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A preliminary study of international migration of the Chinese people

Zhu G

Chin J Popul Sci, 1994;6(4):403-15.
PMID: 12319210
A probe into reasons for international migration in Fujian Province

Zhu G

Chin J Popul Sci, 1990;2(3):229-46.
PMID: 12284987
Fulltext Integrative computational approach identifies immune-relevant biomarkers in ulcerative colitis

He T, Wang K, Zhao P, Zhu G, Yin X, Zhang Y, et al.

FEBS Open Bio, 2022 02;12(2):500-515.
PMID: 34939750 DOI: 10.1002/2211-5463.13357

Ulcerative colitis is a common inflammatory bowel disease with a complex genetic and immune etiology. Immune infiltration plays a vital role in the development of ulcerative colitis. To explore potential biomarkers for ulcerative colitis and analyze characteristics of immune cell infiltration, we used bioinformatic analyses, including machine learning algorithms, cell type deconvolution methods, and pathway enrichment methods. In this study, we identified 216 differentially expressed mRNAs (DEMs), of which 153 were upregulated, and 63 were downregulated genes. DEMs were mainly enriched in infiltrating neutrophils and regulation of leukocyte migration. Moreover, eight candidate biomarkers, DPP10, MST1L, DPP10-AS1, CEP55, ACSL1, MGP, OLFM4, and SGK1, were identified. Of these candidate biomarkers, MST1L, OLFM4, and DPP10 were then validated in the GSE48958 dataset and were predicted to be strongly correlated with infiltrating immune cells of ulcerative colitis. The underlying mechanism of these key genes in the development of colitis was also predicted by gene set variation analysis. To further validate these biomarkers' expression in ulcerative colitis, we determined mRNA levels of SGK1, CEP55, ACSL1, OLFM4, and DPP10 in lipopolysaccharides (LPS)-stimulated Raw264.7 cells by quantitative reverse transcription-polymerase chain reaction. We also examined SGK1, CEP55, ACSL1, OLFM4, DPP10, and MGP expression in the colon tissues of dextran sodium sulfate-induced colitis mice. Consistent with the predicted computational results, the mRNA levels of these candidate genes were markedly changed in LPS-stimulated Raw264.7 cells and inflamed colon tissues. Hence, our findings indicated that these critical genes may act as diagnostic biomarkers for ulcerative colitis and that differential immune infiltration cells may help illustrate the progression of ulcerative colitis.
Road to entire insulation for resonances from a forced mechanical system

Zhu G, Cao Q, Wang Z, Zhang Y, Chen Y, Woo KC

Sci Rep, 2022 Dec 07;12(1):21167.
PMID: 36477007 DOI: 10.1038/s41598-022-25691-4

The effective solution to avoid machinery damage caused by resonance has been perplexing the field of engineering as a core research direction since the resonance phenomenon was discovered by Euler in 1750. Numerous attempts have been performed to reduce the influence of resonance since the earlier of last century, by introducing a nonlinear structure or a closed-loop control system. However, the existed methodologies cannot eliminate resonance completely even extra problems were introduced inevitably, which means the technical choke-point of resonance-free remains unsolved. Here we propose a designable archetype model, which establishes a mapping between the mechanical properties and its structure. A general inverse method for structure construction is proposed based upon the required property for the system with quasi-zero stiffness of any designed finite order and the zero-stiffness properties. It is shown that an ellipse trajectory tracking of the designed model is the sufficient and necessary condition to satisfy the zero-stiffness property. Theoretical analysis shows that no resonant response happens in a zero-stiffness system to the full-band frequency excitation, or equivalently, the system can completely isolate the energy transfer between the load and environment, when the damping ratio approaches zero. Finally, an experimental rig for the prototype structure is built up according to the sufficient and necessary condition of the zero-stiffness system, for which the special dynamic behaviours are verified through experiments of frequency-sweep and random-vibration as well. Experimental results show that the prototype of the initial vibration isolation frequency of zero-stiffness system is much lower than 0.37 Hz, and the vibration attenuation of the proposed model is about 16.86 dB, 45.63 dB, and 112.37 dB at frequencies of 0.37 Hz, 1 Hz, and 10 Hz, respectively. The distinguished geometric structure of the zero-stiffness system leads to a new inspiration for the design of resonance-free in metamaterial unit and the inverse method can even adapt the design for a more targeted applications based on an arbitrary complex dynamic requirement.
Vegetation restoration effects on soil carbon and nutrient concentrations and enzymatic activities in post-mining lands are mediated by mine type, climate, and former soil properties

Yuan C, Wu F, Wu Q, Fornara DA, Heděnec P, Peng Y, et al.

