MyMedR

Fulltext Pleomorphic adenoma of the trachea

Ashwaq AM, Sani A

Med J Malaysia, 2007 Jun;62(2):162-3.

Primary tracheal tumors are very rare. Pleomorphic adenoma is rarely found in the trachea, despite being the most common histological form of salivary gland neoplasm. We present a case of pleomorphic adenoma of the trachea. Bronchoscopic excision using cold instruments resulted in apparently normal tracheal mucosa.

Matched MeSH terms: Adenoma, Pleomorphic/diagnosis*; Adenoma, Pleomorphic/pathology; Adenoma, Pleomorphic/surgery

Benign chondroid syringoma of the orbit: an atypical location

Yap JF, Madatang A, Hanafi H

Orbit, 2020 Apr;39(2):135-138.

PMID: 31023118 DOI: 10.1080/01676830.2019.1604766

A 31-year-old male with no known medical illness presented with painless left eye protrusion for the past 2 years. Radiographic features were of an extraconal superior orbital mass with no invasion of adjacent structures. The patient underwent an excisional biopsy of the left superior extraconal mass a week later. The histopathological examination revealed a well-circumscribed lobulated mass with chondroid and myxoid stroma enveloping benign bland-appearing epithelial and myoepithelial cells. These pathological features were consistent with benign chondroid syringoma of the orbit. The patient had an uneventful recovery with no active ocular complaint post-operatively.Despite chondroid syringoma of the orbit being a rare tumour, it should be considered in the differential diagnosis of periorbital masses. Excision of the tumour remains the treatment of choice with histopathological examination as the gold standard of diagnosis. Regular follow-up is warranted in view of possible local recurrence or metastasis.

Matched MeSH terms: Adenoma, Pleomorphic/pathology; Adenoma, Pleomorphic/surgery*

The distinctive features of the tumours of the salivary glands in Malaya

MARSDEN AT

Br. J. Cancer, 1951 Dec;5(4):375-81.

PMID: 14904833

Matched MeSH terms: Adenoma, Pleomorphic*

A SWEAT GLAND TUMOUR OF THE MIXED-SALIVARY TYPE OF THE RIGHT MIDDLE TOE

KHOO TK, TZE KB

Med J Malaysia, 1964 Dec;19:128-33.

PMID: 14279235

Matched MeSH terms: Adenoma, Pleomorphic*

Fulltext Carcinoma ex pleomorphic adenoma: a case report and review of literature

Khanna D, Chaubal T, Bapat R, Abdulla AM, Philip ST, Arora S

Afr Health Sci, 2019 Dec;19(4):3253-3263.

PMID: 32127904 DOI: 10.4314/ahs.v19i4.50

Background: Carcinoma ex pleomorphic adenoma (CA-ex-PA) is extremely unusual in minor salivary glands of oral cavity. CAex-PA is a carcinomatous change as a primary or as a recurrence of pleomorphic adenoma.

Objective: Due to resemblance of clinical symptoms of Ca ex PA and benign pleomorphic adenoma, it is mandatory for surgeons to keep high degree of clinical alertness, considering the peculiarity of this tumor.

Case Report: 54-year-old male presented with swelling on left side in the pre-auricular region from the middle of zygomatic arch to mastoid process and from tragus of the ear up to angle of mandible. Fine needle aspiration cytology revealed a mixture of benign and malignant components. Total left parotidectomy with left radical neck dissection followed by reconstruction with cervicodeltopectoral flap was performed. Combination of chemotherapy and radiotherapy were given to patient. Histologic examination and pre-operative fine needle aspiration cytology confirmed the diagnosis of Carcinoma ex pleomorphic adenoma (CA-ex-PA). Two-year follow-up of patient showed no recurrence of the lesion.

Conclusion: Due to the similarity in the clinical symptoms of CA-ex-PA and benign pleomorphic adenoma, it is vital that clinicians maintain a high degree of clinical vigilance, considering the oddity of this malignancy.

