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Fulltext Nipah virus, an emerging zoonotic disease causing fatal encephalitis

Alam AM

Clin Med (Lond), 2022 Jul;22(4):348-352.
PMID: 35760448 DOI: 10.7861/clinmed.2022-0166

Nipah virus is an acute febrile illness that can cause fatal encephalitis. It is an emerging zoonotic paramyxovirus endemic to south-east Asia and the western Pacific, and can be transmitted by its primary reservoir of fruit bats, through intermediate animal vectors and by human-to-human spread. Outbreaks of Nipah virus encephalitis have occurred in Malaysia, Singapore, Philippines, India and Bangladesh, with the most recent outbreak occurring in Kerala, India in late 2021. Extremely high case fatality rates have been reported from these outbreaks, and to date no vaccines or therapeutic management options are available. Combining this with its propensity to present non-specifically, Nipah virus encephalitis presents a challenging diagnosis that should not be missed in patients returning from endemic regions. Raising awareness of the epidemiology, clinical presentation and risk factors of contracting Nipah virus is vital to recognise and manage potential outbreaks of this disease in the UK.
Dual-channel photoplethysmography synchronization using a Barker sequence

Zahedi E, M Ali M

Conf Proc IEEE Eng Med Biol Soc, 2007 2 7;2005:1952-5.
PMID: 17282604

A Barker sequence is employed for the synchronization of two photoplethysmogram (PPG) channels. The correctness of this technique is demonstrated by recording a PPG signal, injecting a Barker sequence at the start of this trace and producing a delayed version of it. After preprocessing, cross-correlation techniques are utilized for accurate time alignment of the two traces. The algorithm can correct for any time misalignment as long as the synchronization sequence appears on both channels.
Fulltext Optical parameters in food and agricultural processing

Mohd Ali, M., Hashim, N., Bejo, S. K., Shamsudin, R.

International Food Research Journal, 2017;24(3):908-914.
MyJurnal

The non-destructive feature of optical techniques has gained interests for quality assessment
of various agricultural produce as well as in food processing technology. The principle and
interaction of light with food and agricultural produce provide essential information for quality
assessment which promotes non-destructive inspection methods. This review encompasses the
determination of optical properties associated with the evaluation of the quality of agricultural
produce. The understanding of how light interacts with turbid agricultural produce is also
presented, including light characteristics such as absorption and scattering. A brief overview of
the estimation and application of the optical parameters in food and agricultural processing are
discussed. The problems and implementation of optical parameters as well as its future trend
are also included.
A new deformable model based on fractional Wright energy function for tumor segmentation of volumetric brain MRI scans

Ibrahim RW, Hasan AM, Jalab HA

Comput Methods Programs Biomed, 2018 Sep;163:21-28.
PMID: 30119853 DOI: 10.1016/j.cmpb.2018.05.031

BACKGROUND AND OBJECTIVES: The MRI brain tumors segmentation is challenging due to variations in terms of size, shape, location and features' intensity of the tumor. Active contour has been applied in MRI scan image segmentation due to its ability to produce regions with boundaries. The main difficulty that encounters the active contour segmentation is the boundary tracking which is controlled by minimization of energy function for segmentation. Hence, this study proposes a novel fractional Wright function (FWF) as a minimization of energy technique to improve the performance of active contour without edge method.
METHOD: In this study, we implement FWF as an energy minimization function to replace the standard gradient-descent method as minimization function in Chan-Vese segmentation technique. The proposed FWF is used to find the boundaries of an object by controlling the inside and outside values of the contour. In this study, the objective evaluation is used to distinguish the differences between the processed segmented images and ground truth using a set of statistical parameters; true positive, true negative, false positive, and false negative.
RESULTS: The FWF as a minimization of energy was successfully implemented on BRATS 2013 image dataset. The achieved overall average sensitivity score of the brain tumors segmentation was 94.8 ± 4.7%.
CONCLUSIONS: The results demonstrate that the proposed FWF method minimized the energy function more than the gradient-decent method that was used in the original three-dimensional active contour without edge (3DACWE) method.
Fulltext Exploring the theory of planned behaviour (TPB) in relation to a halal food scandal: the Malaysia Cadbury chocolate case

Ali, M. H., Ismail, A., Alam, S. S., Makhbul, Z. M., Omar, N. A.

