MyMedR

Ultrastructural study was carried out 2 groups of pollen with numerous, arranged and spirals on convex. Five species was studied; Desmos chinensis Lour. Fl., Desmos cochinchinensis Lour Fl. , Desmos dumonsus (Roxb.) Safford. , Desmos dunalii (Hk. F. et Th.) Safford. and Desmos dasymaschalus (Bl.) Safford. Pollen was collected from UKM Herbarium specimens and fresh specimen was collected at difference area in the Malaysia. They were acetolysis and dried by CPD method. Parameter studied via scanning electron microscope are mounted pollen, were stamen material; shape, P/E, size, surface structure and calpus ornamentation. Results obtained showed that pollen was inaperturate with needle structure and solitary globus. The morphology of pollen grains of all the species is presented and an identification key base on scanning electron microscope observations is tested.

Matched MeSH terms: Drug Hypersensitivity

A palynological investigation of Vatica L. (Dipterocarpaceae) in Peninsular Malaysia

Houssein M.A. El-Taguri, Latiff A

Sains Malaysiana, 2014;43:1283-1293.

Pollen morphology of 24 species of Vatica L. had been investigated using light and scanning electron microscopes. Vatica is a stenopalynous genus, the pollens are radially symmetrical, isopolar, subprolate to suboblate sometimes prolate rarely oblate, all tricolpate. Exine ornamentation varies from thin to medium reticulate. On the basis of pollen shape two groups of Vatica have been recognized. Within the genus pollen diversity is valuable for identification and delimiting species.

Matched MeSH terms: Drug Hypersensitivity

Fulltext Dapsone syndrome--first Malaysian paediatric case report

Zurina Z, Elizawaty O, Thevarajah S, Norlijah O

Med J Malaysia, 2012 Feb;67(1):105-7.

PMID: 22582558

Dapsone syndrome is a potentially fatal hypersensitivity reaction to sulphone. We report a 12-year-old girl who developed high grade fever associated with intense jaundice, exfoliative skin rash and hepatomegaly after five weeks of starting the multidrug regimen for the treatment of Hansen's disease. Laboratory investigations revealed presence of leucocytosis with eosinophilia, deranged liver enzymes and an abnormal coagulation profile. Immediate cessation of the offending drug and administration of steroid proved successful. A high level of clinical awareness is fundamental for early diagnosis of dapsone syndrome as initiation of a prompt treatment may lead to rapid recovery.

Matched MeSH terms: Drug Hypersensitivity/diagnosis*

Fulltext Suxamethonium sensitivity -- yet another case

Sivaneswaran N, Inbasegaran K

Med J Malaysia, 1982 Dec;37(4):298-9.

PMID: 7167078

Abnormal variants of plasma cholinesterase are a rarity in this region and to date there is only one reported case of suxamethonium sensitivity in a Malaysian population. We now report a case of a Malaysian Chinese patient who received suxamethonium, developed prolonged apnoea and on investigation found to be a homozygote for the silent gene. His family was screened for abnormal variants of plasma cholinesterase. The results are discussed.

Matched MeSH terms: Drug Hypersensitivity/genetics*

Should known allergy status be included as a medication administration 'right'?

Mortell M

Br J Nurs, 2019 Nov 14;28(20):1292-1298.

PMID: 31714835 DOI: 10.12968/bjon.2019.28.20.1292

This article employs a paediatric case study, involving a 3-year-old child who had an anaphylactic reaction that occurred as a result of the multidisciplinary team's failure to identify and acknowledge the patient's documented 'known allergy' status. It examines and reconsiders the ongoing healthcare dilemma of medication errors and recommends that known allergy status should be considered the second medication administration 'right' before the prescribing, transcribing, dispensing and administration of any drug. Identifying and documenting drug allergy status is particularly important when caring for paediatric patients, because they cannot speak for themselves and must rely on their parents, guardians or health professionals as patient advocates. The literature states that medication errors can be prevented by employing a 'rights of medication administration' format, whether that be the familiar '5 rights' or a more detailed list. However, none of these formats specify known allergy status as a distinct 'right'. The medication safety literature is also found wanting in respect of the known allergy status of the patient. When health professionals employ a medication administration rights format prior to prescribing, transcribing, dispensing or administering a medication, the 'known allergy status' of the patient should be a transparent inclusion.

