The COVID-19 outbreak was declared a pandemic by the World Health Organization in March 2020 due to rapid intercontinental spread and high morbidity and mortality. Globally, the disease has had a major impact on human lives, including health, economic, employment, psychological, and overall well-being. The COVID-19, besides causing respiratory, neurological, and cardiovascular diseases, has had significant impact on mental health. Major mental health disorders, including depression, anxiety, and stress, have risen in parallel with increasing prevalence of COVID-19. Many population groups, including children, the elderly, those with chronic illnesses, and health care workers, have been affected. This review gives an overall assessment of the prevalence of COVID-19-associated psychological morbidity. In countries in the Asia-Pacific region, prevalence of depression ranged between 4.9% and 43.1%, anxiety from 7.0% to 43.0%, and stress from 3.4% to 35.7%. As COVID-19 continues to severely affect the psychosocial well-being of the population at large, countries have developed and revised policies, guidelines, and introduced new initiatives to curb mental health issues among their citizens. In the long run, pre-disaster preparedness is important to alleviate long-term post-pandemic psychiatric morbidity and to develop psychological resilience toward disasters and pandemic, alongside investment for better mental health coverage.
Synthesis of carboxymethylcellulose (CMC) from natural cellulose is an important industrial process. The effect of process parameters on the synthesis process is important information for the efficiency improvement of production process. Most of the previous studies on the effect of process parameters
on the synthesis of CMC are based on the One-Factor-At-Time (OFAT); therefore, in this work, the response surface methodology (RSM) was used. Here, the cellulose was converted to CMC through
carboxymethylation process using a technique of William etherification in heterogeneous system. The process parameters studied include the solvent ratio, reaction temperature and reactant ratio (molar ratio of NaOH to SMCA). Meanwhile, the analysis and optimization of the responses of the process, degree of substitution (DS) and yield were also performed using the response surface methodology. The validity of the synthesis process was identified by the determination of CMC spectrum using the fast Fourier infrared spectrometer (FTIR). The analysis of the results shows that carboxymethylation is strongly affected by combination of process parameters studied. The results obtained also show that the optimum responses, degree of substitution (DS) is 0.87 and yield is 1.80, whereas the optimum process parameters, solvent ratio is 0.70v/v, reaction temperature at 56.03oC, and molar ratio of NaOH to SMCA at 1.00mol/mol. These findings conclude that the DS and yield of carboxymethylation of cellulose are strongly affected by the combination of the process parameters.