PET/CT Scan with obGa-labelled analogs is of increasing interest in Nuclear Medicine and currently
is being performed all over the world. However, such labeling procedure requires high purity and
concentrated solutions of°sGa. Here we report the purification and concentration of the eluate of
SnOi-Based obGe/obGa generators via the anion exchange method. Three different anion columns were
selected to purify and concentrate the6SGa eluat.es which are Chromafix, Oasis WAX and AG 1-X8
columns. The different anion columns were compared and evaluated in terms of their capability in
adsorption and desorption of ""Ga from, the generator. While the optimum molarity of Hydrocholric
Acid (HCl) for highest 6dGa retention was also determined starting from the ranges of fM to 7M of
HCl. The results showed that the percentage of 68Ga retention or adsorption .started to be plateau at
molarity of 5.5M for all three anion cartridges. One-way ANOVA analysis proved that there is no
significant difference between 5.5M with 6.0M, 6.5M and 7.0M which means that the retention of
gallium-68 is equal at those molarities. At 5.5M, Chromafix and Oasis WAX cartridges showed the
highest retention of gallium-68 which is 98.30%. The lowest 6"Ga retention was gained by AG 1-X8
column which is 97.07%'. While for desorption of 6bGa, the highest percentage was obtained by using
Oasis WAX cart/ridges which, is 70.f9% followed by Chromafix which, is 70.36%. The lowest desorption
of gallium-68 was obtained by using AG 1-X8 column which is only 58.56%. Therefore, from this
study, the most suitable cartridge and HCl molarity that should be applied in purification and
concentration of Gallium-68 eluate fromÿ a SnOs Based °*Ge/*Ga generator is Oasis® WAX column
with a HCl molarity of 5.5M respectively.