Matched MeSH terms: Drug Hypersensitivity*

Fulltext Life-threatening Chlorhexidine Anaphylaxis: A Case Report

Kow RY, Low CL, Ruben JK, Zaharul-Azri MZ, Ng MS

Malays Orthop J, 2017 Jul;11(2):72-74.

PMID: 29021884 MyJurnal DOI: 10.5704/MOJ.1707.008

Chlorhexidine is a common antiseptic and disinfectant used in the medical field. Allergy to chlorhexidine has been reported in the literature but life-threatening anaphylactic shock is rare. We present a case of severe anaphylactic shock due to chlorhexidine occurring during surgery. Literatures suggest that profound anaphylactic shock to chlorhexidine is commonly preceded by milder, non-specific reactions. These mild symptoms are often dismissed by both the patient and physicians alike. Direct questioning of these symptoms is necessary as a part of the pre-operative assessment and the patient should be referred for further immunology testing if indicated.

Matched MeSH terms: Drug Hypersensitivity

Fulltext Recommendations for HLA-B*15:02 and HLA-A*31:01 genetic testing to reduce the risk of carbamazepine-induced hypersensitivity reactions

Amstutz U, Shear NH, Rieder MJ, Hwang S, Fung V, Nakamura H, et al.

Epilepsia, 2014 Apr;55(4):496-506.

PMID: 24597466 DOI: 10.1111/epi.12564

To systematically review evidence on genetic risk factors for carbamazepine (CBZ)-induced hypersensitivity reactions (HSRs) and provide practice recommendations addressing the key questions: (1) Should genetic testing for HLA-B*15:02 and HLA-A*31:01 be performed in patients with an indication for CBZ therapy to reduce the occurrence of CBZ-induced HSRs? (2) Are there subgroups of patients who may benefit more from genetic testing for HLA-B*15:02 or HLA-A*31:01 compared to others? (3) How should patients with an indication for CBZ therapy be managed based on their genetic test results?

Matched MeSH terms: Drug Hypersensitivity/diagnosis; Drug Hypersensitivity/genetics*

Effectiveness of drug allergy card to prevent repeated prescribing of allergenic medications in a Malaysian public hospital

Lee FY, Chan HK, Wong HS

Pharmacoepidemiol Drug Saf, 2019 05;28(5):760-761.

PMID: 30919516 DOI: 10.1002/pds.4780

Matched MeSH terms: Drug Hypersensitivity/epidemiology; Drug Hypersensitivity/prevention & control*

The rubber elongation factor of rubber trees (Hevea brasiliensis) is the major allergen in latex

Czuppon AB, Chen Z, Rennert S, Engelke T, Meyer HE, Heber M, et al.

J Allergy Clin Immunol, 1993 Nov;92(5):690-7.

PMID: 8227860

BACKGROUND: Allergy to latex-containing articles is becoming more and more important because it can result in unexpected life-threatening anaphylactic reactions in sensitized individuals.

METHODS: A protein of 58 kd with an isoelectric point of 8.45 was purified from raw latex and from latex gloves and identified as the major allergen, completely blocking specific IgE antibodies in the serum of latex-sensitized subjects. The allergen is a noncovalent homotetramer molecule, in which the 14.6 kd monomer was identified, by amino acid composition and sequence homologies of tryptic peptides, to be the rubber elongation factor found in natural latex of the Malaysian rubber tree.

RESULTS: Competitive immunoinhibition tests showed that the starch powder covering the finished gloves is the airborne carrier of the allergen, resulting in bronchial asthma on inhalation. The purified allergen can induce allergic reactions in the nanogram range.

CONCLUSION: The identification of the allergen (Hev b I) may help to eliminate it during the production of latex-based articles in the future.

Matched MeSH terms: Drug Hypersensitivity/etiology; Drug Hypersensitivity/immunology*

Association of HLA-B*15:13 and HLA-B*15:02 with phenytoin-induced severe cutaneous adverse reactions in a Malay population

Chang CC, Ng CC, Too CL, Choon SE, Lee CK, Chung WH, et al.

