Displaying all 10 publications

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  1. Siblings with Thickened Palms and Soles
    Albela H, Leong KF
    J Pediatr, 2021 Nov;238:329-330.
    PMID: 34181985 DOI: 10.1016/j.jpeds.2021.06.049
  2. Secukinumab in the treatment of a child with congenital ichthyosiform erythroderma with ABCA12 mutation
    Albela H, Leong KF
    Int J Dermatol, 2023 Jan;62(1):e27-e29.
    PMID: 35933655 DOI: 10.1111/ijd.16378
  3. Successful treatment of paediatric generalized pustular psoriasis with secukinumab: a case series
    Albela H, Begum S, Leong KF
    J Dermatolog Treat, 2021 Mar 11.
    PMID: 33706651 DOI: 10.1080/09546634.2021.1899111
    Generalized Pustular Psoriasis (GPP) is a rare, severe, life-threatening form of psoriasis and accounts for up to 13.1% of all childhood psoriasis. Common first-line systemic treatment for pediatric patients with GPP include oral acitretin, cyclosporin and methotrexate which have varying efficacy and side effects but multiple interventions are often needed to induce remission and maintain long term control. Recently, the anti IL 17 A monoclonal antibody secukinumab have been shown to be effective in adult patients with GPP; however, there is lack of evidence of its usage in the pediatric population. We describe a case series of 4 pediatric patients with GPP who were treated with off-label use of secukinumab. All four patients had marked clearance and reduction in Generalized Pustular Psoriasis Area & Severity Score (GPPASI) within first 48 h of first injection with subsequent almost complete to complete clearance of skin lesions by 1 month follow up. In conclusion, secukinumab was found to be successful in inducing remission, with rapid clearance and maintaining remission, with or without combination with other systemic agents for pediatric GPP.
  4. Fulltext Acute gastroenteritis among indigenous paediatric patients – a descriptive study in a rural district hospital, Sarawak
    Cheah, W. L., Lee, P. Y., Kamarudin, K., Syed Alwi, S. A. R., Albela, H., Lau, E. H., et al.
    Malaysian Journal of Medicine and Health Sciences, 2011;7(2):3-7.
    MyJurnal
    Introduction: Acute gastroenteritis (AGE) is one of the frequent causes of hospitalization in children under the age of five, particularly in a rural setting. This study was conducted to determine the epidemiology of acute gastroenteritis in indigenous children admitted to a rural district hospital in Sarawak. Methods: A retrospective review of indigenous paediatrics cases of acute gastroenteritis
    admitted to the ward of Serian District Hospital, a rural district hospital in Sarawak, between the years
    2006-2007. The data was collected from the patients’ case notes, obtained with permission from the
    hospital management. Data was entered and analyzed using SPSS version 16. Results: During the study period, 234 indigenous children with acute gastroenteritis were admitted with the highest prevalence in 2006 (53.4%). The findings showed higher prevalence was found in children aged 3 years and below (76.5%) and male (56.4%) The minimum duration of hospital stay is 1 day, and the maximum stay is 5 days. The clinical findings showed that the majority of the cases presented with vomiting, diarrhea, dry mouth and tongue, sunken eye, with the majority (76%) reported having mild dehydration. The most common treatment used is oral rehydration solutions (85.4%), followed by intravenous bolus or drip (82.3%), paracetamol (79%) and antibiotic (36.2%). Peak incidence of admissions was between November to January. About 38.5% of the AGE cases admitted were found to be underweight (weight for- age below -2SD). Conclusion: The findings indicated children aged 3 years and below are the most vulnerable to AGE and malnutrition could be one of the predisposing factors. The peak incidence during the raining season at the end of the year indicated a possible relationship between AGE and seasonal type of virus infection. Prevention in the form of proper hygiene at the household level probably will prove to be useful.
  5. A large purplish swelling on the arm of a newborn
    Joo NY, Ji LQ, Albela H
    Clin Exp Dermatol, 2024 Aug 22.
    PMID: 39172539 DOI: 10.1093/ced/llae352
  6. Fulltext Efficacy and Tolerability of Methotrexate in the Treatment of Severe Paediatric Alopecia Areata
    Albela H, Begum S, Wee AL, Ponnuthurai N, Leong KF
    Skin Appendage Disord, 2022 May;8(3):206-210.
    PMID: 35707294 DOI: 10.1159/000521238
    INTRODUCTION: Alopecia areata (AA) is a chronic, autoimmune condition affecting hair follicles, and its occurrence in the paediatric population is associated with poorer prognosis and limited treatment options compared to adults. Treatment with oral methotrexate (MTX) has been documented in adults, but there is a paucity of data for its use in the paediatric population. We aimed to study the efficacy and tolerability of MTX in severe paediatric AA.

    METHODS: We performed a retrospective review on paediatric patients with severe AA who were treated with MTX in our centre from January 2019 to December 2020.

    RESULTS: Thirteen patients were included (6 boys and 7 girls) aged between 4 and 16 years at the initiation of MTX (mean age of 8.8 years). The interval from diagnosis of AA to commencement of MTX was between 8 months and 9 years (mean duration of 3.3 years). Oral MTX was administered once weekly with a mean maximal dose of 0.4 mg/kg/dose. Out of 12 assessable patients, 5 were considered treatment success as they had more than 50% regrowth, while the other 7 were treatment failures. No serious side effects were reported.

    CONCLUSION: MTX was shown to have variable efficacy for the treatment of paediatric AA with overall good tolerability. MTX can be considered in the treatment of severe refractory AA for children.

  7. Juvenile Pityriasis Rubra Pilaris in a 4-year-old Child Treated Successfully with Secukinumab
    Albela H, Lee WQ, Nordin SN, Gopinathan LP, A Ramli MN, Leong KF
    Indian J Dermatol, 2022;67(5):601-603.
    PMID: 36865822 DOI: 10.4103/ijd.ijd_1079_21
  8. Secukinumab for Netherton syndrome: a Malaysian experience
    Ting IPL, Lee TS, Teo HG, Albela H, Tang MM, Leong KF
    Clin Exp Dermatol, 2023 Nov 16;48(12):1366-1369.
    PMID: 37503742 DOI: 10.1093/ced/llad253
  9. Secukinumab therapy for paediatric patients with various phenotypes of congenital ichthyosis
    Albela H, Ting IPL, Lee TS, Ooi D, Leong KF
    Clin Exp Dermatol, 2024 Jul 19;49(8):920-922.
    PMID: 38470562 DOI: 10.1093/ced/llae082
  10. Baricitinib as a treatment for recalcitrant paraneoplastic pemphigus in a young child
    Albela H, Sies NS, Shin LT, Ooi D, Leong KF
    Int J Dermatol, 2024 Dec;63(12):e437-e439.
    PMID: 38807277 DOI: 10.1111/ijd.17275
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