Displaying publications 141 - 160 of 438 in total

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  1. Uniocular blindness following thermal injury
    Ayanniyi AA, Fasasi MK
    Malays J Med Sci, 2013 Jan;20(1):88-91.
    PMID: 23613660
    A hot water burn is a thermal injury that results in cell death. Thermal eye injury triggers inflammatory processes, including inflammatory cell influx and/or the activation of various inflammatory cells, which result in the rapid accumulation of extravascular fluid in the ocular tissue. The ocular effect depends on the temperature of the water, and the final visual outcome depends on the severity of the damage to the intraocular structures. We report a 23-year-old woman who experienced a facial hot water burn that resulted in blindness. The patient presented late to the hospital after the unsuccessful use of traditional medication. Facial burns are a known cause of blindness. Public health education on prompt hospital presentation, and resistance to the use of potentially harmful traditional medicine in facial burns is suggested.
    Matched MeSH terms: Eye; Eye Injuries
  2. Dirofilaria causing eye infection in a patient from Malaysia
    Rohela M, Jamaiah I, Hui TT, Mak JW, Ithoi I, Amirah A
    Southeast Asian J Trop Med Public Health, 2009 Sep;40(5):914-8.
    PMID: 19842373
    Human dirofilariasis caused by Dirofilaria immitis and Dirofilaria repens have been reported in Malaysia. This is the fourth reported case of dirofilariasis caused by D. repens. The patient was a Chinese male from Kuching Sarawak, Malaysia who presented with a one day history of redness and itchiness over the temporal aspect of his left eye. A worm was seen and later removed from beneath the conjunctiva under local anesthesia and based on the morphological characteristics, it was identified as an immature Dirofilaria repens.
    Matched MeSH terms: Eye Infections, Parasitic/parasitology*
  3. Fulltext Low vision rehabilitation and ocular problems among industrial workers in a developing country
    Omar R, Knight VF, Aziz Mohammed MA
    Malays Fam Physician, 2014;9(3):27-33.
    PMID: 26425302 MyJurnal
    Work-related ocular injuries and illnesses were among the major causes of job absenteeism. This study was conducted to determine if low vision rehabilitation was provided following work-related ocular problems among industrial workers in a developing country. This was a retrospective analysis of case records.
    Matched MeSH terms: Eye
  4. Fulltext Visual outcome in open globe injuries
    Thevi T, Mimiwati Z, Reddy SC
    Nepal J Ophthalmol, 2012;4(2):263-70.
    PMID: 22864032 DOI: http://dx.doi.org/10.3126/nepjoph.v4i2.6542
    To determine the factors affecting the visual outcome in patients with open globe injuries of eye.
    Matched MeSH terms: Eye Injuries, Penetrating/diagnosis; Eye Injuries, Penetrating/physiopathology*; Eye Injuries, Penetrating/surgery
  5. Primary non-Hodgkins lymphoma of the lacrimal sac: mortality-related epiphora
    Maharajah KR, Hussein A, Mohamad H, Khan SA, At LS
    Orbit, 2009;28(5):306-8.
    PMID: 19874126 DOI: 10.3109/01676830903044346
    We report a case of primary non-Hodgkins lymphoma of the lacrimal sac in a 60-year-old Asian lady, who presented with persistent epiphora and recurrent medial canthal swelling. Primary lymphoma of the lacrimal sac is rare and it can be easily misdiagnosed. Delayed in diagnosis may be related to mortality. To minimize the risk of overlooking specific pathology it is important to assess the appearance of the lacrimal sac and its surrounding structures intraoperatively. Biopsy of the lacrimal sac is required in cases where specific pathology is suspected.
    Matched MeSH terms: Eye Neoplasms/complications; Eye Neoplasms/diagnosis*; Eye Neoplasms/therapy
  6. Fulltext The use of preserved bovine pericardium for emergency temporizing graft in corneal perforation
    Koay AC, Yew YH, Ngo CT, Loo VP, Intan G, Chua CN
    Med J Malaysia, 2008 Dec;63(5):421-2.
