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  1. Izawa KP, Oka K
    Rev Recent Clin Trials, 2020 5 26;15(3):214-218.
    PMID: 32448105 DOI: 10.2174/1574887115666200524235754
    BACKGROUND: The purpose of the present study was to clarify the differences in social demographic factors and sedentary behavior by gender in Japanese living overseas in Malaysia.

    METHODS: First, 130 subjects were surveyed by self-entry questionnaire for statistical factors related to social demographics and sedentary behavior. These factors were age (years), gender (man/woman), body mass index (BMI, kg/m2), educational history (>13 years, %), employment (full-time or part-time, yes, %), alcohol intake (a certain amount, yes, %), smoking behavior (yes, %), and marital status (yes, %). BMI, as obtained from the participants' weight and height, was collected from the self-reported questionnaire and assessed. Sitting behavior time as an index of sedentary behavior on workdays, non-workdays, and total time was identified by questionnaire. Data were analyzed using the chi square-test and t-test, respectively. The criterion for a statistically significant difference was p < 0.05.

    RESULTS: Finally, 107 subjects (68 men, 39 women) were analyzed. The ratios of social demographic factors of the men versus women group were age (58.5 ± 14.7 vs. 61.0 ± 12.1 years, p = 0.36), BMI (23.1 ± 2.6 vs. 21.8 ± 2.6 kg/m2, p = 0.01), educational history (86.7% vs. 56.4%, p < 0.001), employment (51.5% vs. 10.3%, p <0.001), alcohol intake (86.7% vs. 35.9%, p < 0.001), smoking behavior (30.9% vs. 10.3%, p = 0.01), and marital status (88.2% vs. 100%, p = 0.02). Sitting behavior time was 501.8 ± 254.6 vs. 346.0 ± 153.4 minutes (p < 0.001) on workdays, 415.1 ± 225.3 vs. 320.6 ± 178.7 minutes (p = 0.019) on non-workdays, and 458.5 ± 203.9 vs. 333.3 ± 132.1 minutes (p < 0.001) in total.

    CONCLUSION: These findings indicated that social demographic factors and sitting behavior time differed by gender. However, there are some limitations. This was a cross-sectional study conducted in only one city with a small number of participants who completed a self-entry questionnaire. In conclusion, assessment of the differences in social demographic factors and postponement of sedentary behavior for both genders may reduce sitting behavior time in overseas Japanese residents and may help in developing public health strategies.

  2. Izawa KP, Oka K
    Gerontol Geriatr Med, 2018 10 25;4:2333721418808117.
    PMID: 30386811 DOI: 10.1177/2333721418808117
    This study aimed to determine differences in sitting behavior time (SBT) and health-related quality of life (HRQOL) based on application of the transtheoretical model (TTM) to exercise behavior in overseas-dwelling Japanese. SBT, HRQOL, and various sociodemographic factors were measured in 108 Japanese living in Ipoh, Malaysia. Subjects were classified into the non-exercise (NE), preparation (P), and exercise (E) groups. Workday, non-workday, and total-day SBTs were identified by self-reported questionnaire. The mental component summary (MCS) score for HRQOL was also assessed with the Medical Outcome Study 36-Item Short Form Health Survey (Japanese version). Differences in SBTs and HRQOL based on the TTM were calculated by one-way analysis of variance (ANOVA). After adjusting for sociodemographic factors, there were differences in workday (F = 8.19, p < .001), non-workday (F = 5.96, p = .001), and total-day (F = 9.30, p < .001) SBTs and MCS scores (F = 10.29, p < .001). Non-workday (338.6 ± 210.8 vs. 510.5 ± 213.4 min, p < .05) and total-day (376.8 ± 181.1 vs. 511.8 ± 183.3 min, p < .05) SBTs were lower and the MCS score (53.9 ± 9.5 vs. 48.4 ± 9.6, p < .05) for HRQOL was higher in the E group versus P group. These differences in SBT and HRQOL in relation to exercise behavior indicate that promotion of exercise behavior may be an important public health strategy to reduce SBT and increase HRQOL in overseas-dwelling Japanese.
  3. Izawa KP, Oka K
    Rev Recent Clin Trials, 2022;17(2):120-125.
    PMID: 35289254 DOI: 10.2174/1574887117666220314112244
    BACKGROUND: Recently, the number of Japanese people living in Asia has increased. A previous study suggested that obesity and overweight are growing health problems both in Malaysia and worldwide that result from lifestyle changes such as a decrease in physical activity, an increase in sedentary behaviour, and poor eating habits.

