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Preliminary safety evaluation and biochemical efficacy of a Carum carvi extract: results from a randomized, triple-blind, and placebo-controlled clinical trial

Kazemipoor M, Radzi CW, Hajifaraji M, Cordell GA

Phytother Res, 2014 Oct;28(10):1456-60.
PMID: 24638976 DOI: 10.1002/ptr.5147

Carum carvi L. (Apiaceae) is known as caraway, and its derivatives find wide medicinal use for health purposes, including for gastrointestinal problems and obesity. Since there is inconsistency among the reports on the safety of this plant in humans, this research was aimed at assessing the safety of a characterized caraway aqueous extract (CAE) in a randomized, triple-blind, placebo-controlled study. Seventy, overweight and obese, healthy women were randomly assigned into placebo (n = 35) and plant extract (n = 35) groups. Participants received either 30 ml/day of CAE or placebo. Subjects were examined at baseline and after 12 weeks for changes in heart rate, blood pressure, urine test, 25-item blood chemistries, and general health status. No significant changes of blood pressure, heart rate, urine specific gravity, and serum blood tests were observed between the two groups before and after treatment. However, in the complete blood count test, red blood cell levels were significantly (p
Computational Intelligence Techniques for Assessing Anthropometric Indices Changes in Female Athletes

Kazemipoor M, Rezaeian M, Kazemipoor M, Hamzah S, Shandilya SK

Curr Med Imaging, 2020;16(4):288-295.
PMID: 32410532 DOI: 10.2174/1573405614666180905111814

BACKGROUND: Physical characteristics including body size and configuration, are considered as one of the key influences on the optimum performance in athletes. Despite several analyzing methods for modeling the slimming estimation in terms of reduction in anthropometric indices, there are still weaknesses of these models such as being very demanding including time taken for analysis and accuracy.
OBJECTIVES: This research proposes a novel approach for determining the slimming effect of a herbal composition as a natural medicine for weight loss.
METHODS: To build an effective prediction model, a modern hybrid approach, merging adaptivenetwork- based fuzzy inference system and particle swarm optimization (ANFIS-PSO) was constructed for prediction of changes in anthropometric indices including waist circumference, waist to hip ratio, thigh circumference and mid-upper arm circumference, on female athletes after consumption of caraway extract during ninety days clinical trial.
RESULTS: The outcomes showed that caraway extract intake was effective on lowering all anthropometric indices in female athletes after ninety days trial. The results of analysis by ANFIS-PSO was more accurate compared to SPSS. Also, the efficiency of the proposed approach was confirmed using the existing data.
CONCLUSION: It is concluded that a development in predictive accuracy and simplification capability could be attained by hybrid adaptive neuro-fuzzy techniques as modern approaches in detecting changes in body characteristics. These developed techniques could be more useful and valid than other conventional analytical methods for clinical applications.
Appraisal of adaptive neuro-fuzzy computing technique for estimating anti-obesity properties of a medicinal plant

Kazemipoor M, Hajifaraji M, Radzi CW, Shamshirband S, Petković D, Mat Kiah ML

Comput Methods Programs Biomed, 2015 Jan;118(1):69-76.
PMID: 25453384 DOI: 10.1016/j.cmpb.2014.10.006

This research examines the precision of an adaptive neuro-fuzzy computing technique in estimating the anti-obesity property of a potent medicinal plant in a clinical dietary intervention. Even though a number of mathematical functions such as SPSS analysis have been proposed for modeling the anti-obesity properties estimation in terms of reduction in body mass index (BMI), body fat percentage, and body weight loss, there are still disadvantages of the models like very demanding in terms of calculation time. Since it is a very crucial problem, in this paper a process was constructed which simulates the anti-obesity activities of caraway (Carum carvi) a traditional medicine on obese women with adaptive neuro-fuzzy inference (ANFIS) method. The ANFIS results are compared with the support vector regression (SVR) results using root-mean-square error (RMSE) and coefficient of determination (R(2)). The experimental results show that an improvement in predictive accuracy and capability of generalization can be achieved by the ANFIS approach. The following statistical characteristics are obtained for BMI loss estimation: RMSE=0.032118 and R(2)=0.9964 in ANFIS testing and RMSE=0.47287 and R(2)=0.361 in SVR testing. For fat loss estimation: RMSE=0.23787 and R(2)=0.8599 in ANFIS testing and RMSE=0.32822 and R(2)=0.7814 in SVR testing. For weight loss estimation: RMSE=0.00000035601 and R(2)=1 in ANFIS testing and RMSE=0.17192 and R(2)=0.6607 in SVR testing. Because of that, it can be applied for practical purposes.
Slimming and Appetite-Suppressing Effects of Caraway Aqueous Extract as a Natural Therapy in Physically Active Women

Kazemipoor M, Hamzah S, Hajifaraji M, Radzi CW, Cordell GA

Phytother Res, 2016 Jun;30(6):981-7.
PMID: 26988309 DOI: 10.1002/ptr.5603

Following the current 'Globesity' trend, there is an increasing demand for alternative natural therapies for weight management. Numerous phytoconstituents reduce body weight through suppressing appetite and reducing food intake. Caraway (Carum carvi L.) is one of the medicinal plants that is traditionally used for weight loss. In this study, the appetite-suppressing effects of caraway aqueous extract (CAE) on 70 aerobically trained, overweight, and obese women were examined in a triple-blind, placebo-controlled, clinical study. Subjects were randomly allocated into placebo and experimental groups and consumed either 30 mL/day of CAE or placebo without changing their diet or physical activity over a period of 90 days. Calorie and macronutrient intake and anthropometric indices were measured before and after the intervention. In addition, appetite changes were assessed through a visual analog scale and an ad libitum pizza test. After the intervention, the results showed a significant reduction in appetite levels and carbohydrate intake of the experimental group compared with the placebo group. All of the anthropometric indices were reduced significantly in CAE compared with placebo group (p
Fulltext Antiobesity effect of caraway extract on overweight and obese women: a randomized, triple-blind, placebo-controlled clinical trial

Kazemipoor M, Radzi CW, Hajifaraji M, Haerian BS, Mosaddegh MH, Cordell GA

Evid Based Complement Alternat Med, 2013;2013:928582.
PMID: 24319489 DOI: 10.1155/2013/928582

Caraway (Carum carvi L.), a potent medicinal plant, is traditionally used for treating obesity. This study investigates the weight-lowering effects of caraway extract (CE) on physically active, overweight and obese women through a randomized, triple-blind, placebo-controlled clinical trial. Seventy overweight and obese, healthy, aerobic-trained, adult females were randomly assigned to two groups (n = 35 per group). Participants received either 30 mL/day of CE or placebo without changing their diet or physical activity. Subjects were examined at baseline and after 90 days for changes in body composition, anthropometric indices, and clinical and paraclinical variables. The treatment group, compared with placebo, showed a significant reduction of weight, body mass index, body fat percentage, and waist-to-hip ratio. No changes were observed in lipid profile, urine-specific gravity, and blood pressure of subjects. The results suggest that a dietary CE with no restriction in food intake, when combined with exercise, is of value in the management of obesity in women wishing to lower their weight, BMI, body fat percentage, and body size, with no clinical side effects. In conclusion, results of this study suggest a possible phytotherapeutic approach for caraway extract in the management of obesity. This trial is registered with NCT01833377.