researchers and public health practitioners who are facing problems in the implementation of control programmes in low- and middle-income countries.
    Matched MeSH terms: Developing Countries
  14. Maalouf A, Agamuthu P
    Waste Manag Res, 2023 Sep;41(9):1420-1434.
    PMID: 37125680 DOI: 10.1177/0734242X231160099
    This review provides the history and current paradigms of waste management (WM) practices in developing nations during the last five decades. It explores the evolution of the challenges, complexities, and trends during this period. This paper, for the first time, presents an estimation of the amount of municipal solid waste (MSW) generated in developing nations in the last five decades based on the material flow analysis approach. Overall, the amount of MSW in developing countries has increased from about 0.64 billion Mt in 1970 to 2 billion Mt in 2019. This review demonstrates the importance of finding new WM approaches in developing nations in the context of formulating policies, strategies, and highlights the major trends that re-define WM in developing countries. It also aims to present the holistic changes in technology, economic and environmental feasibility aspects to attain an integrated sustainable WM system in developing countries. Specific focus on open-burning, open-dumping, informal recycling, food waste, plastic pollution, and waste collection with reference to Sustainable Development Goals are explained. Drivers for the way forward including circular economy are investigated.
    Matched MeSH terms: Developing Countries
  15. Hassali MA, Ahmadi K, Yong GC
    Am J Pharm Educ, 2013 Aug 12;77(6):112.
    PMID: 23966715 DOI: 10.5688/ajpe776112
    Matched MeSH terms: Developing Countries
  16. Jagun ZT, Daud D, Ajayi OM, Samsudin S, Jubril AJ, Rahman MSA
    Environ Sci Pollut Res Int, 2023 Nov;30(55):116644-116655.
    PMID: 35867301 DOI: 10.1007/s11356-022-21990-5
    Growing populations, expanding economies, industrialisation, and urbanisation pose a problem for waste management in developing countries. Their waste management methods, on the other hand, are not as efficient as they could be. Most developing countries' current waste management practices do not fully conform to developed countries' best practices for meeting socioeconomic goals. As a result, the importance of waste management in developing countries has grown in recent years. In order to highlight the socioeconomic perspectives of waste management practices, the present study examines the existing literature, policies, information, and records on waste management in developing nations. The findings indicate that essential socioeconomic factors such as finances, population density, per capita income, education level, policies, and technology have a significant impact on waste management, which encompasses waste generation, collection, composition, and disposal/treatment. Nonetheless, waste management has a number of economic benefits, including financial stability, job creation, and community cohesion. This study will inspire further research on the need for developing nations to consider the socioeconomic benefits of proper waste management and to develop a policy plan to achieve these benefits.
    Matched MeSH terms: Developing Countries
  17. Saedi TA, Md Noor S, Ismail P, Othman F
    PMID: 25250054 DOI: 10.1155/2014/494136
    In developing countries, herbal therapy is the first and basis form of treatment for most types of diseases. About 75-80% of the world's population prefers herbal therapy as a major treatment due to its better adequacy and satisfactoriness, which enhance human body's symmetry with minimal side effects. Fruits and plants have been presented from the past as promising tools in becoming a natural anticancer agents. Many of these plant extracts are currently used in cancer therapy and prevention. This review paper will particularly explore and emphasize on herbs and fruits used in the treatment of the leukaemia.
    Matched MeSH terms: Developing Countries
  18. Ooi SH, Ng KP, Sthaneshwar P, Lim SK, Khor PY, Lim JY, et al.
    BMC Nephrol, 2024 Apr 05;25(1):122.
    PMID: 38580977 DOI: 10.1186/s12882-024-03498-x
    BACKGROUND: The commonest indication for hospitalization in COVID-19 patients is hypoxemia or severe respiratory symptoms. However, COVID-19 disease may result in extrapulmonary complications including kidney-related pathology. The reported incidence of renal involvement related to COVID infection varies based on geographical location.

    OBJECTIVE: This study aimed to assess the incidence rate of AKI in hospitalized COVID-19 patients and identify risk factors and prognostic predictors.