Sci Total Environ, 2023 Jun 25;879:163059.
PMID: 36963687 DOI: 10.1016/j.scitotenv.2023.163059

Vegetation restoration is a widely used, effective, and sustainable method to improve soil quality in post-mining lands. Here we aimed to assess global patterns and driving factors of potential vegetation restoration effects on soil carbon, nutrients, and enzymatic activities. We synthesized 4838 paired observations extracted from 175 publications to evaluate the effects that vegetation restoration might have on the concentrations of soil carbon, nitrogen, and phosphorus, as well as enzymatic activities. We found that (1) vegetation restoration had consistent positive effects on the concentrations of soil organic carbon, total nitrogen, available nitrogen, ammonia, nitrate, total phosphorus, and available phosphorus on average by 85.4, 70.3, 75.7, 54.6, 58.6, 34.7, and 60.4 %, respectively. Restoration also increased the activities of catalase, alkaline phosphatase, sucrase, and urease by 63.3, 104.8, 125.5, and 124.6 %, respectively; (2) restoration effects did not vary among different vegetation types (i.e., grass, tree, shrub and their combinations) or leaf type (broadleaved, coniferous, and mixed), but were affected by mine type; and (3) latitude, climate, vegetation species richness, restoration year, and initial soil properties are important moderator variables, but their effects varied among different soil variables. Our global scale study shows how vegetation restoration can improve soil quality in post-mining lands by increasing soil carbon, nutrients, and enzymatic activities. This information is crucial to better understand the role of vegetation cover in promoting the ecological restoration of degraded mining lands.
Antibacterial polyene-polyol macrolides and cyclic peptides from the marine-derived Streptomyces sp. MS110128

Jiang L, Huang P, Ren B, Song Z, Zhu G, He W, et al.

Appl Microbiol Biotechnol, 2021 Jun;105(12):4975-4986.
PMID: 34146138 DOI: 10.1007/s00253-021-11226-w

Marine microbes provide an important resource to discover new chemical compounds with biological activities beneficial to drug discovery. In our study, two new polyene macrolides, pyranpolyenolides A (1) and B (2), and one new natural cyclic peptide (9), together with two known polyenes (7 and 8) and three known cyclic peptides (10-12), were isolated from a culture of the marine Streptomyces sp. MS110128. In addition, four new polyene macrolides, pyranpolyenolides C-F (3-6), were identified as olefin geometric isomers that were most likely produced by photochemical conversion during the cultivation or isolation procedures. The pyranpolyenolides are 32-membered macrolides endowed with a conjugated tetraene and several pairs of 1,3-dihydroxyl groups. Pyranpolyenolides that contain a hydropyran group have not been previously reported. Four cyclic peptides (9-12) showed significant activities against Bacillus subtilis, Staphylococcus aureus, and methicillin-resistant S. aureus with supporting MIC values ranging from 0.025 to 1.25 μg/mL. These cyclic peptides containing piperazic moieties showed moderate activities with MIC values of 12.5 μg/mL against Bacille Calmette Guerin (BCG), an attenuated form of the bovine. Additionally, cyclic peptide 12 showed moderate antifungal activity against Candida albicans with an MIC value of 12.5 μg/mL. KEY POINTS: • Discovery of new polyenes and cyclic peptides from a marine-derived Actinomycete. • Cyclic peptides containing piperazic moieties exhibited good antibacterial activity.
Fulltext Performance in the Fundamentals of Laparoscopic Surgery: Does it reflect global rating scales in the Objective Structured Assessment of Technical Skills in porcine laparoscopic surgery?

Tiong HY, So WZ, Yuen-Chun Teoh J, Isotani S, Zhu G, Ong TA, et al.

