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INHIBITION OF LACTATION USING HORMONES

LLEWELLYN-JONES D

Med J Malaysia, 1963 Sep;18:13-5.
PMID: 14064289
Matched MeSH terms: Lactation*
Effect of age at first calving and milking system on the lactation performance of F1 Bos indicus/Bos taurus crossbreds in Sabah

Edwards MD

Trop Anim Health Prod, 1985 Nov;17(4):201-8.
PMID: 4089967 DOI: 10.1007/BF02356977

This paper examines the effect of age at first calving and milking system on the overall lactation performance and incidence of lactation failure of 442 F1 Bos indicus/Bos taurus dairy crossbreds in Sabah. The two types of crossbred used in the study were imported F1 Sahiwal x Friesian and locally bred Friesian x Local Indian Dairy. Heifers which did not lactate for at least 120 days or produced less than 20 kg of milk during the fourteenth week of lactation were considered to have failed to establish a lactation. The imported and locally bred heifers recorded failure rates of 23.4 and 21.4% respectively. Three milking systems were examined namely machine milking without calf, machine milking with calf and hand milking. They produced failure rates of 30, 12 and 5.6% respectively. The cows that passed recorded 120 day milk production figures of 878, 1,134 and 1,054 kg respectively. The three age groups of less than 30 months, 30 to 34 months and greater than 34 months recorded failure rates of 37, 22 and 10% respectively. The heifers machine milked without their calf which calved at less than 30 months of age recorded a failure rate of 44% while those which calved at greater than 34 months recorded a failure rate of only 17%.
Study site: Tawau and Sebrang Livestock Breeding Centres, Sabah, Malaysia

Matched MeSH terms: Lactation*
Benign Disorders of the Breast in Pregnancy and Lactation

Taib NA, Rahmat K

Adv Exp Med Biol, 2020;1252:43-51.
PMID: 32816261 DOI: 10.1007/978-3-030-41596-9_6

Benign cystic or solid lumps frequently occur in the breasts of young women, and consequently can also be seen during pregnancy and lactation. Simple cysts do not increase the risk of malignancy. The current management is routine follow-up. Complex cysts are thick walled or contain a mass, and should be followed by a US-guided biopsy and then treated similar to any non-gravid, non-lactating patient.Galactoceles can be detected during the last trimester of pregnancy and during or after stopping lactation. Aspiration can be done to confirm the content. Co-existence of galactocele and malignancy is extremely rare, and the key is to follow up until it resolves.Fibroadenoma is the most frequent lesion found during pregnancy and lactation. Management is usually conservative after triple assessment. Surgery is usually not recommended in pregnant and lactating women unless rapid increase in size occurs or there is discordance in the triple assessment.Lactating adenomas are sometimes interpreted as a variant of fibroadenoma . They can naturally disappear at the end of pregnancy or lactation. Management is usually conservative, and an excisional biopsy is only mandated if it is rapidly enlarging or if there is discordance in the triple assessment.Gestational gigantomastia is a rare condition consisting of diffuse severe hypertrophy of both breasts during pregnancy . Mastectomy and reconstruction may rarely be required in such cases.

Matched MeSH terms: Lactation*
Short-term liveweight changes of dairy cows measured by stationary and walk-over weighing scales

Mardhati M, González LA, Thomson PC, Clark CEF, García SC

J Dairy Sci, 2021 Jul;104(7):8202-8213.
PMID: 33865596 DOI: 10.3168/jds.2020-19912