    METHOD: In this retrospective study, we recruited hospitalized COVID-19 patients from January 2021 until June 2021 at the University Malaya Medical Center. The inclusion criteria were hospitalized for ≥ 48 h with confirmed COVID-19 infection and at least 18 years old. Patient demographic and clinical data were collected from electronic medical records. The staging of AKI was based on criteria as per KDIGO guidelines.

    RESULTS: One thousand five hundred twenty-nine COVID patients fulfilled the inclusion criteria with a male-to-female ratio of 759 (49.6%) to 770 (50.3%). The median age was 55 (IQR: 36-66). 500 patients (32.7%) had diabetes, 621 (40.6%) had hypertension, and 5.6% (n = 85) had pre-existing chronic kidney disease (CKD). The incidence rate of AKI was 21.1% (n = 323). The percentage of COVID patients in different AKI stages of 1,2 and 3 were 16.3%, 2.1%, and 2.7%, respectively. Fifteen hospitalized patients (0.98%) required renal replacement therapy. 58.8% (n = 190) of AKI group had complete recovery of kidney function. Demographic factors included age (p 

    Matched MeSH terms: Developing Countries
  19. Garegnani L, Franco JVA, Escobar Liquitay CM, Brant LCC, Lim HM, de Jesus Jessen NP, et al.
    Prev Med, 2023 Jul;172:107534.
    PMID: 37146731 DOI: 10.1016/j.ypmed.2023.107534
    BACKGROUND: In 2010 the American Heart Association defined the concept of ideal cardiovascular health to renew the focus on primordial prevention for cardiovascular disease. Evidence primarily from high-income countries suggests ideal CVH prevalence is low and decreases with age, with vulnerable populations differentially affected. We aimed to identify and characterize the evidence relevant to CVH metrics in low- and middle-income countries (LMICs).

    METHODS: We followed the Joanna Briggs Institute guideline for the conduct of this scoping review. We searched MEDLINE, Embase, LILACS and study registers from inception to 14 March 2022. We included cross-sectional and cohort studies in populations representing a geographically-defined unit (urban or rural) in LMICs, and with data on CVH metrics i.e. all health or clinical factors (cholesterol, blood pressure, glycemia and body mass index) and at least one health behavior (smoking, diet or physical activity). We report findings following the PRISMA-Scr extension for scoping reviews.

    RESULTS: We included 251 studies; 85% were cross-sectional. Most studies (70.9%) came from just ten countries. Only 6.8% included children younger than 12 years old. Only 34.7% reported seven metrics; 25.1%, six. Health behaviors were mostly self-reported; 45.0% of studies assessed diet, 58.6% physical activity, and 90.0% smoking status.

    CONCLUSIONS: We identified a substantial and heterogeneous body of research presenting CVH metrics in LMICs. Few studies assessed all components of CVH, especially in children and in low-income settings. This review will facilitate the design of future studies to bridge the evidence gap. This scoping review protocol was previously registered on OSF: https://osf.io/sajnh.

    Matched MeSH terms: Developing Countries
  20. Lee JSF, Cohen RM, Khan RA, Burry J, Casas EC, Chung HY, et al.
    Lancet Glob Health, 2024 Sep;12(9):e1552-e1559.
    PMID: 39151989 DOI: 10.1016/S2214-109X(24)00225-0
    Amphotericin B has long been crucial for treating many serious infectious diseases, such as invasive fungal infections and visceral leishmaniasis, particularly for patients who are immunocompromised, including those with advanced HIV infection. The conventional amphotericin B deoxycholate formulation has largely been replaced in high-income countries with liposomal amphotericin B (LAmB), which has many advantages, including lower rates of adverse events, such as nephrotoxicity and anaemia. Despite an evident need for LAmB in low-income and middle-income countries, where mortality from invasive fungal infections is still substantial, many low-income and middle-income countries still often use the amphotericin B deoxycholate formulation because of a small number of generic formulations and the high price of the originator LAmB. The pricing of LAmB is also highly variable between countries. Overcoming supply barriers through the availability of additional quality-assured, generic formulations of LAmB at accessible prices would substantially facilitate equitable access and have a substantial effect on mortality attributable to deadly fungal infections.
    Matched MeSH terms: Developing Countries
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