Pharmacogenomics J, 2017 03;17(2):170-173.

PMID: 26927288 DOI: 10.1038/tpj.2016.10

Phenytoin (PHT) is a common cause of severe cutaneous adverse reactions (SCARs), including Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN) and drug reaction with eosinophilia and systemic symptoms (DRESS). Although HLA-B*15:02 is associated with PHT-induced SJS/TEN (PHT-SJS/TEN) in Han Chinese and Thais, the genetic basis for susceptibility to PHT-induced SCARs (PHT-SCAR) in other populations remains unclear. We performed a case-control association study by genotyping the human leukocyte antigen (HLA)-B alleles of 16 Malay PHT-SCAR patients (13 SJS/TEN and 3 DRESS), 32 PHT-tolerant controls and 300 healthy ethnicity-matched controls. A novel genetic biomarker, HLA-B*15:13, showed significant association with PHT-SJS/TEN (53.8%, 7/13 cases) (odds ratio (OR) 11.28, P=0.003) and PHT-DRESS (100%, 3/3 cases) (OR 59.00, P=0.003) when compared with PHT-tolerant controls (9.4%, 3/32 controls). We also confirmed HLA-B*15:02 association with PHT-SJS/TEN (61.5%, 8/13 cases vs 21.9%, 7/32 controls; OR 5.71, P=0.016) when compared with PHT-tolerant controls. These alleles may serve as markers to predict PHT-SCAR in Malays.

Matched MeSH terms: Drug Hypersensitivity Syndrome/diagnosis; Drug Hypersensitivity Syndrome/genetics*; Drug Hypersensitivity Syndrome/immunology

Fulltext Reappraisal of bovril as a source of arginine in the arginine stimulation test for growth hormone deficiency

Loh HH, Norlela S, Nor Azmi K

Med J Malaysia, 2015 Jun;70(3):208-9.

PMID: 26248787 MyJurnal

The purpose of this case study is to report the use of oral Bovril (a food supplement which contains arginine) as an alternative test for growth hormone stimulation test. We performed oral Bovril test in 3 patients -- one with suspected growth hormone deficiency in whom insulin tolerance test could not be performed (subject A), one sex-matched control (subject B), and one with confirmed growth hormone deficiency (subject C). 14g/m(2) of oral Bovril was mixed with 150ml of warm water and was given to all three subjects. Blood for growth hormone was taken at baseline, and every 30 minutes till 150 minutes after ingestion of oral Bovril. The ingestion of oral Bovril showed a positive response in subjects A and B, with highest growth hormone levels of 28.4mIU/L and 42.0mIU/L respectively at 150 minutes. Subject C had suppressed growth hormone throughout the test. Oral Bovril is readily available and is a safe alternative for standard growth hormone stimulation test.

Matched MeSH terms: Drug Hypersensitivity

Fulltext Misleading free thyroxine (FT4): a case report

Nurul Hidayah Hashim, Intan Nureslyna Samsudin, Ana Dalila Masiman, Subashini C. Thambiah

Malaysian Journal of Medicine and Health Sciences, 2020;16(2):320-322.

MyJurnal

Interpretation of thyroid function test (TFT) is often straightforward but in certain scenarios, discordance between the clinical impression and the laboratory results exists. A 50-year-old woman with a ten years history of hypothyroidism on levothyroxine presented with a recent notable change in TFT [elevated free thyroxine (FT4) and thyroid-stimulat- ing hormone (TSH)], in an otherwise clinically euthyroid and previously stable TFT, leading to levothyroxine being withheld. This case report highlights the possibility of assay interference as a cause of discordant TFT. It also draws the importance of close collaboration between clinicians and the laboratory to avoid unnecessary investigations and inappropriate management of such a case.

Matched MeSH terms: Drug Hypersensitivity

Fulltext Temperature-Driven Structural and Morphological Evolution of Zinc Oxide Nano-Coalesced Microstructures and Its Defect-Related Photoluminescence Properties

Lim K, Abdul Hamid MA, Shamsudin R, Al-Hardan NH, Mansor I, Chiu W

Materials (Basel), 2016 Apr 20;9(4).

