MyMedR

Epidemiology of cervical carcinoma in Brunei Darussalam. Analysis of data on 27,208 women screened with cytologic examinations

Affandi MZ, Dun T, Mantuano V, Sidhu R, Lumplugh C, Telisinghe PU

Acta Cytol., 1993 Mar-Apr;37(2):175-80.

PMID: 8465637

During the five-year period from January 1985 to December 1989 a total of 27,208 women, representing 44.0% of the total female population over age 15 years in Brunei Darussalam, underwent a cytologic examination. The majority of them were Malays (62.32%), followed by Chinese (22.23%), while the remainder were the expatriate population living in the country. High grade squamous intraepithelial lesion (moderate dysplasia) was detected in 88 women (3.3/1,000), high grade squamous intraepithelial lesion (carcinoma in situ) was seen in 32 women (1.22/1,000), and invasive carcinoma was found in 43 women (1.37/1,000). The overall detection rate for cervical cancer was 2.79/1,000 women in the population screened. In Brunei Darussalam Malay women marry at an early age, 44% by the age of 19 years, leading to sexual contact before the age of 20. However, the incidence of cervical cancer is low among them. This could be because they belong to the Orthodox Muslim Society, in which promiscuity is not permitted. Hence, multiple sex partners could be an important factor in the etiology of cervical cancer, confirming the current trend of thought that cervical cancer is a sexually transmitted disease. A comparison of the epidemiologic risk factors among the various races living in Brunei Darussalam is made.

Matched MeSH terms: Carcinoma in Situ/epidemiology*; Carcinoma in Situ/pathology; Carcinoma, Squamous Cell/epidemiology*; Carcinoma, Squamous Cell/prevention & control

Serological markers in the diagnosis of histopathological types of nasopharyngeal carcinoma

Sam CK, Prasad U, Pathmanathan R

Eur J Surg Oncol, 1989 Aug;15(4):357-60.

PMID: 2547665

The titres of IgA against Epstein-Barr virus, viral capsid antigens and the titres of IgG against early antigen were found to be useful markers for the diagnosis of different histopathological types of nasopharyngeal carcinoma.

Matched MeSH terms: Carcinoma/diagnosis*; Carcinoma/pathology; Carcinoma, Squamous Cell/diagnosis*; Carcinoma, Squamous Cell/pathology

Differential diagnostic significance of HBME-1, CK19 and S100 in various thyroid lesions

Palo S, Biligi DS

Malays J Pathol, 2017 Apr;39(1):55-67.

PMID: 28413206

OBJECTIVE: Due several overlapping histomorphological features and pitfalls in thyroid pathology, there is need to establish a panel of immunomarkers that would aid in proper diagnosis. This study was carried out to investigate the ability of HBME-1, CK19, and S100 in differentiating between hyperplastic, benign and malignant thyroid lesions.

MATERIALS AND METHODS: Immunohistochemical analysis of 60 thyroidectomy specimens (10 hyperplastic nodules, 14 follicular adenomas and 36 malignant thyroid neoplasms) was carried out. The extent and intensity of HBME-1, CK19, and S100 immunoreactivity was assessed in each case.

RESULTS: HBME-1 positivity was noted in 86.1% of malignant cases while the majority of the benign lesions were negative. Diffuse strong CK19 positivity was documented in 27/31 papillary carcinoma whereas all cases of follicular carcinoma and medullary carcinoma were negative. Most of the hyperplastic nodules and follicular adenomas were also CK19 negative, although focal weak staining was noted in a few cases. S100 was positive only in medullary carcinoma. HBME-1 was most sensitive (86.1%) and specific (87.5%) in distinguishing between benign and malignant thyroid lesions. The diagnostic accuracy was further increased when HBME-1 was used simultaneously with CK19/S100/CK19+S100. The sequential use of HBME-1 and CK19 also proved beneficial in discriminating between the various follicular-patterned thyroid lesions.

CONCLUSION: HBME-1 immunolabeling suggests malignancy, whereas strong diffuse CK19 positivity substantiates papillary differentiation. The utilization of these markers (alone or in combination) along with histomorphological evaluation is helpful in the differential diagnosis. S100 has minimal utility in this regard.

Matched MeSH terms: Carcinoma, Papillary/diagnosis*; Carcinoma, Papillary/pathology; Carcinoma, Neuroendocrine/diagnosis*; Carcinoma, Neuroendocrine/pathology

Fulltext NTCU induced pre-malignant and malignant stages of lung squamous cell carcinoma in mice model

Zakaria MA, Rajab NF, Chua EW, Selvarajah GT, Masre SF

Sci Rep, 2021 Nov 18;11(1):22500.

