MyMedR

Use of vaginal mesh; an Asian perspective footnote from the pan-Asia meeting

Lo TS, Tan YL

Int Urogynecol J, 2020 04;31(4):675-677.

PMID: 31932916 DOI: 10.1007/s00192-019-04219-x

Matched MeSH terms: Vagina*

Fulltext Uncomplicated term vaginal delivery following magnetic resonance-guided focused ultrasound surgery for uterine fibroids

Zaher S, Lyons D, Regan L

Biomed Imaging Interv J, 2010 04 01;6(2):e28.

PMID: 21611041 DOI: 10.2349/biij.6.2.e28

A 35 year-old para 1+0 underwent MRgFUS per study protocol for multiple uterine fibroids, the largest of which measured 5 cm. She conceived 10 months following the procedure. The patient was induced at 41+6 weeks and underwent a normal vaginal delivery.

Matched MeSH terms: Vagina

Imperforate vaginal septum with haematocolpos

Chuan OK, Ping WW

Med J Malaysia, 1974 Jun;28(4):279-82.

PMID: 4278941

Matched MeSH terms: Vagina/abnormalities*; Vagina/surgery

Fulltext Foreign bodies in the vagina after childbirth

Goh TH

Med J Malaysia, 1985 Mar;40(1):54-5.

PMID: 3831738

Matched MeSH terms: Vagina*

Fulltext Coital injuries of the vagina

Subramaniam N, Yogaraj R

Med J Malaysia, 1986 Dec;41(4):343-6.

PMID: 3670158

This article is an analysis of seven patients who presented to the Gynaecology Unit, General Hospital, Ipoh, during the period 1984-1985 with vaginal injury sustained during normal coitus.
Four patients were between 22-34 years of age. The remaining three were in the 51-64 year group; all the three had undergone previous gynaecological surgery.
History of coitus as the precipitating cause was elicited in all our patients and having reached a diagnosis, subsequent management was fairly straightforward. Two patients presented with clinical features of haemorrhagic shock and required initial resuscitation with blood transfusion. Five patients required definitive surgical repair of the vaginal injuries, and in only two patients was conservative management possible. Both these patients were in the menopausal age group.
Study site: Hospital Ipoh, Perak, Malaysia

Matched MeSH terms: Vagina/injuries*

An evaluation of the vaginal hysterectomy-repair operation for utero-vaginal prolapse

Cheng M

Med J Malaya, 1971 Sep;26(1):56-8.

PMID: 4258577

Matched MeSH terms: Vagina/surgery*

A cucumber in the abdomen penetrating through the vagina

Lee TT

Med J Malaya, 1970 Sep;25(1):53.

PMID: 4249497

Matched MeSH terms: Vagina/injuries*

Fulltext Isolation of Vaginal Epithelial Cells: In Preparation of Autologous Vaginal Tissue Lining for Congenital Absence of Vagina Patients

Lih Yuan T, Sulaiman N, Nur Azurah AG, Maarof M, Razali RA, Koh B, et al.

Int J Mol Sci, 2023 May 15;24(10).

PMID: 37240142 DOI: 10.3390/ijms24108798

Infertility is a condition affecting women who are born with an underdeveloped or absent vagina, a birth defect known as congenital absence of the vagina. It is a rare disorder where the development of the Mullerian duct is obstructed by unidentified causes. The case is seldom reported due to the low prevalence and sparse epidemiology studies worldwide. A potential solution for the disorder is neovaginal creation with in vitro cultured vaginal mucosa. Limited studies have reported its application, but none are reproducible or specific regarding the established processes for acquiring vaginal epithelial cells from vaginal biopsies. These research gaps were adequately answered with an epidemiology study of inpatient details in Hospital Canselor Tuanku Muhriz, Malaysia, established methods and outcomes of vaginal tissue processing and isolation, and characterization of vaginal epithelial cells using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium bromide (MTT) and immunofluorescence assays. The reported evidence and speculation that the disorder arises because of a cellular transition event between epithelial and mesenchymal cells during the development of the Mullerian duct could be key in the creation of neovaginas using established culture procedures to improve surgical results and restore fertility.

