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Fulltext Hailey-Hailey disease--case report

Mohamed KN

Med J Malaysia, 1983 Sep;38(3):188-90.

Hailey-Hailey disease or Chronic Benign Familial Pemphigus is probably rare in this region and to date there is no case report from Malaysia. I report here a Malay patient with this disease but with no family history and who was believed to be suffering from Atopic Eczema for several years. Dapsone effectively controlled the disease in this patient. The clinical features, histology and the therapy are discussed.

Matched MeSH terms: Pemphigus/diagnosis; Pemphigus/genetics; Pemphigus/pathology*

Visual Dermatology: Scalp Involvement in Pemphigus Vegetans

Huei LT, Yee EYW

J Cutan Med Surg, 2020 05 22;25(3):329.

PMID: 32442016 DOI: 10.1177/1203475420928927

Matched MeSH terms: Pemphigus/diagnosis*

A case of acantholytic dermatosis of the vulva with features of pemphigus vegetans

Wong KT, Wong KK

J Cutan Pathol, 1994 Oct;21(5):453-6.

PMID: 7868757

We report an unusual case of vulvar acantholytic dermatosis with features of pemphigus vegetans in a 22-year-old Indian girl who presented with a "warty" lesion in her left labium majus. Following excision of this lesion, she presented with 2 localized recurrent lesions on the left and right labia majora about 2 1/2 years later which were also excised. All 3 biopsies showed histological features typical of pemphigus which included extensive suprabasal acantholysis with bullae formation, prominent villus-like processes at the base of the bullae, focal hyperkeratosis and papillomatosis, and the occasional mixed neutrophil and eosinophilic intraepidermal abscess. IgG and C3 immunofluorescence was positive in the intercellular spaces of the epidermis. These lesions, which probably represent a form of pemphigus vegetans, have not been previously reported as a cause of localized vulvar acantholytic dermatosis.

Matched MeSH terms: Pemphigus/pathology*

The recurrent intertriginous rash

How KN, Bhullar A

Eur J Intern Med, 2018 07;53:e4-e5.

PMID: 29307504 DOI: 10.1016/j.ejim.2017.12.016

Matched MeSH terms: Pemphigus, Benign Familial/diagnosis*; Pemphigus, Benign Familial/genetics; Pemphigus, Benign Familial/pathology*

Pemphigus vulgaris

Nayak V, Kini R, Rao PK, Shetty U

BMJ Case Rep, 2020 May 13;13(5).

PMID: 32404374 DOI: 10.1136/bcr-2020-235410

Matched MeSH terms: Pemphigus/diagnosis*; Pemphigus/drug therapy

Painful oral and genital ulcers

Ch'ng CC, Wong SM, Lee YY

Cutis, 2017 Jan;99(1):E1-E3.

PMID: 28207013

Matched MeSH terms: Pemphigus/diagnosis*; Pemphigus/pathology

Fulltext Pemphigus vulgaris in a pregnant woman and her neonate

Ibrahim SB, Yashodhara BM, Umakanth S, Kanagasabai S

BMJ Case Rep, 2012;2012.

PMID: 22744241 DOI: 10.1136/bcr.02.2012.5850

A 23-year-old pregnant woman in her second trimester of pregnancy presented with blisters on the face, abdomen and the leg. Based on the clinical presentation and skin biopsy (histopathology and direct immunofluorescence) the diagnosis of pemphigus vulgaris was established. The child born to this patient also had similar skin lesions. The lesions in the mother and the child improved after treatment. The authors report a rare case of pemphigus vulgaris in a pregnant lady and neonatal pemphigus in her child, both of whom were treated successfully.

Matched MeSH terms: Pemphigus/complications; Pemphigus/drug therapy*; Pemphigus/genetics

Fulltext Childhood Occurrence of Pemphigus

U Patil R, T Anegundi R, R Gujjar K, Indushekar KR

Int J Clin Pediatr Dent, 2017 06 01;10(2):196-200.

PMID: 28890623 DOI: 10.5005/jp-journals-10005-1434

Pemphigus is a chronic mucocutaneous disease that initially manifests in the form of intraoral blisters which spread to other mucous membrane and skin. This study describes an unusual case of chronic generalized childhood pemphigus disease in an 11-year-old girl, who presented with multiple vesicles all over her body. Such a condition is seen more often in older people rather than children. It is crucial for dental professionals to be familiar with the diagnosis of bullous skin diseases in children and adolescents, especially in its initial stages in order to prevent the serious consequences and morbidity. The article highlights clinical presentation, histopathology, and successful management strategies useful for pediatric dental practice.

HOW TO CITE THIS ARTICLE: Patil RU, Anegundi RT, Gujjar KR, Indushekar KR. Childhood Occurrence of Pemphigus. Int J Clin Pediatr Dent 2017;10(2):196-200.

Matched MeSH terms: Pemphigus

The Evaluation of Serum Lipids Profile in Patients with Pemphigus Vulgaris: A Case-Control Study

Rezazadeh F, Moshaverinia M, Handjani F, Khoshkholgh F, Saki N, Heiran A

Malays J Med Sci, 2020 Mar;27(2):57-63.