Matched MeSH terms: Adenoma, Pleomorphic/diagnosis*; Adenoma, Pleomorphic/physiopathology; Adenoma, Pleomorphic/surgery*

Fulltext Nodular fasciitis: a diagnostic dilemma

Mallina S, Rosalind S, Philip R, Harvinder S, Gurdeep S, Sabaria MN

Med J Malaysia, 2007 Dec;62(5):420-1.

PMID: 18705482 MyJurnal

A 65 year old man presented with a right upper cervical mass. A diagnosis of pleomorphic adenoma was reported on fine needle aspiration cytology (FNAC). CT scan however reported an intramuscular sternocleidomastoid swelling. The tumor was excised and a diagnosis of nodular fasciitis was made. It is important to be aware of this diagnosis and that FNAC reports may mimic that of a pleomorphic adenoma.

Matched MeSH terms: Adenoma, Pleomorphic/diagnosis

Pleomorphic adenoma in the palpebral lobe of the lacrimal gland misdiagnosed as chalazion

Ramlee N, Ramli N, Tajudin LS

Orbit, 2007 Jun;26(2):137-9.

PMID: 17613864

We reported a case of pleomorphic adenoma of the lacrimal gland involving the palpebral lobe in young teenage girl of Asian origin. The presentation at young age group is rare, which initially misdiagnosed as a large chalazion. The benign tumor with its intact pseudocapsule was removed through lateral orbitotomy together with the suspicious looking orbital lobe.

Matched MeSH terms: Adenoma, Pleomorphic/diagnosis*; Adenoma, Pleomorphic/surgery

Metastatic Pleomorphic Adenoma in the infratemporal fossa and neck following total parotidectomy after 30 years

Wong DKC, Muhamad NS, Sobri SS, Amin WAM, Yusof Z

Med J Malaysia, 2019 04;74(2):85-86.

PMID: 31079134

Metastasising pleomorphic adenoma is rare and may occur years after surgical excision of a pleomorphic adenoma (PA). We present a 61-year-old woman with a right infratemporal PA with metastases to the cervical lymph nodes after 30 years following a total parotidectomy. She was treated successfully with a resection of the tumour with combined neck and mandibulotomy approach along with postoperative radiotherapy given subsequently.

Matched MeSH terms: Adenoma, Pleomorphic/diagnosis*; Adenoma, Pleomorphic/etiology; Adenoma, Pleomorphic/pathology; Adenoma, Pleomorphic/therapy

Fulltext Carcinoma Ex Pleomorphic Adenoma Presented as a Gigantic Tumor: Treatment and Diagnostic Challenges

Maruthamuthu T, Saniasiaya J, Mohamad I, Nadarajah S, Lazim NM, Wan Abdul Rahman WF

Oman Med J, 2018 Jul;33(4):342-345.

PMID: 30038735 DOI: 10.5001/omj.2018.62

Parotid gland surgery can be challenging due to intricate relationship between the gland and facial nerve. Besides complete removal of the lesion, the main focus of surgery is centered on the facial nerve. Surgery can be technically demanding especially when the tumor is large or involves the deep lobe. We report a patient with a 30-year history of gigantic parotid mass, which initial fine-needle aspiration cytology reported as pleomorphic adenoma. The tumor, weighing 1.3 kg, was successfully resected with facial nerve preservation. Histopathological examination of the excised mass confirmed as carcinoma ex pleomorphic adenoma (CaExPA) of adenocarcinoma, not otherwise specified type. We describe the specific surgical and reconstruction techniques for successful removal of large parotid tumors with facial nerve preservation. To our knowledge, this is the heaviest CaExPA of the parotid gland in South-East Asian region.

Matched MeSH terms: Adenoma, Pleomorphic

Fulltext Pleomorphic adenoma of the frontal sinus masquerading as a mucocele

Chew YK, Brito-Mutunayagam S, Chong AW, Prepageran N, Chandran PA, Khairuzzana B, et al.

Ear Nose Throat J, 2015 Dec;94(12):E4-6.

