Displaying publications 1 - 20 of 72 in total

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  1. Antena tompok mikrojalur bertindan untuk aplikasi gandaan tinggi
    Norbahiah Misran, Farizah Ansarudin, Mohammad Tariqul Islam
    Sains Malaysiana, 2010;39.
    Teknik reka bentuk untuk meningkatkan gandaan bagi menambah baik prestasi antena tompok mikrojalur konvensional dibincangkan. Kaedah suapan prob tersongsang jalur lebar bagi antena tompok mikrojalur berbilang lubang alur bertindan dicadangkan. Reka bentuk tersebut menggabungkan beberapa teknik kontemporari iaitu kaedah suapan prob, struktur tompok tersongsang dan tompok berbilang lubang alur bertindan. Kesan komposit daripada penyatuan pelbagai teknik ini dan dengan memperkenalkan bentuk elemen tompok yang baru, memberikan profil yang rendah, jalur lebar yang lebih luas, gandaan tinggi dan elemen antena yang padat. Keputusan menunjukkan peningkatan gandaan di mana gandaan maksimum adalah 11.42 dBi. Reka bentuk ini sesuai untuk aplikasi tata susunan terutama untuk stesen tapak.
    Matched MeSH terms: Drugs, Chinese Herbal
  2. Fulltext Licorice: A Potential Herb in Overcoming SARS-CoV-2 Infections
    Ng SL, Khaw KY, Ong YS, Goh HP, Kifli N, Teh SP, et al.
    J Evid Based Integr Med, 2021;26:2515690X21996662.
    PMID: 33787349 DOI: 10.1177/2515690X21996662
    The management of the global pandemic outbreak due to the coronavirus disease (COVID-19) has been challenging with no exact dedicated treatment nor established vaccines at the beginning of the pandemic. Nonetheless, the situation seems to be better controlled with the recent COVID-19 vaccines roll-out globally as active immunisation to prevent COVID-19. The extensive usage and trials done in recent outbreak in China has shown the effectiveness of traditional Chinese Medicines (TCM) in improving the wellbeing of COVID-19 patients. Therefore, COVID-19 Prevention and Treatment guidelines has listed a number of recommended concoctions meant for COVID-19 patients. Licorice, more commonly known as Gancao in Chinese Pinyin, is known as one of the most frequently used ingredients in TCM prescriptions for treatment of epidemic diseases. Interestingly, it is deemed as food ingredient as well, where it is normally used in Western cuisines' desserts and sweets. The surprising fact that licorice appeared in the top 10 main ingredients used in TCM prescriptions in COVID-19 has drawn great attention from researchers in revealing its biological potential in overcoming this disease. To date, there are no comprehensive review on licorice and its benefits when used in COVID-19. Thus, in this current review, the possible benefits, mechanism of actions, safety and limitations of licorice were explored in hope to provide a quick reference guide for its preclinical and clinical experimental set-up in this very critical moment of pandemic.
    Matched MeSH terms: Drugs, Chinese Herbal/pharmacology; Drugs, Chinese Herbal/therapeutic use*
  3. Fulltext A qualitative study: the perception on antismoking campaign among smokers in Kuantan
    Muhammad Lokman, M.I., Normalina, A., Afzan, M.Y., Mohamad Helmy, J.
    Medicine & Health, 2020;15(1):129-140.
    MyJurnal
    Tabiat merokok adalah perilaku yang tidak sihat malah membahayakan bukan sahaja diri sendiri malahan masyarakat sekeliling. Walaupun terdapat banyak kempen anti-merokok telah diperkenalkan oleh kerajaan, namun keberkesanannya masih di tahap rendah. Oleh itu objektif kajian ini adalah untuk meneroka faktor utama kegagalan kempen anti-merokok di Malaysia, meneroka keberkesanan “Klinik Berhenti Merokok” dan menemui penyelesaian terbaik untuk memastikan kempen yang dijalankan berkesan pada masa akan datang. Ini adalah kajian rentas kualitatif di mana temuduga dijalankan di kalangan lima sukarela responden yang terdiri dari perokok dan bekas perokok di kawasan awam dan tiga klinik berhenti merokok yang terpilih. Data dianalisis dengan menggunakan analisis bertema. Kajian ini mendapati beberapa faktor penyumbang dari perspektif perokok dan pihak berkuasa perlu diberi keutamaan untuk penambahbaikan iaitu kurang kreativiti yang minimum dalam menguruskan promosi anti-merokok, kurang kreatitivi dah terhadap kesihatan, permintaan bahan pencetus semangat di tempat kerja, dan dalam pengurusan tekanan yang lemah. Hasil kajian mengesyorkan bahawa kempen bermula di sekolah rendah dan menengah, improvisasi tanda amaran penyakit, meluaskan kawasan promosi, memberi ganjaran semasa kempen dan perokok perlu mengambil inisiatif melibatkan diri dalam program ini. Kerajaan perlu menumpukan perhatian kepada program pencegahan merokok terlebih dahulu, daripada program intervensi berhenti merokok yang mungkin melibatkan kos kewangan yang tinggi.