PMID: 34795360 DOI: 10.1038/s41598-021-01988-8

Mice have served as an excellent model to understand the etiology of lung cancer for years. However, data regarding dual-stage carcinogenesis of lung squamous cell carcinoma (SCC) remain elusive. Therefore, we aim to develop pre-malignant (PM) and malignant (M) lung SCC in vivo using N-nitroso-tris-chloroethylurea (NTCU). BALB/C mice were allotted into two main groups; PM and M groups which received treatment for 15 and 30 weeks, respectively. Then, the mice in each main group were allotted into three groups; control, vehicle, and cancer (n = 6), which received normal saline, 70% acetone, and 0.04 M NTCU by skin painting, respectively. Histopathologically, we discovered a mix of hyperplasia, metaplasia, and dysplasia lesions in the PM group and intracellular bridge; an SCC feature in the M group. The M group was positive for cytokeratin 5/6 protein which confirmed the lung SCC subtype. We also found significantly higher (P

Matched MeSH terms: Carcinoma, Non-Small-Cell Lung/chemically induced; Carcinoma, Non-Small-Cell Lung/physiopathology*; Carcinoma, Squamous Cell/chemically induced; Carcinoma, Squamous Cell/physiopathology*

Fulltext Endobronchial metastasis from resected renal cell carcinoma causing total lung collapse

Poh ME, Liam CK, Pang YK, Chua KT

Respirol Case Rep, 2013 Dec;1(2):26-7.

PMID: 25473534 DOI: 10.1002/rcr2.16

We report a man presenting with dyspnea, cough, and hemoptysis due to left lung collapse from an endobronchial tumor obstructing the left main bronchus. Endobronchial biopsy of the tumor showed renal cell carcinoma, identical to a previous specimen of renal cell carcinoma removed by a radical left nephrectomy five years ago. The endobronchial tumor was removed by snare diathermy through a flexible bronchoscope, following which his symptoms resolved and the left lung re-expanded. Endobronchial metastasis from renal cell carcinoma is rare and can mimic obstruction from other endobronchial etiologies, such as bronchogenic carcinoma. Total lung collapse as a result is even more uncommon, although atelectasis is well described. Endobronchial techniques, such as snare diathermy, can relieve obstruction, providing symptom palliation even in advanced disease.

Matched MeSH terms: Carcinoma, Bronchogenic; Carcinoma, Renal Cell

Fulltext EGFR mutation testing practices within the Asia Pacific region: results of a multicenter diagnostic survey

Yatabe Y, Kerr KM, Utomo A, Rajadurai P, Tran VK, Du X, et al.

J Thorac Oncol, 2015 Mar;10(3):438-45.

PMID: 25376513 DOI: 10.1097/JTO.0000000000000422

The efficacy of epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors in EGFR mutation-positive non-small-cell lung cancer (NSCLC) patients necessitates accurate, timely testing. Although EGFR mutation testing has been adopted by many laboratories in Asia, data are lacking on the proportion of NSCLC patients tested in each country, and the most commonly used testing methods.

Matched MeSH terms: Carcinoma, Non-Small-Cell Lung/diagnosis; Carcinoma, Non-Small-Cell Lung/genetics*; Carcinoma, Non-Small-Cell Lung/epidemiology; Carcinoma, Squamous Cell/diagnosis; Carcinoma, Squamous Cell/genetics*; Carcinoma, Squamous Cell/epidemiology

Fulltext Thyroid papillary carcinoma in a 'hot' thyroid nodule

Kuan YC, Tan FH

QJM, 2014 Jun;107(6):475-6.

PMID: 24106316 DOI: 10.1093/qjmed/hct204

Matched MeSH terms: Carcinoma/diagnosis*

Fulltext The importance of considering sebaceous gland carcinoma in presumed chalazia in South Asian patients?

Sagili S, Malhotra R

Br J Gen Pract, 2013 Feb;63(607):74.

PMID: 23700655

A 51-year-old Malaysian female was referred with a left lower eyelid lesion noticed 4 years ago. She consulted her GP a year ago and was diagnosed to have a chalazion. Her GP requested funding for treatment. The primary care trust (PCT) considered this a low-priority procedure and declined funding. One year later she approached her GP again and was referred to a hospital for management of this eyelid lesion (Figure 1). She underwent a biopsy and the histology was suspicious of a squamous cell carcinoma. She was referred to our unit. On examination, she had a left lower eyelid, firm 4mm nodule with thickening and distortion of tarsal conjunctiva. With a clinical suspicion of sebaceous gland carcinoma (SGC), a wedge excision of the lesion was performed. Paraffin section histology confirmed complete excision of SGC. Delayed repair required a Tenzel flap. She remains asymptomatic at 5-month follow-up.

Matched MeSH terms: Carcinoma, Squamous Cell/diagnosis*

Fulltext Diffuse peritoneal lymphomatosis simulating peritoneal carcinomatosis

Sharifah MI, Zamzami NA, Rafeah TN

Med J Malaysia, 2011 Aug;66(3):270-2.

