MyMedR

Ocular abnormalities in children from a Malaysian school for the deaf

Elango S, Reddy TN, Shriwas SR

Ann Trop Paediatr, 1994;14(2):149-52.

The prevalence of ocular abnormalities was studied in 165 children from a Malaysian school for the deaf. Ninety-five children (57.6%) had one or more ocular abnormalities. Rubella retinopathy was the commonest form of ocular abnormality (35.2%). Refractive errors were found in 23 children (13.9%). Refractive errors in the rubella group were significantly more common than in the non-rubella group of deaf children (p < 0.001) (chi 2 test). Thirteen children had congenital anomalies causing significantly impaired vision. Ophthalmological examination of deaf children helps in the detection of cases with rubella eye signs and thus helps to identify the cause of deafness. Since deaf children are at greater risk of visual and ocular abnormalities, periodical ophthalmological examination should be carried out in these children.

Matched MeSH terms: Eye Abnormalities/complications*; Eye Abnormalities/epidemiology

Fulltext A review of intraocular foreign bodies treated at the University Hospital Kuala Lumpur

Teoh GH, Yow CS

Med J Malaysia, 1982 Mar;37(1):7-10.

PMID: 7121351

A retrospective study of intraocular foreign bodies treated at the University Hospital over 10 years from 1970 - 1979 was carried out. Of the 48 cases reviewed, nine were anterior chamber foreign bodies while the rest were posterior segment foreign bodies. The anterior chamber foreign bodies had better visual prognosis as compared to the posterior segment foreign bodies. Most of the patients were young Chinese males and most of the injuries were due to accidents at work involving the 'hand hammer' (includes other implements used as a hammer).

Matched MeSH terms: Eye Foreign Bodies/epidemiology*; Eye Foreign Bodies/therapy

Fulltext Retained intraocular foreign bodies and visual prognosis

Tan PL

Med J Malaysia, 1980 Sep;35(1):58-60.

PMID: 7254000

3 cases of perforating injury with retention of intra-ocular foreign body are presented. Their clinical presentation, management and final visual results are discussed. Despite the generally poor prognosis associated with these injuries, some cases surprisingly have good visual results.

Matched MeSH terms: Eye Foreign Bodies/complications; Eye Foreign Bodies/therapy*

Advanced retinoblastoma in Malaysian children

Sinniah D, Narasimha G, Prathap K

Acta Ophthalmol, 1980 Oct;58(5):819-24.

PMID: 7211270

Twenty children with retinoblastoma are reviewed who were treated at the University Hospital, Kuala Lumpur over a 10-year-period. They constitute 6.6% of childhood malignancies and without exception all presented with advanced disease. Hereditary cases were notably absent in the the series probably because past cases have almost invariably succumbed without an opportunity to transmit the gene. With enucleation and radiotherapy six of the patients have survived from 2 to 12 years. The addition of vincristine and cyclophosphamide has not been associated with improved survival.

Matched MeSH terms: Eye Neoplasms/epidemiology*; Eye Neoplasms/therapy

Multiple retentive means for prosthetic restoration of a large facial defect - a case report

Abdulhadi LM

Chin J Dent Res, 2010;13(1):61-6.

PMID: 20936194

A 70-year-old man who suffered from extensive extra and intraoral defects was rehabilitated with a prosthesis using multiple retaining means. The treatment was performed in two parts: externally involving the construction of an episthesis supported only by the remaining intact boundaries of the defect and retained by mini-dental implants and spectacle frame with a modified ear hook; and intraorally by an acrylic resin obturator to restore the function of the hemi-sectioned hard and soft palate. The episthesis was securely retained with minimal movement and/or dislodgment of the prosthesis during function. Multiple retentive techniques may be used to fix heavy external prostheses as an alternative to conventional implants or biological adhesives.

Matched MeSH terms: Eye Neoplasms/rehabilitation; Eye, Artificial

Latanoprost Quantification in Ocular Implants and Tissues: HPLC-Fluorescence vs HPLC-UV

Soliman K, Jirjees F, Sonawane R, Sheshala R, Wang Y, Jones D, et al.

J Chromatogr Sci, 2021 Jan 01;59(1):64-70.