    Matched MeSH terms: Drugs, Chinese Herbal
  4. Fulltext Typhonium divaricatum (rodent tuber): a promising local plant in the fight against cancer
    Neoh CK
    Med J Malaysia, 1992 Mar;47(1):86-8.
    PMID: 1387458
    Matched MeSH terms: Drugs, Chinese Herbal/pharmacology*
  5. New Determination Method of Two Bioactive Saponins in Lysimachia capillipes Hemsl. by Quantitative Analysis of Multi-Components by Single-Marker
    Zhang X, Chen X, Jin J, Gong M, He Q, Li S, et al.
    J Chromatogr Sci, 2021 Oct 29;59(10):941-948.
    PMID: 33728454 DOI: 10.1093/chromsci/bmab028
    Capilliposide B (CPS-B) and Capilliposide C (CPS-C), as the key components in Lysimachia capillipes Hemsl., increasingly aroused the interest and research concern of many researchers due to the good bioactivities. Nowadays, the reference standards of CPS-B and CPS-C yield were very limited. Due to the deficit of reference standards, the determination could be difficult to carry out, and the quality control and evaluation would be restrained afterwards. To solve this urgent problem, a quantitative analysis of multi-components by single-marker (QAMS) method was proposed and established based on high-performance liquid-chromatography tandem evaporative light-scattering detector. In this QAMS method, the content of the two bioactive components could be calculated by buddlejasaponin IV, which is applied as an external standard and readily obtained. And the methodological experiments were evaluated and indicated accuracy, stability and feasibility of this QAMS method. Therefore, in this study, this built method would properly meet the requirement of determination of CPS-B, CPS-C and quality control of the L. capillipes Hemsl. plant.
    Matched MeSH terms: Drugs, Chinese Herbal*
  6. [Molecular mechanisms of insulin resistance and interventional effects of Chinese herbal medicine]
    Yee HY, Yang JJ, Wan YG, Chong FL, Wu W, Long Y, et al.
    Zhongguo Zhong Yao Za Zhi, 2019 Apr;44(7):1289-1294.
    PMID: 31090283 DOI: 10.19540/j.cnki.cjcmm.20181105.003
    It is considered that insulin resistance(IR)and its signaling pathway disorder are one of pathogenesis that causes insulin target-organs/issues lesions and their slow progression. The clinical diagnosis index of IR is the homeostatic model of insulin resistance(HOMA-IR)based on fasting blood-glucose and fasting serum insulin. Furthermore, the emerging IR biomarkers including adiponectin may be the references for clinical diagnosis. The influence factors of IR are obesity, chronic microinflammation and a lack of exercise. The major signaling pathways of IR include insulin receptor substrate 1(IRS1)/phosphatidylinositiol-3-kinase(PI3 K)/serine-threonine kinase(Akt)pathway, mitogen-activated protein kinase(MAPK)pathway and Smad3 pathway. In clinics, insulin sensibility and IR could be increased and improved via promoting insulin secretion and enhancing insulin signaling activation. At present, insulin sensitizers treating IR not only have the classic thiazolidinediones and its ramifications but also have the newly discovered metformin and vitamin D. In addition, it is reported that some extracts from single Chinese herbal medicine(CHM)and Chinese herbal compound prescription such as total flavone from the flowers of Abelmoschl manihot, berberine, astragalus polysaccharides and Huang-qi decoction also have the beneficial effects in ameliorating IR. In the field of chronic kidney disease, targeting a common insulin target-organs/issues lesion, the early renal damage in diabetic mellitus, the intervention studies regarding to regulating podocyte IR signaling pathways by CHM will be one of the significant directions in the future.