International Food Research Journal, 2018;25(101):79-86.
MyJurnal

The aim of this paper is to revisit the theory of planned behaviour (TPB) in relation to the halal food market, specifically in the context of the Cadbury scandal. The present survey (with 132 respondents) replicates the original study of TPB in the context of halal food, done before the scandal, and the results are compared. We rationalize the differences, and assess the impact of the halal scandal on consumer purchasing behaviour. In doing so, we validate the impact of a food scandal in terms of the purchasing intentions of halal customers under a new (post-scandal) condition of uncertainty. The results provide in-depth insights into halal purchasing behaviour and are intended to be used: (a) to increase the understanding of the impact of a food scandal on purchasing behaviour, (b) to clarify whether a food scandal has a real effect on customers, and (c) to ascertain whether the determinants of purchasing intention are similar before and after a food scandal.
Fulltext Comparison of habitual visual acuity and stereoacuity between children attending kemas and urban private preschools

Naufal, N., Narayanasamy S., Ahmad, M., Hairol, M.I., Sharanjeet K., Kadar, M., et al.

Medicine & Health, 2020;15(1):225-236.
MyJurnal

Penilaian status visual kanak-kanak prasekolah adalah penting kerana ia adalah salah satu faktor yang menentukan ketersediaan mereka untuk bersekolah. Walau bagaimanapun, tidak semua kanak-kanak prasekolah mendapat peluang untuk mengikuti program saringan penglihatan. Dalam kajian ini, akuiti visual jauh dan dekat serta tahap stereoakuiti diukur di kalangan kanak-kanak berumur enam tahun (n=385). Parameter tersebut kemudiannya dibandingkan di antara kanak-kanak prasekolah swasta bandar dan prasekolah KEMAS daripada keluarga berpendapatan rendah di luar bandar. Tujuh peratus kanak-kanak prasekolah KEMAS adalah gagal dalam ujian saringan penglihatan jauh berbanding dengan 6% kanak-kanak prasekolah swasta. Untuk ujian penglihatan dekat, kadar kegagalan adalah masing-masing 8.7% dan 4.9% bagi kanak-kanak prasekolah swasta dan KEMAS masing-masing. Untuk ujian stereoakuiti, seramai 3.3% kanak-kanak prasekolah swasta dan 2.5% kanak-kanak prasekolah KEMAS dikategorikan sebagai lemah stereopsis. Semua perbezaan tersebut adalah tidak signifikan secara statistik (semua p>0.05). Peratusan kanak-kanak yang gagal ujian saringan penglihatan adalah serupa untuk kedua-dua jenis prasekolah. Oleh itu, program saringan penglihatan perlu dijalankan di semua jenis prasekolah untuk memastikan sebarang masalah penglihatan dapat dikesan, didiagnos, dirawat dan dicegah.
Prevalens Goiter dan Performans Mental di Kalangan Orang Asli di Sinderut, Pahang (Goitre Prevalence and Mental Performance Amongst the Aborigines in Sinderut, Pahang)

Zaleha M.I., Osman A., Iskandar Z.A., Zainuddin B., Mohd. Ali M., Khalid B.A.K.

Sains Malaysiana, 1996;25(2):51-58.