PMID: 26670764 DOI: 10.1177/014556131509401202

Pleomorphic adenoma is the most common type of benign salivary gland tumor. It can also be found in the larynx, ear, neck, and nasal septum. It is rarely found in the maxillary sinus, and it has never been reported in the frontal sinus. We report a case of pleomorphic adenoma of the frontal sinus that masqueraded as a mucocele. We discuss the clinical presentation, diagnosis, and treatment of this patient, and we review the literature.

Matched MeSH terms: Adenoma, Pleomorphic

Benign parotid lesions: is near total parotidectomy justified?

Arshad AR

Ann Acad Med Singap, 2006 Dec;35(12):889-91.

PMID: 17219001

INTRODUCTION: Benign tumours of the parotid gland constitute about 80% of parotid tumours. The most common benign tumour of the parotid gland is pleomorphic adenoma. Other conditions, like Kimura's disease, may mimic a tumour when they present as a parotid mass. Various modes of treatment have been advocated for the treatment of benign parotid lesions, ranging from enucleation to near-total parotidectomy.

MATERIAL AND METHODS: This is an audit of an 18-year period where 173 lesions of the parotid gland (34 malignant and 139 benign lesions) were treated by the author.

RESULTS: There were 139 benign lesions, of which 123 were benign tumours and 16 non-tumour conditions. Fourteen cases of recurrent pleomorphic adenoma of parotid that had been treated elsewhere were also operated on. Near-total parotidectomy was performed on all these cases with benign lesions.

CONCLUSIONS: There has been no recurrence in all the patients who was treated this way. Near-total parotidectomy should be considered when there is a need to treat benign parotid swellings.

Matched MeSH terms: Adenoma, Pleomorphic/surgery

Immunohistochemical study of the distribution of S-100 protein in pleomorphic adenomas of minor salivary glands

Siar CH, Ng KH

J Nihon Univ Sch Dent, 1992 Jun;34(2):96-105.

PMID: 1380072

Twelve pleomorphic adenomas of minor salivary gland origin were examined for the distribution of S-100 protein, detected using the peroxidase-antiperoxidase (PAP) method. Strong S-100 protein immunoreactivity was noted in areas containing plasmacytoid cells, stellate and spindle cells against a myxochondroid or hyalinous stroma, and solid epithelial areas. Tubular and duct-like structures showed variable stainability. Stromal tissue and normal salivary glands were generally negative for S-100 protein. These findings were compared with those reported elsewhere.

Matched MeSH terms: Adenoma, Pleomorphic/pathology*; Adenoma, Pleomorphic/chemistry

Fulltext Oral and maxillofacial pathologic lesion: retrospective studies on prevalence and sociodemographic features

Nurhayu Ab Rahman

Archives of Orofacial Sciences, 2014;9(2):65-75.

MyJurnal

The aim was to study the prevalence and sociodemographic features of odontogenic, non-odontogenic and salivary glands lesions among patients seen in Hospital Universiti Sains Malaysia. This information is essential to assist clinician in formulating reliable differential diagnosis of such lesion. Data on patient demographics, lesion location, tissue of origin and microscopic diagnosis were extracted from the Laboratory and Diagnosis record registries for biopsy specimen accessioned from year 2000 to 2012. This data was subsequently analyzed based on World Health Organization Classification of Head and Neck Tumours (2005). A total of 748 cases were included in the study. Out of the total number of cases, 367 cases were males and 377 cases were females. Ninety seven cases (13%) were of odontogenic origin, while 90 cases (12%) and 197 cases (26%) were of non-odontogenic and salivary gland origin respectively. Forty five percent of cases involved oral mucosal lesions. The most prevalent odontogenic lesion reported within the twelve years period was radicular cyst and ameloblastoma. Non-odontogenic bone lesion was rarely encountered with it making up less than two percent of total cases reported. Pleomorphic adenoma was the most prevalent benign salivary glands neoplasm reported within similar time period.

Matched MeSH terms: Adenoma, Pleomorphic

Fulltext A review Of parotid tumours In Negeri Sembilan, Malaysia

Ambu, Valuyeetham Kamaru, Ramalinggam, Ganesh, Kaur, Kirandeep

Malaysian Journal of Medicine and Health Sciences, 2014;10(2):61-69.