PMID: 33047781 DOI: 10.1093/chromsci/bmaa078

Anti-glaucoma latanoprost-loaded ocular implants provide prolonged delivery and enhanced bioavailability relative to the conventional eye drops. This study aims at the development and validation of a reversed-phase high-performance liquid chromatography method for quantitative analysis of nanogram levels of latanoprost in the eye, and for the first time, compares the use of fluorescence vs ultraviolet (UV) detectors in latanoprost quantification. The mobile phase was composed of acetonitrile:0.1% v/v formic acid (60:40, v/v) with a flow rate of 1 mL/min and separation was done using a C18 column at temperature 40°C. The fluorescence excitation and emission wavelengths were set at 265 and 285 nm, respectively, while the UV absorption was measured at 200 nm. The latanoprost concentration-peak area relationship maintained its linearity (R2 = 0.9999) over concentration ranges of 0.063-10 μg/mL and 0.212-10 μg/mL for the fluorescence and UV detectors, respectively. The UV detector showed better precision, while the fluorescence detector exhibited higher robustness and greater sensitivity, with a detection limit of 0.021 μg/mL. The fluorescence detector was selected for quantification of latanoprost released from ocular implants in vitro and in porcine ocular tissues. The developed method is a robust, rapid and cost-effective alternative to liquid chromatography-mass spectrometry for routine analysis of latanoprost released from ocular implants.

Matched MeSH terms: Eye/chemistry; Eye, Artificial

Spectral sensitivity in patients with dysthyroid eye disease

Sharanjeet-Kaur, Dickinson CM, O'Donoghue E, Murray IJ

Ophthalmic Physiol Opt, 1997 May;17(3):232-8.

PMID: 9196665 DOI: 10.1111/j.1475-1313.1997.0_749.x

The majority of patients with dysthyroid eye disease have an acquired colour vision defect. However, no psychophysical investigation of selective damage to colour or flicker pathways has been carried out. In order to clarify the nature of the visual pathology, we have used a psychophysical technique (spectral sensitivity) to selectively stimulate the chromatic and achromatic mechanisms. Spectral spots of size 1 degree presented at a rate of 1 Hz on a bright 1000 td white background are detected by the chromatic mechanism but a rate of 25 Hz reveals the achromatic mechanism. Fifteen patients (28 eyes) between the ages of 50-70 years were tested. The study showed that all patients had reduced spectral sensitivity, either 1 Hz, 25 Hz or both. The patients with reduced 1 Hz or 25 Hz spectral sensitivity only had a shorter systemic and ocular duration of the condition, had no proptosis, normal intraocular pressures in primary gaze, slightly higher intraocular pressures on upgaze, normal visual field plots and FM 100-Hue error scores higher than the normal age-matched values. The patients with reduced both 1 Hz and 25 Hz spectral sensitivities had a longer systemic and ocular duration of the condition, had proptosis, normal intraocular pressures in primary position, higher intraocular pressures on upgaze and higher FM 100-Hue error scores than the age-matched normals and those in Groups 1 and 2. A total of 50% of patients in Group 3 had defective visual field plots. These data suggest that there is a damage of the large achromatic fibres and small chromatic fibres in dysthyroid eye disease. The mechanism of the damage could be one of ischaemic or mechanical or both.

Matched MeSH terms: Eye Diseases/etiology; Eye Diseases/physiopathology*

Filaria in the vitreous of the eye of man in peninsular Malaysia

Dissanaike AS, Ramalingam S, Fong A, Pathmayokan S, Thomas V, Kan SP

Am J Trop Med Hyg, 1977 Nov;26(6 Pt 1):1143-7.

PMID: 596511

An active worm was seen in the right eye of a 62-year-old man in Malaysia. The worm was behind the lens and attached at one end to some vitreous fibers. It was tentatively identified as an immature Dirofilaria immitis. There appear to be only five previous authentic reports of filariae in the vitreous.

Matched MeSH terms: Eye Diseases/drug therapy; Eye Diseases/parasitology

Early-Stage Multifocal Candida chorioretinitis in an Immunocompromised Woman

Chen KJ, Chou HD, Teh WM

Ophthalmol Retina, 2019 10;3(10):887.

PMID: 31585711 DOI: 10.1016/j.oret.2019.05.023

Matched MeSH terms: Eye Infections, Fungal/diagnosis*; Eye Infections, Fungal/microbiology

Fulltext Recent Updates on Treatment of Ocular Microbial Infections by Stem Cell Therapy: A Review

Teh SW, Mok PL, Abd Rashid M, Bastion MC, Ibrahim N, Higuchi A, et al.

Int J Mol Sci, 2018 Feb 13;19(2).