PMID: 22111459 MyJurnal

Burkitt's lymphoma is a form of Non-Hodgkin's B-cell lymphoma. We report a case of Burkitt's lymphoma mimicking peritoneal carcinomatosis. We will discuss the imaging and clinical findings that differentiate between peritoneal carcinomatosis and Burkitt's lymphoma. A 26-year-old man presented with nonspecific abdominal pain, vomiting and diarrhea associated with significant amount of loss of weight. Computed tomography images showed extensive peritoneal and mesenteric mass associated generalized lymphadenopathy. Core biopsy of the mass confirmed Burkitt's lymphoma. CT scan features are helpful indicator to differentiate Burkitt's lymphoma and peritoneal carcinomatosis. Focal or diffuse nodular thickening of the bowel wall with extensive lymphadenopathy are likely to be lymphomatosis over carcinomatosis. However, final and confirmatory diagnosis is histopathology examination.

Matched MeSH terms: Carcinoma/diagnosis*

Age specific histologic types of carcinoma breast in Malaysians

Sheikh MK, Khan FA, Imran Abdul Khalid IK, Kumar G

J Coll Physicians Surg Pak, 2009 Mar;19(3):201-2.

PMID: 19268026 DOI: 03.2009/JCPSP.201202

The influence of age on various histological types of breast cancer at both age <50 years and >50 years to simulate menopause was studied retrospective from 2002 to 2004 in Malaysia. One hundred and fifty five cases were reviewed. Ninety two cases recorded at age <50 years, 60 (65.2%, 95%CI: 54.6 - 74.8%) were infiltrating ductal carcinoma in 11(12.0%, 95% CI: 6.1-20.4%), ductal carcinoma in situ (DCIS) in 9 (9.8%, 95% CI: 4.6-17.8%), medullary carcinoma in 6 (6.5%, 85%CI: 2.4-13.6%), invasive lobular carcinoma in 4 (4.3%, 95%CI: 1.2-10.8%), mucinous carcinoma and poorly differentiated carcinoma in 2 cases (2.2%, 95%CI: 0.3-7.6%). At >50 years of age, 63 cases were recorded. Forty seven (74.6%, 95%CI: 62.0- 84.7%) cases were of infiltrating ductal carcinoma, ductal carcinoma in situ in 9 (14.3%, 95%CI: 6.7-25.4%), mucinous carcinoma in 5 (7.9%, 95%CI: 2.6-17.6%), medullary carcinoma (8.5%) and papillary carcinoma in 1 case each (1.6%, 95%CI: 0.0-8.5%). Infiltrating ductal carcinoma was the commonest histology at both age <50 years and >50 years.

Matched MeSH terms: Carcinoma/pathology*

Fulltext The use of paramedian forehead flap reconstruction after wide excision of basal cell carcinoma of the nose

Chew YK, Noorizan Y, Khir A, Brito-Mutunayagam S, Prepagaran N

Med J Malaysia, 2008 Oct;63(4):339-40.

PMID: 19385500 MyJurnal

Basal cell carcinoma (BCC) is an indolent, slow-growing malignant skin tumour. Approximately 70% of the tumours occur in the head and neck region. The nose is a common site for malignant skin tumours, such as basal cell carcinoma and squamous cell carcinoma because it is exposed to the sun. Excision of the BCC will leave the nose with a soft tissue defect which requires reconstruction. This report illustrates a case of BCC of nose whereby a wide excision and reconstruction was performed with a paramedian forehead flap.

Matched MeSH terms: Carcinoma, Basal Cell/surgery*

Fulltext Tumor markers of bladder cancer: the schistosomal bladder tumors versus non-schistosomal bladder tumors

Abdulamir AS, Hafidh RR, Kadhim HS, Abubakar F

J Exp Clin Cancer Res, 2009;28:27.

PMID: 19243595 DOI: 10.1186/1756-9966-28-27

The aim of this study is to comparatively elucidate the underlying molecular pathways and clinicopathological criteria in schistosomal bladder tumor (SBT) versus non-schistosomal bladder tumor (NSBT).

Matched MeSH terms: Carcinoma, Squamous Cell/metabolism; Carcinoma, Squamous Cell/parasitology*; Carcinoma, Squamous Cell/pathology; Carcinoma, Transitional Cell/metabolism; Carcinoma, Transitional Cell/parasitology*; Carcinoma, Transitional Cell/pathology

Fulltext Radiation doses to patient's relatives following radioiodine therapy

Sulaiman BT, Clarke SE

Med J Malaysia, 1996 Mar;51(1):131-3.

