MyMedR

Fulltext Kennicutt-Schmidt Law in the Central Region of NGC 4321 as Seen by ALMA

Azeez JH, Hwang CY, Abidin ZZ, Ibrahim ZA

Sci Rep, 2016 06 01;6:26896.

We present the Atacama Large Millimeter/Sub-millimeter Array (ALMA) cycle-0 science verification data of the CO(1-0) line emission in the central region of NGC 4321 (also known as M100) at the distance of 17.1 Mpc and VLA, L-band data of HI of the same galaxy. We have drawn the center area of M100 in the (12)CO(J = 1-0) line with the resolution of (3.87″ × 2.53″) as viewed by ALMA, along with HI and Spitzer 8 and 3.6 μm data. The relationship between the surface density of molecular gas mass ∑H2 and that of star formation rate ∑SFR has been investigated, in addition to the relationship between the surface density of the neutral atomic hydrogen mass and that of ∑SFR (Kennicutt-Schmidt law) in this galaxy with a high spatial resolution. The results indicate that a significant correlation exists between the SFR surface density and the molecular gas mass density in the ~2 kpc region. The power-law index has been determined for three regions: center, upper and lower arms. The value of this index in the center region is 1.13, which follows the traditional (K-S) law and indicates that the molecular gas is affected by star formation.

Matched MeSH terms: Rhabdomyosarcoma, Alveolar

Fulltext Adult embryonal rhabdomyosarcoma of the ethmoid: a rare entity

Rohaizam J, Doris EJ, Tang PI, Lee SC, Uchang J

Med J Malaysia, 2010 Jun;65(2):160-1.

PMID: 23756807 MyJurnal

Embryonal rhabdomyosarcoma is an exceedingly rare tumor in adult. We report an embryonal rhabdomyosarcoma of the ethmoid in a 59-year-old Iban lady who presented with proptosis and complete ptosis of her left eye for two months. Imaging investigations showed left ethmoidal and left orbital soft tissue mass with extradura and dura involvement. The patient was planned for chemotherapy. Unfortunately, in such an advanced disease, she succumbed before treatment.

Matched MeSH terms: Rhabdomyosarcoma, Embryonal*

Alveolar rhabdomyosarcoma of the left hand with bilateral breast metastases in an adolescent female

Tan GC, Shiran MS, Hayati AR, Sharifah NA, Nuru AS, Rohaizak M

J Chin Med Assoc, 2008 Dec;71(12):639-42.

PMID: 19114329

Rhabdomyosarcoma is a common extramammary malignancy in pediatric age groups, but it rarely metastasizes to the breast. Breast rhabdomyosarcomas are commonly metastatic, with possible primary locations at the head and neck, trunk, extremities, retroperitoneum and perianal region. We report a case of primary alveolar rhabdomyosarcoma of the upper extremities in a 17-year-old adolescent female who presented with bilateral lower limb weakness and bilateral breast lumps.

Matched MeSH terms: Rhabdomyosarcoma, Alveolar/pathology*; Rhabdomyosarcoma, Alveolar/secondary*

Swelling on the Upper Lip: A Diagnostic Challenge

Tegginamani AS, Hs V, Wanjari SG, Dubey G

J Coll Physicians Surg Pak, 2019 Aug;29(8):796.

PMID: 31358112 DOI: 10.29271/jcpsp.2019.08.796

Matched MeSH terms: Rhabdomyosarcoma/diagnosis*

Fulltext Aural polyp with facial asymmetry in an unfortunate infant

Zubir FS, Saniasiaya J, Abdul Gani H

Malays Fam Physician, 2021 Mar 25;16(1):133-135.

PMID: 33948154 DOI: 10.51866/cr1070

Temporal bone rhabdomyosarcoma is an aggressive entity that simulates chronic otitis ear infection. It is the most common soft tissue sarcoma amongst pediatric patients. Herein, we would like to report a case of temporal bone rhabdomyosarcoma involving a 2-year-old boy who presented with a one-month history of otorrhea with facial asymmetry. Early treatment led to remission of this severe neoplasm.

Matched MeSH terms: Rhabdomyosarcoma; Rhabdomyosarcoma, Embryonal

Rare embryonal rhabdomyosarcoma of external acoustic canal: a case report and literature review

Eksan MS, Noorizan Y, Chew YK, Noorafidah MD, Asma A

Am J Otolaryngol, 2014 Nov-Dec;35(6):814-5.