PMID: 29438279 DOI: 10.3390/ijms19020558

Ocular microbial infection has emerged as a major public health crisis during the past two decades. A variety of causative agents can cause ocular microbial infections; which are characterized by persistent and destructive inflammation of the ocular tissue; progressive visual disturbance; and may result in loss of visual function in patients if early and effective treatments are not received. The conventional therapeutic approaches to treat vision impairment and blindness resulting from microbial infections involve antimicrobial therapy to eliminate the offending pathogens or in severe cases; by surgical methods and retinal prosthesis replacing of the infected area. In cases where there is concurrent inflammation, once infection is controlled, anti-inflammatory agents are indicated to reduce ocular damage from inflammation which ensues. Despite advances in medical research; progress in the control of ocular microbial infections remains slow. The varying level of ocular tissue recovery in individuals and the incomplete visual functional restoration indicate the chief limitations of current strategies. The development of a more extensive therapy is needed to help in healing to regain vision in patients. Stem cells are multipotent stromal cells that can give rise to a vast variety of cell types following proper differentiation protocol. Stem cell therapy shows promise in reducing inflammation and repairing tissue damage on the eye caused by microbial infections by its ability to modulate immune response and promote tissue regeneration. This article reviews a selected list of common infectious agents affecting the eye; which include fungi; viruses; parasites and bacteria with the aim of discussing the current antimicrobial treatments and the associated therapeutic challenges. We also provide recent updates of the advances in stem cells studies on sepsis therapy as a suggestion of optimum treatment regime for ocular microbial infections.

Matched MeSH terms: Eye Infections/drug therapy; Eye Infections/therapy*

Current progress and challenges in ocular surface reconstruction using cultivated epithelial sheet transplantation

Inatomi T, Nakamura T, Koizumi N, Sotozono C, Kinoshita S

Med J Malaysia, 2008 Jul;63 Suppl A:42.

PMID: 19024975

The cultivated epithelial transplantation is a new surgical modality for treating a variety of severe ocular surface disorders. This type of tissue-engineered epithelial sheet provides a rapid epithelial coverage on the corneal surface that reduces inflammation and postoperative complications. Although cultivated corneal epithelial transplantation is an effective surgical strategy, autologous transplantation is limited to unilateral cases. Autologous cultivated oral mucosal epithelial transplantation (COMET) enables surgeons to reconstruct the ocular surface using autologous, non-ocular surface cells, and has opened a new pathway for treating severe, bilateral ocular surface disorders.

Matched MeSH terms: Eye/pathology*; Eye Diseases/surgery*; Eye Diseases/therapy

Anterior uveal and episcleral metastases from carcinoma of the breast

Reddy SC, Madhavan M, Mutum SS

Ophthalmologica, 2000 Sep-Oct;214(5):368-72.

PMID: 10965254 DOI: 10.1159/000027523

Breast carcinoma is the most common primary tumor producing intraocular metastasis. Metastases to the iris and ciliary body are relatively rare. The authors report a case of a 61-year-old lady, operated for carcinoma of the left breast 3 years back, who presented with symptoms and signs of acute narrow-angle glaucoma in the right eye. A diffuse whitish plaque-like mass in the upper nasal quadrant of the iris with an episcleral nodule on the limbus in the corresponding area and all the signs of acute narrow-angle glaucoma were present in the right eye. Intraocular pressure was controlled medically. Fine-needle aspiration cytology from the episcleral nodule showed malignant cells. Histopathology of the excised nodule showed metastatic poorly differentiated carcinoma, and the cellular pattern was similar to the carcinoma of the breast. There was no other metastasis anywhere in the body. Fine-needle aspiration cytology from an external lesion of the eye is a less invasive and easier procedure than paracentesis to diagnose the metastatic nature of the lesions. The rare features in our case are the clinical presentation as acute glaucoma and the ocular structures being the first and only site of metastasis.

Matched MeSH terms: Eye Neoplasms/complications; Eye Neoplasms/pathology; Eye Neoplasms/secondary; Eye Neoplasms/therapy

Hemorrhagic Descemet Membrane Detachment Following Syphilitic Interstitial Keratitis

Höllhumer R, Zairani Mz A, Watson S

Cornea, 2016 Sep;35(9):1255-6.

PMID: 27227396 DOI: 10.1097/ICO.0000000000000889

PURPOSE: Syphilitic interstitial keratitis is a stromal inflammatory disease with characteristic secondary vascularization. This case illustrates a late complication of hemorrhagic Descemet membrane detachment.

METHODS: Case report.

RESULTS: The patient presented with painless sudden visual loss and progressive shallowing of the anterior chamber caused by hemorrhagic Descemet membrane detachment. She had corneal neovascularization and a positive syphilis serology. Owing to the risk of pupil block glaucoma, the patient had surgical drainage of the blood via an ab externo approach.

CONCLUSIONS: This case illustrates a previously unreported complication of syphilitic interstitial keratitis. The patient recovered good visual acuity and had residual pigment deposits in the pre-Descemet interface.

Matched MeSH terms: Eye Hemorrhage/diagnosis; Eye Hemorrhage/etiology*; Eye Infections, Bacterial/diagnosis; Eye Infections, Bacterial/microbiology*; Eye Infections, Bacterial/therapy

Punctal plug: a medical device to treat dry eye syndrome and for sustained drug delivery to the eye

Yellepeddi VK, Sheshala R, McMillan H, Gujral C, Jones D, Raghu Raj Singh T

Drug Discov Today, 2015 Jul;20(7):884-9.