    PMID: 19803308 MyJurnal
    Corneal perforation is an ocular emergency that requires early intervention to avoid permanent visual loss from endophthalmitis or irreversible structural changes. Although tectonic keratoplasty is the best choice for patching a large perforation, a donor cornea is not always immediately available. Consequently, an alternative material is required while awaiting a donor cornea. We report the use of preserved bovine pericardium as a temporizing graft to maintain the ocular integrity in two patients with corneal perforation.
    Matched MeSH terms: Eye Injuries, Penetrating/surgery; Eye Infections, Fungal/surgery
  7. Fulltext Orbital compartment syndrome in idiopathic orbital inflammatory disease: A case report
    Tiong KI, Aziz S, Hazlita I
    Med J Malaysia, 2015 Oct;70(5):316-7.
    PMID: 26556124 MyJurnal
    Orbital compartment syndrome (OCS) is a visual threatening ocular emergency. We report a 50-year-old male with acute presentation of OCS, a rare manifestation of idiopathic orbital inflammatory disease. At presentation, high intraocular pressure was reduced by prompt lateral canthotomy and cantholysis. The disease responded to systemic steroids and treatment resulted in good visual outcome. Detail evaluation and early detection and treatment are mandatory to prevent permanent vision loss.
    Keywords: Sarawak General Hospital
    Matched MeSH terms: Eye Diseases
  8. Fulltext Natural Loss of eyeless/Pax6 Expression in Eyes of Bicyclus anynana Adult Butterflies Likely Leads to Exponential Decrease of Eye Fluorescence in Transgenics
    Das Gupta M, Chan SK, Monteiro A
    PLoS One, 2015;10(7):e0132882.
    PMID: 26173066 DOI: 10.1371/journal.pone.0132882
    Commonly used visible markers for transgenesis use fluorescent proteins expressed at the surface of the body, such as in eyes. One commonly used marker is the 3xP3-EGFP cassette containing synthetic binding sites for the eyeless/Pax6 conserved transcription factor. This marker cassette leads to fluorescent eyes in a variety of animals tested so far. Here we show that upon reaching adulthood, transgenic Bicyclus anynana butterflies containing this marker cassette exponentially loose fluorescence in their eyes. After 12 days, transgenic individuals are no longer distinguishable from wild type individuals. The decreased eye fluorescence is likely due to significantly decreased or halted eyeless/Pax6 expression observed in wild type animals upon adult emergence. Implications from these findings include care in screening transgenic animals before these reach adulthood, or shortly thereafter, and in using adult animals of the same age for quantitative screening of likely homozygote and heterozygote individuals.
    Matched MeSH terms: Eye/metabolism*; Eye Proteins/metabolism*
  9. Thyroid eye disease--medical or surgical therapy?
    Khalid BA, Ng ML
    Ann Acad Med Singap, 1991 Mar;20(2):273-6.
    PMID: 1883189
    Thyroid eye disease is autoimmune in nature and associated with Graves' Disease. Autoantibodies to the 64 kDa antigen in thyroid membranes cross-react to the 64 kDa proteins in human eye muscle membranes. Antibody dependent cell mediated cytotoxicity against eye muscle cells are also found in patients with thyroid eye disease. The purpose of this paper is to review the treatment available and to share the authors' experience using cyclosporin A. In the majority of cases, thyroid eye disease is mild, manifest only as bilateral or unilateral proptosis, with/without grittiness of the eyes. This is usually treated conservatively with eye drops. If proptosis is more severe and there is incomplete closure of eyelids, epiphora and conjunctival injection, then lateral tarrsorrhaphy is usually effective, combined with use of eye pads and eye drops. The problem of diplopia can be treated conservatively with special lenses, or with surgical correction of tethered muscles. However when proptosis is severe, with raised intraocular pressure, severe chemosis and danger of blindness, then the choice of therapy is controversial: rapid decompression by surgical means or use of high doses of prednisolone. Most prefer prednisolone therapy initially, surgical decompression if it fails. Various other methods have been tried, aimed at the immunological nature of the disease, namely plasmapheresis, radiotherapy and immunosuppressive drugs such as cyclosporin, with variable success. Our experience with cyclosporin had been mixed and inconclusive.