Monitoring and detecting individual cows' liveweight (LW) and liveweight change (LWC) are important for estimation of nutritional requirements and health management, and could be useful to measure short-term feed intake, water consumption, defecation, and urination. Walk-over weighing (WOW) systems can facilitate measurements of LW for these purposes, providing automated LW recorded at different times of the day. We conducted a field study to (1) quantify the contribution of feed and water intake, as well as urine and feces excretions, to short-term LWC and (2) determine the feasibility of stationary and WOW scales to detect subtle changes in LW as a result of feed and water intake, urination, and defecation. In this experiment, 10 cows walked through a WOW system and then stood individually on a stationary scale collecting weights at 10 and 3.3 Hz, respectively. Cows were offered 4 kg of feed and 10 kg of water on the stationary scale. For each animal, LW before and after eating and drinking was then calculated using different approaches. Liveweight change was calculated as the difference between the initial and final LW before and after eating and drinking for each statistical measure. The weights of feed intake, water consumption, urination, and defecation were measured and used as predictors of LWC. Urine and feces were collected from individual cows while the cow was on the scale, using a container, and weighed separately. The agreement between LWC measured using either stationary or WOW scales was assessed to determine the sensitivity of the scales to detect subtle changes in LW using the coefficient of determination (R2), Lin's concordance correlation coefficient (CCC), and mean bias. The prediction model showed that most of the regression coefficients were not significantly different from +1.0 for feed and water, or -1.0 for urine and feces. The R2 and CCC values demonstrated a satisfactory agreement between calculated and stationary LWC and values ranged from 0.60 to 0.92 and 0.71 to 0.94, respectively. A moderate agreement was achieved between calculated and automated LWC with R2 and Lin's CCC values of 0.45 to 0.63 and 0.60 to 0.74, respectively. Therefore, results demonstrated that new algorithms and data processing methods need to be continuously explored and improved to obtain accurate measurements of LW to measure changes in LW, especially from WOW scales.

Matched MeSH terms: Lactation*
Fulltext Challenges experienced by induced lactation women in Malaysia: An exploratory qualitative study

Che Abdul Rahim N, Sulaiman Z, Ismail TAT

PLoS One, 2024;19(1):e0291758.
PMID: 38277383 DOI: 10.1371/journal.pone.0291758

BACKGROUND: Induction of lactation occurs when breast milk is produced in a human (woman), without going through the process of pregnancy and delivery. Efforts to produce milk by women who had never been pregnant and give birth are not easy. According to the many who have attempted it, it is far more arduous a task than initiating postpartum lactation, but it is possible and worth the effort.
RESEARCH AIM: This study aimed to explore and understand the challenges for women during induced lactation in Malaysia.
METHODS: This qualitative study was done in 2017 and utilized in-depth interview among women who induced lactation in five states based on five regions in Malaysia [Central Region (Selangor), Northern Region (Penang), Southern Region (Johor), East Coast Region (Kelantan), Malaysia Borneo (Sabah)]. All interviews were consented, audio-recorded then transcribed verbatim, followed by identification of main themes.
RESULTS: Data saturation was achieved after interviewing a total of 23 induced lactation women. Data synthesized using thematic analysis revealed six themes describing the main challenges during the induction process were (1) health condition, (2) work commitment, (3) overexertion, (4) not eligible to take leave, (5) inability to follow the treatment plan, and (6) difficulty attaching the adopted baby to initiate breastfeeding during induced lactation process.
CONCLUSIONS: The challenges faced by women during the process of induced lactation were complex and the induced lactation process requires considerable dedication and determination. The findings of this research will help other women and their spouses/partners comprehend the challenges, obstacles, and support that are needed along the induced lactation process. The Government and other stakeholders have roles in more efforts and programs to help these mothers breastfeed their adoptive child and make them feel more accomplished as women and mothers.

Matched MeSH terms: Lactation*
Fulltext Dried small fish provide nutrient densities important for the first 1000 days