PMID: 32788842 DOI: 10.21315/mjms2020.27.2.7

Background: Pemphigus vulgaris (PV) is a chronic autoimmune disease. Dyslipidemia, increased risk of atherosclerosis and higher cardiovascular morbidity, and mortality have been reported in several autoimmune conditions. It has been hypothesised that there might be an association between dyslipidemia and PV. Therefore, the objective of this study was to compare the serum lipid profile of patients with PV with healthy controls.

Methods: This case-control study was carried out on 113 patients with PV and 100 healthy controls. Total cholesterol, high-density lipoprotein (HDL) and triglycerides (TG) levels were measured and low-density lipoprotein (LDL), non-HDL cholesterol (non-HDL-C) and atherogenic index of plasma (AIP) were calculated. Chi-squared test and independent Student t-test (or their alternatives) were used for group comparison.

Results: The mean age and BMI of patients and controls were 47.7 ± 14.5 and 28 ± 6.2 and, 44.5 ± 18.5 and 25.5 ± 5.1, respectively. Total cholesterol, LDL, HDL, non-HDL-C and TG were statistically different between the two groups (P values < 0.001; < 0.001; < 0.001; < 0.001 and 0.021, respectively). However, AIP was not significantly different (P-value = 0.752).

Conclusion: The serum lipid profile was significantly higher in PV patients compared to healthy controls. Therefore, PV patients may be more prone to develop atherosclerosis and this finding can be important in the overall management of these patients.

Matched MeSH terms: Pemphigus

Bullous diseases in Malaysia: epidemiology and natural history

Adam BA

Int J Dermatol, 1992 Jan;31(1):42-5.

PMID: 1737688

The characteristics of three primary bullous diseases, pemphigus, pemphigoid, and dermatitis herpetiformis, seen in this country, probably reflecting this region, are discussed and compared to those reported in the literature in the West. One hundred and forty-eight patients with bullous diseases were seen over a period of 15 years. The criteria for confirmation of clinical diagnosis were the findings of the direct immunofluorescent test. Pemphigus vulgaris was the commonest bullous disease. The incidence of bullous pemphigoid was highest in the Indians of Malaysian origin, and they are also more likely to develop pemphigus vulgaris than any other ethnic group. Linear IgA type formed the entire group of dermatitis herpetiformis. The granular type was not seen at all. The patients were treated with prednisolone alone or together with methotrexate or azathioprine. Dapsone alone controlled the dermatitis herpetiformis. The known association between pemphigus and other diseases with immunologic disturbances was not found in this study. The natural history of the bullous disease as seen in the follow-up patients is described. Deaths in pemphigus and pemphigoid were more due to either complications of steroid therapy or unassociated diseases than the primary disease itself. Introduction of immunofluorescence as a diagnostic tool in pemphigus and extension of this facility to other bullous diseases has led to detailed characterization of these diseases as seen in the West; however, publications in English dealing with epidemiologic aspects of bullous diseases in this region are rare.(ABSTRACT TRUNCATED AT 250 WORDS)

Matched MeSH terms: Pemphigus/drug therapy; Pemphigus/epidemiology*

Bullous diseases: a 7-year survey of experience with 77 patients

Adam BA

Ann Acad Med Singap, 1983 Jan;12(1):19-25.

PMID: 6344741

A prospective study of 77 consecutive patients with bullous diseases was done to study the pattern and natural history. Pemphigus was the commonest with 45 patients (59%) followed by pemphigoid with 21 patients (27%). Pemphigoid was more common in Indians than in other ethnic groups and its age of onset was a decade later than pemphigus. Unusual immunofluorescent findings in both diseases are discussed. Six of the 7 patients with dermatitis herpetiformis had linear IgA in the dermo-epidermal junction and the classical papillary IgA deposits were absent. Ultrastructural findings of pemphigoid and dermatitis herpetiformis confirmed earlier reports. Chronic bullous dermatoses of childhood was seen in 4 patients, all of whom had total remission within one year of onset disease.

Matched MeSH terms: Pemphigus/immunology

Fulltext Strongyloides stercoralis hyperinfection in a diabetic patient: case report

Azira NM, Zeehaida M

Trop Biomed, 2010 Apr;27(1):115-9.

PMID: 20562820 MyJurnal

Strongyloides stercoralis is a widespread, soil-transmitted helminth affecting humans. Autoinfection occurs in S. stercoralis infection and this leads to a continuous build-up of worm burden in human host. This may lead to hyperinfection syndrome which has the potential to cause serious life-threatening disease especially in immunocompromised and immunosuppressed patients. Thus, patient with underlying risk factors should be suspicious of having this infection as severe strongyloidiasis carries a high mortality rate if the diagnosis is delayed. Here, we report a case of S. stercoralis hyperinfection in a diabetic patient.

Matched MeSH terms: Pemphigus/drug therapy

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