Matched MeSH terms: Vagina/abnormalities

Defect-specific rectocele repair: medium-term anatomical, functional and subjective outcomes

Guzmán Rojas R, Kamisan Atan I, Shek KL, Dietz HP

Aust N Z J Obstet Gynaecol, 2015 Oct;55(5):487-92.

PMID: 26172410 DOI: 10.1111/ajo.12347

Rectocele is a herniation of the anterior wall of the rectal ampulla through a defect in the rectovaginal septum causing protrusion of the posterior vaginal wall. Common symptoms include symptoms of prolapse and obstructed defecation.

Matched MeSH terms: Vagina

The place of vaginal hysterectomy in the management of genital prolapse

Menon R

Med J Malaya, 1970 Mar;24(3):194-5.

PMID: 4246800

Matched MeSH terms: Vagina

Development and validation of the genitourinary syndrome of menopause symptoms and vaginal treatments acceptability questionnaire (GSM-SVTAQ): An electronic patient-reported outcomes measure

Hassanein MM, Huri HZ, Baig K, Abduelkarem AR, Al-Momani M

Int J Gynaecol Obstet, 2024 Feb;164(2):613-623.

PMID: 37702968 DOI: 10.1002/ijgo.15106

OBJECTIVES: To develop and validate an electronic, patient-reported outcomes measure (PROM) specific for genitourinary syndrome of menopause (GSM) patients. The PROM aimed to accurately assess the burden of GSM symptoms, their impact on health-related and sexual quality of life, and the acceptability of vaginal treatments.

METHODS: The study encompassed a comprehensive three-stage approach to the development and validation of the PROM. Initially, during the preliminary design stage, the necessity for a new PROM was recognized, an expert panel was formed, and semi-structured qualitative interviews were carried out with GSM patients. In the second stage, the study used the five-step pre-validation methodology established by Prior et al. to generate and refine the PROM items. The third and final stage encompassed the determination of scale and item content validity indexes to ensure validity. Additionally, the reliability of each construct was evaluated using Cronbach's α.

RESULTS: The resulting PROM was named GSM-SVTAQ (GSM-symptoms and vaginal treatments acceptability questionnaire). It demonstrated excellent validity in assessing symptoms burden, health-related and sexual quality of life, and vaginal treatment acceptability, with high content validity indices and strong internal consistency. The scale content validity indices and Cronbach's α coefficients for the three domains were (0.926, 0.939), (0.875, 0.947), and (0.824, 0.855), respectively.

CONCLUSION: The GSM-SVTAQ stands as the first GSM-specific, valid, and reliable PROM capable of comprehensively measuring the three components of GSM and the acceptability of vaginal treatments. Its implementation has the potential to significantly enhance patient care and outcomes in GSM management.

Matched MeSH terms: Vagina*

A new case of zoonotic onchocercosis in northern Kyushu, Japan

Fukuda M, Uni S, Otsuka Y, Eshita Y, Nakatani J, Ihara K, et al.

Parasitol Int, 2015 Dec;64(6):519-21.

PMID: 26209456 DOI: 10.1016/j.parint.2015.07.006

A case of zoonotic onchocercosis has been found in a resident who lived in Iizuka City, Fukuoka Prefecture, Japan for some time. A 24-year-old male developed a painful nodule on the middle finger of his right hand. The nodule was surgically removed from the vagina fibrosa tendinis of the finger at Beppu Medical Center, Beppu City, Oita Prefecture in 2012. The causative agent was identified as a female Onchocerca dewittei japonica based on its histopathological characteristics. The identity of the filarioid has been confirmed by sequencing the cox1 gene. The present study indicates that the zoonotic onchocercosis caused by O. dewittei japonica has been concentrated in northeast Kyushu.

Matched MeSH terms: Vagina

Fulltext Extrapelvic Endometriosis: A report of two cases

Nor Azlin, M.I., Amelia, A.Z., Zainul Rashid, M.R.

International Medical Journal Malaysia, 2006;5(1):1-4.

