Interleukin 31 (IL-31)is one of the cytokines which appears to be an important regulator of Th2 responses. Previous study has been done to determine IL-31 serums levels in atopic dermatitis (AD). However, the serum levels of IL-31 in allergic rhinitis (AR) and atopic asthma (AA) is not many reported and still unclear. The objective of this cross sectional study is to determine an association between IL-31 and other predisposing factors with allergic diseases in HRPZ II (Hospital Raja PerempuanZainab II) and HUSM (Hospital UniversitiSains), Kelantan, Malaysia. This study involved 70 patients of AD, 70 patients of AR, 70 patients of AA and 70 healthy controls from staffs and people in HUSM.Five milliliters of blood were withdrawn and centrifuged for 5 minutes at 2000 rpm to obtain the serum and analyzed for IL-31 levels by using enzymelinked immunosorbent (ELISA) kits (Human IL 31 Duoset, R&D System). Simple and multiple logistic regressions were used to analyze the association between IL-31 levels and predisposing factors among allergic diseases. The levels of IL-31 and other predisposing factors showed significant associations in smoking status, occupational exposure and area of living for AD and AR, however in AA, the significant association only found in smoking status and occupational exposure. In conclusion, we found that there were associations between IL-31 serum levels and other predisposing factors with AD, AR and AA. The findings can be the pilot study to determine IL-31 levels in allergic diseases in Malaysia.
The hydrology hydraulic model is established to assess environmental information on hydrology which
can be used to investigate causes of various environmental problems at the river and natural lake
catchment. This study reports on sediment concentrations at a river using a gravimetric method to
investigate the hydrology system at a lake catchment. The measurement was carried out at the
upstream, midstream, and downstream stations on the river in normal, rainy and post-rainy seasons.
The stations are located along the Chini River, which are connected to a catchment lake (located at
latitude 3°26’36.41”E-3°27’03.26”E and longitude 102°54’31.94”N-102°53’35.49”N). From the
measurements, it is estimated that on average 787.621 tonne/km2 of sediment is transferred into the
natural lake via Chini River annually. The correlation of statistical analysis between the sediment load
and discharge study was very significant (R2 = 0.980). There is a linear relation between the area of
the catchment and sediment load of the connecting river as supported by other studies in Malaysia.
The outcome of the study suggests that the high sedimentation is due to land use activity, existence of
the dam at the downstream of Chini River that traps the sediment, reverse flow from the Pahang River
into Chini River and riverbank erosion factors. From this study, the sediment control steps are
suggested such as creating conservation partially at the lake catchment, modifying the dam system,
riverbank erosion control, and application of “Monkey Cheek” system. These sediment control steps
may help to clean up the high suspended sediment at the whole lake system area, hence solving and
mitigating the environmental problems in the natural lake catchment.