MyJurnal

Parotid tumours represent one of many groups of tumours in the field of
Otorhinolaryngology. However, a local demographical evaluation of parotid tumours and its annual incidences has never been undertaken. This study intends to review local demography in relation to incidence of parotid tumour seen in Otorhinolaryngology (ORL) clinic, Hospital Tuanku Ja’afar Seremban, Negeri Sembilan from the year 2007 till 2012. Methods: A retrospective demographical study on parotid cases seen in ORL clinic, Hospital Tuanku Ja’afar Seremban between 2007 till 2012 involving 56 cases. Data that was collected include patient details, facial nerve involvement on presentation, type of surgery performed, site of tumour, facial nerve injury post operation and final histopathological diagnosis. Results: An average of 10 cases per year was noted from 2007 to 2012. Male to female ratio was found to be 1.4:1. Age range of sample population were 9 to 79 years old with a mean age of 47 at time of diagnosis. Superficial lobe was found to be the most common tumour site (63%). Majority of cases consists of benign tumours in 51 out of 56 cases with Warthin’s tumour and Pleomorphic Adenoma being the most common histopathological finding. Post operative facial nerve injury were noted in 17 cases in which 13 cases were temporary while 4 others were permanent.

Matched MeSH terms: Adenoma, Pleomorphic

Fulltext Pleomorphic Adenoma Originating from Submandibular Salivary Gland in an 8-year-old Girl: A Case Report.

Gani, A.N., Megat Shiraz, M.A.R., Siti Aishah, M.A., Norazizah, M., Mozita, A., Sharifah, N.A.

Medicine & Health, 2007;2(2):164-168.

MyJurnal

Pleomorphic adenoma (PA) typically presents as a benign slow growing, painless neoplasm of the parotid gland. PA arising from the submandibular gland in the paediatric age group is rare. Surgical excision is the treatment of choice. A case of PA in an 8-year-old Malay girl is presented. Clinically she presented with a painless right submandibular mass measuring 2x2cm. A diagnosis of Pleomorphic adenoma was made on Fine Needle Aspiration Cytology (FNAC). She underwent submandibulectomy uneventfully. Postoperatively after two years follow up, she is asymptomatic.

Matched MeSH terms: Adenoma, Pleomorphic

Cytologic features and differential diagnosis in chondroma of the breast: a case report

Sivakumar S, Kaur G

Acta Cytol., 2009 May-Jun;53(3):303-5.

PMID: 19534271 DOI: 10.1159/000325312

BACKGROUND: Extraskeletal (soft tissue) chondromas are rare neoplasms. They are seen most frequently in the soft tissues of hands and feet. A chondroma occurring in the breast is exceedingly uncommon. We present a case of pure chondroma of the breast in a young woman in whom fine needle aspiration (FNA) cytologic features suggested a cartilaginous neoplasm.

CASE: A 28-year-old woman presented with a mobile lump in the left breast. Mammography showed a high-density nodule without microcalcifications. A clinical diagnosis of fibroadenoma was made. A differential diagnosis was obtained on FNA. Excisional biopsy of the lump showed the histopathologic features of chondroma. There was no recurrence or appearance of new lesion during 13 months of follow-up.

CONCLUSION: Chondroma of the breast shows FNA cytologic features of cartilaginous tumor, but specific tumor typing may not be possible. This case highlights the difficulties that may arise in FNA diagnosis of cartilaginous tumor especially when it occurs at an unusual site. Awareness of the cytologic features combined with clinical and radiologic findings should guide the cytopathologist to make correct diagnosis of this neoplasm.

Matched MeSH terms: Adenoma, Pleomorphic/diagnosis

Oral carcinoma in the first three decades of life

Ramanathan K

Med J Malaya, 1972 Sep;27(1):20-6.

PMID: 4345644

Matched MeSH terms: Adenoma, Pleomorphic/epidemiology

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