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A Tête-à-tête with ChatGPT on the impact of artificial intelligence in medical education

Vignesh R, Pradeep P, Balakrishnan P

Med J Malaysia, 2023 Jul;78(4):547-549.
PMID: 37518931

Chat Generative Pre-Trained Transformer (ChatGPT) is an artificial intelligence (AI) language model developed by OpenAI. It is trained to process vast amounts of text and engage in human-like conversational interaction with users. Being accessible by all, it is widely used and its capabilities range from language translation, summarising long texts and creative writing. This article explores the potential role of ChatGPT in medical education and the possible concerns about the misuse of this technology through a conversation with ChatGPT itself via text prompts. The implications of this technology in medical education as told by ChatGPT are interesting and seemingly helpful for both the students and the tutors. However, this could be a double-edged sword considering the risks of compromised students' integrity and concerns of over-reliance. This also calls for counter strategies and policies in place to mitigate these risks.
Fulltext Tori in a Malaysian population: Morphological and ethnic variations

Telang LA, Telang A, Nerali J, Pradeep P

J Forensic Dent Sci, 2020 01 24;11(2):107-112.
PMID: 32082047 DOI: 10.4103/jfo.jfds_66_19

Aim: Tori are nonneoplastic self-limiting, bony exostosis that are commonly called torus palatinus (TP) when seen on the hard palate and termed torus mandibularis (TM) when seen on the lingual surface of the mandible. These lesions have long been known to anthropologists and have mostly been identified incidentally during routine dental examinations. The prevalence of tori varies in different populations from 0.0% to 66% for TP and between 0.1% and 63.4% for TM. The exact etiology is still unclear, but the most accepted theory today is 30% attributed to genetics and 70% to environmental factors. Hence, the aim of this study was to determine the prevalence of tori and study their morphology among various ethnic groups of a Malaysian population.
Materials and Methods: A ross-sectional study was conducted involving the screening of patients that reported to the oral medicine clinics over a 2-year period. Age, gender, ethnicity, morphological variations in shape and size, number, and location of tori were recorded in all positive cases.
Results: Fourteen percent of individuals (n = 624) among the total 4443 who were screened were found to have either palatine tori, mandibular tori, or both. The prevalence of PT and MT was 10.8% and 0.9%, respectively. Tori were found in people in the age range of 5-85 years, with the maximum in the age range of 20-29 years (24.7%). The male-to-female ratio for PT and MT was 1:1.4 and 1:0.68, respectively. The morphologic shapes of palatine tori that were observed were flat (10%), spindle (10%), linear (15%), and nodular (59%) with up to six lobules. Mandibular tori were located either unilaterally or bilaterally; they were nodular in shape (89%) and/or band like (15%), with the band-like shape being described for the first time. Size variations ranging from 0.5 to 5 cm were observed.
Conclusion: The relatively high prevalence of tori among major ethnic groups of this region supports the probable hypothesis of the role of environmental factors. A wide variation in the morphology was also noted, along with a new morphologic variant of band-like TM, which may be due to the influence of diet or an unknown environmental factor.
Spectrum of breast cancer in Asian women

Agarwal G, Pradeep PV, Aggarwal V, Yip CH, Cheung PS

World J Surg, 2007 May;31(5):1031-40.
PMID: 17387549

Breast cancer is the leading cause of cancer-related deaths in Asia, and in recent years is emerging as the commonest female malignancy in the developing Asian countries, overtaking cancer of the uterine cervix. There have been no studies objectively comparing data and facts relating to breast cancer in the developed, newly developed, and developing Asian countries thus far.
Genome-wide analysis of oral squamous cell carcinomas revealed over expression of ISG15, Nestin and WNT11

Vincent-Chong VK, Ismail SM, Rahman ZA, Sharifah NA, Anwar A, Pradeep PJ, et al.

Oral Dis, 2012 Jul;18(5):469-76.
PMID: 22251088 DOI: 10.1111/j.1601-0825.2011.01894.x

Multistep pathways and mechanisms are involved in the development of oral cancer. Chromosomal alterations are one of such key mechanisms implicated oral carcinogenesis. Therefore, this study aims to determine the genomic copy number alterations (CNAs) in oral squamous cell carcinoma (OSCC) using array comparative genomic hybridization (aCGH) and in addition attempt to correlate CNAs with modified gene expression.
Distinct pattern of chromosomal alterations and pathways in tongue and cheek squamous cell carcinoma

Vincent-Chong VK, Karen-Ng LP, Abdul Rahman ZA, Yang YH, Anwar A, Zakaria Z, et al.

Head Neck, 2014 Sep;36(9):1268-1278.
PMID: 31615169 DOI: 10.1002/hed.23448

BACKGROUND: The purpose of this study was to investigate the cause of behavioral difference between tongue and cheek squamous cell carcinomas (SCCs) by verifying the copy number alterations (CNAs).
METHODS: Array comparative genomic hybridization (aCGH) was used to profile unique deletions and amplifications that are involved with tongue and cheek SCC, respectively. This was followed by pathway analysis relating to CNA genes from both sites.
RESULTS: The most frequently amplified regions in tongue SCC were 4p16.3, 11q13.4, and 13q34; whereas the most frequently deleted region was 19p12. For cheek SCC, the most frequently amplified region was identified on chromosome 9p24.1-9p23; whereas the most common deleted region was located on chromosome 8p23.1. Further analysis revealed that the most significant unique pathway related to tongue and cheek SCCs was the cytoskeleton remodeling and immune response effect on the macrophage differentiation pathway.
CONCLUSION: This study has showed the different genetic profiles and biological pathways between tongue and cheek SCCs. © 2013 Wiley Periodicals, Inc. Head Neck 36: 1268-1278, 2014.
Search for Soft Unclustered Energy Patterns in Proton-Proton Collisions at 13 TeV

Hayrapetyan A, Tumasyan A, Adam W, Andrejkovic JW, Bergauer T, Chatterjee S, et al.

Phys Rev Lett, 2024 Nov 08;133(19):191902.
PMID: 39576923 DOI: 10.1103/PhysRevLett.133.191902

The first search for soft unclustered energy patterns (SUEPs) is performed using an integrated luminosity of 138 fb^{-1} of proton-proton collision data at sqrt[s]=13 TeV, collected in 2016-2018 by the CMS detector at the LHC. Such SUEPs are predicted by hidden valley models with a new, confining force with a large 't Hooft coupling. In events with boosted topologies, selected by high-threshold hadronic triggers, the multiplicity and sphericity of clustered tracks are used to reject the background from standard model quantum chromodynamics. With no observed excess of events over the standard model expectation, limits are set on the cross section for production via gluon fusion of a scalar mediator with SUEP-like decays.