MyMedR

Relationship between the corneal surface and the anterior segment of the cornea: An Asian perspective

Lim KL, Fam HB

J Cataract Refract Surg, 2006 Nov;32(11):1814-9.

To determine the values for the anterior best-fit sphere (BFS) and posterior BFS in an Asian population using the Orbscan II (Bausch & Lomb) slit-scanning Placido disk corneal topographer.

Matched MeSH terms: Anterior Eye Segment/anatomy & histology*

Fulltext Can people guess what happened to others from their reactions?

Pillai D, Sheppard E, Mitchell P

PLoS One, 2012;7(11):e49859.

PMID: 23226227 DOI: 10.1371/journal.pone.0049859

Are we able to infer what happened to a person from a brief sample of his/her behaviour? It has been proposed that mentalising skills can be used to retrodict as well as predict behaviour, that is, to determine what mental states of a target have already occurred. The current study aimed to develop a paradigm to explore these processes, which takes into account the intricacies of real-life situations in which reasoning about mental states, as embodied in behaviour, may be utilised. A novel task was devised which involved observing subtle and naturalistic reactions of others in order to determine the event that had previously taken place. Thirty-five participants viewed videos of real individuals reacting to the researcher behaving in one of four possible ways, and were asked to judge which of the four 'scenarios' they thought the individual was responding to. Their eye movements were recorded to establish the visual strategies used. Participants were able to deduce successfully from a small sample of behaviour which scenario had previously occurred. Surprisingly, looking at the eye region was associated with poorer identification of the scenarios, and eye movement strategy varied depending on the event experienced by the person in the video. This suggests people flexibly deploy their attention using a retrodictive mindreading process to infer events.

Matched MeSH terms: Eye Movements/physiology

Fulltext Distribution of axial length, anterior chamber depth, and corneal curvature in an aged population in South China

Chen H, Lin H, Lin Z, Chen J, Chen W

BMC Ophthalmol, 2016 May 01;16(1):47.

PMID: 27138378 DOI: 10.1186/s12886-016-0221-5

BACKGROUND: Ocular biometry is important for preoperative assessment in cataract and anterior segment surgery. The purpose of this study was to investigate normative ocular biometric parameters and their associations in an older Chinese population.

METHODS: This was a cross-sectional observational study. From 2013 to 2014, we recruited inhabitants aged 50 years or older in Guangzhou, China. Among 1,117 participants in the study, data from 1,015 phakic right eyes were used for analyses. Ocular parameters including axial length (AL), anterior chamber depth (ACD), and corneal curvature (K) were measured using an IOL Master.

RESULTS: The mean AL, ACD, and K were 23.48 mm [95 % confidence interval (CI), 23.40-23.55], 3.03 mm (CI, 3.01-3.05), and 44.20 mm (CI, 44.11-44.29), respectively. A mean reduction in ACD with age was observed (P = 0.002) in male subjects but not in female subjects (P = 0.558). Male subjects had significantly longer ALs (23.68 mm versus 23.23 mm, P

Matched MeSH terms: Axial Length, Eye/anatomy & histology*

In Situ Gelling Ophthalmic Drug Delivery System: An Overview and Its Applications

Sheshala R, Kok YY, Ng JM, Thakur RR, Dua K

Recent Pat Drug Deliv Formul, 2015;9(3):237-48.

PMID: 26205681

Ophthalmic drug delivery system is very interesting and challenging due to the normal physiologically factor of eyes which reduces the bioavailability of ocular products. The development of new ophthalmic dosage forms for existing drugs to improve efficacy and bioavailability, patient compliance and convenience has become one of the main trend in the pharmaceuticals industry. The present review encompasses various conventional and novel ocular drug delivery systems, methods of preparation, characterization and recent research in this area. Furthermore, the information on various commercially available in situ gel preparations and the existing patents of in situ drug delivery systems i.e. in situ gel formation of pectin, in situ gel for therapeutic use, medical uses of in situ formed gels and in situ gelling systems as sustained delivery for front of eye are also covered in this review.

