In the perspective of recent bauxite mining in Malaysia, this review aims to identify the potential
environmental and health impacts on miners and surrounding communities. The environmental issues of
bauxite mining include, air, water and soil pollution due to bauxite dust; leaching of bauxite into water
sources resulting in reduced soil fertility as well as affecting agricultural food products and aquatic life.
Bauxite occupational exposure affects the health of miners, and has negative consequences on the health of
surrounding communities, such as increased respiratory symptoms, contamination of drinking water, other
potential health risks from ingestion of bauxite and heavy metals, including noise-induced hearing loss and
mental stress. This review discusses the processes of bauxite mining, its constituents and residual trace
elements, and their impact on the environment and health of exposed workers and communities. It also
explores the Malaysian legal requirements and standards of occupational exposure to bauxite.
Monoclonal antibodies (MAbs) directed against different epitope regions on three sexual stage-specific gamete surface proteins of Plasmodium falciparum, Pfs 25, Pfs 230, and Pfs 48/45, were used to study the genetic diversity of these epitopes among fresh isolates of P. falciparum from Malaysia, using immunofluorescence microscopy (IFA). Among 45 Malaysian isolates, one epitope of Pfs 25, designated region I, showed evidence of variable reactivity with MAbs among different isolates; the Pfs 25 epitope, region II, was universally recognized by MAbs in all isolates. Two apparently distinct epitope regions of Pfs 230 were defined by MAbs, one of which was universally recognized by MAbs among the 45 isolates; the other was conserved in all but three isolates. The epitope regions of gamete-surface protein Pfs 48/45, designated regions I, IIa, IIb, IIc, III, and IV, were examined for reactivity by IFA in 33 isolates. Epitope regions I, IIb, III, and IV were conserved in all isolates; regions IIa and IIc existed in variant forms.