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Fulltext Multiple Painless Cervical Lymphadenopathies Misleading the Diagnosis of Kikuchi's Disease

Apandi A, Wan Mansor WN, Musa Z, Mohd Ali NA

Cureus, 2024 Apr;16(4):e58151.
PMID: 38741836 DOI: 10.7759/cureus.58151

Kikuchi's disease is an unusual and self-limited disease. It manifests as a painful cervical lymphadenopathy and is associated with a low-grade fever and night sweats. Recently, this disease has been reported worldwide, compared to its initial high prevalence among the Japanese population. The etiologies of Kikuchi's disease are still unknown, but it has been proposed to have either infectious or immunological causes. We report the atypical presentation of a young male with Kikuchi's disease. A 22-year-old male presented with a prolonged fever for a week, which was associated with bilateral neck swelling that was painless and gradually increased in size. In our case, histopathological examination of the left cervical lymph node revealed histiocytic necrotizing lymphadenitis in favor of Kikuchi's disease. This case report will highlight the atypical clinical presentation of this patient, thereby increasing awareness of the disease's future manifestation.
Data on combustion, performance and emissions of a 6.8 L, 6-cylinder, Tier II diesel engine

Wan Mansor WN, Abdullah S, Jarkoni MNK, Vaughn JS, Olsen DB

Data Brief, 2020 Dec;33:106580.
PMID: 33304969 DOI: 10.1016/j.dib.2020.106580

A diesel engine has been a desirable machine due to its better fuel efficiency, reliability, and higher power output. It is widely used in transportations, locomotives, power generation, and industrial applications. The combustion of diesel fuel emits harmful emissions such as unburned hydrocarbons (HC), particulate matter (PM), nitrogen oxides (NOx), and carbon monoxides (CO). This article presents data on the efficiency, combustion, and emission of a 4-stroke diesel engine. The engine is a 6.8 L turbocharged 6-cylinder Tier II diesel engine fitted with a common rail injection system. The test was carried out at the Powerhouse Energy Campus, Colorado State University Engines and Energy Conversion facility. The ISO Standard 8178:4 Cycle D2 cycle was adopted for this study consists of five test runs at 1800 rpm. During the testing, CO, carbon dioxide (CO2), oxygen (O2), NOx, PM, unburned HC as a total HC (THC), methane (CH4), formaldehyde (CH2O), and volatile organic compound (VOC) emissions were measured. At the same time, the data acquisition system recorded the combustion data. The engine's performance is characterized by the brake specific fuel combustion (BSFC) and thermal efficiency. A dataset of correlations among the parameters was also presented in this article.
Fulltext Data on Indoor Air Quality (IAQ) in kindergartens with different surrounding activities

Abdullah S, Abd Hamid FF, Ismail M, Ahmed AN, Wan Mansor WN

Data Brief, 2019 Aug;25:103969.
PMID: 31198825 DOI: 10.1016/j.dib.2019.103969

The aim of the measurement of this data is to evaluate the Indoor Air Quality (IAQ) in terms of chemical and physical parameters. Data were collected at three different kindergartens having different surrounding activities (industrial, institutional, residential area). The chemical parameters measured were respirable suspended particulates of PM10, PM2.5, PM1, carbon monoxide and carbon dioxide, and the concentrations are within the acceptable limit. Physical parameters of wind speed are within the standard, while temperature and relative humidity exceeded the acceptable limit. A strong correlation was found between the chemical IAQ parameters with thermal comfort parameters (temperature and relative humidity). The concentration of IAQ pollutants is higher in order of residential > institutional > industrial.
Fulltext Infected Cochlear Implant and Re-implantation in a Pediatric Case