    Matched MeSH terms: Eye Diseases/etiology; Eye Diseases/immunology; Eye Diseases/therapy*
  10. Fulltext Angiogenic potential of extracellular matrix of human amniotic membrane
    Hashim SNM, Yusof MFH, Zahari W, Noordin KBAA, Kannan TP, Hamid SSA, et al.
    Tissue Eng Regen Med, 2016 Jun;13(3):211-217.
    PMID: 30603401 DOI: 10.1007/s13770-016-9057-6
    Combination between tissue engineering and other fields has brought an innovation in the area of regenerative medicine which ultimate aims are to repair, improve, and produce a good tissue construct. The availability of many types of scaffold, both synthetically and naturally have developed into many outstanding end products that have achieved the general objective in tissue engineering. Interestingly, most of this scaffold emulates extracellular matrix (ECM) characteristics. Therefore, ECM component sparks an interest to be explored and manipulated. The ECM featured in human amniotic membrane (HAM) provides a suitable niche for the cells to adhere, grow, proliferate, migrate and differentiate, and could possibly contribute to the production of angiogenic micro-environment indirectly. Previously, HAM scaffold has been widely used to accelerate wound healing, treat bone related and ocular diseases, and involved in cardiovascular repair. Also, it has been used in the angiogenicity study, but with a different technical approach. In addition, both side of HAM could be used in cellularised and decellularised conditions depending on the objectives of a particular research. Therefore, it is of paramount importance to investigate the behavior of ECM components especially on the stromal side of HAM and further explore the angiogenic potential exhibited by this scaffold.
    Matched MeSH terms: Eye
  11. Fulltext Eye tracker as an implied social presence: awareness of being eye-tracked induces social-norm-based looking behaviour
    Wong HK, Stephen ID
    J Eye Mov Res, 2019 Aug 05;12(2).
    PMID: 33828723 DOI: 10.16910/jemr.12.2.5
    Human behaviour is not only influenced by the physical presence of others, but also implied social presence. This study examines the impact of awareness of being eye-tracked on eye movement behaviour in a laboratory setting. During a classic yes/no face recognition task, participants were made to believe that their eye movements were recorded (or not recorded) by eye trackers. Their looking patterns with and without the awareness of being eye-tracked were compared while perceiving social (faces, faces-and-bodies) and non-social (inanimate objects) video stimuli. Area-of-interest (AOI) analysis revealed that misinformed participants (who were not aware that their eye movements were being recorded) looked more at the body (chest and waist) compared to informed participants (who believed they were being eye-tracked), whereas informed participants fixated longer on the mouth and shorter on the eyes of female models than misinformed participants did. These findings highlight the potential impact of an awareness of being eye tracked on one's eye movement pattern when perceiving a social stimulus. We conclude that even within laboratory settings an eye tracker may function as an implied social presence that leads individuals to modify their eye movement behaviour according to socially-derived inhibitory norms.
    Matched MeSH terms: Eye Movements
  12. Inverting peripheral hyperopic defocus into myopic defocus among myopic schoolchildren using addition power of multifocal contact lens
    Allinjawi K, Kaur S, Akhir SM, Mutalib HA
    Saudi J Ophthalmol, 2020 12 28;34(2):94-100.