MyJurnal

Extrapelvic endometriosis is fairly rare and may occur in numerous sites throughout the body. Unnecessary investigation may be performed before the diagnosis could be made. Here we present two cases where endometriotic nodules occurred on a caesarean section scar and in the vagina. Further management is discussed in the report.

Matched MeSH terms: Vagina

Fulltext 12. Concurrent utero-vaginal prolapse with cervical angiomyofibroblastoma: a rare disease with distinct entity

Lee, CL, Ng, Beng Kwang, Chew, KT, Aruku, N, Lim, PS

Journal of Surgical Academia, 2015;5(2):58-61.

MyJurnal

We report the case of a rare, benign mesenchymal tumour arising from the cervix. A 53-year-old post-menopausal woman presented with mass per vagina. Examination revealed stage 2 utero-vaginal prolapse and multiple elongated polyps seen at the cervix. She underwent local excision. Histopathological examination findings and the immunohistochemical studies were consistent with Angiomyofibroblastoma.

Matched MeSH terms: Vagina

Fulltext A rare synchronous presentation of primary malignant melanoma in cervix and vagina

Pai UKN, Pillai S, Arunkumar NR

J Cancer Res Ther, 2023 Oct 01;19(7):2108-2110.

PMID: 38376333 DOI: 10.4103/jcrt.jcrt_1309_21

Malignant melanoma, primarily a cutaneous malignancy, can also involve mucosal surfaces and constitutes 2% to 7% of all gynecological malignancies. Primary melanoma of the uterine cervix is an uncommon tumor and has poor prognosis. In the female genital tract, the synchronous occurrence of primary malignant melanoma in the cervix and vagina is rare. We report a case of a 48-year-old female patient who presented with a blackish vaginal mass and associated growth in the cervix. Biopsy from the vaginal mass was reported as malignant melanoma. Following this, she underwent radical surgery and adjuvant radiotherapy. After 12 months, the patient is doing well.

Matched MeSH terms: Vagina

Vaginal dryness: a review of current understanding and management strategies

Mark JKK, Samsudin S, Looi I, Yuen KH

Climacteric, 2024 Jun;27(3):236-244.

PMID: 38318859 DOI: 10.1080/13697137.2024.2306892

The issue of vaginal dryness in genitourinary syndrome of menopause (GSM) and its pervasive impact on women's quality of life is often overlooked. Extensive surveys conducted worldwide reveal limited understanding of vaginal dryness among public and health-care providers. Physician knowledge on menopause medicine varies globally, highlighting the need for standardized training. Effective communication between physicians and patients plays a crucial role in diagnosing and treating GSM symptoms. There are multiple treatment options to improve vaginal lubrication, including hormonal and non-hormonal therapies, along with lifestyle modifications. Tailoring treatments to individual patient preferences is crucial for compliance. Overall, GSM is multifaceted, from the prevalence of vaginal dryness to the nuances of treatment preferences. The urgency of widespread education and awareness of this matter must be underscored to meet the aim of enhancing the well-being and quality of life for women.

Matched MeSH terms: Vagina

Miniaturized Polymeric Systems for the Intravaginal Gene Therapies: Recent Update on Unconventional Delivery

Pandey M, Ting JSS, Gorain B, Jain N, Mayuren J

Curr Pharm Des, 2023;29(40):3254-3262.

PMID: 37438899 DOI: 10.2174/1381612829666230712162540

The prevalence of vaginal infection is increasing among women, especially at reproductive age. For proper eradication of infection, the effective concentration of a drug is required at the infection site. Therefore, local delivery is recommended to exert a direct therapeutic effect at the site action that causes a reduction in dose and side effects. The main focus of vaginal drug delivery is to enhance retention time and patient compliance. The high recurrence rate of vaginal infection due to the lack of effective treatment strategies opens the door for new therapeutic approaches. To combat these setbacks, intravaginal gene therapies have been investigated. High attention has been gained by vaginal gene therapy, especially for sexually transmitted infection treatment. Despite much research, no product is available in the market, although in vitro and preclinical data support the vaginal route as an effective route for gene administration. The main focus of this review is to discuss the recent advancement in miniaturized polymeric systems for intravaginal gene therapies to treat local infections. An overview of different barriers to vaginal delivery and challenges of vaginal infection treatment are also summarised.