Asian J Urol, 2024 Jul;11(3):443-449.
PMID: 39139525 DOI: 10.1016/j.ajur.2022.12.002

OBJECTIVE: To correlate the utility of the Fundamentals of Laparoscopic Surgery (FLS) manual skills program with the Objective Structured Assessment of Technical Skills (OSATS) global rating scale in evaluating operative performance.
METHODS: The Asian Urological Surgery Training and Educational Group (AUSTEG) Laparoscopic Upper Tract Surgery Course implemented and validated the FLS program for its usage in laparoscopic surgical training. Delegates' basic laparoscopic skills were assessed using three different training models (peg transfer, precision cutting, and intra-corporeal suturing). They also performed live porcine laparoscopic surgery at the same workshop. Live surgery skills were assessed by blinded faculty using the OSATS rating scale.
RESULTS: From March 2016 to March 2019, a total of 81 certified urologists participated in the course, with a median of 5 years of post-residency experience. Although differences in task time did not reach statistical significance, those with more surgical experience were visibly faster at completing the peg transfer and intra-corporeal suturing FLS tasks. However, they took longer to complete the precision cutting task than participants with less experience. Overall OSATS scores correlated weakly with all three FLS tasks (peg transfer time: r=-0.331, r 2=0.110; precision cutting time: r=-0.240, r 2=0.058; suturing with intra-corporeal knot time: r=-0.451, r 2=0.203).
CONCLUSION: FLS task parameters did not correlate strongly with OSATS globing rating scale performance. Although FLS task models demonstrated strong validity, it is important to assimilate the inconsistencies when benchmarking technical proficiency against real-life operative competence, as evaluated by FLS and OSATS, respectively.
Fulltext Asia prostate cancer study (A-CaP Study) launch symposium

Akaza H, Hirao Y, Kim CS, Oya M, Ozono S, Ye D, et al.

Prostate Int, 2016 Sep;4(3):88-96.
PMID: 27689065 DOI: 10.1016/j.prnil.2016.03.001

The Asian Prostate Cancer (A-CaP) Study is an Asia-wide initiative that has been developed over the course of 2 years. The A-CaP Study is scheduled to begin in 2016, when each participating country or region will begin registration of newly diagnosed prostate cancer patients and conduct prognosis investigations. From the data gathered, common research themes will be identified, such as comparisons among Asian countries of background factors in newly diagnosed prostate cancer patients. This is the first Asia-wide study of prostate cancer and has developed from single country research efforts in this field, including in Japan and Korea. The inaugural Board Meeting of A-CaP was held on December 11, 2015 at the Research Center for Advanced Science and Technology, The University of Tokyo, attended by representatives of all participating countries and regions, who signed a memorandum of understanding concerning registration for A-CaP. Following the Board Meeting an A-CaP Launch Symposium was held. The symposium was attended by representatives of countries and regions participating in A-CaP, who gave presentations. Presentations and a keynote address were also delivered by representatives of the University of California San Francisco, USA, and the Peter MacCallum Cancer Centre, Australia, who provided insight and experience on similar databases compiled in their respective countries.
Fulltext Hair Cortisol in Twins: Heritability and Genetic Overlap with Psychological Variables and Stress-System Genes

Rietschel L, Streit F, Zhu G, McAloney K, Frank J, Couvy-Duchesne B, et al.

Sci Rep, 2017 Nov 10;7(1):15351.
PMID: 29127340 DOI: 10.1038/s41598-017-11852-3

Hair cortisol concentration (HCC) is a promising measure of long-term hypothalamus-pituitary-adrenal (HPA) axis activity. Previous research has suggested an association between HCC and psychological variables, and initial studies of inter-individual variance in HCC have implicated genetic factors. However, whether HCC and psychological variables share genetic risk factors remains unclear. The aims of the present twin study were to: (i) assess the heritability of HCC; (ii) estimate the phenotypic and genetic correlation between HPA axis activity and the psychological variables perceived stress, depressive symptoms, and neuroticism; using formal genetic twin models and molecular genetic methods, i.e. polygenic risk scores (PRS). HCC was measured in 671 adolescents and young adults. These included 115 monozygotic and 183 dizygotic twin-pairs. For 432 subjects PRS scores for plasma cortisol, major depression, and neuroticism were calculated using data from large genome wide association studies. The twin model revealed a heritability for HCC of 72%. No significant phenotypic or genetic correlation was found between HCC and the three psychological variables of interest. PRS did not explain variance in HCC. The present data suggest that HCC is highly heritable. However, the data do not support a strong biological link between HCC and any of the investigated psychological variables.