Goitre prevalence and mental performance were determined amongst the Aborigines in Sinderut, a remote rural area in Pahang. A total of 196 subjects aged 4 to 60 years old were selected for study. Goitre status was determined by an experienced endocrinologist using classification suggested by World Health Organization; while mental performance was measured using Raven's test (Oxford Psychologists Press). Blood specimen was also taken for thyroxine (T4) and thyroid stimulating hormone (TSH) measurement. It was found that goitre prevalence was 26.5% (52/196); with visible goitre prevalence of 42.3% (22152). The overall mean of goitre volume was 21.4 ± 19.1 ml (range: 3.0 - 90.8 ml), while the prevalence of mental performance for the percentile value of more than 5.0 was 26.5% (range: 5.0 - 50.0). Mean thyroxine levels was 75.4 ± 19.3 nmol/L (range: 19.9 - 138.1 nmol/ L) while mean levels of thyroid stimulating hormone was 4.9 ± 3.2 mU/L (range: 0.4 - 18.9 mU/L). There was no significant correlation between hormone levels and mental performance score (Pearson Correlation; T4 : r=-0.002, p=0.9736; TSH : r=0.10, p=0.1843). goitre volume and mental performance score (Pearson Correlation; r=-0.02, p=0.8395). Goitre prevalence of more than 20% in this area indicates a moderate endemia, while mental performance showed a low thinking level in the Aborigines particularly those who lived in remote areas.
Neuroprotective effect of cerium oxide nanoparticles in a rat model of experimental diabetic neuropathy

Najafi R, Hosseini A, Ghaznavi H, Mehrzadi S, Sharifi AM

Brain Res Bull, 2017 May;131:117-122.
PMID: 28373151 DOI: 10.1016/j.brainresbull.2017.03.013

OBJECTIVE: Neuropathies are a nerve disorders that caused by diabetes. Neuropathy affects over 50% of diabetic patients. High blood glucose and their toxic byproducts are the main causes for nerve dysfunction. In the present study, we examined the neroprotective effects of cerium oxide (CeO2) nanoparticles in diabetic rats.
METHOD: Rats divided into four groups: control group, diabetic group, the diabetic group treated with CeO2nanoparticle at a dose of 65mg/kg and diabetic group received CeO2nanoparticle at a dose of 85mg/kg. Diabetes was induced by single intraperitoneal injection of 65mg/kg streptozotocin (STZ). 8 weeks after the induction of diabetes, body weight and pain sensitivity in all groups were measured. The blood sample was collected for biochemical analysis. The dorsal root ganglion (DRG) neurons were isolated for histopathological stain and morphometric parameters studies.
RESULTS: Reduction of body weight, total thiol molecules (TTM), total antioxidant power (TAP) and ADP/ATP ratio in diabetic rat was reversed by CeO2nanoparticles administration. We showed that lipid peroxidation (LPO) and nociception latency were significantly increased in STZ-treated rats and decreased after CeO2nanoparticles administration. DRG neurons showed obvious vacuole and various changes in diameter, area and the count of A and B cells in STZ-diabetic rat. CeO2nanoparticles improved the histopathology and morphological abnormalities of DRG neurons.
CONCLUSION: Our study concluded the CeO2nanoparticles have a protective effect against the development of DN.
Fulltext Hybrid PSO-FLC for dynamic global peak extraction of the partially shaded photovoltaic system

Farh HMH, Eltamaly AM, Othman MF

PLoS One, 2018;13(11):e0206171.
PMID: 30388119 DOI: 10.1371/journal.pone.0206171

Particle Swarm Optimization (PSO) is widely used in maximum power point tracking (MPPT) of photovoltaic (PV) energy systems. Nevertheless, this technique suffers from two main problems in the case of partial shading conditions (PSCs). The first problem is that PSO is a time invariant optimization technique that cannot follow the dynamic global peak (GP) under time variant shading patterns (SPs) and sticks to the first GP that occurs at the beginning. This problem can be solved by dispersing the PSO particles using two new techniques introduced in this paper. The two new proposed PSO re-initialization techniques are to disperse the particles upon the SP changes and the other one is upon a predefined time (PDT). The second problem is regarding the high oscillations around steady state, which can be solved by using fuzzy logic controller (FLC) to fine-tune the output power and voltage from the PV system. The new contribution of this paper is the hybrid PSO-FLC with two PSO particles dispersing techniques that is able to solve the two previous mentioned problems effectively and improve the performance of the PV system in both normal and PSCs. A detailed list of comparisons between hybrid PSO-FLC and original PSO using the two proposed methodologies are achieved. The results prove the superior performance of hybrid PSO-FLC compared to PSO in terms of efficiency, accuracy, oscillations reduction around steady state and soft tuning of the GP tracked.
Evaluating the Protective Effects and Mechanisms of Diallyl Disulfide on Interlukin-1β-Induced Oxidative Stress and Mitochondrial Apoptotic Signaling Pathways in Cultured Chondrocytes

