A regression analysis was conducted to assess the link between resilience, supervisor support, family and friend support, psychological empowerment, and facilitating conditions with work engagement using the Statistical Package of Social Sciences (SPSS) 26. This data was obtained from a cross-sectional survey of 259 knowledge workers in Malaysia. Specifically, this article provides data about the participants' demographic characteristics and the descriptive data of participants' responses. Further, the mean, standard deviation, reliability of the measured constructs, and regression analysis model summary are provided. This dataset offers suggestions to the top management in deducing ways to increase employees' work engagement during the COVID-19 pandemic.