PMID: 25128187 DOI: 10.1016/j.amjoto.2014.07.009

Embryonal rhabdomyosarcoma of external ear canal is very rare, even in the pediatric population. We report an embryonal rhabdomyosarcoma of external acoustic canal, occurring in a 12-year-old Chinese girl who presented with left ear canal mass. Wide local excision of the mass was done under local anesthesia. Histopathological examination revealed the diagnosis. She then underwent 20 cycles of radiotherapy. CECT scan post treatment showed clearance of tumor cell. Now, patient is disease free for 5 years. We believe that early diagnosis followed by complete resection of the tumor with clear margin and radiotherapy improves the prognosis of the disease.

Matched MeSH terms: Rhabdomyosarcoma, Embryonal/diagnosis*; Rhabdomyosarcoma, Embryonal/radiotherapy; Rhabdomyosarcoma, Embryonal/surgery

Fulltext A case of osteosarcoma of the maxilla - challenges in diagnosis and management

Abdul Rahim, N.I.H., Ngah, N.A., Ramanathan, A., George, T., Ismail, S.M.

Ann Dent, 2011;18(1):24-29.

MyJurnal

Osteosarcoma is a primary malignant neoplasm of the bone. Osteosarcoma of the jaws especially those of maxilla is rare. The diagnosis of osteosarcomas is difficult and challenging. In this case report we highlight a rare case of osteosarcoma of the maxilla in a 29 year old male patient which was highly aggressive and was initially diagnosed as rhabdomyosarcoma. This case highlights the difficulty in diagnosing osteosarcoma merely from incisional biopsy specimens which may not be representative of the whole tumour. Limited clinical information at incisional biopsy also adds to the difficulty in arriving at the definitive diagnosis. We further discuss the treatment modalities followed in this case.

Matched MeSH terms: Rhabdomyosarcoma

Fulltext Correction to: The effectiveness of a life style modification and peer support home blood pressure monitoring in control of hypertension: protocol for a cluster randomized controlled trial

Su TT, Majid HA, Nahar AM, Azizan NA, Hairi FM, Thangiah N, et al.

BMC Public Health, 2017 11 06;17(1):864.

PMID: 29110641 DOI: 10.1186/s12889-017-4862-y

After publication of the article [1], it has been brought to our attention that the methodology outlined in the original article was not able to be fully carried out. The article planned a two armed randomized control trial. However, due to a lower response than expected and one housing complex dropping out from the study, the method was changed to pre- and post-intervention with no control group. All other methods were conducted as outlined in the original article.

Matched MeSH terms: Rhabdomyosarcoma, Alveolar

Fulltext A successful pregnancy outcome in treated vulval rhabdomyosarcoma

Ariza M, Rafaee T, Adeeb N, Muhaizan WM, Isa MR

Med J Malaysia, 1999 Sep;54(3):371-3.

PMID: 11045067

A 14 year old girl presented in 1986 with a huge perineal swelling which was progressively increasing in size and associated with loss of weight and loss of appetite. Biopsy from the mass revealed rhabdomyosarcoma of the vulva. She was treated with chemotherapy and radium implant. She responded well to the regime. Fibrosis of the vulva and vagina caused difficulty in consummation. Once it was corrected, she conceived easily and proceeded to a normal pregnancy and delivery.

Matched MeSH terms: Rhabdomyosarcoma/drug therapy*; Rhabdomyosarcoma/radiotherapy*

Orbital rhabdomyosarcoma in an HIV positive child

Khairy-Shamel ST, Shatriah I, Adil H, Zunaina E, Bakiah S, Rohaizan Y, et al.

Orbit, 2008;27(5):388-90.

PMID: 18836940 DOI: 10.1080/01676830802336629

We reported a case of orbital rhabdomyosarcoma with an intracranial extension in an HIV-infected child. It was an uncommon sarcoma in a retroviral-positive patient that resulted in a diagnostic and therapeutic dilemma. The child is currently asymptomatic following surgery, chemotherapy, and reinstitution of highly active retroviral therapy (HAART).

