In this study, Global Positioning System (GPS) simulation was employed to study the effect of radio frequency interference (RFI) on two hand-held GPS receivers; Garmin GPSmap 60CSx (evaluated GPS receiver) and Garmin GPSmap 60CS (reference GPS receiver). Both GPS receivers employed the GPS L1 coarse acquisition (C/A) signal. It was observed that the interference signal power levels required to affect the location fixes of the GPS receivers were significantly high compared to the corresponding GPS signal power levels. The noiselike C/A code structure, which modulated the L1 signal over a 2 MHz bandwidth, allowed for the signal to be received at low levels of interferences. The evaluated GPS receiver had better RFI operability as compared to the reference GPS receiver. This is because the evaluated GPS receiver had higher receiver sensitivity, allowing it to have increased carrier-to-noise density (C/N0) levels for GPS satellites tracked by the receiver. The absence of other error parameters, including ionospheric and tropospheric delays, satellite clock, ephemeris and multipath errors, and unintentional signal interferences and obstructions, resulted in the required minimum jamming power levels in this study to be significantly higher as compared to field evaluations. These minimum jamming power levels vary with location and time. This was due to the GPS satellite constellation being dynamic, causing varying GPS satellite geometry over location and time, resulting in the minimum required GPS jamming power levels being location / time dependent. In general, the lowest minimum jamming power levels were observed for readings with the highest position dilution of precision (PDOP) values, and vice versa.