MyMedR

Cancer pain self-management interventions in adults: scoping review

Sjattar EL, Arafat R, Ling LW

BMJ Support Palliat Care, 2024 Nov 20;14(4):411-415.

PMID: 38719570 DOI: 10.1136/spcare-2024-004893

BACKGROUND: The predominant trend in cancer treatment now leans towards outpatient care, placing the responsibility of pain management largely on the patients themselves. Moreover, a significant portion of treatment for advanced cancer occurs in the home environment, so patient self-management becomes increasingly crucial for the effective treatment of cancer pain.

OBJECTIVES: To map self-management for pain in patients with cancer at all phases of the disease before examining the potential of pain self-care interventions for ill patients with cancer.

METHODS: A search was conducted on six electronic databases to locate studies published in English, from 2013 to 2023. We followed Arskey and O'Malley's Scoping Reviews guidelines.

RESULTS: This study thoroughly examined the provision of cancer pain self-management by healthcare professionals and identified four intervention types from 23 studies. Education emerged as the most prevalent form of self-management for cancer pain.

CONCLUSION: Guiding patients in managing their pain effectively, starting from their hospitalisation and extending to their discharge.

Matched MeSH terms: Neoplasms/complications; Neoplasms/therapy

The role of minimal residual disease assessment in ovarian tissue cryopreservation among oncofertility cases

Ahmad MF, Elias MH

Fertil Steril, 2024 Sep;122(3):441-442.

PMID: 38906214 DOI: 10.1016/j.fertnstert.2024.06.012

Matched MeSH terms: Neoplasms/complications; Neoplasms/therapy

The Sirt1/Nrf2 pathway is a key factor for drug therapy in chemotherapy-induced cardiotoxicity: a Mini-Review

Mohammad SIS, Vasudevan A, Enwa FO, Bansal J, Chahar M, Eldesoqui M, et al.

Med Oncol, 2024 Sep 11;41(10):244.

PMID: 39259412 DOI: 10.1007/s12032-024-02494-3

The likelihood of survival for cancer patients has greatly improved due to chemotherapy medicines. However, these antitumor agents might also have unfavorable effects on the cardiovascular system, which could result in sudden or gradual cardiac failure. The production of free radicals that result in oxidative stress appears to be the key mechanism by which chemotherapy-induced cardiotoxicity (CIC) happens. Reports suggest that the Sirtuin-1 (Sirt1)/Nuclear factor E2-associated factor 2 (Nrf2) signaling pathway has been considered an alternative path for counteracting cardiotoxicity by suppressing oxidative stress, inflammation, and apoptosis. This review concludes recent knowledge about CIC with a special focus on the anti-oxidative regulation properties of the Sirt1/Nrf2 pathway.

Matched MeSH terms: Neoplasms/drug therapy; Neoplasms/metabolism

Fulltext Case Report of a Pituitary Metastasis from Lung Adenocarcinoma Masquerading as Pituitary Adenoma

Rajakumar R, Rahmatullah IH, Rahim AA

J ASEAN Fed Endocr Soc, 2020;35(1):133-136.

PMID: 33442183 DOI: 10.15605/jafes.035.01.24

Metastasis to the pituitary gland is an unusual situation in clinical practice and is typically observed in those with underlying malignancy with breast and lung being the commonest primary site. However, we report a case of an apparently well 49-year-old female with metastatic lung adenocarcinoma who presented with visual disturbance and diabetes insipidus related to pituitary metastasis as an initial presentation.

Matched MeSH terms: Breast Neoplasms; Lung Neoplasms; Pituitary Neoplasms

Fulltext The complexity of stromal changes in desmoplastic ameloblastoma

Ramesh V, Singh S, Bailwad S, Kiran K, Agarwal R, Singh A

Ann Med Health Sci Res, 2014 Mar;4(Suppl 1):S14-7.