Matched MeSH terms: Rhabdomyosarcoma, Embryonal/pathology*; Rhabdomyosarcoma, Embryonal/radiography; Rhabdomyosarcoma, Embryonal/surgery

Fulltext An unusual presentation of a rare rhabdomyosarcoma of urinary bladder and prostate - case report

Shanggar, K., Muhilan, P., Dublin, N., Lee, George E.G., Azad Hassan, A.R.

JUMMEC, 2007;10(2):57-59.

MyJurnal

Rhabdomyosarcoma of the genitourinary tract is rare and predominantly affects paediatric patients. We present an unusual case of such a lesion in an adult with extensive occupation of the bladder cavity by the lesion, resulting in bilateral ureteric obstruction, without evidence of ureteric outlet invasion. We outline the unusual CT and macroscopic appearance of this lesion. We also discuss the literature data and management strategies of rhabdomyosarcoma of the genitourinary tract.

Matched MeSH terms: Rhabdomyosarcoma

Rhabdomyosarcoma of the middle ear and mastoid in children

Said H, Phang KS, Razi A, Khuzaiyah R, Patawari PH, Esa R

J Laryngol Otol, 1988 Jul;102(7):614-9.

PMID: 3411216

Three cases of embryonal rhabdomyosarcoma in the middle ear and mastoid in children are presented. Diagnosis was confirmed by histopathology. A multidisciplinary approach employing surgery, chemotherapy and radiation therapy is the method of choice in the management of this rare and highly lethal condition.

Matched MeSH terms: Rhabdomyosarcoma/pathology*; Rhabdomyosarcoma/therapy

Clinicopathological features and survival of testicular tumours in a Southeast Asian university hospital: a ten-year review

Tan GH, Azrif M, Shamsul AS, Ho CC, Praveen S, Goh EH, et al.

Asian Pac J Cancer Prev, 2011;12(10):2727-30.

PMID: 22320982

INTRODUCTION: Testicular cancer mainly affects young men worldwide. There is lack of published data on patients with this malignant condition from the Southeast Asian region. The aim of this study was therefore to determine the clinicopathologic features of testicular cancer patients treated in a Southeast Asian university hospital and their overall survival rate.

MATERIALS AND METHODS: This was a retrospective study of testicular cancer patients treated between January 2001 and February 2011. Their epidemiological data, clinical presentation, pathologic diagnosis, stage of disease and treatment were gathered and the overall survival rate of this cohort was analyzed.

RESULTS: Thirty-one patients were included in this study. The majority of them were of Malay ethnicity. The average age at presentation was 33.7 years. The commonest testicular cancer was non-seminomatous germ cell tumour, followed by seminoma, lymphoma and rhabdomyosarcoma. More than half of all testicular germ cell tumour (GCT) patients had some form of metastasis at diagnosis. All the patients were treated with radical orchidectomy. Adjuvant chemotherapy was given to those with metastatic disease. Four seminoma patients received radiotherapy to the para-aortic lymph nodes. The 5-year survival rate for all testicular cancers in this cohort was 83.9%. The survival rate was 88.9% in 5 years when GCT were analyzed separately.

CONCLUSION: GCT affects patients in their third and fourth decades of life while lymphoma patients are generally older. Most of the patients treated for GCT are of Malay ethnicity. The majority have late presentation for treatment. The survival rate of GCT patients treated here is comparable to other published series in other parts of the world.

Matched MeSH terms: Rhabdomyosarcoma/mortality; Rhabdomyosarcoma/pathology; Rhabdomyosarcoma/surgery

Fulltext Embryonal rhabdomyosarcoma of the middle ear presenting with aural polyp and facial nerve palsy

Vasiwala R, Burud I, Lum SK, Saren RS

Med J Malaysia, 2015 Oct;70(5):314-5.

PMID: 26556123 MyJurnal

Rhabdomyosarcoma is a rare tumour in the middle ear and mastoid cavity in children and the diagnosis is difficult. Repeated histological examination may be essential to confirm the diagnosis. We report a 6 year old boy with a left aural polyp, otorrhoea and facial nerve palsy who was initially thought to have otitis media and mastoiditis. He had polypectomy and the tissue taken for histopathology suggested an inflammatory condition. Subsequently he had mastoidectomy. Tissue taken during mastoidectomy was however reported as rhabdomyosarcoma. The child developed a cerebral abscess and eventually succumbed. A literature review of the disease, radiological findings, immunohistochemical features and treatment options is described.