Hosseinzadeh A, Jafari D, Kamarul T, Bagheri A, Sharifi AM

J Cell Biochem, 2017 Jul;118(7):1879-1888.
PMID: 28169456 DOI: 10.1002/jcb.25907

The protective effects and mechanisms of DADS on IL-1β-mediated oxidative stress and mitochondrial apoptosis were investigated in C28I2 human chondrocytes. The effect of various concentrations of DADS (1, 5 10, 25, 50, and 100 μM) on C28I2 cell viability was evaluated in different times (2, 4, 8, 16, and 24 h) to obtain the non-cytotoxic concentrations of drug by MTT-assay. The protective effect of non-toxic concentrations of DADS on experimentally induced oxidative stress and apoptosis by IL-1β in C28I2 was evaluated. The effects of DADS on IL-1β-induced intracellular ROS production and lipid peroxidation were detected and the proteins expression of Nrf2, Bax, Bcl-2, caspase-3, total and phosphorylated JNK, and P38 MAPKs were analyzed by Western blotting. The mRNA expression of detoxifying phase II/antioxidant enzymes including heme oxygenase-1, NAD(P)H quinine oxidoreductase, glutathione S-transferase-P1, catalase, superoxide dismutase-1, glutathione peroxidase-1, -3, -4 were evaluated by reverse transcription-polymerase chain reaction. DADS in 1, 5, 10, and 25 μM concentrations had no cytotoxic effect after 24 h. Pretreatment with DADS remarkably increased Nrf2 nuclear translocation as well as the genes expression of detoxifying phase II/antioxidant enzymes and reduced IL-1β-induced elevation of ROS, lipid peroxidation, Bax/Bcl-2 ratio, caspase-3 activation, and JNK and P38 phosphorylation. DADS could considerably reduce IL-1β-induced oxidative stress and consequent mitochondrial apoptosis, as the major mechanisms of chondrocyte cell death in an experimental model of osteoarthritis. It may be considered as natural product in protecting OA-induced cartilage damage in clinical setting. J. Cell. Biochem. 118: 1879-1888, 2017. © 2017 Wiley Periodicals, Inc.
Enhanced QoS Routing Protocol for an Unmanned Ground Vehicle, Based on the ACO Approach

Ali AM, Ngadi MA, Sham R, Al Barazanchi II

Sensors (Basel), 2023 Jan 28;23(3).
PMID: 36772471 DOI: 10.3390/s23031431

Improving models for managing the networks of firefighting unmanned ground vehicles in crowded areas, as a recommendation system (RS), represented a difficult challenge. This challenge comes from the peculiarities of these types of networks. These networks are distinguished by the network coverage area size, frequent network connection failures, and quick network structure changes. The research aims to improve the communication network of self-driving firefighting unmanned ground vehicles by determining the best routing track to the desired fire area. The suggested new model intends to improve the RS regarding the optimum tracking route for firefighting unmanned ground vehicles by employing the ant colony optimization technique. This optimization method represents one of the swarm theories utilized in vehicles ad-hoc networks and social networks. According to the results, the proposed model can enhance the navigation of self-driving firefighting unmanned ground vehicles towards the fire region, allowing firefighting unmanned ground vehicles to take the shortest routes possible, while avoiding closed roads and traffic accidents. This study aids in the control and management of ad-hoc vehicle networks, vehicles of everything, and the internet of things.
Fulltext Sectoral output, energy use, and CO2 emission in middle-income countries

Sohag K, Al Mamun M, Uddin GS, Ahmed AM

Environ Sci Pollut Res Int, 2017 Apr;24(10):9754-9764.
PMID: 28251538 DOI: 10.1007/s11356-017-8599-z

