MyMedR

Displaying all 2 publications

Abstract:

Sort:

Fulltext In-vitro comparative study of marginal leakage and penetration ability of moisture-tolerant and conventional resin-based pit and fissure sealants with different surface preparations

Thavamalar Marimuthoo, Nor Atika Md Asfar, Mariati Abd. Rahman, S. Nagarajan M.P. Sockalingam

Archives of Orofacial Sciences, 2017;12(1):12-22.
MyJurnal

This in-vitro study aimed to evaluate and compare the marginal leakage and penetration ability of
a moisture-tolerant (Embrace WetBondTM) and a conventional (ClinproTM) resin-based sealants under three
different enamel surface preparations (acid etched, acid etched and saliva contaminated and bur
preparation and acid etched). One hundred and twenty extracted caries free human premolars teeth were
cleaned and randomly divided into six groups of equal numbers, according to the type of sealants used and
surface preparations. All the sealed teeth were subjected to thermocycling and immersed in a methylene
blue dye. Each tooth was then embedded into acrylic resin before it was sectioned into four sections per
tooth. Marginal leakage and unfilled surface area (indicating penetration depth of resin) were then
measured using an optical 3D measurement device (Alicona Infinite Focus®). Both sealants exhibited
comparable proportion of marginal leakage on acid etched only surfaces. Moisture-tolerant sealant showed
the least proportion of marginal leakage on bur prepared and etched surfaces. Presence of saliva has
detrimental effect on adhesion of both sealants. Nevertheless, depth of penetration of sealant into the
fissures is comparable with both sealant types irrespective of the surface preparations.
Aqueous calyxes extract of Roselle or Hibiscus sabdariffa Linn supplementation improves liver morphology in streptozotocin induced diabetic rats

Nazratun Nafizah AH, Budin SB, Zaryantey AH, Mariati AR, Santhana RL, Osman M, et al.

Arab J Gastroenterol, 2017 Mar;18(1):13-20.
PMID: 28336227 DOI: 10.1016/j.ajg.2017.02.001

BACKGROUND AND STUDY AIMS: The complex series of deleterious events among diabetes patients leads to multiple organ failure. Therefore, a holistic approach of treatment is urgently required to prevent worsening of complications. The present investigation was carried out to study the possible protective effects of Roselle or Hibiscus sabdariffa Linn (HSL) calyxes aqueous extract, as an antidiabetic and antioxidant agent against oxidative liver injury in streptozotocin-induced diabetic rats.
MATERIAL AND METHODS: A single dose of streptozotocin (45mg/kg body weight, iv) was used to induced diabetes in male Sprague Dawley rats which were then divided into two groups: Diabetic control (DC) and HSL-treated diabetic (DR) group. Normal rats were divided into normal control (NC), HSL-treated control (NR). Aqueous calyxes extract of HSL (100mg/kg/day, orally) was given for 28 consecutive days in the treated group. Weight, biochemical and histopathological (light and electron microscopic) parameters were compared in all groups.
RESULTS: Supplementation of HSL significantly lowered the level of fasting blood glucose and increased plasma insulin level in DR group compared to DC group (p<0.05). Alanine aminotransaminases and aspartate aminotransferase enzymes level were found to be significantly reduced in DR compared to DC. Microscopic examination demonstrated destruction of the liver architecture, cytoplasmic vacuolation of the hepatocytes and signs of necrosis in diabetic rats. Moreover, dilatation and congestion of blood vessels with leucocytes adherence were detected. Ultrastructural study using electron microscope showed homogeneous substance accumulation in nuclear chromatin, a decrease of organelles and mitochondrial degeneration in the diabetic rats.
CONCLUSION: Administration of HSL in diabetic rats causes significant decrease in hepatocyte destruction and prevented the changes associated with the diabetic condition. Thus, our findings provide a scientific rationale for the use of HSL as promising agent in preventing liver injury in diabetes.

Filters

Please provide feedback to Administrator ([email protected])

External Links