    Matched MeSH terms: Drugs, Chinese Herbal/therapeutic use*
  7. Fulltext Virtual screening of functional foods and dissecting their roles in modulating gene functions to support post COVID-19 complications
    Afroz S, Fairuz S, Joty JA, Uddin MN, Rahman MA
    J Food Biochem, 2021 12;45(12):e13961.
    PMID: 34676581 DOI: 10.1111/jfbc.13961
    COVID-19 has become the focal point since 2019 after the outbreak of coronavirus disease. Many drugs are being tested and used to treat coronavirus infections; different kinds of vaccines are also introduced as preventive measure. Alternative therapeutics are as well incorporated into the health guidelines of some countries. This research aimed to look into the underlying mechanisms of functional foods and how they may improve the long-term post COVID-19 cardiovascular, diabetic, and respiratory complications through their bioactive compounds. The potentiality of nine functional foods for post COVID-19 complications was investigated through computational approaches. A total of 266 bioactive compounds of these foods were searched via extensive literature reviewing. Three highly associated targets namely troponin I interacting kinase (TNNI3K), dipeptidyl peptidase 4 (DPP-4), and transforming growth factor beta 1 (TGF-β1) were selected for cardiovascular, diabetes, and respiratory disorders, respectively, after COVID-19 infections. Best docked compounds were further analyzed by network pharmacological tools to explore their interactions with complication-related genes (MAPK1 and HSP90AA1 for cardiovascular, PPARG and TNF-alpha for diabetes, and AKT-1 for respiratory disorders). Seventy-one suggested compounds out of one-hundred and thirty-nine (139) docked compounds in network pharmacology recommended 169 Gene Ontology (GO) items and 99 Kyoto Encyclopedia of Genes and Genomes signaling pathways preferably AKT signaling pathway, MAPK signaling pathway, ACE2 receptor signaling pathway, insulin signaling pathway, and PPAR signaling pathway. Among the chosen functional foods, black cumin, fenugreek, garlic, ginger, turmeric, bitter melon, and Indian pennywort were found to modulate the actions. Results demonstrate that aforesaid functional foods have attenuating roles to manage post COVID-19 complications. PRACTICAL APPLICATIONS: Functional foods have been approaching a greater interest due to their medicinal uses other than gastronomic pleasure. Nine functional food resources have been used in this research for their traditional and ethnopharmacological uses, but their directive-role in modulating the genes involved in the management of post COVID-19 complications is inadequately studied and reported. Therefore, the foods types used in this research may be prioritized to be used as functional foods for ameliorating the major post COVID-19 complications through appropriate science.
    Matched MeSH terms: Drugs, Chinese Herbal*
  8. Steroids masquerading as natural herbs: a case for regulatory control
    Reti S
    N Z Med J, 2002 Aug 9;115(1159):U125.
    PMID: 12362169
    Matched MeSH terms: Drugs, Chinese Herbal*
  9. Fulltext Keberkesanan program interventif remaja dikalangan remaja berisiko di tiga buah penempatan pembangunan tanah di Semenanjung Malaysia
    Hidayah, N.I., Hanafiah, M.S., Idris, M.N., Rosnah, S., Haslina, M., Azlin, I., et al.
    Malaysian Journal of Public Health Medicine, 2005;5(1):10-15.
    MyJurnal
    Kajian kuasbeksperimental telah di lakukan di tiga buah penempatan pembangunan tanah di negeri Johor, Pahang dan Perak, Semenanjung Malaysia daripada Januari 2003 sehingga Disember 2003 untuk menilai keberkesanan satu program intervensi yang komprehensif dalam mengurangkan tingkahlaku berisiko dikalangan remaja. Tiga buah sekolah yang diberi intervensi (disebut sebagai sekolah kes) dan tiga buah lagi sekolah tidak diberi sebarang intervensi (sekolah kawalan) telah dipilih untuk ketiga»tiga kawasan penempatan pembangunan tanah tersebut. Data pra»intervensi dan pos-intervensi telah diambil daripada setiap remaja tingkatan satu yang menjadi sampel kajian. Walaupun terdapat peningkatan signifikan dalam peratusan remaja yang bertingkahlaku berisiko pos-intervensi, namun peningkatan tersebut adalah lebih tinggi (32 .2%) di sekolah kawalan berbanding
    Y sekolah kes (29.2%). Penurunan yang signifikan dikalangan mereka yang telah dikenalpasti sebagai bertingkahlaku berisiko semasa pra»intervensi berlaku cli sekolah kes (25.8%) dan juga kawalan (32.6%). Kajian ini telah menunjukkan kepentingan program interventif remaja yang bukan sahaja boleh mengurangkan bilangan remaja yang bertingkahlaku berisiko malah mencegah
    sebahagian besar remaja daripada bertingkahlaku berisiko.
