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Earlier onset of motor complications in Parkinson's patients with comorbid diabetes mellitus

Mohamed Ibrahim N, Ramli R, Koya Kutty S, Shah SA

Mov Disord, 2018 12;33(12):1967-1968.
PMID: 30427552 DOI: 10.1002/mds.27526
Adsorption kinetics of colour removal from palm oil mill effluent using wastewater sludge carbon in column studies

Kutty SRM, Almahbashi NMY, Nazrin AAM, Malek MA, Noor A, Baloo L, et al.

Heliyon, 2019 Oct;5(10):e02439.
PMID: 31667371 DOI: 10.1016/j.heliyon.2019.e02439

Treated palm oil mill effluents (POME) is of great concern as it still has colour from its dissolved organics which may pollute receiving water bodies. In this study, the removal of colour from treated palm oil mill effluent were investigated through adsorption studies using carbon derived from wastewater sludge (WSC). Sludge from activated sludge plants were dried and processed to produce WSC. In this study, three different bed depths of WSC were used: 5 cm, 10 cm, and 15 cm. For each bed depth, the flowrate was varied at three different values: 100 mL/hr, 50 mL/hr and 25 mL/hr. It was found that at bed depth of 5 cm, the breakthrough curves were occurred at 360 min, 150 min and 15 min for flowrates of 25, 50 and 100 mL/hr respectively. It was observed that at a particular depth the exhaustion time for column reduced as flow rate increases. Kinetic models, Adams-Bohart and Yoon-Nelson were used to analyze the performance of the adsorption. It was found that rate constant for Adams Bohart model decreased with the increase in bed depth. Adsorption capacity obtained from Adams-Bohart model ranged from 2676.19 mg/L up to 8938.78 mg/L. The maximum adsorption capacity increases with smaller bed depth. For Yoon-Nelson model, the rate constant decreases with increase in bed depth. The required time for 50% breakthrough obtained from the models ranged from 17.01 to 104.17 minutes for all three bed depths. The reduction of colour was found to be effective at all bed depths. The experimental data was best described by both models as with higher values of correlation coefficient (R2).
Huntington disease-like phenotype in a patient with ANO3 mutation

Koya Kutty S, Mulroy E, Magrinelli F, Di Lazzaro G, Latorre A, Bhatia KP

Parkinsonism Relat Disord, 2021 09;90:120-122.
PMID: 33640251 DOI: 10.1016/j.parkreldis.2021.02.022
Fulltext Late-Onset Chorea in JAK2-Associated Essential Thrombocythemia

Koya Kutty S, Di Lazzaro G, Magrinelli F, Mulroy E, Latorre A, Bhatia KP

Mov Disord Clin Pract, 2021 Jan;8(1):145-148.
PMID: 33426172 DOI: 10.1002/mdc3.13105
Sequencing batch reactor technology for landfill leachate treatment: A state-of-the-art review

Jagaba AH, Kutty SRM, Lawal IM, Abubakar S, Hassan I, Zubairu I, et al.

J Environ Manage, 2021 Mar 15;282:111946.
PMID: 33486234 DOI: 10.1016/j.jenvman.2021.111946

Landfill has become an underlying source of surface and groundwater pollution if not efficiently managed, due to the risk of leachate infiltration into to land and aquifers. The generated leachate is considered a serious environmental threat for the public health, because of the toxic and recalcitrant nature of its constituents. Thus, it must be collected and appropriately treated before being discharged into the environment. At present, there is no single unit process available for proper leachate treatment as conventional wastewater treatment processes cannot achieve a satisfactory level for degrading toxic substances present. Therefore, there is a growing interest in examination of different leachate treatment processes for maximum operational flexibility. Based on leachate characteristics, discharge requirements, technical possibilities, regulatory requirements and financial considerations, several techniques have been applied for its degradation, presenting varying degrees of efficiency. Therefore, this article presents a comprehensive review of existing research articles on the pros and cons of various leachate degradation methods. In line with environmental sustainability, the article stressed on the application and efficiency of sequencing batch reactor (SBR) system treating landfill leachate due to its operational flexibility, resistance to shock loads and high biomass retention. Contributions of integrated leachate treatment technologies with SBR were also discussed. The article further analyzed the effect of different adopted materials, processes, strategies and configurations on leachate treatment. Environmental and operational parameters that affect SBR system were critically discussed. It is believed that information contained in this review will increase readers fundamental knowledge, guide future researchers and be incorporated into future works on experimentally-based SBR studies for leachate treatment.
Anatomical Classification and Posttreatment Remodeling Characteristics to Guide Management and Follow-Up of Neonates and Infants With Coronary Artery Fistula: A Multicenter Study From the Coronary Artery Fistula Registry

Gowda ST, Latson L, Sivakumar K, Hiremath G, Crystal M, Law M, et al.

Circ Cardiovasc Interv, 2021 12;14(12):e009750.
PMID: 34903033 DOI: 10.1161/CIRCINTERVENTIONS.120.009750

BACKGROUND: Coronary artery fistulas (CAFs) presenting in infancy are rare, and data regarding postclosure sequelae and follow-up are limited.
METHODS: A retrospective review of all the neonates and infants (<1 year) was conducted from the CAF registry for CAF treatment. The CAF type (proximal or distal), size, treatment method, and follow-up angiography were reviewed to assess outcomes and coronary remodeling.
RESULTS: Forty-eight patients were included from 20 centers. Of these, 30 were proximal and 18 had distal CAF; 39 were large, 7 medium, and 2 had small CAF. The median age and weight was 0.16 years (0.01-1) and 4.2 kg (1.7-10.6). Heart failure was noted in 28 of 48 (58%) patients. Transcatheter closure was performed in 24, surgical closure in 18, and 6 were observed medically. Procedural success was 92% and 94 % for transcatheter closure and surgical closure, respectively. Follow-up data were obtained in 34 of 48 (70%) at a median of 2.9 (0.1-18) years. Angiography to assess remodeling was available in 20 of 48 (41%). I. Optimal remodeling (n=10, 7 proximal and 3 distal CAF). II. Suboptimal remodeling (n=7) included (A) symptomatic coronary thrombosis (n=2, distal CAF), (B) asymptomatic coronary thrombosis (n=3, 1 proximal and 2 distal CAF), and (C) partial thrombosis with residual cul-de-sac (n=1, proximal CAF) and vessel irregularity with stenosis (n=1, distal CAF). Finally, (III) persistent coronary artery dilation (n=4). Antiplatelets and anticoagulation were used in 31 and 7 patients post-closure, respectively. Overall, 7 of 10 (70%) with proximal CAF had optimal remodeling, but 5 of 11 (45%) with distal CAF had suboptimal remodeling. Only 1 of 7 patients with suboptimal remodeling were on anticoagulation.
CONCLUSIONS: Neonates/infants with hemodynamically significant CAF can be treated by transcatheter or surgical closure with excellent procedural success. Patients with distal CAF are at higher risk for suboptimal remodeling. Postclosure anticoagulation and follow-up coronary anatomic evaluation are warranted.