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Inhibitory effect of asiatic acid on acetylcholinesterase, excitatory post synaptic potential and locomotor activity

Nasir MN, Abdullah J, Habsah M, Ghani RI, Rammes G

Phytomedicine, 2012 Feb 15;19(3-4):311-6.

PMID: 22112723 DOI: 10.1016/j.phymed.2011.10.004

The asiatic acid, a triterpenoids isolated from Centella asiatica was used to delineate its inhibitory effect on acetylcholinesterase (AChE) properties, excitatory post synaptic potential (EPSP) and locomotor activity. This study is consistent with asiatic acid having an effect on AChE, a selective GABA(B) receptor agonist and no sedative effect on locomotor.

Fulltext Neuronavigation-guided endoscopic and hodotopic approach to an arachnoid cyst

Idris Z, Nandrajog P, Abdullah JM, Ghani RI, Idris B

Surg Neurol Int, 2013;4:120.

PMID: 24083055 DOI: 10.4103/2152-7806.118492

BACKGROUND: Arachnoid cysts are intraarachnoid benign cystic lesions filled with cerebrospinal fluid and should be treated without incurring further morbidity to the patients.

CASE DESCRIPTION: The authors present a case of a 68-year-old elderly female with a large right fronto-parieto-temporal arachnoid cyst who has been suffering from mild left hemiparesis for the past 4 years and presented with sudden onset of seizures. The 3 Tesla MR system with diffusion tensor imaging (DTI) and MR tractography of the brain showed a large right fronto-parieto-temporal cystic lesion measuring 7 × 5 × 5 cm with a midline shift of 1 cm, suggestive of an arachnoid cyst with surrounding ipsilateral white matter projection pathways and inferior occipito-frontal fasciculus or inferior longitudinal white matter tracts. The cyst was successfully treated with neuronavigation-guided endoscopic and hodotopical approach to fenestrate the arachnoid cyst into the sylvian cistern, avoiding inadvertent injury to major white matter tracts portrayed by DTI. Postoperatively, a repeated computed tomography (CT) scan of the brain revealed a smaller arachnoid cyst with correction of the midline shift. The patient was weaned off from the ventilator and her hemiplegia improved gradually.

CONCLUSION: This case report emphasizes the value of neuronavigation-guided endoscopic and hodotopic approach to fenestrate the intra-axial arachnoid cyst.

Prognostic study of using different monitoring modalities in treating severe traumatic brain injury

Idris Z, Ghani RI, Musa KI, Ibrahim MI, Abdullah M, Nyi NN, et al.

Asian J Surg, 2007 Jul;30(3):200-8.

PMID: 17638640

To determine whether or not multimodality monitoring technique would result in a better outcome score than single modality monitoring in severely head injured patients.

Transfrontal Transaqueductal, Transtrigonal, and Suboccipital Infratentorial Supracerebellar Endoscopic Fenestration of Posterior Fossa Arachnoid Cysts: Three Surgical Cases

Idris Z, Tan YC, Kandasamy R, Ghani RI, Abdullah JM

J Neurol Surg A Cent Eur Neurosurg, 2017 Mar;78(2):210-215.

PMID: 26968147 DOI: 10.1055/s-0035-1571161

Symptomatic intracranial arachnoid cysts are commonly treated using neuroendoscopy. Cysts located within the posterior fossa may present a greater surgical challenge to the neurosurgeon due to the numerous vital neurovascular structures located within this confined space. Adding neuronavigation during endoscopy helps a neurosurgeon to visualize and utilize both anterior and posterior corridors safely to access and manage these lesions. We present three symptomatic posterior fossa arachnoid cysts that were treated successfully using minimally invasive neuronavigation-guided endoscopic neurosurgery utilizing the anterior transfrontal transaqueductal, anterior transfrontal transtrigonal, and posterior suboccipital infratentorial supracerebellar approaches.

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