Meor Abdul Malik MF, Hashim ND, Wan Mansor WN, Abdul Gani N

Cureus, 2023 Feb;15(2):e35613.
PMID: 37007321 DOI: 10.7759/cureus.35613

Cochlear implant (CI) surgery is relatively safe, however reports of complications and failure following cochlear implant surgery are higher nowadays due to the increasing number of patients with CI. Herein, we report a case of infected cochlear implant 10 months after surgery. A three-year-six-month-old girl underwent right cochlear implantation for bilateral profound sensorineural hearing loss. From day one until six months after the surgery, it was uneventful and the wound healed well. However, at 10 months post-surgery, she presented with a chronic discharging wound over the previous surgical site. Despite being on IV antibiotics for six weeks and daily dressing, the wound over the implant site keep discharging and eventually the implant was removed two months later. She was later re-implanted with a cochlear implant on the same side at the age of five years 10 months old. Currently, she is showing good speech improvement with the right CI. Her aided hearing threshold is at 30-40 dB at all frequencies. Early diagnosis is crucial, and the proper course of action should be taken as soon as possible if implant failure is suspected. Prior to implant surgery, any potential risk factors that could lead to implant failure should be identified and addressed appropriately to reduce the risk of an infected cochlear implant.
Rapamycin and PF4 induce apoptosis by upregulating Bax and down-regulating survivin in MNU-induced breast cancer

Al-Astani Tengku Din TA, Shamsuddin SH, Idris FM, Ariffin Wan Mansor WN, Abdul Jalal MI, Jaafar H

Asian Pac J Cancer Prev, 2014;15(9):3939-44.
PMID: 24935577

BACKGROUND: To elucidate the role of rapamycin and PF4 on apoptosis regulation via Bax (pro-apoptosis), Bcl-2 (anti-apoptosis) and survivin activation on the growth in the 1-methyl-1-nitrosourea -induced invasive breast carcinoma model.
MATERIALS AND METHODS: Thirty five female Sprague Dawley rats at age 21-day old were divided into 4 groups; Group 1 (control, n=10), Group 2 (PF4, n=5), Group 3 (rapamycin, n=10) and Group 4 (rapamycin+PF4, n=10). MNU was administered intraperitionally, dosed at 70 mg/kg body weight. The rats were treated when the tumors reached the size of 14.5 ± 0.5 mm and subsequently sacrificed after 5 days. Rapamycin and PF4 were administered as focal intralesional injections at the dose of 20 μg/lesion. The tumor tissue was then subjected to histopathological examinations for morphological appraisal and immunohistochemical assessment of the pro-apoptotic marker, Bax and anti-apoptotic markers, Bcl-2 and survivin.
RESULTS: The histopathological pattern of the untreated control cohort showed that the severity of the malignancy augments with mammary tumor growth. Tumors developing in untreated groups were more aggressive whilst those in treated groups demonstrated a transformation to a less aggressive subtype. Combined treatment resulted in a significant reduction of tumor size without phenotypic changes. Bax, the pro-apoptotic marker, was significantly expressed at higher levels in the rapamycin-treated and rapamycin+PF4-treated groups compared to controls (p<0.05). Consequently, survivin was also significantly downregulated in the rapamycin-treated and rapamycin+PF4-treated group and this was significantly different when compared to controls (p).
CONCLUSIONS: In our rat model, it could be clearly shown that rapamycin specifically affects Bax and survivin signaling pathways in activation of apoptosis. We conclude that rapamycin plays a critical role in the induction of apoptosis in MNU-induced mammary carcinoma.
Fulltext Data on greenhouse gases emission of fuels in power plants in Malaysia during the year of 1990-2017

Wan Mansor WN, Abdullah S, Che Wan Othman CWMN, Jarkoni MNK, Chao HR, Lin SL

Data Brief, 2020 Jun;30:105440.
PMID: 32300616 DOI: 10.1016/j.dib.2020.105440

Energy has a significant influence on Malaysia's industry. It is used in electricity generation, refineries, gas processing plants and end-user applications such as transportation, residential, agriculture and fishing. These burning fossil fuel activities produce greenhouse gases (GHG) emissions. This article presents the emissions data of fuel used in power plants in Malaysia during the year of 1990 until 2017. The fuel used in power plants is coal and coke, natural gas, diesel oil and residual fuel oil. The energy data used in power plants were gathered from the Malaysia Energy Information Hub, published by the Malaysian Energy Commission. The GHG emissions data were calculated using the emission factors method. The climate impact of different GHGs in terms of CO2-equivalent (CO2-e) was also calculated using global warming potentials. The article also presents population data in Malaysia during the year. A correlation between the fuels, GHG emission and the population is also investigated using statistical analysis. The data presented here may facilitate the Malaysian government to identify the source of the pollutants and undertake a climate change mitigation plan.