MyMedR

Fulltext Validity and Reliability of the Malay Version of Duke University Religion Index (DUREL-M) Among A Group of Nursing Student

Nurasikin, M.S., Aini, A., Aida Syarinaz, A.A., Ng, C.G.

Malaysian Journal of Psychiatry, 2010;19(2):1-5.

MyJurnal

Background: Duke University Religion Index (DUREL) is a brief and easy to use instrument for measurement of religious commitment. Objective: The aim of this study was to validate the Malay version of DUREL (DUREL-M) among a group of nursing students. Methods: This is a cross-sectional validation study conducted in a nursing school involved a group of year 1 nursing students. The students were given the Malay version of DUREL, Malay version of General Health Questionnaire (GHQ), Malay version of Brief COPE, Malay version of Depression Anxiety Stress Scale (DASS21), English version of DUREL. A week later, they were again given the Malay version of DUREL. Results: The instrument displayed good parallel reliability (0.70), test-retest reliability (0.68) (Spearman’s rho, p.

Right vertebral artery injury as a result of misplaced internal jugular vein catheter withdrawal

Pau CP, Aini A

Med J Malaysia, 2019 04;74(2):182-183.

PMID: 31079133

Central venous cannulation is a common procedure done for various medical indications. The use of the central venous cannula is associated with various immediate complications such as pneumothorax, vascular injury, and arrhythmia. The following is an unusual case of delayed presentation of a right vertebral artery injury due to central venous cannulation which resulted in a posterior circulation stroke. This is a condition that can be difficult to diagnose and has a significant impact on patient's quality of life. Clinicians and radiologists should be alert to this possibility to prevent further morbidity resulting from the iatrogenic injury.

Fulltext Correlation of computed tomography and nasal endoscopic findings in chronic rhinosinusitis

Shahizon AM, Suraya A, Rozmnan Z, Aini AA, Gendeh BS

Med J Malaysia, 2008 Aug;63(3):211-5.

PMID: 19248692 MyJurnal

This is a cross sectional study of 40 patients diagnosed with chronic rhinosinusitis using the Lanza Kennedy diagnostic criteria based on nasal endoscopy (NE), and on computer tomography (CT) of the paranasal sinuses. The purpose of the study is to demonstrate the effectiveness and limitations of CT, and NE in the assessment of chronic rhinosinusitis. This study shows that CT was superior in detecting OMC involvement, presence of concha bullosa, paradoxical turbinate and nasal septal deviation. NE was better at detecting polyps.

Religiousness, religious coping methods and distress level among psychiatric patients in Malaysia

Nurasikin MS, Khatijah LA, Aini A, Ramli M, Aida SA, Zainal NZ, et al.

Int J Soc Psychiatry, 2013 Jun;59(4):332-8.

PMID: 22408116 DOI: 10.1177/0020764012437127

Patients having psychiatric diagnoses often experience high level of distress. Religiousness is often used by them as part of their coping mechanism and problem-solving strategies.

An unexpected case of primary peritoneal carcinoma

Nur-Syahrina R, Siti-Aishah MA, Swaminathan M, Ng PH, Ismail S, Syazarina SO, et al.

Clin Ter, 2010;161(3):261-3.

PMID: 20589359

Primary peritoneal carcinoma (PPC) is a rare tumor that is histologically and immunohistochemically indistinguishable from epithelial ovarian carcinoma. The diagnosis is usually made after excluding gross ovarian involvement or the ovarian involvement is only confined to the surface. A 68-year-old lady presented with right iliac fossa pain and increasing CA125. The CT scan showed bilateral pelvic adnexal masses with peritoneal deposits within the right side of abdomen. She was initially diagnosed as carcinomatosis peritonei from the omental cake removed after exploratory surgery. She was managed as advanced ovarian tumor with peritoneal metastasis and was then administered six cycles of chemotherapy. Surgical intervention included debulking surgery consisting of total abdominal hysterectomy, bilateral salpingooophorectomy and omentectomy and also with right hemicolectomy. The histopathological findings were of primary peritoneal serous carcinoma with only minimal involvement of the serosal surface of the right ovarian capsule. No microscopic invasion into underlying ovarian cortex and stroma was observed. Multiple tumor deposits were also seen over the right paratubal and paraovarian tissue, both parametrium as well as serosal surface of the terminal ileum and periappendicular tissue. Immunohistochemically, the malignant cells were positive to CA125, focally positive to CK7 and negative to CD20 and Calretinin. PPC is one of important differential diagnosis which needs to be considered in cases of advanced ovarian tumor, although the former can only be ascertained after excluding the ovarian involvement microscopically.

Fulltext Combined assessment of TGF-beta-1 and alpha-fetoprotein values improves specificity in the diagnosis of hepatocellular carcinoma and other chronic liver diseases in Malaysia

Yasmin Anum MY, Looi ML, Nor Aini AH, Merican I, Wahidah A, Mohd Radzi AH, et al.

Med J Malaysia, 2009 Sep;64(3):223-7.

PMID: 20527273 MyJurnal

Transforming growth factor beta-1 (TGF-beta-1) is a multifunctional cytokine involved in the regulation of growth and differentiation of both normal and transformed cells. The main aim of this study was to determine whether TGF-beta-1 or alpha fetoprotein (AFP) or the combination of the two is a better indicator for hepatocellularcarcinoma (HCC). Serum TGF-beta-1 and AFP were measured by ELISA in 40 healthy subjects, 23 patients with hepatocellular carcinoma (HCC), 70 patients with hepatitis B, 26 patients with hepatitis C and 16 patients with liver cirrhosis (LC). Patients with liver diseases showed significantly higher serum TGF-beta-1 values (> 3 fold) compared to control subjects. As for serum AFP, significant elevation was only observed for HCC cases. Serum TGF-beta-1 exhibited higher percent sensitivity compared to serum AFP in all liver diseases. Combination of serum TGF-beta-1 and AFP increased specificities in all cases studied. In conclusion, serum TGF-beta-1 is a more sensitive marker for HCC when compared to serum AFP and its specificity is increased when combined with serum AFP.