PMID: 25031898 DOI: 10.4103/2141-9248.131694

Ameloblastoma is usually considered a homogenous neoplasm and is thought of as the most primitive of all odontogenic neoplasms. However, detailed investigations have proven clinicopathological diversity in a significant number of cases, thus mounting the evidence in favor of considering ameloblastoma as a mysterious lesion. The purpose of this article is to report a unique case of desmoplastic ameloblastoma and to throw light on the atypical changes noticed in the stromal component. The findings of this case have served to add interesting parameters to the study of stromal changes associated with this perplexing odontogenic tumor.

Matched MeSH terms: Mandibular Neoplasms

Fulltext Lung adenocarcinoma with ipsilateral pleural and breast metastases

Liam CK, Pang YK, Kow KS

J Thorac Oncol, 2014 Jan;9(1):e8-9.

PMID: 24346108 DOI: 10.1097/01.JTO.0000438376.45132.9c

Matched MeSH terms: Breast Neoplasms/secondary*; Lung Neoplasms/pathology*

Plexiform schwannoma of the clitoris in a young girl: a case report

Azurah AG, Grover S, McGregor D

J Reprod Med, 2013 Jul-Aug;58(7-8):365-8.

PMID: 23947092

Schwannoma (neurilemoma) is a benign, slow-growing tumor of the nerve sheath. These tumors are rarely found in the female genitalia and to date only 1 case of clitoral schwannoma has been reported in a young girl. We report here the second case of schwannoma of the clitoris.

Matched MeSH terms: Vulvar Neoplasms/diagnosis*; Vulvar Neoplasms/pathology; Vulvar Neoplasms/surgery

Fulltext A rare case of nasopharyngeal carcinosarcoma

Lim AL, Zahirrudin Z, Pua KC

Med J Malaysia, 2012 Aug;67(4):428-9.

PMID: 23082458 MyJurnal

Nasopharnygeal carcinoma is known to be the commonest tumour of the nasopharynx. However, the incidence of nasopharngeal carcinosarcoma is extremely rare. Carcinosarcoma has been reported to be aggressive in nature and therefore early diagnosis and prompt treatment is important. We report a young lady who was diagnosed with nasopharyngeal carcinosarcoma in our centre. She presented with only 2 weeks history of nose block and was noted to have a mass occupying the nasopharynx with neck metastasis. She underwent panendoscope and biopsy with radical radiotherapy.

Matched MeSH terms: Nasopharyngeal Neoplasms/diagnosis; Nasopharyngeal Neoplasms/pathology*; Nasopharyngeal Neoplasms/therapy

Fulltext Does lightning strike twice?

Qi Qi C, Ajit Singh V

BMJ Case Rep, 2012;2012.

PMID: 22892228 DOI: 10.1136/bcr.01.2012.5518

The authors present an interesting case under our follow-up who has had five different forms of tumours with different pathologies throughout his lifetime. He started off with hepatoma, followed by pleomorphic sarcoma of the thigh, adenocarcinoma of the prostate, meningioma and finally schwanoma. He is still alive to this date.

Matched MeSH terms: Liver Neoplasms/diagnosis; Liver Neoplasms/pathology*; Liver Neoplasms/therapy; Neoplasms, Multiple Primary/diagnosis; Neoplasms, Multiple Primary/pathology*; Neoplasms, Multiple Primary/therapy; Prostatic Neoplasms/diagnosis; Prostatic Neoplasms/pathology*; Prostatic Neoplasms/therapy; Soft Tissue Neoplasms/diagnosis; Soft Tissue Neoplasms/pathology*; Soft Tissue Neoplasms/therapy

Fulltext Orbital myxoma--an unusual cause of inferoorbital mass

Ting SL, Koay CL, Ngo CT, Chieng LL, Chua CN

Med J Malaysia, 2010 Sep;65(3):224-6.

PMID: 21939174

To describe a case of isolated infraorbital mass which had been present for the past 9 years in a young woman. Despite the size, the mass was successfully excised in total.