PMID: 10967992

A total of 10 volunteers were monitored for radiation doses, whose spouses were given radio-iodine (131I) orally. Nine of the spouses were given radio-iodine for Graves' disease and one for thyroid carcinoma. It was found that the highest radiation dose received by the volunteer was only 13.5% of the annual dose limit for individual members of the public. Hence, patients treated with radio-iodine do not pose a significant radiation hazard to the public.

Matched MeSH terms: Carcinoma/radiotherapy*

Fulltext An unusual presentation of lepramatous leprosy

Selliah K, Ayasamy A

Med J Malaysia, 1982 Sep;37(3):213-4.

PMID: 7176999

Matched MeSH terms: Carcinoma, Squamous Cell/diagnosis

Fulltext Primary excision and immediate reconstruction for advanced cancer of the cheek

Krishnan MMS, Janakarajah N

Med J Malaysia, 1983 Mar;38(1):43-6.

PMID: 6633335

Carcinoma of the buccal mucosa is the commonest intra-oral malignancy seen in Malaysia. The purpose of this paper is to present 12 patients with carcinoma of the buccal mucosa who were seen by the authors between January 1981 to September 1981. The principal problems are those of late presentation and treatment, these aspects are illustrated, with a view of early return to normal life.

Matched MeSH terms: Carcinoma/surgery*

Fulltext Primary liver cancer in Malaysian children

Sinniah D, Sumithran E, Lin HP, Chan LL, Toh CK

Med J Malaysia, 1980 Mar;34(3):265-8.

PMID: 6251351

The high incidence of primary liver cancer in Malaysian males is not observed in childhood, where it constitutes 0.16 per 1000 paediatric hospital admissions and 3.20/0 of all childhood malignancies at the University Hospital, Kuala Lumpur. This frequency is comparable to that reported from several developed countries. The commonest liver tumour in children is the hepatoblastoma which is probably of embryonal origin and has a similar world wide "incidence. The relative infrequency of hepatocellular carcinoma in childhood and its association with cirrhosis, the hepatitis B antigen and its prevalence in the older age group helps to substantiate an acquired environmental aetiology.

Matched MeSH terms: Carcinoma, Hepatocellular/epidemiology*

Fulltext Lacrimal gland carcinoma

Sivanesan S, Chandran S

Med J Malaysia, 1982 Sep;37(3):257-60.

PMID: 6294490

Three consecutive cases of lacrimal gland carcinoma seen at the University Hospital during a twelve-year period are presented. One case was unusual, presenting at the age of sixteen years and developing metastases to the lungs. Adenoid cystic carcinoma is the commonest type of lacrimal malignancy and its clinico-pathological features and surgical management are discussed.

Matched MeSH terms: Carcinoma, Adenoid Cystic/pathology*

Fulltext Squamous cell carcinoma involving the tibia treated by reimplantation of autoclaved resected bone

Pan KL, Mourougayah V, Jayamalar T

Med J Malaysia, 2003 Dec;58(5):783-5.

PMID: 15190672

We present an elderly patient with a squamous cell carcinoma over the subcutaneous aspect of the leg involving the tibia. En bloc resection of the tumour together with a 10 centimetre segment of the tibia was done. The resected bone was autoclaved, replaced in its original position and stabilized with bone cement and a locked nail. This allowed early ambulation with minimal cost.

Matched MeSH terms: Carcinoma, Squamous Cell/surgery*

Fulltext Incidence of nasopharyngeal carcinoma in Malaysia, 1968--1977

Armstrong RW, Kannan Kutty M, Dharmalingam SK, Ponnudurai JR

Br. J. Cancer, 1979 Oct;40(4):557-67.

PMID: 497106

A record of all known cases of nasopharyngeal carcinoma in Malaysia is complete for 10 years from 1968 to 1977. Special efforts in case-finding were made in the State of Selangor where conditions are optimal. Age-adjusted incidence rates among Chinese males and females were 16.5 and 7.2 per 100,000, among Malay males and females 2.3 and 0.7 and among Indian males, 1.0. There were no significant changes in incidence rates over the 10-year period for sex and ethnic groups, or for Chinese subethnic groups. In Chinese subethnic groups, rates were highest among Cantonese, moderate among Khek and lowest among Hokkien and Teochiu. Standardized incidence ratios using Selangor as the standard population indicate considerable under-reporting in the less urban states of Malaysia, particularly among females. In Selangor, incidence rates were similar for urban and rural residents, but the frequency of cases was higher among Chinese working in industry and living in poor neighbourhoods.

Matched MeSH terms: Carcinoma/epidemiology*

Metastatic tumours of the jaws

Chan YF

Med J Malaya, 1972 Sep;27(1):48-51.

PMID: 4264825

Matched MeSH terms: Carcinoma, Squamous Cell/diagnosis*

Displaying publications 201 - 220 of 1065 in total