Byrd KA, Pincus L, Pasqualino MM, Muzofa F, Cole SM

Matern Child Nutr, 2021 Oct;17(4):e13192.
PMID: 33942983 DOI: 10.1111/mcn.13192

Inadequate nutrient intakes are prevalent among many populations in sub-Saharan Africa and increasing fish consumption among pregnant/lactating women and children is one strategy to improve diets and address nutrient deficiencies. We report the nutrient content of two fish-based recipes-fish powder and fish chutney-that contain dried small fish available in local markets in Zambia. The contribution of a serving of each recipe to the recommended daily intakes of iron, zinc, calcium and docosahexaenoic acid (DHA) for pregnant/lactating women and children 6-24 months was calculated because these nutrients are commonly deficient in African diets. We found that one 10-g serving of fish powder provides 20% or more of the daily calcium recommendation and 37% or more of the daily DHA recommendation for both pregnant/lactating women and children. A 30-g serving of fish chutney provides over 40% of the daily calcium recommendation for pregnant women and over 50% for lactating women. Additionally, we investigated the nutrient density (nutrients per kilocalorie) of the fish powder and compared it with the nutrient density of a small-quantity lipid-based nutrient supplement plus (SQ-LNS-plus). SQ-LNS-plus is designed to enhance children's diets by providing micronutrients and DHA. Fish powder is similar to SQ-LNS-plus in iron and zinc density and even higher in calcium and DHA density. Consuming dried small fish as part of a daily meal can be a viable strategy for combatting nutrient deficiencies in the first 1000 days.

Matched MeSH terms: Lactation*
Clinical Study on Plant Galactagogue Worldwide in Promoting Women's Lactation: a Scoping Review

Kwan SH, Abdul-Rahman PS

Plant Foods Hum Nutr, 2021 Sep;76(3):257-269.
PMID: 34292494 DOI: 10.1007/s11130-021-00901-y

Human milk is recommended by the World Health Organization (WHO) for the general well-being of infants. However, many mothers face an insufficient milk supply to breastfeed their children. Galactagogue, in particular, plant galactagogue, serves as a method to promote lactation. This in-depth review examines the evidence supporting different plants' galactagogic activity through clinical studies around the globe. A scoping review approach was adopted to establish the research questions, and define the findings, selection and analysis of the study. This scoping review highlights and compiles the clinical research performed globally involving plant galactagogue to better inform the medical practitioners, lactation consultants, nursing mothers, communities and relevant personnel on practicing, guidelines, policymaking and research. In general, a total of 1041 research publications were retrieved from different global bibliographic databases, of which only 13 articles were retained for analysis after applying the exclusion criteria. A total of 14 types of plants have undergone clinical studies in the past decade to verify their galactagogic activity. All but two showed a positive effect on promoting milk production. There were 42 articles categorised as excluded studies. The category includes review articles, surveys, case reports, introductory articles of regional plant galactagogue and preclinical studies, which involves animal testing and the studies exploring other issues related to plant galactagogue. The findings demonstrate that there is a significant research gap on the plant galactagogue using clinical studies. More clinical research is necessary to identify and verify the efficacy of various types of plant galactagogue for the benefit of humankind.

Matched MeSH terms: Lactation
Fulltext A shared agenda for gender and COVID-19 research: priorities based on broadening engagement in science

George AS, Lopes CA, Vijayasingham L, Mothupi MC, Musizvingoza R, Mishra G, et al.

BMJ Glob Health, 2023 May;8(5).
PMID: 37217235 DOI: 10.1136/bmjgh-2022-011315

While the acute and collective crisis from the pandemic is over, an estimated 2.5 million people died from COVID-19 in 2022, tens of millions suffer from long COVID and national economies still reel from multiple deprivations exacerbated by the pandemic. Sex and gender biases deeply mark these evolving experiences of COVID-19, impacting the quality of science and effectiveness of the responses deployed. To galvanise change by strengthening evidence-informed inclusion of sex and gender in COVID-19 practice, we led a virtual collaboration to articulate and prioritise gender and COVID-19 research needs. In addition to standard prioritisation surveys, feminist principles mindful of intersectional power dynamics underpinned how we reviewed research gaps, framed research questions and discussed emergent findings. The collaborative research agenda-setting exercise engaged over 900 participants primarily from low/middle-income countries in varied activities. The top 21 research questions included the importance of the needs of pregnant and lactating women and information systems that enable sex-disaggregated analysis. Gender and intersectional aspects to improving vaccine uptake, access to health services, measures against gender-based violence and integrating gender in health systems were also prioritised. These priorities are shaped by more inclusive ways of working, which are critical for global health as it faces further uncertainties in the aftermath of COVID-19. It remains imperative to address the basics in gender and health (sex-disaggregated data and sex-specific needs) and also advance transformational goals to advance gender justice across health and social policies, including those related to global research.