Matched MeSH terms: Eye/metabolism

Fulltext Ocular biometry in the subtypes of primary angle closure glaucoma in University Malaya Medical Centre

Mimiwati Z, Fathilah J

Med J Malaysia, 2001 Sep;56(3):341-9.

PMID: 11732081

Thirty-seven consecutive patients (41 eyes) diagnosed with primary angle closure glaucoma (PACG) attending the Glaucoma Clinic in University Malaya Medical Centre, over a period of 6 months were categorized into acute, subacute and chronic PACG from their clinical presentation. Each case was subjected to automated refraction, A-scan biometry for anterior chamber depth, axial length and lens thickness, keratometry and corneal diameter measurement. Calculations for the relative lens position and the lens thickness: axial length index were performed. The data collected was analysed by the nonparametric test (Kruskal-Wallis), one way analysis of variance (ANOVA), chi-square test, Spearman's nonparametric correlations and regression analysis. For controls 15 eyes from 15 normal subjects matched for age, sex, refractive error and race were chosen and subjected to the same examinations. Chronic PACG was the predominant subtype (53.6% of patients and 58.5% of eyes). The ocular biometric measurements of acute PACG eyes deviated most from normals in having the shallowest anterior chamber depth, shortest axial length, smallest corneal diameter, steepest corneal radius, thickest and most anteriorly situated lens, and the greatest lens thickness: axial length index. The subacute subtype was closest to normal and chronic PACG subtype fell in between in most of the biometric characteristics. These findings were not statistically significant. All PACG eyes as a group however showed statistically significant shallower anterior chamber depth (p < 0.05), and a more anterior relative lens position (p < 0.05) compared to normals.

Matched MeSH terms: Eye/pathology*

Unusual clinical features of foetal alcohol syndrome

Chaudhuri JD

J Indian Med Assoc, 2002 Feb;100(2):107-8, 110.

PMID: 12206352

Foetal alcohol syndrome (FAS) is a collection of signs and symptoms seen in children of women who consume alcohol during pregnancy. With the increasing incidence of FAS, there is a great variation of its clinical features different from that described in the standard textbooks. This article aims to report on the unusual clinical features of FAS. It also aims to explain the mechanism of action of alcohol as a teratogenic agent.

Matched MeSH terms: Eye Abnormalities/diagnosis

Fulltext Prevalence of dry eye in University Malaya Medical Centre

Jamaliah R, Fathilah J

Med J Malaysia, 2002 Dec;57(4):390-7.

PMID: 12733162

Two hundred outpatients (115 females and 85 males) attending the University Malaya Medical Center (UMMC) eye clinic, aged 20 years and above and without any ocular surface disorder were recruited for this study. Their tear film status was determined subjectively by their symptoms and quantitatively by the cotton thread test, Schirmer's test, marginal tear film meniscus assessment, fluorescein corneal staining and tear break-up time. Dry eye was considered present if at least one symptom was experienced often or always, within the past 3 months. Dry eye was also considered present if one of these tests was positive; Schirmer's test < 5 mm, Phenol red thread (PRT) test < 10 mm and tear film breakup time (BUT) < 8 seconds. The prevalence of dry eye in this sample population as defined by presence of symptoms and an abnormal test result is 14.5%. Presence of dry eye as detected by clinical testing is higher in the Chinese race (p < 0.01), in the group 40-59 years (p = 0.024). There is no difference between females and males. A lower BUT score was more strongly associated with presence of dry eye symptoms (p = 0.02). Elderly patients have a lower BUT and Schirmer's score. There is lack of agreement between PRT and Schirmer's test, although both are measures of tear quantity.
Study site: Eye clinic, University Malaya Medical Center (UMMC), Kuala Lumpur, Malaysia

Matched MeSH terms: Dry Eye Syndromes/epidemiology*

Fulltext A study of perforating eye injuries at the Ophthalmology Department, National University of Malaysia

Zainal M, Goh PP

Med J Malaysia, 1997 Mar;52(1):12-6.

