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Fulltext Tracheoesophageal fistula (TOF)-blind pouch intubation: a case report

Arshad R

Med J Malaysia, 1984 Jun;39(2):159-62.
PMID: 6513857

A case of Tracheoesophageal Fistula (TOF) was presented where the blind upper esophageal pouch was mistakenly intubated; in spite of this, adequate lung ventilation was possible for more than one hour. This was only noticed by the surgeon upon incision of the lower end of the pouch.
Fulltext Living related renal transplantation in Kuala Lumpur

Suleiman AB, Awang H, Proehoeman F, Arshad R

Med J Malaysia, 1982 Sep;37(3):273-5.
PMID: 6757687

Fifty-six living related renal transplants were performed between December 1975 and December 1980. All except eight of the recipients were male. The mean age was 29.5 years. Patient and graft survival were 86 percent and 73 percent at 1 year and 83 percent and 68 percent at 2 years respectively. Infection was the main cause of death and acute and chronic rejection were the main causes of graft failure. The donors were aged between 18 and 72 years old. There were 21 parent and 35 sibling donors. Donor nephrectomies were performed without mortality and our experience so far with the transplantation of kidneys from elderly donors has been encouraging.
Examining the Components of Integrity

Zahari AI, Said J, Arshad R

Integr Psychol Behav Sci, 2021 Jul 12.
PMID: 34251611 DOI: 10.1007/s12124-021-09626-8

The purpose of this paper is to understand the underlying components of integrity and examine its value. The approach is through identifying and expanding on the common values of integrity such as honesty, conscientiousness and principle. There is a need to find a common ground in the sense of giving specific values towards integrity. Current works of literature indicate that there is a gap in assigning the core values of integrity. This information was collected through a semi-structured qualitative interview with 15 experienced participants from a wide range of background and has extensive experience with the fields of integrity. Such samples are from academic experts, government practitioners, representatives of government agencies, and non-governmental organisations. The identified components are then projected and validated through this list of participants. One of the objectives of this study is to understand the components of integrity through the life experience of people who are commonly associated with the areas of "integrity". The common core values of integrity was identified through a process of systematic literature review and summarised in this study. Content analysis of the data identified multiple dimensions and sub-dimensions on integrity. The findings suggest that integrity is more than being honest, conscientious and with principle as other factors are determining factors of being a component of integrity. Values such as responsibility, sincerity, consistency, compliance, conscious, pride, social norms, ruling policies and awareness play a major role in the value of integrity. The paper builds a model of integrity components based on these interpreted values. This paper contributes to the growing interest in the concept of integrity and attempts to streamline the central components of integrity. The studies of integrity are timely contemporary issues which deserve scientific attention. The building of sophisticated models and empirical investigations in their own right are opportunities for society to improve on their understandings of human behaviour. The integrity model provides an opportunity and useful addition for governments, private institutions, and individuals to improve each of their core values towards integrity.
Safety climate and safety behaviors: Adapting and validating a positively worded safety climate scale through the time-lagged approach

Mirza MZ, Memon MA, Javaid MU, Arshad R

Work, 2023 Sep 28.
PMID: 37781850 DOI: 10.3233/WOR-230150

BACKGROUND: Contemporary literature raises serious questions about the inclusion of negatively worded items in the safety climate scale. Despite these reservations, limited efforts have been made to address this shortcoming.
OBJECTIVE: The present study aims to adapt and empirically validate the ten-items group-level safety climate scale with the purpose of replacing negatively worded items with positively worded ones after a thorough validation process. The present study is one of the first to propose an empirically validated group-level safety climate scale that uses positive items to measure the safety climate construct.
METHODS: Study 1 was conducted using a sample of 135 participants. Study 2 used a time-lagged approach to validate the scale, with a sample of 173 production workers from six oil and gas organizations in Malaysia. The Partial Least Squares Structural Equation Modeling (PLS-SEM) method was used to test the hypothesized relationships.
RESULTS: In Study 1, the results of the exploratory factor analysis showed good reliability for the revised scale. In Study 2, the results of the PLS-SEM analysis demonstrated a positive relationship between safety climate and safety behaviors, thereby validating the revised and translated scale of safety climate.
CONCLUSION: The revised safety climate scale will not only improve data quality, but it will also increase response rates. Additionally, the revised scale will assist managers in understanding the true perceptions of safety climate in their organization, regardless of the cultural context in which the scale is used.
Fulltext Chronic haemodialysis

Suleiman AB, Morad Z, Kamaluddin MA, Kong CT, Awang H, Arshad R, et al.

