This study aims to assess the influence of a rib on the base pressure and the flow development in an abruptly expanded duct at sonic Mach number. Initially, the simulations were done to validate the experimental results, keeping all the parameters the same. Accordingly, a duct-of-area ratio of 6.25 was considered for validation. Five ribs of aspect ratios 3:1, 3:2, and 3:3 were used as a first step, and simulations were performed for the same nozzle pressure ratios. Results indicate that for an area ratio of 6.25, there is a continuous decrease in the base pressure despite the nozzles being highly under-expanded. The lower aspect ratio of the rib tends to reduce the base pressure, whereas a higher aspect ratio effectively increases the base pressure for an area ratio of 6.25. Later simulations considered a single rib instead of five ribs, varying the rib's heights from 1 mm to 5 mm. Results show that the base pressure increases considerably when rib heights are 4 mm and 5 mm. The influence of ribs at two duct diameters (25 mm and 18 mm) is studied to assess the impact of a decrease in the area ratio and, hence, a decrease in the relief available to the flow. Results of duct 18 mm show that passive control becomes very effective when a rib of 3 mm height is located at a 3D position. The differences in the base pressure, velocity, and pressure field for each case are explored. The simulation results indicate that the rib breaks the primary vortex at the base and forms multiple vortices. Turbulent kinetic energy increases in the presence of ribs more than without a rib.
In this study, we have used aldehyde function of cinnamaldehyde to synthesize N, N'-Bis (cinnamaldehyde) ethylenediimine [C20H20N2] and Co(II) complex of the type [Co(C40H40N4)Cl2]. The structures of the synthesized compounds were determined on the basis of physiochemical analysis and spectroscopic data ((1)H NMR, FTIR, UV-visible and mass spectra) along with molar conductivity measurements. Anticandidal activity of cinnamaldehyde its ligand [L] and Co(II) complex was investigated by determining MIC80, time-kill kinetics, disc diffusion assay and ergosterol extraction and estimation assay. Ligand [L] and Co(II) complex are found to be 4.55 and 21.0 folds more efficient than cinnamaldehyde in a liquid medium. MIC80 of Co(II) complex correlated well with ergosterol inhibition suggesting ergosterol biosynthesis to be the primary site of action. In comparison to fluconazole, the test compounds showed limited toxicity against H9c2 rat cardiac myoblasts. In confocal microscopy propidium iodide (PI) penetrates the yeast cells when treated with MIC of metal complex, indicating a disruption of cell membrane that results in imbibition of dye. TEM analysis of metal complex treated cells exhibited notable alterations or damage to the cell membrane and the cell wall. The structural disorganization within the cell cytoplasm was noted. It was concluded that fungicidal activity of Co(II) complex originated from loss of membrane integrity and a decrease in ergosterol content is only one consequence of this.
The last few decades have seen an alarming rise in fungal infections, which currently represent a global health threat. Despite extensive research towards the development of new antifungal agents, only a limited number of antifungal drugs are available in the market. The routinely used polyene agents and many azole antifungals are associated with some common side effects such as severe hepatotoxicity and nephrotoxicity. Also, antifungal resistance continues to grow and evolve and complicate patient management, despite the introduction of new antifungal agents. This suitation requires continuous attention. Cinnamaldehyde has been reported to inhibit bacteria, yeasts, and filamentous molds via the inhibition of ATPases, cell wall biosynthesis, and alteration of membrane structure and integrity. In this regard, several novel cinnamaldehyde derivatives were synthesized with the claim of potential antifungal activities. The present article describes antifungal properties of cinnamaldehyde and its derivatives against diverse classes of pathogenic fungi. This review will provide an overview of what is currently known about the primary mode of action of cinnamaldehyde. Synergistic approaches for boosting the effectiveness of cinnamaldehyde and its derivatives have been highlighted. Also, a keen analysis of the pharmacologically active systems derived from cinnamaldehyde has been discussed. Finally, efforts were made to outline the future perspectives of cinnamaldehyde-based antifungal agents. The purpose of this review is to provide an overview of current knowledge about the antifungal properties and antifungal mode of action of cinnamaldehyde and its derivatives and to identify research avenues that can facilitate implementation of cinnamaldehyde as a natural antifungal.
Compact multi-rotor unmanned aerial vehicles (UAVs) can be operated in many challenging environmental conditions. In case the UAV requires certain considerations in designing like lightweight, efficient propulsion system and others depending upon the application, the hybrid UAV comes into play when the usual UAV types cannot be sufficient to meet the requirements. The propulsion system for the UAV was selected to be coaxial rotors because it has a high thrust-to-weight ratio and to increase the efficiency of the propulsion system, a unique propeller was proposed to achieve higher thrust. The proposed propeller was uniquely designed by analyzing various airfoil sections under different Reynolds's number using X-Foil tool to obtain the optimum airfoil section for the propellers. Since the design with duct increases efficiency, the Hybrid UAV presented in this paper has the modified novel convergent-divergent (C-D)-based duct which is a simplified model of a conventional C-D duct. The yawing and rolling maneuverings of the UAV could be achieved by the thrust vectoring method so that the design is simpler from a structural and mechanical perspective. The use of UAVs has risen in recent years, especially compact UAVs, which can be applied for applications like surveillance, detection and inspection, and monitoring in a narrow region of space. The design of the UAV is modeled in CATIA, and its further performance enactment factors are picked from advanced computational simulations relayed bottom-up approach. The predominant computational fluid dynamics (CFD) and fluid structure interaction (FSI) investigations are imposed and optimized through Computational Analyses using Ansys Workbench 17.2, which includes analysis of structural behaviour of various alloys, CFRP and GFRP based composite materials. From the structural analysis Titanium alloy came out to be the best performing materials among the others by having lower total deformation and other parameters such as normal and equivalent stress. The dynamics control response is obtained using MATLAB Simulink. The validations are carried out on the propeller using a thrust stand for CFD and on the duct through a high-jet facility for structural outcomes to meet the expected outcome.