    PMID: 33575529 DOI: 10.4103/1319-4534.305035
    PURPOSE: The purpose was to determine the minimum near-addition power needed using Proclear® multifocal D-Design contact lens (adds: +1.50 D, +2.50 D, +3.00 D, and +3.50 D) to invert the pattern of relative hyperopic defocus in the peripheral retina into relative myopic defocus among the eyes of myopic schoolchildren.

    METHODS: Twenty-seven right eyes (24 females and 3 males) of 27 myopic schoolchildren aged between 13 and 15 years were included in this study. The measurements of central refraction, peripheral refraction (between 35° temporal and 35° nasal visual field in 5° steps), and lag of accommodation were conducted using the Grand-Seiko WR-5100K open-field autorefractometer initially without correction (WC), followed by with correction using four different addition powers of Proclear® multifocal D-Design contact lens in random sequence. Axial length was measured using a handheld probe ultrasound A-scan (Tomey AL-2000).

    RESULTS: The relative peripheral refractive error showed high hyperopic defocus of +1.08 ± 1.24 D at 35° nasal and +1.06 ± 1.06 D at 35° temporal visual field WC. All Proclear multifocal contact lenses (MFCLs) decreased the peripheral hyperopic defocus with increasing addition powers (F [2.938, 47.001] = 13.317, P < 0.001). However, only +3.00 D addition and +3.50 D addition (P = 0.001) could invert the peripheral hyperopic defocus into peripheral myopic defocus. Apart from that, the +3.00 D addition lens showed the lowest lag of accommodation (+1.10 ± 0.83 D) among the other MFCL adds (P = 0.002).

    CONCLUSION: A +3.00 D addition Proclear MFCL is the optimal addition power that can invert the pattern of peripheral hyperopic defocus into myopic defocus.

    Matched MeSH terms: Eye Diseases, Hereditary
  13. Fulltext Variation in Morphometric Characters in Four Sand Crab (Albunea symmysta) Populations Collected from Sumatra and Java Island, Indonesia
    Pramithasari FA, Butet NA, Wardiatno Y
    Trop Life Sci Res, 2017 Jan;28(1):103-115.
    PMID: 28228919 DOI: 10.21315/tlsr2017.28.1.7
    Variation in morphometric characters in four sand crab (Albunea symmysta) populations from four intertidal areas in Sumatra (Aceh and Bengkulu) and Java (Cilacap and Yogyakarta) were studied. Crabs collected from the four sites were measured to obtain 10 morphometric characters, i.e., carapace length (CL), carapace width (CW), ocular peduncle length and width (LOP and WOP), telson length and width (LT and WT), merus length (ML), carpus length (CaL), propodus length (PL), and dactylus length (DL). Allometric relationships were established among three morphometric characters (CW, PL, and DL) for each site, in which CL was fixed on the abscissa as a reference variable. The analysis of covariance showed that population from Yogyakarta had a greater carapace width and the Aceh population had a longer dactylus length. In terms of propodus length, the Aceh population had a longer dactylus length than the Bengkulu population. Two group populations were detected by cluster analysis with 10 morphometric characters, i.e., the Sumatra population and the Java population.
    Matched MeSH terms: Eye
  14. Fulltext Bartonella henselae Neuroretinitis: A Rare Coinfection in POEMS Syndrome
    Ab Kahar MEPI, Muhammed J, Hitam WHW, Husin A
    Turk J Ophthalmol, 2020 12 29;50(6):371-376.
    PMID: 33389938 DOI: 10.4274/tjo.galenos.2020.83873
    Bartonella henselae is a recognized cause of neuroretinitis in cat scratch disease. Meanwhile, polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, skin changes (POEMS) syndrome with Castleman disease (evidence of lymph node hyperplasia), is a chronic debilitating condition that predisposes to various superimposed infections. B. henselae neuroretinitis implicated in POEMS syndrome has not been reported previously. A 34-year-old asymptomatic man was referred for an eye assessment. Examination showed visual acuity of 6/18 in the right eye and 6/24 in the left eye. On fundus examination, both eyes exhibited typical features of neuroretinitis (optic disc swelling and incomplete macular star). There was otherwise no vitritis or chorioretinitis. Serology for B. henselae revealed high immunoglobulin M (IgM) titer (1:96) indicative of acute disease, and positive immunoglobulin G (IgG) (1:156). He was treated with oral azithromycin for 6 weeks and a short course of oral prednisolone. Subsequently, the visual acuity in both eyes improved with resolution of macular star. However, both optic discs remained swollen.