PMID: 25668579 DOI: 10.1016/j.drudis.2015.01.013

Punctal plugs (PPs) are miniature medical implants that were initially developed for the treatment of dry eyes. Since their introduction in 1975, many PPs made from different materials and designs have been developed. PPs, albeit generally successful, suffer from drawbacks such as epiphora and suppurative canaliculitis. To overcome these issues intelligent designs of PPs were proposed (e.g. SmartPLUG™ and Form Fit™). PPs are also gaining interest among pharmaceutical scientists for sustaining drug delivery to the eye. This review aims to provide an overview of PPs for dry eye treatment and drug delivery to treat a range of ocular diseases. It also discusses current challenges in using PPs for ocular diseases.

Matched MeSH terms: Dry Eye Syndromes/drug therapy*; Dry Eye Syndromes/physiopathology

Phospholipase A2 group v in benign familial fleck retina in a set of triplets

Bin NJ, Heng HM, Poh R, Noor SM, Subrayan V

Retina, 2015 Jun;35(6):1266-72.

PMID: 25549071 DOI: 10.1097/IAE.0000000000000446

To evaluate the association of phospholipase A2, Group V (PLA2G5), with benign familial fleck retina in a consanguineous family with triplets.

Matched MeSH terms: Eye Diseases, Hereditary/diagnosis; Eye Diseases, Hereditary/genetics*

Ocular surface infections in northeastern state of malaysia: a 10-year review of bacterial isolates and antimicrobial susceptibility

Rahman ZA, Harun A, Hasan H, Mohamed Z, Noor SS, Deris ZZ, et al.

Eye Contact Lens, 2013 Sep;39(5):355-60.

PMID: 23982472 DOI: 10.1097/ICL.0b013e3182a3026b

Ocular surface infections that include infections of conjunctiva, adnexa, and cornea have the potential risk of causing blindness within a given population. Empirical antibiotic therapy is usually initiated based on epidemiological data of common causative agents. Thus, the aims of this study were to determine the bacterial agents and their susceptibility patterns of isolates from ocular surface specimens in our hospital.

Matched MeSH terms: Eye Infections, Bacterial/drug therapy; Eye Infections, Bacterial/microbiology*

Lateral rectus myositis mimicking an abducens nerve palsy in a pregnant woman

Haslinda AR, Shatriah I, Azhany Y, Nik-Ahmad-Zuky NL, Yunus R

Ophthalmic Plast Reconstr Surg, 2013 3 28;30(1):e13-5.

PMID: 23531952 DOI: 10.1097/IOP.0b013e31828957ae

Myositis is a rare unknown inflammatory disorder of the skeletal muscle tissue. Generalized inflammatory myopathies, polymyositis, and dermatomyositis have been reported during pregnancy. Isolated orbital myositis in pregnancy has not been previously described in the literature. The authors report a case of left isolated orbital myositis in a primigravida at 38 weeks gestation affecting the patient's left lateral rectus muscle. MRI of the orbit was consistent with the diagnosis. She showed remarkable clinical improvement with oral corticosteroids therapy.

Matched MeSH terms: Eye Pain/diagnosis; Eye Pain/drug therapy

A recurrent nasopharyngeal carcinoma with lacrimal sac involvement: a case report

Tang IP, Periyannan P, Prepageran N, Shashinder S, Singh A, Bhagubhai PN

Eur J Cancer Care (Engl), 2011 Jan;20(1):93-5.

PMID: 20088917 DOI: 10.1111/j.1365-2354.2009.01147.x

We report a very rare case of recurrent nasopharyngeal carcinoma with local involvement of lacrimal sac. The patient was treated with chemotherapy and there was no recurrence noted after 1 year of follow-up.

Matched MeSH terms: Eye Neoplasms/pathology*; Eye Neoplasms/therapy

Reddy SC, Tajunisah I

Ann Ophthalmol (Skokie), 2008;40(1):39-44.

PMID: 18556981

Fifty-six contact lens-related corneal ulcers (central in 32; hypopyon in 24 and stromal abscess in 6) were studied. Culture was positive in 78.9%. Corneal ulcers healed with intense antibiotic therapy in nearly all patients. Increased awareness of lens care/disinfection and frequent replacement of storage cases and solution, and early detection of pathogens and intensive appropriate antibiotic therapy are key points in management.

Matched MeSH terms: Eye Infections, Bacterial/drug therapy; Eye Infections, Bacterial/microbiology*

Late closure of argon laser iridotomies following regrowth of iris pigment epithelium

Teoh LO, Ishikawa H, Liebmann JM, Ritch R

Arch. Ophthalmol., 2000 Jul;118(7):989-90.

PMID: 10900117

Matched MeSH terms: Pigment Epithelium of Eye/pathology*; Pigment Epithelium of Eye/ultrasonography

Displaying publications 181 - 200 of 438 in total