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  1. Husin MN, Khan AR, Awan NUH, Campena FJH, Tchier F, Hussain S
    PLoS One, 2024;19(5):e0302276.
    PMID: 38713692 DOI: 10.1371/journal.pone.0302276
    Based on topological descriptors, QSPR analysis is an incredibly helpful statistical method for examining many physical and chemical properties of compounds without demanding costly and time-consuming laboratory tests. Firstly, we discuss and provide research on kidney cancer drugs using topological indices and done partition of the edges of kidney cancer drugs which are based on the degree. Secondly, we examine the attributes of nineteen drugs casodex, eligard, mitoxanrone, rubraca, and zoladex, etc and among others, using linear QSPR model. The study in the article not only demonstrates a good correlation between TIs and physical characteristics with the QSPR model being the most suitable for predicting complexity, enthalpy, molar refractivity, and other factors and a best-fit model is attained in this study. This theoretical approach might benefit chemists and professionals in the pharmaceutical industry to forecast the characteristics of kidney cancer therapies. This leads towards new opportunities to paved the way for drug discovery and the formation of efficient and suitable treatment options in therapeutic targeting. We also employed multicriteria decision making techniques like COPRAS and PROMETHEE-II for ranking of said disease treatment drugs and physicochemical characteristics.
  2. Hadi SH, Shaba TG, Madhi ZS, Darus M, Lupaş AA, Tchier F
    MethodsX, 2024 Dec;13:102842.
    PMID: 39071992 DOI: 10.1016/j.mex.2024.102842
    The study of holomorphic functions has been recently extended through the application of diverse techniques, among which quantum calculus stands out due to its wide-ranging applications across various scientific disciplines. In this context, we introduce a novel q-differential operator defined via the generalized binomial series, which leads to the derivation of new classes of quantum-convex (q-convex) functions. Several specific instances within these classes were explored in detail. Consequently, the boundary values of the Hankel determinants associated with these functions were analyzed. All graphical representations and computational analyses were performed using Mathematica 12.0.•These classes are defined by utilizing a new q-differential operator.•The coefficient values | a i | ( i = 2 , 3 , 4 ) are investigated.•Toeplitz determinants, such as the second T 2 ( 2 ) and the third T 3 ( 1 ) order inequalities, are calculated.
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