Med J Malaysia, 1985 Sep;40(3):239-42.
PMID: 3842719

Review of the haemodialysis experience revealed patient survival between 1976 and 1982 to be 90%, 77% and 44% at one, three and six years respectively. This was similar to other published reports. Patients under the age of 50 years did better than those above 50 years, and diabetics did worst of all. There was a high rate of rehabilitation and return to employment or household responsibilities. Our policy of self-care dialysis allowed more patients to be treated without increasing the number of staff Dialysis encephalopathy and sudden deaths were important causes of death.
Sero-epidemiology and risk factor analysis of human brucellosis in Punjab, Pakistan: a cross sectional study

Nawaz Z, Shafique M, Zahoor MA, Siddique AB, Ali S, Arshad R, et al.

Trop Biomed, 2021 Sep 01;38(3):413-419.
PMID: 34608115 DOI: 10.47665/tb.38.3.084

Human brucellosis is a neglected zoonotic problem worldwide with a high degree of morbidity in humans and is mostly overlooked due to other febrile conditions. The aim of this study was to evaluate the sero-prevalence and risk factors of human brucellosis among subjects living in Punjab, Pakistan. In this cross-sectional study, human blood samples were collected from seven districts of Punjab, Pakistan. Information regarding personal data, demographic data and potential risk factors was collected through a structured questionnaire. Detection of anti-Brucella antibodies was done through Rose Bengal Plate Test (RBPT) and Enzyme Linked Immunosorbent Assay (ELISA). Descriptive analysis, Chi square test and Odds ratio was applied using STATA software version 12. The sero-prevalence of human brucellosis was 13.13% with significantly higher percentage in males 17.23% and age group 25-40 years 16.50% (P=< 0.001). The demographic factors positively associated with human brucellosis were lack of education (P = 0.003; OR = 1.85) and farming as an occupation (P =<0.001; OR = 2.50) Similarly, among the risk factors studied, keeping animals at home (P =<0.001; OR = 2.03), slaughtering of animals (P =<0.001; OR = 15.87) and consuming raw milk (P =<0.001; OR = 5.42) were the factors strongly connected with human brucellosis. A massive awareness should be given to livestock farmers and individuals directly linked to animals regarding risk factors and transmission of brucellosis. Consumption of unpasteurized milk and its products should be condemned to curtail this neglected disease.
Fulltext High EZH2 Protein Expression Is a Poor Prognostic Predictor in IDH1 R132H-Negative Gliomas

Wong YP, Che Abdul Aziz R, Noor Aizuddin A, Mohd Saleh MF, Mohd Arshad R, Tan GC

Diagnostics (Basel), 2022 Sep 30;12(10).
PMID: 36292072 DOI: 10.3390/diagnostics12102383