Matched MeSH terms: Rhabdomyosarcoma

Fulltext A rare case of solitary unifocal Langerhans cell histiocytosis with orbital extension: Diagnostic dilemma

Addenan M, May CM, Hooi TK, Ismail F, Kamalden TA

Oman J Ophthalmol, 2018 12 7;11(3):284-287.

PMID: 30505126 DOI: 10.4103/ojo.OJO_149_2017

Langerhans cell histiocytosis (LCH) is rarely encountered in ophthalmology practice. It is a spectrum of disorder characterized by accumulation of histiocytes in various tissues. Diagnosis is challenging as it may simulate periorbital hematoma, rhabdomyosarcoma, and neuroblastoma. We report a case of unifocal LCH with orbital extension. Diagnosis was obtained from incisional biopsy, and histopathological examination showed numerous histiocytes with eosinophilic infiltrations. The presence of Langerhans cells was confirmed by the presence of protein S-100, CD1a, and/or Langerin (CD207). Treatment depends on the degree of organ involvement. She responded well to cytotoxic drugs and steroids. This emphasized that prompt tissue diagnosis is crucial for early management.

Matched MeSH terms: Rhabdomyosarcoma

Fulltext Orbital rhabdomyosarcoma: a case series

Chen, C.Y., Nor Hidayah, A.B., Adil, H.

Malaysian Journal of Medicine and Health Sciences, 2013;9(2):69-72.

MyJurnal

In this paper, we report three cases of orbital rhabdomyosarcoma in different age groups with different histopathologic types. Case 1 is a 10-year old Malay boy who presented with painless proptosis of the left eye. Magnetic resonance imaging (MRI) showed soft tissue mass arising from the lateral rectus muscle. Tissue biopsy revealed rhabdomyosarcoma of embryonal type. Case 2 is a 32-year old Malay man who presented with a progressive left eye proptosis associated with pain and redness. Computed Tomography (CT) scan showed a retrobulbar mass extending medially in the left orbit. Meanwhile, biopsy showed rhabdomyosarcoma of pleomorphic type. Case 3 is a 67-year old Malay woman who presented with proptosis and fungating growth of left orbital region, epistaxis and nasal blockage. CT scan revealed an ill-defined mass filling up the left orbital cavity. Biopsy showed rhabdomyosarcoma of alveolar type. Rhabdomyosarcoma is the most common in childhood but it should be considered as a differential diagnosis of orbital tumours irrespective of age.

Matched MeSH terms: Rhabdomyosarcoma

Fulltext Can I give food or drink to my terminally ill child?

Taufiq Hidayat, Zahoor Iqbal, Ariffin Nasir, Norsarwany Mohamad, Fahisham Taib

Education in Medicine Journal, 2015;7(3):73-78.

MyJurnal

Food is considered as a social responsibility of caregivers to their children. It has cultural connotation for all races notwithstanding their background and religious belief; that social responsibility should not be separated even in terminally ill patients. We recorded a case scenario of a terminally ill child who faced difficult end of life with inability to take oral fluids or food due to mechanical obstruction of duodenum by the pelvic rhabdomyosarcoma. From cultural context, the physical act of giving food and fluids to a sick person is considered “a display of one’s affection”. It is understandable that, once the dying phase has reached, and the body starts to shut down, administering fluids may not be useful despite it is deemed necessary from cultural point of view. This case illustrates an ethical dilemma in managing a child with end stage metastatic disease with multiple systemic complications, compounded with futility of medical care and complex social circumstances. It is quite challenging for physicians and relatives to provide good end of life care to patients in palliative care setting. Ensuring good quality of care, quality of life and quality of death are paramount to avoid suffering and distress among the patients and family members.

Matched MeSH terms: Rhabdomyosarcoma

Li-Fraumeni syndrome in a Malaysian kindred

Ariffin H, Martel-Planche G, Daud SS, Ibrahim K, Hainaut P

Cancer Genet. Cytogenet., 2008 Oct;186(1):49-53.