Matched MeSH terms: Orbital Neoplasms/pathology; Orbital Neoplasms/radiography; Orbital Neoplasms/surgery*

Fulltext Trilateral retinoblastoma

Limn YS, Juraida E, Alagaratnam J, Menon BS

Med J Malaysia, 2011 Jun;66(2):156-7.

PMID: 22106703 MyJurnal

Trilateral retinoblastoma is the association of hereditary bilateral or unilateral retinoblastoma with a pineal neuroblastic tumour. We describe two cases of trilateral retinoblastoma from a total of 141 cases of retinoblastoma seen over an 8.5 year period. Both had a fatal outcome, with survival times of only 4 and 8 months respectively.

Matched MeSH terms: Retinal Neoplasms/diagnosis*; Retinal Neoplasms/etiology; Retinal Neoplasms/therapy*

Fulltext Leiomyosarcoma of the maxillary sinus

Chew YK, Noorizan Y, Khir A, Brito-Mutunayagam S

Med J Malaysia, 2009 Jun;64(2):174-5.

PMID: 20058584 MyJurnal

Leiomyosarcoma is a malignant smooth-muscle tumour that has a predilection for the gastrointestinal and female genital tract. It is locally fast-spreading and highly aggressive, and the prognosis is poor. We report a rare case of leiomyosarcoma of the maxilla in a patient who sought treatment for maxillary swelling, nasal obstruction with no epistaxis, orbital involvement or cervical lymph node metastasis. The patient underwent subtotal maxillectomy followed by radiotherapy. At present, he is symptom free with no recurrence and under regular follow up.

Matched MeSH terms: Maxillary Sinus Neoplasms/diagnosis; Maxillary Sinus Neoplasms/pathology*; Maxillary Sinus Neoplasms/therapy

Fulltext Respiratory clinics: haemoptysis, breathlessness and chest pain in a 46-year-old man

Khajotia R

Malays Fam Physician, 2010;5(2):105-6.

PMID: 25606198

Matched MeSH terms: Lung Neoplasms

Breast cancer in Asia

Yip CH

Methods Mol Biol, 2009;471:51-64.

PMID: 19109774 DOI: 10.1007/978-1-59745-416-2_3

Breast cancer is the commonest cancer in most countries in Asia. The incidence rates remain low, although increasing at a more rapid rate than in western countries, due to changes in the lifestyle and diet. There are many differences between breast cancer in Asia compared with western countries. The mean age at onset is younger than in the west, and unlike the west, the age-specific incidence decreases after the age of 50 years. Because there is no population-based breast cancer screening program in the majority of Asian countries, the majority of patients present with advanced disease. There is a higher proportion of hormone receptor-negative patients, and some evidence that the cancers in Asia are of a higher grade. Most of the Asian countries are low- and middle-income countries, where access to effective care is limited. Because of the late detection and inadequate access to care, survival of women with breast cancer in Asia is lower than in western countries. Improving breast health in most of the Asian countries remains a challenge that may be overcome with collaboration from multiple sectors, both public and private.

Matched MeSH terms: Breast Neoplasms/diagnosis*; Breast Neoplasms/epidemiology; Breast Neoplasms/prevention & control*

Fulltext Pleomorphic adenoma of the trachea

Ashwaq AM, Sani A

Med J Malaysia, 2007 Jun;62(2):162-3.

PMID: 18705454 MyJurnal

Primary tracheal tumors are very rare. Pleomorphic adenoma is rarely found in the trachea, despite being the most common histological form of salivary gland neoplasm. We present a case of pleomorphic adenoma of the trachea. Bronchoscopic excision using cold instruments resulted in apparently normal tracheal mucosa.

Matched MeSH terms: Tracheal Neoplasms/diagnosis*; Tracheal Neoplasms/pathology; Tracheal Neoplasms/surgery

Choristoma of the base of the tongue

Naik VR, Wan Faiziah WA, Musa MY

Indian J Pathol Microbiol, 2009 1 13;52(1):86-7.