    Matched MeSH terms: Eye Infections, Bacterial/complications; Eye Infections, Bacterial/diagnosis*; Eye Infections, Bacterial/microbiology
  15. Fulltext The association between myopia and gender in Indian schoolchildren in Kuala Lumpur
    Norhani Mohidin, Saadah Mohd Akhir, Bariah Mohd Ali, Zainora Mohammed, Sharanjeet, K., Chung, K.M.
    Jurnal Sains Kesihatan Malaysia, 2005;3(2):49-54.
    MyJurnal
    A vision screening study was carried out among Indian schoolchildren around Kuala Lumpur to determine whether the prevalence of myopia was higher in boys or girls. Altogether 749 students (49.7% boys and 50.3% girls) aged 7-18 years were screened and their refractive error examined using retinoscopy without cycloplegia. For the right eye 15.1% of the girls' eyes were found to be myopic as compared to 16.9% of the boys, of which chi-square showed no significant difference (p = 0.44). For the left eye 18.8% of the girls' eyes were myopic as compared to 16.4% of the boys. Chi square also showed no significant difference (p = 0.26). When high myopia (> -6.00D) was considered, there was no difference found between boys and girls. The number of students with high myopia greater than -6.00D was also very small (0.3%-0.5%). In conclusion, it was found that there was no significant difference in myopia between girls and boys among Indian schoolchildren.
    Matched MeSH terms: Eye
  16. Fulltext Bilateral Panuveitis in a Case of Ocular Sarcoidosis
    Payman, A.K., Tajunisah, I., Ahmad, F.
    International Medical Journal Malaysia, 2008;7(1):0-0.
    MyJurnal
    Glaucoma is a major cause of permanent visual loss in patients with sarcoid uveitis.In this case glaucoma occurred early in the course of the disease and IOP started to rise up after one month from the initial presentation. Uveitic glaucoma can be extremely difficult to treat; pilocarpine is not normally used in eyes with active inflammation. Patients with uveitis respond poorly to laser trabeculoplasty, and filtering procedures usually fail. Success of modified goniotomy, trabeculectomy and Molteno valve implantation were reported. More drastic therapy, such as cyclodestructive procedures, may be required in the most severe cases. In this case the challenge in preserving the vision. by keeping the balance between the need to control the inflammation and the necessity to avoid the treatment related complications.
    Matched MeSH terms: Eye
  17. Fulltext An adult patient with double vision
    Koh KC
    Malays Fam Physician, 2013;8(1):50-52.
    PMID: 25606271 MyJurnal
    A 27-year old Nepali man presented with a four-day history of fever, vomiting and horizontal diplopia. There was no history of trauma. The patient has esotropia of the left eye or what is commonly known as a squint or strabismus. The squint is an inward squint (synonyms include convergent squint or esodeviation of the eye). Esotropia is a condition where either one or both eyes are turned inward. Congenital esotropia, often seen in infants below six years old, may give rise to amblyopia. Accommodative esotropia is common among patients with moderate amounts of
    hypermetropia or hyperopia. Esotropias can be concomitant, where the degree of deviation is independent of the direction of the gaze, or incomitant, where the degree of deviation is influenced by the direction of the gaze. This patient had incomitant esotropia as the squint was revealed when he was asked to look to the left. A comprehensive step-bystep approach to a patient presenting with a squint has been described extensively in literature.
