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Fulltext Is Ebola a sexually transmitted disease? Implication of Ebola RNA persistence in the semen

Sulaiman WAW, Mat LNI, Hoo FK, Mohamed MH, Lim SMS

J Infect Public Health, 2017 07 27;11(2):299.
PMID: 28757292 DOI: 10.1016/j.jiph.2017.07.015
Fulltext Incomplete anterior choroidal artery syndrome in a pregnant female

Mat LNI, Sulaiman WAW, Hoo FK, Apandi LMA, Basri H

Ci Ji Yi Xue Za Zhi, 2019 09 16;31(4):292-293.
PMID: 31867263 DOI: 10.4103/tcmj.tcmj_20_19
Association of GCK (rs1799884), GCKR (rs780094), and G6PC2 (rs560887) Gene Polymorphisms with Type 2 Diabetes among Malay Ethnics

Ansari N, Ramachandran V, Mohamad NA, Salim E, Ismail P, Hazmi M, et al.

Glob Med Genet, 2023 Jan;10(1):12-18.
PMID: 36703777 DOI: 10.1055/s-0042-1760384

Background Type 2 diabetes mellitus (T2DM) is a complex metabolic disorder, and the underlying causes remain unknown and have not been fully elucidated. Several candidate genes have been associated with T2DM in various populations with conflicting results. The variations found in glucokinase ( GCK ), glucokinase regulatory protein ( GCKR ), and glucose-6-phosphatase 2 ( G6PC2 ) genes were not well studied, particularly among Asians. Aims The main objective of this study was to determine the candidate genetic polymorphisms of GCK (rs1799884), GCKR (rs780094), and G6PC2 (rs560887) genes in T2DM among Malay ethnics. Methods In this candidate gene association study, a total of 180 T2DM subjects and 180 control subjects were recruited to determine the genotypes using polymerase chain reaction-restriction fragment length polymorphism and Taqman probe assay methods. Genotype and allele frequencies in case and control samples were compared using the chi-squared test to determine a significant difference. Results The body mass index, fasting blood glucose, hemoglobin A1c, systolic and diastolic blood pressure, and total cholesterol were significantly different ( p
Fulltext Prevalence and Factor Associated with Anti-N-Methyl-D-Aspartate Receptor Encephalitis Among Patients with Medical Conditions: A Systematic Review and Meta-Analysis

Lee KW, Khan AHKY, Ching SM, Kumar SJ, Raj CLVP, Chia PK, et al.

Neurol India, 2024 May 01;72(3):476-486.
PMID: 39041960 DOI: 10.4103/neuroindia.NI_981_20

BACKGROUND: Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis is a severe autoimmune encephalitis due to immune production of anti-NMDAR antibodies against the NR1 subunit of the NMDA receptor which is present throughout the central nervous system. This condition had been reported to be prevalent in patients with certain medical conditions; however so far, there have been limited systematic reviews and meta-analyses on the prevalence and factors associated.
OBJECTIVE: This study was to determine the prevalence and factors associated with anti-NMDAR encephalitis among affected patients.
MATERIAL AND METHODS: The protocol of this study has been registered (2019: CRD42019142002) with the International Prospective Register of Systematic Reviews (PROSPERO). The primary outcome was the incidence or prevalence of anti-NMDAR encephalitis and secondary outcomes were factors associated with anti-NMDAR encephalitis.
RESULTS: There were 11 studies and a total of 873 million patients taken from high-risk populations across 11 countries that were included in the primary analysis. The overall pooled prevalence of anti-NMDAR encephalitis among patients with medical conditions was 7.0% (95% CI = 4.4, 9.6). Those with first episode of psychosis or schizophrenia were at a higher risk of developing anti-NMDAR encephalitis with an odds ratio of 5.976 (95% CI = 1.122, 31.825).
CONCLUSION: We found that almost one-tenth of patients with medical conditions had anti-NMDAR encephalitis; particularly those with first episode of psychosis or schizophrenia were among the high-risk medical conditions.