PMID: 10968048

One hundred and sixty seven (167) perforating eye injuries involving 159 patients were analyzed in a retrospective study over a three-year period. The degree of blindness and their associated factors were determined. Most patients were in the first three decades of life and were males. One hundred and seven (64%) eyes had vision of 3/60 or worse at initial assessment. Of these only 45% of eyes had improved vision to 6/36 or better at six months of follow-up. Fifty-five per cent of eyes were blind. The only significant associated factor identified was the extent of injury. Age, time interval and mechanism of injury were not significant factors.

Matched MeSH terms: Eye Injuries/epidemiology*

Critical review: effects of optical defocus on refractive development and ocular growth and relation to accommodation

Chung KM

Optom Vis Sci, 1993 Mar;70(3):228-33.

PMID: 8483585

Studies of optical defocus on refractive development and ocular growth in animals are presented and discussed in relation to the accommodation hypothesis. None of these studies fully support the accommodation hypothesis. The problems encountered in these studies are also discussed.

Matched MeSH terms: Eye/growth & development*

Ocular dimensions and refractive power in Malay and Melanesian children

Garner LF, Meng CK, Grosvenor TP, Mohidin N

Ophthalmic Physiol Opt, 1990 Jul;10(3):234-8.

PMID: 2216470

A cross-sectional study of 753 Melanesian children in Vanuatu and 904 Malay children in Malaysia included measurement of refractive error and ocular dimensions. All children were between the ages of 6 and 17 years. The prevalence of myopia in Malay children was 4.3% at 7-8 years and 25.6% at 15-16 years with corresponding figures of 0.8% and 4.3% for Melanesian children. The range of refractive error was greater for Malay children at all ages. Mean refractive error for Malay children showed greater hypermetropia, together with a shorter axial length at 6 years, than Melanesian children, but at 17 years the situation reversed and Malay children had more myopia and longer axial lengths than their Melanesian counterparts.

Matched MeSH terms: Eye/pathology*

Fulltext The role of tranexamic acid (Cyklokapron) in the treatment of traumatic hyphaema

Sukumaran K

Med J Malaysia, 1988 Jun;43(2):155-8.

PMID: 3237131

Matched MeSH terms: Eye Injuries/complications*

Actinomycetic corneal ulcer

Singh M, Kaur B

Eye (Lond), 1989;3 ( Pt 4):460-2.

PMID: 2606221

A rare case of keratoactinomycosis developing in the absence of any known ocular trauma is described. It showed a dramatic response to penicillin therapy. Steroids should be cautiously used in the presence of active corneal disease. This case highlights the importance of repeated examination of corneal scrapings.

Matched MeSH terms: Eye Infections, Fungal/complications*

Long-term phenothiazine administration and the eye in 100 Malaysians

Ngen CC, Singh P

Br J Psychiatry, 1988 Feb;152:278-80.

PMID: 3167349

Seventy-three out of a hundred Malaysians on phenothiazines for more than 24 months had ocular pigmentation. Seventy-one had conjunctiva pigmentation. No pigmentary retinopathy or visual impairment was detected. Frequency of pigmentation increased with age and with higher total dosage prescribed, but there was no critical level below which pigmentation was not detected.

Matched MeSH terms: Eye/drug effects*

Fulltext Juvenile rhegmatogenous retinal detachment in Malaysia

Singh M

Med J Malaysia, 1986 Jun;41(2):156-60.

PMID: 3821612

45 patients (50 eyes) were treated for juvenile rhegmatogenous retinal detachments between August 1979 and July 1984. A review of these cases revealed high myopia and trauma to be the main aetiological factors. Eight-six per cent detachments were successfully reattached. Visual acuity of 6/36 or better was present in 16% preoperatively and in 52% postoperatively, some of the characteristics of juvenile rhegmatogenous retinal detachments in Malaysian population are discussed.