    Matched MeSH terms: Drugs, Chinese Herbal
  10. Rapid authentication and identification of different types of A. roxburghii by Tri-step FT-IR spectroscopy
    Chen Y, Huang J, Yeap ZQ, Zhang X, Wu S, Ng CH, et al.
    Spectrochim Acta A Mol Biomol Spectrosc, 2018 Jun 15;199:271-282.
    PMID: 29626818 DOI: 10.1016/j.saa.2018.03.061
    Anoectochilus roxburghii (Wall.) Lindl. (Orchidaceae) is a precious traditional Chinese medicinal herb and has been perennially used to treat various illness. However, there were unethical sellers who adulterated wild A. roxburghii with tissue cultured and cultivated ones. Therefore, there is an urgent need for an effective authentication method to differentiate between these different types of A. roxburghii. In this research, the infrared spectroscopic tri-step identification approach including Fourier transform infrared spectroscopy (FT-IR), Second derivative infrared spectra (SD-IR) and two-dimensional correlation infrared spectra (2D-IR) was used to develop a simple and rapid method to discriminate between wild, cultivated and tissue cultivated A. roxburghii plant. Through this study, all three types of A. roxburghii plant were successfully identified and discriminated through the infrared spectroscopic tri-step identification method. Besides that, all the samples of wild, cultivated and tissue cultivated A. roxburghii plant were analysed with the Soft Independent Modelling of Class Analogy (SIMCA) pattern recognition technique to test and verify the experimental results. The results showed that the three types of A. roxburghii can be discriminated clearly as the recognition rate was 100% for all three types and the rejection rate was more than 60%. 70% of the validated samples were also identified correctly by the SIMCA model. The SIMCA model was also validated by comparing 70 standard herbs to the model. As a result, it was demonstrated that the macroscopic IR fingerprint method and the classification analysis could discriminate not only between the A. roxburghi samples and the standard herbs, it could also distinguish between the three different types of A. roxburghi plant in a direct, rapid and holistic manner.
    Matched MeSH terms: Drugs, Chinese Herbal/classification*; Drugs, Chinese Herbal/isolation & purification; Drugs, Chinese Herbal/chemistry*
  11. Perbandingan anggaran parameter terhadap Model Kecemerlangan Prestasi Institut Pengajian Tinggi (IPT) bersandarkan nilai teras: Pendekatan penganggaran kebolehjadian maksimum (ML) dan kuasa dua terkecil separa (PLS)
    Mohd Rashid Ab Hamid, Zainol Mustafa, Nur Riza Mohd Suradi, Fazli Idris, Mokhtar Abdullah
    Sains Malaysiana, 2013;42:1159-1166.
    Pemodelan persamaan struktur (SEM) merupakan analisis statistik multivariat yang mengkaji hubungan antara konstruk mengikut teori atau kajian terdahulu melalui model hipotesis yang dibina. Kebiasaannya, kaedah penganggaran yang digunakan dalam analisis pemodelan ini adalah penganggaran kebolehjadian maksimum (ML). Kaedah penganggaran tersebut memerlukan taburan data yang bersifat kenormalan multivariat di samping memenuhi bilangan sampel yang tertentu. Oleh itu, penganggaran kuasa dua terkecil separa (PLS) amat berperanan dalam mengatasi dua kekangan berkenaan dan isu multikolineariti. Oleh itu, makalah ini bertujuan untuk melakukan analisis perbandingan keputusan pemodelan terhadap anggaran parameter dalam Model Kecemerlangan Prestasi Institusi Pengajian Tinggi (IPT) bersandarkan nilai teras bagi mendapatkan model akhir yang mematuhi kedua-dua teknik penganggaran ML dan PLS berkenaan. Model akhir merupakan model kecemerlangan yang disemak semula berdasarkan tahap kesignifikanan secara statistik dan penting secara praktikal bagi semua pekali lintasan dalam model. Kesimpulannya, kedua-dua teknik penganggaran yang digunakan saling melengkapi antara satu sama lain dan memberikan nilai tambah kepada model hipotesis yang diuji.