Fulltext Long term Tai Chi exercise reduced DNA damage and increased lymphocyte apoptosis and proliferation in older adults

Goon JA, Noor Aini AH, Musalmah M, Yasmin Anum MY, Wan Ngah WZ

Med J Malaysia, 2008 Oct;63(4):319-24.

PMID: 19385493 MyJurnal

Effect of Tai Chi exercise on the level of DNA damage using the comet assay, lymphocyte viability and frequency of sister chromatid exchange (SCE) were determined in adults aged above 45. Tai Chi participants of 7 years (n=35), showed higher level of normal DNA and lower level of mild and severely damaged DNA as compared to the sedentary subjects (n=35). The former are suggested to have effective DNA repair mechanism as their frequency of SCE was markedly lower. Higher lymphocyte apoptosis and proliferation found in the Tai Chi participants also indicated that the exercise promotes renewal and regeneration of lymphocytes.

Fulltext Self-care behaviour among type 2 diabetes patients

Siti Khuzaimah AS, Aini A, Surindar Kaur SS, Hayati Adilin MAM, Padma AR

Pertanika Journal of Science & Technology, 2014;22(2):471-488.

MyJurnal

Self-care behaviour involves all activities type 2 diabetes patients engage in to care for their disease. In our local population, however, most patients do not manage their disease appropriately. This study aimed to determine the level of self-care behaviour and to examine the differences in self-care behaviour according to type 2 diabetes patients’ demographic data and health condition at University Malaya Medical Centre. Sample of this study comprised 388 patients (respondents) and data were collected from December 2010 to February 2011 using self-administered questionnaires. Results showed that the level of self-care behaviour was moderately high (mean = 38.94, SD=11.93). There were significant differences between self-care behaviour and ethnicity [Wilk’s Lambda = 0.92, F(12, 1008) = 2.70, p < 0.05], age group [Wilk’s Lambda = 0.96, F(4, 383) = 4.39, p < 0.05], education level [Wilk’s Lambda = 0.94, F(12, 1008) = 1.85, p < 0.05], type of treatment [Wilk’s Lambda = 0.92, F(12, 1008) = 2.84, p < 0.05], health education [Wilk’s Lambda = 0.97, F(4, 383) = 3.33, p< 0.05]. Respondents who are Indian, elderly, had lower level of education, on insulin treatment, had received health education on diabetes and not smoking had better self-care behaviour scores. It can be concluded that high risk type 2 diabetes patients should be taught individually so as to help them improve physical and psychological outcome.
Study site: diabetic clinic; medical, nephrology, orthopedic, and surgery wards, University Malaya Medical Centre (UMMC)

Effect of Tai Chi exercise on DNA damage, antioxidant enzymes, and oxidative stress in middle-age adults

Goon JA, Aini AH, Musalmah M, Anum MY, Nazaimoon WM, Ngah WZ

J Phys Act Health, 2009 Jan;6(1):43-54.

PMID: 19211957

BACKGROUND: The biochemical mechanisms involving oxidative stress to explain the relationship between exercise and healthy aging are still unclear.

METHODS: Tai Chi participants and matched sedentary volunteers age 45 and above were enrolled. Glutathione peroxidase (GPx), superoxide dismutase (SOD), and catalase (CAT) activities; levels of DNA damage using the comet assay; and malondialdehyde (MDA) and advanced glycation end products (AGE) were determined at 0, 6, and 12 months.

RESULTS: Tai Chi subjects had decreased normal and increased mildly damaged DNA with elevated GPx activity after 6 months (n=25). Plasma MDA and AGE concentrations decreased significantly after 12 months (n=15) accompanied by increased SOD activity. This may be attributed to the hormesis effect, whereby mild induction of oxidative stress at the first 6 months of exercise resulted in stimulation of antioxidant defenses. These parameters were unchanged in the sedentary subjects in the first 6 months (n=27) except for elevated SOD activity. After 12 months, the sedentary subjects (n=17) had decreased normal DNA and increased severely damaged DNA with unaltered MDA and AGE levels while SOD and GPx activities were significantly elevated.

CONCLUSION: Regular Tai Chi exercise stimulated endogenous antioxidant enzymes and reduced oxidative damage markers.

Fulltext Effects of plateletpheresis on blood coagulation parameters in healthy donors at National Blood Centre, Kuala Lumpur, Malaysia

Siti Nadiah AK, Nor Asiah M, Nur Syimah AT, Normi M, Anza E, Aini AN, et al.

Transfus Apher Sci, 2013 Dec;49(3):507-10.

PMID: 24055412 DOI: 10.1016/j.transci.2013.08.004

Plateletpheresis is a method used to remove platelet from the body either from random volunteer donors, patient's family members or HLA matched donors. A cross sectional study was carried out on 59 plateletpheresis donors aged between 18 and 55 years at National Blood Center (NBC), Kuala Lumpur. We compared the blood parameters before and after plateletpheresis and we found that the platelet count, FVIII, fibrinogen and thrombophilia markers anti-thrombin (AT), protein C and protein S were significantly reduced (p<0.05) with prolonged PT and APTT. There were significant changes in blood coagulation parameters but it is within acceptable range.

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