Accumulating data indicates that enhancer of zeste homology 2 (EZH2) and isocitrate dehydrogenase 1 (IDH1) are implicated in promoting tumourigenesis in a myriad of malignancies including gliomas. We aimed to determine the immunoexpression of EZH2 in gliomas and its correlation with clinicopathological variables. The prognostic value of the combined immunoexpression of EZH2 and IDH1 was further explored in a retrospective analysis involving 56 patients with histologically confirmed gliomas in Universiti Kebangsaan Malaysia Medical Centre from 2010 to 2016. The patients were then followed up for a period of five years. EZH2 and IDH1 R132H immunoexpressions were performed and analysed on respective tissue blocks. Five-year progression-free survival (PFS) and overall survival (OS) were estimated by Kaplan−Meier analysis. Univariate and multivariate Cox proportional hazard regression models were performed to evaluate the value of EZH2 as an independent factor for the prediction of PFS and OS. High EZH2 immunoexpression was demonstrated in 27 (48.2%) gliomas. High EZH2 expression was significantly correlated with older age (p = 0.003), higher tumour grade (p < 0.001), negative IDH1 R132H immunoexpression (p = 0.039), a poor 5-year PFS (mean = 9.7 months, p < 0.001) and 5-year OS (mean = 28.2 months, p = 0.007). In IDH1 R132H-negative gliomas, there was a trend toward shorter 5-year PFS (mean = 8.0 months, p = 0.001) and 5-year OS (mean = 28.7 months, p = 0.06) in gliomas demonstrating high EZH2 expression compared with those with low EZH2 expression. High EZH2 immunoexpression is an unfavourable independent prognostic predictor of poor survival in gliomas. EZH2 analysis might therefore be of clinical value for risk stratification, especially in patients with IDH1 R132H-negative gliomas.
Fulltext Does US monetary policy uncertainty affect returns of Asian Developed, emerging, and frontier equity markets? Empirical evidence by using the quantile-on-quantile approach

Arshad R, Zada H, Sohag K, Wong WK, Ullah E, Raza H

Heliyon, 2024 Jun 30;10(12):e32962.
PMID: 38948042 DOI: 10.1016/j.heliyon.2024.e32962

This paper examines the impact of the Monetary Policy Uncertainty (MPU) of the United States on Asian developed, emerging, and frontier stock markets using a Quantile-on-Quantile (QQR) approach by using monthly data from January 2006 to December 2022 of 14 Asian countries. The study finds that US monetary policy significantly negatively influences Asian stock markets. This is primarily due to the widespread use of the US dollar as a universal currency, resulting in substantial ripple effects on other nations through trade relationships. In Asian developed markets, MPU is negatively related to Australia and New Zealand. At the same time, it has a positive relationship with Hong Kong and Japan at the upper quantiles. Among Asian emerging markets, MPU negatively impacts Taiwan's, India's, and China's returns, increasing this negative relationship at higher MPU quantiles. Additionally, MPU has a significant negative relationship with Thailand, Indonesia, Korea, and Malaysia returns. In contrast, higher quantiles of MPU have no discernible impact on the Philippines stock returns. In Asian frontier markets, MPU negatively impacts Pakistan's and Sri Lanka's returns. The implications of these findings are twofold: for investors, this study provides valuable insights for hedging activities, allowing for more informed decisions based on the MPU of other countries to identify profitable stocks. For policymakers, this research aids in formulating effective monetary policy strategies. Furthermore, future studies can build upon these results by exploring other markets and comparing their outcomes with the findings presented in this study.
Fulltext ZnO-NPs embedded biodegradable thiolated bandage for postoperative surgical site infection: In vitro and in vivo evaluation

Arshad R, Sohail MF, Sarwar HS, Saeed H, Ali I, Akhtar S, et al.

PLoS One, 2019;14(6):e0217079.
PMID: 31170179 DOI: 10.1371/journal.pone.0217079

Post-operative surgical site infections (SSI) present a serious threat and may lead to complications. Currently available dressings for SSI lack mucoadhesion, safety, efficacy and most importantly patient compliance. We aimed to address these concerns by developing a bioactive thiolated chitosan-alginate bandage embedded with zinc oxide nanoparticles (ZnO-NPs) for localized topical treatment of SSI. The FTIR, XRD, DSC and TGA of bandage confirmed the compatibility of ingredients and modifications made. The porosity, swelling index and lysozyme degradation showed good properties for wound healing and biodegradation. Moreover, in-vitro antibacterial activity showed higher bactericidal effect as compared to ZnO-NPs free bandage. In-vivo wound healing in murine model showed significant improved tissue generation and speedy wound healing as compared to positive and negative controls. Over all, thiolated bandage showed potential as an advanced therapeutic agent for treating surgical site infections, meeting the required features of an ideal surgical dressing.