MyMedR

Fulltext 'A recurrent cutaneous eruption'

Devaraj NK

BMJ Case Rep, 2019 Feb 01;12(2).

PMID: 30709894 DOI: 10.1136/bcr-2018-228355

Matched MeSH terms: Exanthema/diagnosis*

Fulltext Atypical presentation of adult rubella

Jayaprakash B, Sudha V, Shashikiran U

Med J Malaysia, 2006 Jun;61(2):242-4.

PMID: 16898322 MyJurnal

A 55 year old female presented with fever, skin rash and subconjunctival hemorrhage. She also developed hepatitis. Fever and skin rash lasted for more than three weeks. This patient was diagnosed to have rubella, highlighting the fact that rubella can present with atypical features like prolonged fever and rash, subconjunctival hemorrhage and hepatitis, especially in adults.

Matched MeSH terms: Exanthema/diagnosis

Fulltext Dermatological features of an imported case of chikungunya in an infant

Lee CY, Ng LC, Koh TH

Singapore Med J, 2008 Nov;49(11):959-60.

PMID: 19037568

Matched MeSH terms: Exanthema/diagnosis

Plasma alpha-1-acid glycoprotein as a potential predictive biomarker for non-haematological adverse events of docetaxel in breast cancer patients

Jabir RS, Ho GF, Annuar MABA, Stanslas J

Biomarkers, 2018 Mar;23(2):142-146.

PMID: 28554261 DOI: 10.1080/1354750X.2017.1334152

CONTEXT: Rash and oral mucositis are major non-haematological adverse events (AEs) of docetaxel, in addition to fatigue, nausea, vomiting and diarrhoea, which restrict the use of the drug in cancer therapy. Alpha-1-acid glycoprotein (AAG) is an acute phase reactant glycoprotein and is a primary carrier of docetaxel in the blood. Docetaxel has extensive binding (>98%) to plasma proteins such as AAG, lipoproteins and albumin.

OBJECTIVE: To study the association between plasma AAG level and non-haematological AEs of docetaxel in Malaysian breast cancer patients of three major ethnic groups (Malays, Chinese and Indians).

MATERIALS AND METHODS: One hundred and twenty Malaysian breast cancer patients receiving docetaxel as single agent chemotherapy were investigated for AAG plasma level using enzyme-linked immunosorbent assay technique. Toxicity assessment was determined using Common Terminology Criteria of Adverse Events v4.0. The association between AAG and toxicity were then established.

RESULTS: There was interethnic variation of plasma AAG level; it was 182 ± 85 mg/dl in Chinese, 237 ± 94 mg/dl in Malays and 240 ± 83 mg/dl in Indians. It was found that low plasma levels of AAG were significantly associated with oral mucositis and rash.

CONCLUSIONS: This study proposes plasma AAG as a potential predictive biomarker of docetaxel non-haematological AEs namely oral mucositis and rash.

Matched MeSH terms: Exanthema/diagnosis

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