    Matched MeSH terms: Drugs, Chinese Herbal
  12. Effect of Traditional Chinese Medicine on Musculoskeletal Symptoms in Breast Cancer: A Systematic Review and Meta-Analysis
    Poo CL, Dewadas HD, Ng FL, Foo CN, Lim YM
    J Pain Symptom Manage, 2021 07;62(1):159-173.
    PMID: 33278502 DOI: 10.1016/j.jpainsymman.2020.11.024
    CONTEXT: Traditional Chinese Medicine (TCM) has been widely used as a complementary medical treatment for arthralgia and other types of pain. The available literature on the effectiveness of TCM on breast cancer patients with musculoskeletal symptoms reports controversial results.

    OBJECTIVES: The objective of this review is to assess the effectiveness of TCM as a treatment option for musculoskeletal symptoms in patients with breast cancer who were treated with aromatase inhibitors (AIs).

    METHODS: A comprehensive literature search was conducted using PubMed, the Cochrane Library, SAGE journals, Scopus, EMBASE, Web of Science, Medline, Cumulated Index to Nursing and Allied Health Literature (CINAHL), Chinese Biomedical Literature Database (CBM), Chinese National Knowledge Infrastructure (CNKI), Chinese Scientific Journal Database (VIP), Wanfang, and Chinese Medical Journal Database (CMJ) from May 2020 to November 2020. The literature review included randomized controlled trials (RCTs) of TCM for AI-related musculoskeletal symptoms.

    RESULTS: Four RCTs incorporating TCM were assessed by meta-analysis and reported favorable effects in reducing worst pain score (n = 284, mean difference [MD]: 2.31; 95% CI, 1.74 to 2.88; P 

    Matched MeSH terms: Drugs, Chinese Herbal*
  13. Risk assessment of plant food supplements and other herbal products containing aristolochic acids using the margin of exposure (MOE) approach
    Abdullah R, Diaz LN, Wesseling S, Rietjens IM
    Food Addit Contam Part A Chem Anal Control Expo Risk Assess, 2017 Feb;34(2):135-144.
    PMID: 27892830 DOI: 10.1080/19440049.2016.1266098
    After the incidences of induction of aristolochic acid nephropathy after consumption of herbal weight loss preparations that accidentally contained aristolochic acids (AAs), several countries defined national restrictions on the presence of AAs in food, including plant food supplements (PFS) and herbal products. This study investigates whether the risks associated with exposure to AAs via PFS and herbal products are at present indeed negligible. Data reported in literature on AA levels in PFS and other herbal products and also obtained from a new series of PFS in the present study were used to calculate the estimated daily intakes (EDIs) and corresponding margins of exposure (MOEs). Available literature data revealed that 206 out of 573 samples were found to contain aristolochic acid I (AAI) and/or aristolochic acid II (AAII). The results obtained from recently collected PFS revealed that both AAI and AAII were detected in three out of 18 analysed PFS at levels up to 594.8 and 235.3 µg g(-1), respectively, being in line with the levels reported in literature. The EDIs resulting from intake of these PFS resulted in MOEs that were generally below 10,000, corroborating the priority for risk management. Although these results refer to PFS collected by targeted sampling strategies, the data reveal that AA-containing PFS are still freely available. When considering that the use of these samples may be limited to shorter periods of time, the EDIs might be lower, but MOE values would still be lower than 10,000 for more than 50% of the AA-containing PFS and herbal products. In conclusion, the presence of AAs in PFS and herbal products even several years after instalment of the legal restrictions still raises concern, especially for people who frequently use the respective PFS and herbal products.
    Matched MeSH terms: Drugs, Chinese Herbal/analysis*
  14. Fulltext Spinal cord injury - assessing tolerability and use of combined rehabilitation and NeuroAiD (SATURN) study - primary results of an exploratory study
    Kumar R, Htwe O, Baharudin A, Rhani SA, Ibrahim K, Nanra JS, et al.
    J Spinal Cord Med, 2023 Jul;46(4):682-686.
    PMID: 35604343 DOI: 10.1080/10790268.2022.2067972
    OBJECTIVE: MLC601/MLC901 has demonstrated neuroprotective and neuroregenerative properties that enhance neurological recovery in stroke and traumatic brain injury. We aimed to evaluate its safety and potential efficacy in patients with severe spinal cord injury.