    OBJECTIVE: The purpose of the present study was to investigate the effects of differences in social demographic factors and domain-specific sedentary behaviour and health-related quality of life by age in Japanese living overseas.

    METHODS: We surveyed 109 participants by self-entry questionnaire for social demographic factors and domain-specific sedentary behaviour by life scenario and by Short Form-36 (SF-36) for healthrelated quality of life. The subjects were divided into the ≥65 years group and <65 years group.

    RESULTS: Significant differences were noted in age, employment, alcohol intake, and marital status between the groups, whereas none were noted for transportation, driving, television viewing, and smartphone/personal computer use. Work time and total sitting time of sedentary behaviour were higher, and leisure-time activity and SF-36 Mental Component Score for health-related quality of life were lower in the <65 years group.

    CONCLUSION: By assessing differences in social demographic factors and discouraging sedentary behaviour, sitting time in overseas-dwelling Japanese residents may be reduced, and effective strategies to improve health-related quality of life can be developed to combat such behaviour.

  4. Phung VLH, Oka K, Honda Y, Hijioka Y, Ueda K, Seposo XT, et al.
    Environ Res, 2023 Feb 01;218:114988.
    PMID: 36463996 DOI: 10.1016/j.envres.2022.114988
    BACKGROUND: Climate change and its subsequent effects on temperature have raised global public health concerns. Although numerous epidemiological studies have shown the adverse health effects of temperature, the association remains unclear for children aged below five years old and those in tropical climate regions.

    METHODS: We conducted a two-stage time-stratified case-crossover study to examine the association between temperature and under-five mortality, spanning the period from 2014 to 2018 across all six regions in Malaysia. In the first stage, we estimated region-specific temperature-mortality associations using a conditional Poisson regression and distributed lag nonlinear models. We used a multivariate meta-regression model to pool the region-specific estimates and examine the potential role of local characteristics in the association, which includes geographical information, demographics, socioeconomic status, long-term temperature metrics, and healthcare access by region.

    RESULTS: Temperature in Malaysia ranged from 22 °C to 31 °C, with a mean of 27.6 °C. No clear seasonality was observed in under-five mortality. We found no strong evidence of the association between temperature and under-five mortality, with an "M-" shaped exposure-response curve. The minimum mortality temperature (MMT) was identified at 27.1 °C. Among several local characteristics, only education level and hospital bed rates reduced the residual heterogeneity in the association. However, effect modification by these variables were not significant.

    CONCLUSION: This study suggests a null association between temperature and under-five mortality in Malaysia, which has a tropical climate. The "M-" shaped pattern suggests that under-fives may be vulnerable to temperature changes, even with a small temperature change in reference to the MMT. However, the weak risks with a large uncertainty at extreme temperatures remained inconclusive. Potential roles of education level and hospital bed rate were statistically inconclusive.

  5. Kusamoto A, Harada M, Minemura A, Matsumoto A, Oka K, Takahashi M, et al.
    Front Cell Dev Biol, 2024;12:1365624.
    PMID: 38590777 DOI: 10.3389/fcell.2024.1365624
    The gut microbiome is implicated in the pathogenesis of polycystic ovary syndrome (PCOS), and prenatal androgen exposure is involved in the development of PCOS in later life. Our previous study of a mouse model of PCOS induced by prenatal dihydrotestosterone (DHT) exposure showed that the reproductive phenotype of PCOS appears from puberty, followed by the appearance of the metabolic phenotype after young adulthood, while changes in the gut microbiota was already apparent before puberty. To determine whether the prenatal or postnatal nurturing environment primarily contributes to these changes that characterize prenatally androgenized (PNA) offspring, we used a cross-fostering model to evaluate the effects of changes in the postnatal early-life environment of PNA offspring on the development of PCOS-like phenotypes and alterations in the gut microbiota in later life. Female PNA offspring fostered by normal dams (exposed to an abnormal prenatal environment only, fostered PNA) exhibited less marked PCOS-like phenotypes than PNA offspring, especially with respect to the metabolic phenotype. The gut microbiota of the fostered PNA offspring was similar to that of controls before adolescence, but differences between the fostered PNA and control groups became apparent after young adulthood. In conclusion, both prenatal androgen exposure and the postnatal early-life environment created by the DHT injection of mothers contribute to the development of PCOS-like phenotypes and the alterations in the gut microbiota that characterize PNA offspring. Thus, both the pre- and postnatal environments represent targets for the prevention of PCOS and the associated alteration in the gut microbiota in later life.
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