PMID: 19136792

Choristoma is a benign tumor where new bone formation occurs. It occurs exclusively in the flat bones of the skull and face. These are slow growing lesions that are usually completely asymptomatic and only present when there is a disruption in the function of the organ due to its large size as it grows. These choristomas can rarely occur in soft tissues especially in the head, eye, tongue, or extremities. Choristomas of the soft tissues are very rare. Only 61 cases of choristomas of the tongue have been reported in literature. Here we report a case of choristoma in the base of the tongue in a 25-year-old Malay female.

Matched MeSH terms: Tongue Neoplasms/diagnosis*; Tongue Neoplasms/pathology*; Tongue Neoplasms/surgery

Fulltext Nasal cause of sixth cranial nerve palsy

Irfan M

Malays Fam Physician, 2013;8(3):54.

PMID: 25893063

Matched MeSH terms: Nasopharyngeal Neoplasms

Fulltext Commentary: adherence and detection rates in colorectal cancer screening

Hilmi I, Goh KL

Aliment Pharmacol Ther, 2013 Jan;37(1):156-7; discussion 157-8.

PMID: 23205475 DOI: 10.1111/apt.12122

Matched MeSH terms: Neoplasms/diagnosis*; Colorectal Neoplasms/diagnosis*

Changing trends of prostate cancer in Asia

Pu YS, Chiang HS, Lin CC, Huang CY, Huang KH, Chen J

Aging Male, 2004 Jun;7(2):120-32.

PMID: 15672937

Although Asian people have the lowest incidence and mortality rates of prostate cancer in the world, these rates have risen rapidly in the past two decades in most Asian countries. Prostate cancer has become one of the leading male cancers in some Asian countries. In 2000, the age-adjusted incidence was over 10 per 100000 men in Japan, Taiwan, Singapore, Malaysia, the Philippines and Israel. Although some of the increases may result from enhanced detection, much of the increased incidence may be associated with westernization of the lifestyle, with increasing obesity and increased consumption of fat. The differences in incidences between native Americans and Asian immigrants are getting smaller, reflecting a possible improvement of diagnostic efforts and changes of environmental risk factors in Asian immigrants. Nevertheless, the huge variations in incidences among ethnic groups imply that there are important genetic risk factors. The stage distributions of prostate cancer in Asian populations are still unfavorable compared to those of Western developed countries. However, a trend towards diagnosing cancer with more favorable prognosis is seen in most Asian countries. Both genetic and environmental risk factors responsible for elevated risks in Asian people are being identified, which may help to reduce prostate cancer incidence in a chemopreventive setting.

Matched MeSH terms: Prostatic Neoplasms/diagnosis; Prostatic Neoplasms/etiology; Prostatic Neoplasms/epidemiology*

Fibroblast activation and senescence in oral cancer

Prime SS, Cirillo N, Hassona Y, Lambert DW, Paterson IC, Mellone M, et al.

J Oral Pathol Med, 2017 Feb;46(2):82-88.

PMID: 27237745 DOI: 10.1111/jop.12456

There is now compelling evidence that the tumour stroma plays an important role in the pathogenesis of cancers of epithelial origin. The pre-eminent cell type of the stroma is carcinoma-associated fibroblasts. These cells demonstrate remarkable heterogeneity with activation and senescence being common stress responses. In this review, we summarise the part that these cells play in cancer, particularly oral cancer, and present evidence to show that activation and senescence reflect a unified programme of fibroblast differentiation. We report advances concerning the senescent fibroblast metabolome, mechanisms of gene regulation in these cells and ways in which epithelial cell adhesion is dysregulated by the fibroblast secretome. We suggest that the identification of fibroblast stress responses may be a valuable diagnostic tool in the determination of tumour behaviour and patient outcome. Further, the fact that stromal fibroblasts are a genetically stable diploid cell population suggests that they may be ideal therapeutic targets and early work in this context is encouraging.

Matched MeSH terms: Mouth Neoplasms/metabolism; Mouth Neoplasms/pathology*; Mouth Neoplasms/physiopathology

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