Matched MeSH terms: Lactation
Fulltext Adequacy of lactation: dysreflexia vs. maternal nutrition

Jelliffe DB

Med J Malaysia, 1986 Mar;41(1):77-83.
PMID: 3796355

Problems with assessing the effect of maternal nutrition and lactation performance are presented in relation to a conceptual mathematical ziggurat. Difficulties, variations and flows are to be found in stages of this sequence of "logic" [e.g., assessment of maternal nutrition, volume and composition of breast milk, nutritional satisfactions of the nursling). It is concluded that the various steps in this process of reasoning are subject to much more variation and adaptation than appreciated. Much so-called "faltering" in the second trimester is physiologically normal ("pseudo-faltering").

Matched MeSH terms: Lactation/physiology*
Development of smallholder dairy units in Malaysia

Wan Hassan WE, Phipps RH, Owen E

Trop Anim Health Prod, 1989 Aug;21(3):175-82.
PMID: 2799944

In experiments conducted over a four-year period the effect of pasture type (Setaria sphacelata and a Brachiaria decumbens/Leucaena leucocephala mixture), management system (rotational grazing and cut and carry) and level of concentrate supplement (0, 4 and 6 kg fresh weight/cow per day) on milk production in smallholder dairy units was examined. All units were 1 ha in size and stocked with five Sahiwal X Friesian cows. Milk yields/ha were higher from rotational grazing and the brachiaria/leucaena pasture when compared with the cut and carry system and the setaria pasture respectively. In subsequent experiments smallholder units were based on brachiaria/leucaena and rotational grazing. A supplement of 4 kg fresh weight of concentrate (11 MJ/kg DM and 150 g/kg DM CP) increased milk yield/ha from 7,760 to 13,045 kg while in a third trial milk yield/ha was further increased from 14,148 to 16,760 kg when concentrate level was raised from 4 to 6 kg fresh weight/day. The results indicate that smallholder dairy units in Malaysia could be economically viable and competitive with other agricultural enterprises such as rubber and oil palm.

Matched MeSH terms: Lactation*
Inhibition of post-partum lactation with quinestrol

Chuan OK, Ping WW, Fook CW

Med J Malaysia, 1976 Jun;30(4):296-8.
PMID: 790111
Matched MeSH terms: Lactation/drug effects*
Fulltext Assessment of breastfeeding problems experienced by mothers in the first six months postpartum: a process of tool development

Manjilala, Februhartanty, Judhiastuty, Basuki, Dian N.

Malays J Nutr, 2014;20(3):351-365.
MyJurnal

Introduction: Studies have found that breastfeeding problems are associated with negative breastfeeding outcomes. Unfortunately, assessing breastfeeding problems can be quite difficult. The objective of the paper is to share the process of tool development for the assessment of breastfeeding problem in an Indonesian setting. Methods: The development of the tool was a two-stage process, consisting of understanding the range and pattern of breastfeeding problems (through literature review, discussions with lactation experts, and in-depth interviews with nursing mothers) and the production of the tool (through discussions with graphic designers and communication practitioners, pre-testing the tools, and finalising a workable, viable tool). The process led the authors to use flash cards for assessing the breastfeeding problems. Each card consisted of information about age, a code number, an image and a description of the breastfeeding problem. Each set of the flash cards represented an age period of 0-1, 1-3, and 3-6 months. The final flash cards were used in a cross-sectional study of 205 mothers of infants aged 6-12 months in Maros District, South Sulawesi. Results: The flash cards captured patterns of breastfeeding problems experienced by mothers within the first month, such as sore nipple, no milk production, fatigue, breast engorgement, and sleepy baby, or those problems that persisted throughout the six-month period such as infants' refusal to breastfeed and mothers feeling fatigued. The decreasing or increasing magnitude of a problem over time was also reflected in the flash cards. Conclusion: Identification of the dynamic patterns and magnitude of breastfeeding problems was successfully captured with the use of flash cards.