    METHODS: Patients with American Spinal Injury Association (ASIA) Impairment Scale (AIS) A and B were included in an open-label cohort study. Each received a course of MLC601/MLC901 for 6 months in addition to standard care and rehabilitation. Key endpoints were safety, AIS grade and motor scores at month 6 (M6).

    RESULTS: Among 30 patients included (mean age 42.2 ± 17.6 years, 24 men), 20 patients had AIS A while 10 patients had AIS B at baseline. Ten patients experienced 14 adverse events including one serious adverse event and six deaths, none were considered treatment-related. AIS improved in 25% of AIS A and 50% of AIS B. Improvement in ASIA motor score was seen most with cervical injury (median change from baseline 26.5, IQR: 6-55). These findings appear to be better than reported rates of spontaneous recovery for SCI AIS A and B.

    CONCLUSION: MLC601/MLC901 is safe and may have a role in the treatment of patients with SCI. A controlled trial is justified.

    Matched MeSH terms: Drugs, Chinese Herbal*
  15. Fulltext Correlation of iatrogenic mild hyperkalaemia and bradyarrhythmia: a problem of polypharmacy in elderly
    Ahmad, N. H., Tan, T. L.
    Medicine & Health, 2017;12(2):329-334.
    MyJurnal
    Mild hyperkalaemia does not typically cause cardiac symptoms. However, for an elderly patient on atrio-ventricular (AV) nodal blocker, even mild hyperkalaemia may result in disastrous outcome. We report a case of persistent bradyarrythmia caused by iatrogenic hyperkalaemia in a patient who had concomitant use of AV nodal medication. An 81-year-old lady with multiple comorbidities and a long list of medications presented with symptomatic bradyarrhythmia. She, in fact, had two AV nodal blockers in her prescription, a beta-blocker and amiodarone. Her potassium level was found to be mildly elevated due to acute renal failure. She remained bradycardic despite initial treatment and was subsequently dependant on intravenous isoproterenol until her renal function improved. This case highlights the different threshold for manifestation of hyperkalaemic symptoms in a growing group of patients: elderly patients with multiple comorbidities and polypharmacy.
    Keywords: bradyarrythmia, bradycardia, elderly, hyperkalaemia, polypharmacy
    Matched MeSH terms: Drugs, Chinese Herbal
  16. Chronic hepatitis B and herbal therapy
    Shahidah KN, Merican I
    Med J Malaysia, 2005 Jul;60 Suppl B:35-8.
    PMID: 16108171
    Matched MeSH terms: Drugs, Chinese Herbal/pharmacology; Drugs, Chinese Herbal/therapeutic use*
  17. Phytotherapeutic potential of natural herbal medicines for the treatment of mild-to-severe atopic dermatitis: A review of human clinical studies
    Hussain Z, Thu HE, Shuid AN, Kesharwani P, Khan S, Hussain F
    Biomed Pharmacother, 2017 Sep;93:596-608.
    PMID: 28686974 DOI: 10.1016/j.biopha.2017.06.087
    For many decades, natural herbal medicines, polyherbal formulations and/or decoctions of plant-derived materials have widely been accepted as alternative complementary therapies for the treatment, cure or prevention of a wide range of acute and chronic skin diseases including chronic herpes, prurigo, acute and chronic wounds, psoriasis and atopic dermatitis (AD). This review was aimed to summarize and critically discuss about the therapeutic viability and clinical applicability of natural herbal medicines for the treatment of AD in human. The critical analysis of the literature revealed that oral (in the form of capsules, syrup or granules) and/or topical application (alone or in conjunction with wet-wrap dressing and/or acupuncture) of natural herbal medicines exhibit remarkable potential for the treatment of mild-to-severe AD in adults, children, infants and in the pregnant women. In this review, the clinical efficacy of various herbal formulations such as Chinese herbal therapies, Korean medicines, Iranian medicines, honey, natural herbal oils (coconut oil, olive oil and mineral oil), beeswax, dodder seeds and whey for the treatment of AD has been discussed. The clinical anti-AD efficacy of these complementary therapies has been observed in terms of down-regulation in Scoring Atopic Dermatitis (SCORAD) index, erythematic intensity, Children's Dermatology Life Quality Index (CDLQI), Dermatology Life Quality Index (DLQI), pruritus and itching frequency, transepidermal water loss (TEWL) and expression of AD-mediated chemokines. Conclusively, we recognized that natural herbal medicines demonstrate remarkable clinical efficacy when used alone or in conjunction with other complementary therapies for the treatment of AD in patients of all ages as well as pregnant women.