PMID: 18786442 DOI: 10.1016/j.cancergencyto.2008.06.004

We report on a Malaysian kindred with Li-Fraumeni syndrome. The proband was an 8-year-old girl who presented with embryonal rhabdomyosarcoma of the trunk at the age of 8 months and developed a brain recurrence at the age of 7 years, which was 5 years after remission. A younger sister later developed adrenocortical carcinoma at the age of 6 months. Their mother and maternal grandmother were diagnosed with breast cancer at the ages of 26 and 38 years, respectively. TP53 mutation detection in this family revealed a duplication of a GGCGTG motif starting at nucleotide 17579 in exon 10, resulting in an in-frame insertion of two amino acids between residues 334 and 336 in the tetramerization domain of the p53 protein. This mutation was found in the proband and her affected sister as well as her mother. In addition, the mutation was detected in two other siblings (a brother aged 3 years and a sister aged 18 months) who have not yet developed any malignancy. Sequencing of TP53 in the father and two other asymptomatic siblings revealed wild-type TP53. To our knowledge, this is a first report of a Li-Fraumeni syndrome family in Southeast Asia.

Matched MeSH terms: Rhabdomyosarcoma, Embryonal/genetics

Scavenger receptor B2 is a cellular receptor for enterovirus 71

Yamayoshi S, Yamashita Y, Li J, Hanagata N, Minowa T, Takemura T, et al.

Nat Med, 2009 Jul;15(7):798-801.

PMID: 19543282 DOI: 10.1038/nm.1992

Enterovirus 71 (EV71) belongs to human enterovirus species A of the genus Enterovirus within the family Picornaviridae. EV71, together with coxsackievirus A16 (CVA16), are most frequently associated with hand, foot and mouth disease (HFMD). Although HFMD is considered a mild exanthematous infection, infections involving EV71, but not CVA16, can progress to severe neurological disease, including fatal encephalitis, aseptic meningitis and acute flaccid paralysis. In recent years, epidemic and sporadic outbreaks of neurovirulent EV71 infections have been reported in Taiwan, Malaysia, Singapore, Japan and China. Here, we show that human scavenger receptor class B, member 2 (SCARB2, also known as lysosomal integral membrane protein II or CD36b like-2) is a receptor for EV71. EV71 binds soluble SCARB2 or cells expressing SCARB2, and the binding is inhibited by an antibody to SCARB2. Expression of human SCARB2 enables normally unsusceptible cell lines to support EV71 propagation and develop cytopathic effects. EV71 infection is hampered by the antibody to SCARB2 and soluble SCARB2. SCARB2 also supports the infection of the milder pathogen CVA16. The identification of SCARB2 as an EV71 and CVA16 receptor contributes to a better understanding of the pathogenicity of these viruses.

Matched MeSH terms: Rhabdomyosarcoma/virology

Fulltext A case report of unusual para-meningeal rhabdomyosarcoma

Jamilu Abdullahi Faruk, Fahisham Taib

Malaysian Journal of Paediatrics and Child Health, 2019;23(2):60-63.

MyJurnal

A Case Report Of Unusual Para-Meningeal RhabdomyosarcomaMalaysian Journal of Paediatrics and Child Health, Vol. 23 (2), December 2017: 60-63© 2017 MJPCH. All Rights Reserved.60CASE REPORTA CASE REPORT OF UNUSUAL PARA-MENINGEAL RHABDOMYOSARCOMAJamilu Abdullahi Faruk1, Fahisham Taib21.Department of Paediatrics, Ahmadu Bello University Teaching Hospital, PMB -06, Shika-Zaria, Kaduna State,Nigeria.2.Paediatric Department, Hospital Universiti Sains Malaysia, Kubang Kerian Kelantan, Malaysia.AbstractRhabdomyosarcomas arise from mesenchymal cells destined to form skeletal muscle, but they are often found at sites where skeletal muscle is typically not found. The parameningeal site has a poor prognostic risk, if it is associated with intra-cranial extensions and skull bone erosions.This is a case report of a five-year-old girl who presented with cranial nerve palsy, and later diagnosed as rhabdomyosarcoma of the mastoid and middle ear, with infiltration of the cerebellopontine angle of the brain. She did not respond to chemotherapyand rapidly deteriorated, succumbed to the disease within a short time following the diagnosis.

Matched MeSH terms: Rhabdomyosarcoma

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