Matched MeSH terms: Lactation; Lactation Disorders
Changes in human milk vitamin E and total lipids during the first twelve days of lactation

Ali J, Kader HA, Hassan K, Arshat H

Am J Clin Nutr, 1986 Jun;43(6):925-30.
PMID: 3717068

Our previous study showed vitamin E deficiency in newborns (69.7%) and mothers at term (85.9%) when the ratio between serum vitamin E in mg/dl and total lipids in g/dl was used as an indicator of vitamin E status. This study was conducted to determine the human milk content of vitamin E. During the first 12 days of lactation milk vitamin E levels remained almost constant (day 1, 0.68 mg/dl; day 12, 0.65 mg/dl), milk total lipid levels increased daily (day 1, 1.11 g/dl; day 12, 3.60 g/dl), and the ratio between milk vitamin E and total lipids dropped steadily (day 1, 1.3; day 12, 0.2). In spite of this drop in vitamin E status, it is unlikely that vitamin E availability will be affected in neonates, because normal neonates absorb milk fats well and this ability increases with age.

Matched MeSH terms: Lactation*
Fulltext Effectiveness of 18-hour lactation management course organised by district health office for health staff

Tan, K.L., Ghani, S.N.

JUMMEC, 2007;10(1):21-24.
MyJurnal

This was a cross-sectional study which attempts to assess the effectiveness of the 18-hour lactation management course organised by Klang District Health Office for its health staff. The course was conducted for three days from 19 to 21 September, 2006 with a total of 18 hours, comprising 15 hours of lectures and three hours of supervised clinical experience. There were a total of 46 participants for the course. The pre- and post-test scores of the participants from the course were used for analysis. This study showed that the mean pre-test versus mean post-test scores were 12.63 and 19.87. The difference in the mean score was statistically significant (p < 0.001, 95%CI -8.285, -6.193). The difference was significant for the staff nurse, community nurse and assistant nurse but not for doctors. In conclusion, the 18-hour duration lactation management course was effective at improving the knowledge and skills on breastfeeding management for the health staff.

Matched MeSH terms: Lactation
Reproductive biology of Eonycteris spelaea, Dobson (Megachiroptera) in West Malaysia

Beck AJ, Lim BL

Acta Trop, 1973;30(4):251-60.
PMID: 4147874
Matched MeSH terms: Lactation
Fulltext Natal tooth with Riga Fede disease: a case report

Nurjasmine Aida Jamani, Yunita Dewi Ardini, Nor Asilah Harun

International Medical Journal Malaysia, 2017;16(21):47-47.
MyJurnal

: Natal tooth and neonatal tooth is a rare occurrence but can have a significant impact
on lactation. A 45-day-old baby girl was referred for problem with breastfeeding. Her mother
complained of painful nipple during nursing for the past two weeks. (Copied from article).

Matched MeSH terms: Lactation
Fitting multiphasic logistic functions to the lactation curves of gir x friesian crossbred dairy cattle in Malaysia

Majid A, Shariff A, Merican A, Bong Y

Sains Malaysiana, 2014;43:987-883.

The data used in this study consisted of milk yield (kg) taken at approximately fortnightly intervals from Gir x Friesian crossbred dairy cattle raised at Institut Haiwan Kluang, Malaysia. The data were first edited, smoothed and then fitted with mono-, di- and triphasic logistic functions. In general, parameter estimates for the first lactation were reasonable. However, for the second lactation the estimates were erratic and unreasonable because this was the atypical lactation for which the multiphasic functions were obviously unsuitable. Residual mean squares for the di- and triphasic functions of the first lactation were very similar (0.0002 and 0.0004, respectively) and smaller for the monophasic function (0.0894). For the second lactation, residual mean squares for the triphasic function (0.001) was the lowest compared to those for the mono- and diphasic functions (0.0345 and 0.0315). For the first lactation, the monophasic function did not fit the data well because it had large residuals. The di- and triphasic functions were almost similar in fitting the lactation and had low residuals. For the second lactation, both the mono- and diphasic functions did not fit the data very well and had rather large residuals. The triphasic function was the most fitting and had small residuals. Derived functions were generally lower for the first lactation than the second lactation: initial milk yields (4.88 to 6.0 kg versus 9.9 to 11.8 kg); peak milk yields (5.8 to 9.6 kg versus 12.8 to 15.7 kg) and 305-day milk yields (1147.7 to 1328.6 kg versus 1687.4 to 2296.1 kg).

