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Fulltext Radioiodine ablation in postpartum patient with differentiated thyroid cancer: a case report and review of literature

Zaid, Z. A., Fadzilah, H., Ali, A. K. M.

Asian Journal of Medicine and Health Sciences, 2018;1(1):2-6.
MyJurnal

Well differentiated thyroid carcinoma is the most commonly seen thyroid cancer. One of
the presenting symptoms is thyroid nodule. In most cases following initial workup and
whereby tumour is resectable, surgery is the mainstay of treatment. The subsequent
postsurgical management utilising radionuclide Iodine-131 (I-131) has long been
established and extensively being studied and discussed. This present case report
illustrates the general overview of differentiated thyroid cancer (DTC) as well as the
concerns related to radioiodine ablation in a postpartum patient with DTC.
Assessing bone marrow involvement in diffuse large B-cell lymphoma with 18F-FDG PET/CT: A preliminary experience at Hospital Pulau Pinang

Siti Maisarah MN, Mahayuddin AM, Fadzilah H

Med J Malaysia, 2021 09;76(5):665-671.
PMID: 34508372

BACKGROUND: Bone marrow biopsy (BMB) is the standard of care for detecting bone marrow involvement (BMI) in newly diagnosed diffuse large B-cell lymphoma (DLBCL). The role of 18F-FDG PET/CT has been explored as a non-invasive method for detecting BMI in newly diagnosed DLBCL. Due to limited evidence, this method has not been adopted as a mainstream investigation for BMI in Malaysia. The aim of this study was to identify the role of 18F-FDG PET/CT for the detection of BMI in newly diagnosed DLBCL patients at Hospital Pulau Pinang (HPP).
METHODS: DLBCL patients at HPP who underwent 18F-FDG PET/CT and BMB were recruited between November 2016 to February 2018. Two reviewers, blinded to the BMB results, evaluated the 18F-FDG PET/CT scans to identify and characterize BMI. The diagnostic performance of 18F-FDG PET/CT was calculated using the BMB histopathological evaluation as the reference standard.
RESULTS: A total of 21 DLBCL patients were enrolled. Seven patients demonstrated BMI on PET/CT (3 with multifocal uptake were concordant with BMB). Fourteen scans were negative for BMI and concordant with BMB. The sensitivity and specificity of 18F-FDG PET/CT scans for detecting BMI is 100% and 77.8%, respectively.
CONCLUSION: 18F-FDG PET/CT is excellent for ruling-out the presence of BMI. A negative 18F-FDG PET/CT scan for BMI can preclude the need for BMB in certain cases. Although 18F-FDG PET/CT can accurately detect BMI in multifocal pattern of infiltration, it cannot fully replace BMB, which is still considered as the gold standard for evaluating BMI in DLBCL.
Does abuse in late life worsen sleep quality? A two-year prospective cohort study among rural older adults

Yunus RM, Hairi NN, Yuen C, Sooryanarayana R, Hairi F, Ismail N, et al.

Int J Geriatr Psychiatry, 2019 01;34(1):60-66.
PMID: 30230023 DOI: 10.1002/gps.4986

BACKGROUND: Elder abuse and neglect (EAN) is a growing public health problem, and numerous adverse health effects of abuse in late life have been documented. Little is known, however, about the impact of elder abuse on sleep quality. This study examines the longitudinal relationship between EAN and sleep quality.

METHODS: This was a 2-year prospective cohort study involving 1927 older adults in a rural Malaysian district, Kuala Pilah. A multi-stage cluster sampling strategy was employed. After 2 years, 1189 respondents were re-assessed. EAN was determined using the modified Conflict Tactic Scale, while sleep quality was measured using the Pittsburgh Sleep Quality Index (PSQI).

RESULTS: The prevalence of elder abuse was 8.1% (95% CI:6.9,9.3). Longitudinal analysis using generalized estimating equations showed that elder abuse contributed to higher PSQI scores (B:0.49, 95% CI:0.17,0.58). Sub-analyses demonstrated that psychological abuse and neglect had significant longitudinal relationships with increase of PSQI scores, while other subtypes did not.

CONCLUSION: Abuse in late life, particularly psychological abuse and neglect, result in greater PSQI scores. Even though this may imply decline in sleep quality, our findings were not considered clinically significant as they did not exceed the clinical cut-off score of five. Nevertheless, sleep quality is an important determinant of health and a predictor of mortality among older adults; thus, understanding its relationship with abuse is useful to health care providers and policy-makers in improving health services and upgrading preventive measures.

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