Matched MeSH terms: Administration, Intravaginal; Vagina

Fulltext The pudendal thigh fasciocutaneous flap for vaginal atresia reconstruction

Azman WS, Halim AS, Samad IA

Med J Malaysia, 2005 Oct;60(4):505-7.

PMID: 16570718

Vaginal defects can either be congenital or acquired due to tumor or trauma. The reconstructions are aimed in producing a good physical and functional result with the least donor site morbidity. The pudendal thigh flap is a sensate fasciocutaneous flap based on the terminal branch of the superficial perineal artery, the continuation of the internal pudendal artery. Although various flaps have been described for vaginal reconstruction, the pudendal thigh flap offers a very attractive alternative.

Matched MeSH terms: Vagina/abnormalities; Vagina/surgery*

Fulltext A microbiological study of vaginal discharge in women attending a Malaysian gynaecological clinic

Cheong YM, Ng YP, Chin CS, Thambu J

Med J Malaysia, 1992 Mar;47(1):44-50.

PMID: 1387449

Vaginal discharge is a common complaint of women attending gynaecological clinics. The purpose of this study was to compare the occurrence of commonly implicated microorganisms in vaginal discharge amongst women with or without the complaint, attending a gynaecological and family planning clinic. The association of Gardnerella vaginalis with bacterial vaginosis was also studied. It was found that there were no significant differences between the cases and controls in the isolation rate of Gardnerella vaginalis, Torulopsis glabrata, Ureaplasma urealyticum, Mycoplasma ssp and Group B streptococcus (p greater than 0.05). Only the isolation rate of Candida albicans was significantly higher in the cases than controls (p less than 0.01). However, there was a significant association of G. vaginalis with bacterial vaginosis.

Matched MeSH terms: Vagina/microbiology*; Vagina/secretion

Fulltext Vaginal microbiota and the potential of Lactobacillus derivatives in maintaining vaginal health

Chee WJY, Chew SY, Than LTL

Microb Cell Fact, 2020 Nov 07;19(1):203.

PMID: 33160356 DOI: 10.1186/s12934-020-01464-4

Human vagina is colonised by a diverse array of microorganisms that make up the normal microbiota and mycobiota. Lactobacillus is the most frequently isolated microorganism from the healthy human vagina, this includes Lactobacillus crispatus, Lactobacillus gasseri, Lactobacillus iners, and Lactobacillus jensenii. These vaginal lactobacilli have been touted to prevent invasion of pathogens by keeping their population in check. However, the disruption of vaginal ecosystem contributes to the overgrowth of pathogens which causes complicated vaginal infections such as bacterial vaginosis (BV), sexually transmitted infections (STIs), and vulvovaginal candidiasis (VVC). Predisposing factors such as menses, pregnancy, sexual practice, uncontrolled usage of antibiotics, and vaginal douching can alter the microbial community. Therefore, the composition of vaginal microbiota serves an important role in determining vagina health. Owing to their Generally Recognised as Safe (GRAS) status, lactobacilli have been widely utilised as one of the alternatives besides conventional antimicrobial treatment against vaginal pathogens for the prevention of chronic vaginitis and the restoration of vaginal ecosystem. In addition, the effectiveness of Lactobacillus as prophylaxis has also been well-founded in long-term administration. This review aimed to highlight the beneficial effects of lactobacilli derivatives (i.e. surface-active molecules) with anti-biofilm, antioxidant, pathogen-inhibition, and immunomodulation activities in developing remedies for vaginal infections. We also discuss the current challenges in the implementation of the use of lactobacilli derivatives in promotion of human health. In the current review, we intend to provide insights for the development of lactobacilli derivatives as a complementary or alternative medicine to conventional probiotic therapy in vaginal health.

Matched MeSH terms: Vagina/microbiology*; Vagina/physiology*

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