Matched MeSH terms: Lactation
Lactation failure in crossbred Sahiwal Friesian cattle

Murugaiyah M, Ramakrishnan P, Omar AR, Knight CH, Wilde CJ

J Dairy Res, 2001 May;68(2):165-74.
PMID: 11504381

Milk producers in Malaysia make extensive use of crossbred Sahiwal Friesian dairy cattle. These animals have, however, been found susceptible to lactation failure. A survey of cows in an experimental herd of F1 Sahiwal Friesian animals indicated that, in 30% of animals, milk yield decreased to negligible levels within the first 8 weeks post partum. Lactation failure was associated with a progressive increase in the amount of residual milk left in the udder after normal milking. By week 3 of lactation, residual milk volume was significantly greater than that in animals that, based on previous lactation history were not susceptible to lactation failure, and accounted for up to 30% of milk available at the morning milking. The cellular consequences of residual milk accumulation were evident in the activities of acetyl-CoA carboxylase, fatty acid synthetase and galactosyltransferase, key enzyme markers of cellular differentiation, which decreased in glands undergoing lactation failure and were lower than values measured in tissue of control cows. Mammary cell number, estimated by tissue DNA content, was also reduced in animals undergoing lactation failure. These indices of mammary development indicate that lactation failure is the result of premature involution in susceptible animals. Premature involution is a predictable consequence of progressive milk stasis in failing lactation, and attributable to an increase in autocrine feedback by inhibitory milk constituents. The progressive increase in residual milk is, on the other hand, unlikely to be attributable to impaired mammary development. Measurements of milk storage during milk accumulation showed no differences between control and lactation failure cows in the distribution of milk between alveolar and cisternal storage compartments. We conclude that lactation failure in Sahiwal Friesian cows is due to a failure of milk removal, and probably the result of an impaired milk ejection reflex rather than to the glands' milk storage characteristics.

Matched MeSH terms: Lactation/genetics*; Lactation Disorders/genetics; Lactation Disorders/veterinary*
The application of a computerised recording system to smallholder dairy extension in Malaysia

Abu Hassan MA, Kamaruddin MI, Pharo HJ

Acta Vet Scand Suppl, 1988;84:110-2.
PMID: 3232593
Matched MeSH terms: Lactation
Fulltext Serum prolactin levels during pregnancy, intrapartum and postpartum periods in Malay women

Rajikin MH, Abdullah R, Arshat H, Satgunasingam N

Med J Malaysia, 1982 Mar;37(1):72-5.
PMID: 6981751

Serum human prolactin (hPRL) levels in Malay women during pregnancy, intrapartum and immediately postpartum have been invest£gated by means of a double-antibody radioimmunoassay technique. There was a progressioe rise of serum prolactin concentration from 31.9 ± 10.4 ng/ml in the first trimester to 242.0 ± 24.6 ng/ml at 36 weeks pregnancy unth. the mean values during the second and third trimester of 118.9 ± 12.7 ng/ml and 214.7 ± 10.3 ng/ml respectively. During intrapartum the concentration of hPRL was 191.9 ± 26.9 ng/ml and ithat of immediately postpartum was 178.3 ± 14.5 ng/ml. Suckling of the breast within 6 hours postpartum has resulted in a minor elevation of prolactin level, and this could have been due to the greater basal prolactin level, and/or the ineffectiveness of suckling as a potent stimulus during this period.

Matched MeSH terms: Lactation

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