Matched MeSH terms: Eye Injuries/complications

Ocular complications in longstanding leprosy patients at the Tampoi Leprosarium, Johore, West Malaysia

Deva JP

Med J Malaysia, 1976 Mar;30(3):201-6.

PMID: 183087

Matched MeSH terms: Eye Diseases/etiology*

Fulltext Reducing the failure rate of ocular prosthesis at Hospital Sultanah Aminah

Muhamad Imran Abdulah, Ikmal Abdul Hakim, Rosni Amin, Rosliza Parumo, Ma, Bee Chai, Noraziyah Abdul Aziz, et al.

Q Bulletin, 2020;1(29):16-27.

MyJurnal

The Department of Oral & Maxillofacial Surgery at Hospital Sultanah Aminah, Johor Bahru started managing patients who lost their eyeballs with ocular prosthesis in 2013. Unfortunately, there was an increasing trend of failed ocular prosthesis from 2013-2015. The failure rate went from 28.6% in 2013 to 40% in 2014 and increased to 44.4% in 2015. Failed ocular prosthesis not only leads to dissatisfied patients but also an increase in cost due to redoing of prosthesis. The objective of this project was to reduce the incidence rate of failed ocular prosthesis. A failed case is when the prosthesis does not pass the issue stage and has to be redone from the beginning. The standard failure rate is 0%, as the average number of cases per year is only about 10 cases. We determined the contributing factors of failed ocular prosthesis by analysing retrospective data from patients’ dental and lab records. This was followed by a self-administered questionnaire on reasons for failed cases which was distributed among the dentists and lab technicians in our department. The contributing factors that were identified included insufficient knowledge or skill of dentist and lab technicians in the construction of the ocular prosthesis, as well as improper screening of new cases which was the main factor of all the failed cases. The strategies for change included improving the process of care by creating a checklist for proper screening of new patients, mentoring of new staff, and continuous training on construction of ocular prosthesis, Fabricated Iris Mould innovation technique and early referral for insertion of eye conformer. The interventions that were implemented reduced the failure rate to 20% in 2016 followed by 0% in 2017, 2018 and 2019. Ongoing efforts are being done to replicate this project in other Oral & Maxillofacial Surgery clinics in Johor.

Matched MeSH terms: Eye, Artificial; Eye Enucleation

Fulltext Some experiences in ophthalmology

Lowther AH

Journal of the Malaya Branch of the British Medical Association, 1938;2(3):144-64.

Matched MeSH terms: Eye Diseases; Eye Infections

Fulltext OFD1 is mutated in X-linked Joubert syndrome and interacts with LCA5-encoded lebercilin

Coene KL, Roepman R, Doherty D, Afroze B, Kroes HY, Letteboer SJ, et al.

Am J Hum Genet, 2009 Oct;85(4):465-81.

PMID: 19800048 DOI: 10.1016/j.ajhg.2009.09.002

We ascertained a multi-generation Malaysian family with Joubert syndrome (JS). The presence of asymptomatic obligate carrier females suggested an X-linked recessive inheritance pattern. Affected males presented with mental retardation accompanied by postaxial polydactyly and retinitis pigmentosa. Brain MRIs showed the presence of a "molar tooth sign," which classifies this syndrome as classic JS with retinal involvement. Linkage analysis showed linkage to Xpter-Xp22.2 and a maximum LOD score of 2.06 for marker DXS8022. Mutation analysis revealed a frameshift mutation, p.K948NfsX8, in exon 21 of OFD1. In an isolated male with JS, a second frameshift mutation, p.E923KfsX3, in the same exon was identified. OFD1 has previously been associated with oral-facial-digital type 1 (OFD1) syndrome, a male-lethal X-linked dominant condition, and with X-linked recessive Simpson-Golabi-Behmel syndrome type 2 (SGBS2). In a yeast two-hybrid screen of a retinal cDNA library, we identified OFD1 as an interacting partner of the LCA5-encoded ciliary protein lebercilin. We show that X-linked recessive mutations in OFD1 reduce, but do not eliminate, the interaction with lebercilin, whereas X-linked dominant OFD1 mutations completely abolish binding to lebercilin. In addition, recessive mutations in OFD1 did not affect the pericentriolar localization of the recombinant protein in hTERT-RPE1 cells, whereas this localization was lost for dominant mutations. These findings offer a molecular explanation for the phenotypic spectrum observed for OFD1 mutations; this spectrum now includes OFD1 syndrome, SGBS2, and JS.