    Matched MeSH terms: Eye
  18. Fulltext Data on the effects of imidazo[1,2-a]benzimidazole and pyrimido[1,2-a]benzimidazole compounds on intraocular pressure of ocular normotensive rats
    Marcus AJ, Iezhitsa I, Agarwal R, Vassiliev P, Spasov A, Zhukovskaya O, et al.
    Data Brief, 2018 Jun;18:523-554.
    PMID: 29896529 DOI: 10.1016/j.dib.2018.03.019
    This data is to document the intraocular pressure (IOP) lowering activity of imidazo[1,2-a]benzimidazole and pyrimido[1,2-a]benzimidazole compounds in ocular normotensive rats. Effects of single drop application of imidazo[1,2-a]benzimidazole and pyrimido[1,2-a]benzimidazole compounds on IOP in ocular normotensive rats are presented at 3 different concentrations (0.1%, 0.2% and 0.4%). Time course of changes in IOP is presented over 6 h period post-instillation. The IOP lowering activities of test compounds were determined by assessing maximum decrease in IOP from baseline and corresponding control, duration of IOP lowering and area under curve (AUC) of time versus response curve. Data shown here may serve as benchmarks for other researchers studying IOP-lowering effect of imidazo[1,2-a]benzimidazole and pyrimido[1,2-a]benzimidazole compounds and would be useful in determining therapeutic potential of these test compounds as IOP lowering agents.
    Matched MeSH terms: Eye
  19. Fulltext Integrating campus community through outdoor education
    Jaffry Zakaria
    Jurnal Sains Sukan & Pendidikan Jasmani, 2012;1(1):89-95.
    MyJurnal
    The racial riot incident on 13th of May 1969 had opened the eyes of many people to realize on how important serious efforts to be focused in managing the sensitivity and the differences in multiracial society in countries like Malaysia. Many experts believe that integration can be build through outdoor education activities. The author will try to unravel and discuss on the outdoor education activity relations and integration campus community. This discussion will cover the latest issues and a variety of previous studies and personal experiences of the author as an outdoor education activist.
    Matched MeSH terms: Eye
  20. Fulltext Delayed onset porous polyethylene implant-related inflammation after orbital blowout fracture repair: four case reports
    Aryasit O, Ng DS, Goh ASC, Woo KI, Kim YD
    BMC Ophthalmol, 2016 Jul 07;16:94.
    PMID: 27387333 DOI: 10.1186/s12886-016-0287-0
    BACKGROUND: Porous polyethylene implants are commonly used in orbital blowout fracture repair because of purported biocompatibility, durability, and low frequency of complications. Delayed inflammation related to porous polyethylene sheet implants is very rare and no case series of this condition have been reported.

    CASE PRESENTATION: This is a retrospective review of clinical presentations, radiographic findings, histopathological findings, treatments, and outcomes of patients who developed delayed complications in orbital blowout fracture repair using porous polyethylene sheets. Four male patients were included with a mean age of 49 years (range 35-69 years). Blowout fracture repair was complicated with implant-related inflammation 10 months, 2 years, 3 years, and 8 years after surgery. Chronic and subacute orbital inflammatory signs were noted in two patients and acute fulminant orbital inflammation was found in two patients. Three patients developed peri-implant abscesses and one patient had a soft tissue mass around the implant. All patients underwent implant removal and two of these patients with paranasal sinusitis had sinus surgery. Histopathological findings revealed chronic inflammatory changes with fibrosis, and one patient had foreign body granuloma with culture positive Staphylococcus aureus.

    CONCLUSIONS: Delayed complications with porous polyethylene sheets used in orbital blowout fracture repair may occur many years following the initial surgery in immunocompetent patients. Low-grade or fulminant inflammation could complicate blowout fracture repair related with the implant.

    Matched MeSH terms: Eye Diseases/etiology*; Eye Infections, Bacterial/etiology
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