Middle-income countries are currently undergoing massive structural changes towards more industrialized economies. In this paper, we carefully examine the impact of these transformations on the environmental quality of middle-income countries. Specifically, we examine the role of sector value addition to GDP on CO2 emission nexus for middle-income economies controlling for the effects of population growth, energy use, and trade openness. Using recently developed panel methods that consider cross-sectional dependence and allow for heterogeneous slope coefficients, we show that energy use and growth of industrial and service sectors positively explain CO2 emissions in middle-income economies. We also find that population growth is insignificantly associated with CO2 emission. Hence, our paper provides a solid ground for developing a sustainable and pro-growth policy for middle-income countries.
Fulltext Genotyping-by-Sequencing and QTL Mapping of Biomass Yield in Two Switchgrass F1 Populations (Lowland x Coastal and Coastal x Upland)

Razar RM, Qi P, Devos KM, Missaoui AM

Front Plant Sci, 2022;13:739133.
PMID: 35665173 DOI: 10.3389/fpls.2022.739133

The prevalence of genetic diversity in switchgrass germplasm can be exploited to capture favorable alleles that increase its range of adaptation and biomass yield. The objectives of the study were to analyze the extent of polymorphism and patterns of segregation distortion in two F1 populations and use the linkage maps to locate QTL for biomass yield. We conducted genotyping-by-sequencing on two populations derived from crosses between the allotetraploid lowland genotype AP13 (a selection from "Alamo") and coastal genotype B6 (a selection from PI 422001) with 285 progeny (AB population) and between B6 and the allotetraploid upland VS16 (a selection from "Summer") with 227 progeny (BV population). As predictable from the Euclidean distance between the parents, a higher number of raw variants was discovered in the coastal × upland BV cross (6 M) compared to the lowland × coastal AB cross (2.5 M). The final number of mapped markers was 3,107 on the BV map and 2,410 on the AB map. More segregation distortion of alleles was seen in the AB population, with 75% distorted loci compared to 11% distorted loci in the BV population. The distortion in the AB population was seen across all chromosomes in both the AP13 and B6 maps and likely resulted from zygotic or post-zygotic selection for increased levels of heterozygosity. Our results suggest lower genetic compatibility between the lowland AP13 and the coastal B6 ecotype than between B6 and the upland ecotype VS16. Four biomass QTLs were mapped in the AB population (LG 2N, 6K, 6N, and 8N) and six QTLs in the BV population [LG 1N (2), 8N (2), 9K, and 9N]. The QTL, with the largest and most consistent effect across years, explaining between 8.4 and 11.5% of the variation, was identified on 6N in the AP13 map. The cumulative effect of all the QTLs explained a sizeable portion of the phenotypic variation in both AB and BV populations and the markers associated with them may potentially be used for the marker-assisted improvement of biomass yield. Since switchgrass improvement is based on increasing favorable allele frequencies through recurrent selection, the transmission bias within individuals and loci needs to be considered as this may affect the genetic gain if the favorable alleles are distorted.
Fulltext Intelligent Traffic Model for Unmanned Ground Vehicles Based on DSDV-AODV Protocol

Ali AM, Ngadi MA, Al Barazanchi II, JosephNg PS

Sensors (Basel), 2023 Jul 15;23(14).
PMID: 37514720 DOI: 10.3390/s23146426

Traffic systems have been built as a result of recent technological advancements. In application, dependable communication technology is essential to link any system needs. VANET technology is used to communicate data about intelligent traffic lights, which are focused on infrastructure during traffic accidents and mechanisms to reduce traffic congestion. To ensure reliable data transfer in VANET, appropriate routing protocols must be used. This research aims to improve data transmission in VANETs implemented in intelligent traffic lights. This study investigates the capability of combining the DSDV routing protocol with the routing protocol AODV to boost AODV on an OMNET++ simulator utilizing the 802.11p wireless standard. According to the simulation results obtained by analyzing the delay parameters, network QoS, and throughput on each protocol, the DSDV-AODV routing protocol performs better in three scenarios compared to QoS, delay, and throughput parameters in every scenario that uses network topology adapted to the conditions on the road intersections. The topology with 50 fixed + 50 mobile nodes yields the best results, with 0.00062 s delay parameters, a network QoS of 640 bits/s, and a throughput of 629.437 bits/s. Aside from the poor results on the network QoS parameters, the addition of mobile nodes to the topology influences both the results of delay and throughput metrics.
Parametric differential approach for modeling the upper limb human vasculature