    Matched MeSH terms: Drugs, Chinese Herbal/pharmacology*; Drugs, Chinese Herbal/therapeutic use*
  18. Beneficial effects of traditional Chinese medicine on the treatment of osteoporosis on ovariectomised rat models
    Rufus P, Mohamed N, Shuid AN
    Curr Drug Targets, 2013 Dec;14(14):1689-93.
    PMID: 24354584
    Osteoporosis is a metabolic bone disorder that affects both men and women worldwide. It causes low bone mass and therefore increases bone susceptibility to fracture when bone undergoes a minor trauma. Lack of estrogen is the principal cause of osteoporosis. Estrogen, calcium, calcitonin, vitamin D and several antioxidants help in the prevention of osteoporosis. In order to effectively treat osteoporosis, there has been an extended research on the biological activities of traditional medicines since synthetic medicines possess several side effects that reduce their efficacy. Therefore, there is a need to develop new treatment alternatives for osteoporosis. This review centres on the scientific researches carried out on the evaluation of Chinese traditional medicines in the treatment of osteoporosis. Various plants like Achyranthes bidentata, Davallia formosana, polygonatum sibiricum, Cibotium barometz, Er-Zhi-Wan, Curculigo orchioides and a combined treatment of Hachimi-jio-gan (Ba-Wei-Di-Huang-Wan) with alendronate proved active in preventing post-menopausal osteoporosis.
    Matched MeSH terms: Drugs, Chinese Herbal/administration & dosage; Drugs, Chinese Herbal/therapeutic use*
  19. Toona sinensis Roem tender leaf extract inhibits SARS coronavirus replication
    Chen CJ, Michaelis M, Hsu HK, Tsai CC, Yang KD, Wu YC, et al.
    J Ethnopharmacol, 2008 Oct 30;120(1):108-11.
    PMID: 18762235 DOI: 10.1016/j.jep.2008.07.048
    Severe acute respiratory syndrome (SARS) is a life-threatening disease caused by the SARS coronavirus (SARS-CoV). The development of new antiviral agents for SARS-CoV is an important issue. We tried to find potential resource from Traditional Chinese medicine (TCM) for development of new drugs against SARS-CoV.
    Matched MeSH terms: Drugs, Chinese Herbal/pharmacology; Drugs, Chinese Herbal/chemistry
  20. alpha-Amylase inhibitory activity of some Malaysian plants used to treat diabetes; with particular reference to Phyllanthus amarus
    Ali H, Houghton PJ, Soumyanath A
    J Ethnopharmacol, 2006 Oct 11;107(3):449-55.
    PMID: 16678367
    Extracts of six selected Malaysian plants with a reputation of usefulness in treating diabetes were examined for alpha-amylase inhibition using an in vitro model. Inhibitory activity studied by two different protocols (with and without pre-incubation) showed that Phyllanthus amarus hexane extract had alpha-amylase inhibitory properties. Hexane and dichloromethane extracts of Anacardium occidentale, Lagerstroemia speciosa, Averrhoa bilimbiPithecellobium jiringa and Parkia speciosa were not active when tested without pre-incubation. Extraction and fractionation of Phyllanthus amarus hexane extract led to the isolation of dotriacontanyl docosanoate, triacontanol and a mixture of oleanolic acid and ursolic acid. Dotriacontanyl docosanoate and the mixture of oleanolic acid and ursolic acid are reported from this plant species for the first time. All compounds were tested in the alpha-amylase inhibition assay and the results revealed that the oleanolic acid and ursolic acid (2:1) mixture was a potent alpha-amylase inhibitor with IC(50)=2.01 microg/ml (4.41 microM) and that it contributes significantly to the alpha-amylase inhibition activity of the extract. Three pure pentacyclic triterpenoids, oleanolic acid, ursolic acid and lupeol were shown to inhibit alpha-amylase.
    Matched MeSH terms: Drugs, Chinese Herbal/pharmacology*; Drugs, Chinese Herbal/chemistry
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