Matched MeSH terms: Eye Proteins/genetics*

Fulltext Comparison of open-ended and close-ended questions to determine signs and symptoms of eye problems among children

Chen AH, Bakar NA, Lam CS

J Optom, 2019 10 16;13(2):81-87.

PMID: 31629682 DOI: 10.1016/j.optom.2019.07.002

BACKGROUND: Parents play important role in providing information regarding their children's health status to healthcare providers. However, parents' ability in reporting signs and symptoms of eye problems among their children required more in-depth investigation. Our study aimed to compare the differences of parental report regarding eye problems among their children using two different question approaches.

METHODS: A total of 416 parents with children aged between two months old and 17 years old were participated in this cross-sectional survey. The responses of parents' observation on signs and symptoms of eye problems were compared between one open-ended question and ten close-ended questions. We also examined the demographic contributing factors that could influence parental responses.

RESULTS: The total count of reported signs and symptoms through open-ended and close-ended question was 164 and 529 reports, respectively. Parents reported more diverse (70% higher) categories of signs and symptoms in open-ended compared to close-ended questions. Parent's ability to report eye problems using open-ended question was associated with their gender (p<0.05), but no similar significant association was found in close-ended questions.

CONCLUSION: Parents reported more signs and symptoms of eye problems among their children through close-ended questions (regardless of gender) and more diversified categories through open-ended question in this study suggested that different communication approaches might be needed in clinical practice between those who requested specific appointment and those attending screening or routine assessment. The discrepancy might imply the importance to enhance the parent's role in preventive eye care. Effective communication between eyecare providers and parents has the potential to improve paediatric eyecare delivery.

Matched MeSH terms: Eye Diseases/diagnosis*

Fulltext Corneal laceration caused by river crab

Vinuthinee N, Azreen-Redzal A, Juanarita J, Zunaina E

Clin Ophthalmol, 2015;9:203-6.

PMID: 25678769 DOI: 10.2147/OPTH.S74548

A 5-year-old boy presented with right eye pain associated with tearing and photophobia of 1-day duration. He gave a history of playing with a river crab when suddenly the crab clamped his fingers. He attempted to fling the crab off, but the crab flew and hit his right eye. Ocular examination revealed a right eye corneal ulcer with clumps of fibrin located beneath the corneal ulcer and 1.6 mm level of hypopyon. At presentation, the Seidel test was negative, with a deep anterior chamber. Culture from the corneal scrapping specimen grew Citrobacter diversus and Proteus vulgaris, and the boy was treated with topical gentamicin and ceftazidime eyedrops. Fibrin clumps beneath the corneal ulcer subsequently dislodged, and revealed a full-thickness corneal laceration wound with a positive Seidel test and shallow anterior chamber. The patient underwent emergency corneal toileting and suturing. Postoperatively, he was treated with oral ciprofloxacin 250 mg 12-hourly for 1 week, topical gentamicin, ceftazidime, and dexamethasone eyedrops for 4 weeks. Right eye vision improved to 6/9 and 6/6 with pinhole at the 2-week follow-up following corneal suture removal.

Matched MeSH terms: Eye Abnormalities; Eye Pain

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