Zahedi E, Alauddin Mohd Ali M

Conf Proc IEEE Eng Med Biol Soc, 2007 2 3;2006:742-5.
PMID: 17271784

A parametric approach is proposed for the characterization of the upper vascular tree. The novelty of the approach resides in it being differential: the processed signals are the photoplethysmograms obtained non-invasively from the left and right indexes. The investigated model is an ARX (auto-regressive with exogenous input) where the order has been estimated utilizing standard techniques. The model coefficients show a relatively high degree of stability.
Fulltext Solution of the Falkner-Skan wedge flow by a revised optimal homotopy asymptotic method

Madaki AG, Abdulhameed M, Ali M, Roslan R

Springerplus, 2016;5:513.
PMID: 27186477 DOI: 10.1186/s40064-016-2147-z

In this paper, a revised optimal homotopy asymptotic method (OHAM) is applied to derive an explicit analytical solution of the Falkner-Skan wedge flow problem. The comparisons between the present study with the numerical solutions using (fourth order Runge-Kutta) scheme and with analytical solution using HPM-Padé of order [4/4] and order [13/13] show that the revised form of OHAM is an extremely effective analytical technique.
Fulltext Intraarticular fractures of the distal radius in young adults--a review of the outcome of treatment

Pan KL, Masbah O, Ali M

Med J Malaysia, 2001 Jun;56 Suppl C:19-25.
PMID: 11814243

A retrospective review of 30 intraarticular fractures of the distal radius in 27 patients was done. Only young adults aged between 18 and 40 were included. Road traffic accidents accounted for 25 of the cases (23 motorcyclists). Fourteen fractures were treated by closed reduction and a plaster cast. Sixteen fractures were treated by open reduction with internal fixation using a buttress plate or multiple Kirschner wires. At a mean follow-up of 17 months, 63% of the wrists had a satisfactory result and 37% unsatisfactory result. The main adverse factor was intraarticular congruity. The grip strength on the injured side averaged 56% of that of the uninjured side and the pinch strength averaged 73%. Most of the patients were able to return to their former occupation in an average of four months.
Need and demand for dental care in a group of Malaysian elderly

Razak IA, Ali MM

Gerodontics, 1988 Oct;4(5):265-7.
PMID: 3271724
Ethnic and sex variations in dental care utilization patterns in a group of Malaysian elderly

Razak IA, Ali MM

Gerodontology, 1988;7(2):77-80.
PMID: 3273286
Unperceived dental needs in a group of Malaysian elderly patients

Razak IA, Ali MM

Ann Acad Med Singap, 1989 Sep;18(5):516-8.
PMID: 2619242

The present study analysed the records of 342 elderly subjects aged 55 years and above of different ethnic groups to ascertain the types and level of their unperceived dental needs. The overall percentage of unperceived needs was highest among the Malays (96.1% or 74/77 subjects) and among the men (88.5% or 139/157 subjects). The unperceived need for prosthetic treatment was highest among the Malays and Chinese as well as among women, whereas the unperceived need for treatment for periodontal disease was highest among the Indians. The data for unperceived needs for prosthetic treatment as well as for treatment for caries and periodontal disease were somewhat similar among men. Within each ethnic group, variations among sex in the unperceived needs for the various dental symptoms were also noticeable. Further research is indicated to ascertain the role of traditional and cultural concepts and dogmas in determining the importance attached to the various dental health symptoms within each ethnic group.

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