PMID: 28773425 DOI: 10.3390/ma9040300

In this paper, we address the synthesis of nano-coalesced microstructured zinc oxide thin films via a simple thermal evaporation process. The role of synthesis temperature on the structural, morphological, and optical properties of the prepared zinc oxide samples was deeply investigated. The obtained photoluminescence and X-ray photoelectron spectroscopy outcomes will be used to discuss the surface structure defects of the prepared samples. The results indicated that the prepared samples are polycrystalline in nature, and the sample prepared at 700 °C revealed a tremendously c-axis oriented zinc oxide. The temperature-driven morphological evolution of the zinc oxide nano-coalesced microstructures was perceived, resulting in transformation of quasi-mountain chain-like to pyramidal textured zinc oxide with increasing the synthesis temperature. The results also impart that the sample prepared at 500 °C shows a higher percentage of the zinc interstitial and oxygen vacancies. Furthermore, the intensity of the photoluminescence emission in the ultraviolet region was enhanced as the heating temperature increased from 500 °C to 700 °C. Lastly, the growth mechanism of the zinc oxide nano-coalesced microstructures is discussed according to the reaction conditions.

Matched MeSH terms: Drug Hypersensitivity

Fulltext Prevalence of latex hypersensitivity among health care workers in Malaysia

Shahnaz M, Azizah MR, Hasma H, Mok KL, Yip E, Ganesapillai T, et al.

Med J Malaysia, 1999 Mar;54(1):26-31.

PMID: 10972001

Health care workers have been reported to constitute one of the few high-risk groups related to IgE-mediated hypersensitivity associated with the use of latex products. This paper describes the first ever study of prevalence carried out in Malaysia among these workers. One hundred and thirty health care personnel from Hospital Kuala Lumpur were skin tested. Extracts used were prepared from seven different brands of natural rubber latex gloves with varying levels of extractable protein (EPRRIM). Out of the 130 volunteers, 4 (3.1%) had positive skin test to latex with extracts with high levels of EPRRIM (> 0.7 mg/g). The prevalence among the Malaysian health care workers can be considered to be low in comparison to that of some consumer countries as the USA which reported a prevalence of as high as 16.9%.

Matched MeSH terms: Drug Hypersensitivity/epidemiology*

Hypersensitivity reaction to dapsone: report from Malaysia

Mohamed KN

Lepr Rev, 1984 Dec;55(4):385-9.

PMID: 6527602

Matched MeSH terms: Drug Hypersensitivity/etiology*

Vernal Keratoconjunctivitis-When Medication Fails

Abd Hamid MR, Tai ELM, Wan Hazabbah WH, Ramli N

J Allergy Clin Immunol Pract, 2019 Apr;7(4):1308-1309.

PMID: 30581132 DOI: 10.1016/j.jaip.2018.11.016

Matched MeSH terms: Drug Hypersensitivity/diagnosis*

Characterization of a monoclonal antibody against latex protein associated with latex allergy

Kurup VP, Kumar A, Kelly KJ, Fink JN

J Allergy Clin Immunol, 1993 Nov;92(5):638-43.

PMID: 8227854 DOI: 10.1016/0091-6749(93)90005-z

Several hybridomas were produced against antigens extracted from the latex sap of Hevea brasiliensis. One of the monoclonal antibodies (LA-E3) reacted with antigens demonstrating binding to patient sera on crossed enzyme immunoelectrophoresis. This monoclonal antibody reacted with 2 of 10 glove extracts studied and with both Malaysian and Indian latex plant extracts. The antigens purified with monoclonal antibody affinity chromatography demonstrated specific IgE in the sera of patients with latex allergy as determined by ELISA. This monoclonal antibody can thus be utilized to obtain reliable antigens useful in the diagnosis of latex sensitivity, although additional antigens will likely be necessary to enhance sensitivity and specificity.

Matched MeSH terms: Drug Hypersensitivity/etiology*

Displaying publications 1 - 20 of 41 in total