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Fulltext Bacillus thuringiensis parasporal proteins and their effect on human cancer cells: an overview

Wong, Rebecca Shin Yee

International e-Journal of Science, Medicine & Education, 2010;4(2):-.
MyJurnal

Bacillus thuringiensis is an anaerobic, spore forming bacterium that produces various toxic proteins both during its vegetative stage and sporulative stage. During its sporulative stage, it produces parasporal proteins that have long been used in the agriculture fields as insecticides. Although anticancer effect of Bacillus thuringiensis parasporal proteins can be dated back to the 1970s, research in this area went through a giant leap in the late 1990s, with much of the work being done in Japan. It has been found that some strains of non-insecticidal Bacillus thuringiensis produce parasporal proteins that exhibit anticancer activity. Due to their selectivity against human cancer cells but not normal cells, some of these proteins have been extensively studied for their anticancer effect and the mechanism of action by which these proteins kill cancer cells have also been widely explored in Japan and Malaysia with sporadic reports from other parts of the world. The abundance of these bacilli in nature and their selectivity have made them potential candidates for cancer treatment. However, literature on the in vivo effect of these proteins is scarce. Since different Bacillus thuringiensis strains produce different cytotoxic proteins with wide variations in their anticancer effect and mechanism of action, further investigations are necessary and their effect in vivo must be well established before they can be used in human subjects.

Matched MeSH terms: Japan
[Seasonality of dysentery. 3. Dynamics of dysentery morbidity in different areas of the world]

Beliakov VD, Spitsa LK

Med Parazitol (Mosk), 1971 Mar-Apr;40(2):220-5.
PMID: 5568410
Matched MeSH terms: Japan
Japanese men of science in Malaya during Japanese occupation

CORNER EJ

Nature, 1946 Jul 13;158:63.
PMID: 20991747
Matched MeSH terms: Japan
Fulltext Right medicines for the developing nations

Sreeharan, Nadarajah

Medical Health Reviews, 2009;2009(2):59-69.
MyJurnal

The term Developing Nations has to be used with caution as it had traditionally included a wide array of countries outside the developed world of North America, Western Europe and Japan (and a few other countries such as Australia and South Africa). The characteristics which defined these “emerging markets” were a Gross National Product (GNP) per capita which was below that of the developed economies, the potential for market growth and an environment with continued economic and political instability. However, as many of these countries have grown at different rates and have economic and other drivers which are very different and disparate, definitions of this sector have become more fragmented. (Copied from article).

Matched MeSH terms: Japan
New species and new records of Diptera Pupipara. II. Species from Asia and Africa

Theodor O

J Med Entomol, 1973 Dec 30;10(6):556-69.
PMID: 4779919
Matched MeSH terms: Japan
Fulltext A comparison of staining resistant of two composite resins

Mior Azrizal M. Ibrahim, Wan Zaripah Wan Bakar, Adam Husein

Archives of Orofacial Sciences, 2009;4(1):13-16.
MyJurnal

Composite resins Amaris is claimed to have hydrophobic effect which minimizes the staining intake. This study is to investigate the colour stability of Amaris compared to Filtek Z250 in coffee solution. Sixty discs of composite resins Filtek Z250 (3M ESPE) and Amaris (Voco) with diameter of 5mm and depth of 2mm were fabricated by packing in a drinking straw and sectioned with hard tissue cutter (Exakt, Japan). The surfaces of the specimens were polished with Sof-Lex disc before each group of the samples is immersed in coffee solution. They were kept in the solution for 4 days at 370C and assessed at the period of 2 hours, 1 day, 2 days, 3 days, and 4 days. The staining was assessed visually and recorded using Lobene (1968) Stain Index and score was given accordingly. The colour changes of both groups were not statistically significant (p

Matched MeSH terms: Japan
Fulltext Some characteristics and functional properties of Chunma (Gastrodia Elata) as a food supplement: A short review

Jaswir, I., Octavianti, F., Lestari, W., Hendri, R., Ahmad, H.

International Food Research Journal, 2017;24(101):0-0.
MyJurnal

Gastrodin elata blume (Tianma in Chinese, Chunma in Korean) is a perennial parasitic herbaceous plant native to Korea, Japan and China (Chae et al., 2008). The plant has recently received very good attention, especially in Korea, due to its excellent health-promoting properties. This plant is reported to have excellent antioxidant, anticancer and anti-inflammatory properties. This paper briefly reviews some characteristics and functional properties of Chunma.

Matched MeSH terms: Japan
Fulltext Acute and emergency care for thyrotoxicosis and thyroid storm

Idrose AM

Acute medicine & surgery, 2015 07;2(3):147-157.
PMID: 29123713 DOI: 10.1002/ams2.104

Thyroid hormones affect all organ systems and, in excess, can cause increased metabolic rate, heart rate, ventricle contractility, and gastrointestinal motility as well as muscle and central nervous system excitability. Thyroid storm is the extreme manifestation of thyrotoxicosis with an estimated incidence of 0.20 per 100,000 per year among hospitalized patients in Japan. The mortality of thyroid storm without treatment ranges from 80% to 100%; but with treatment, the mortality rate is between 10% and 50%. The diagnostic strategy for thyroid storm may take into consideration Burch-Wartofsky scoring or Akamizu's diagnostic criteria. Multiple treatment aims need to be addressed in managing thyroid storm effectively. This paper puts together all aspects to be considered for the management of hyperthyroidism and thyroid storm during the acute and emergency phase as well as consideration of special populations.

Matched MeSH terms: Japan
Fulltext Urban coral reefs: Degradation and resilience of hard coral assemblages in coastal cities of East and Southeast Asia

Heery EC, Hoeksema BW, Browne NK, Reimer JD, Ang PO, Huang D, et al.

Mar Pollut Bull, 2018 Oct;135:654-681.
PMID: 30301085 DOI: 10.1016/j.marpolbul.2018.07.041

Given predicted increases in urbanization in tropical and subtropical regions, understanding the processes shaping urban coral reefs may be essential for anticipating future conservation challenges. We used a case study approach to identify unifying patterns of urban coral reefs and clarify the effects of urbanization on hard coral assemblages. Data were compiled from 11 cities throughout East and Southeast Asia, with particular focus on Singapore, Jakarta, Hong Kong, and Naha (Okinawa). Our review highlights several key characteristics of urban coral reefs, including "reef compression" (a decline in bathymetric range with increasing turbidity and decreasing water clarity over time and relative to shore), dominance by domed coral growth forms and low reef complexity, variable city-specific inshore-offshore gradients, early declines in coral cover with recent fluctuating periods of acute impacts and rapid recovery, and colonization of urban infrastructure by hard corals. We present hypotheses for urban reef community dynamics and discuss potential of ecological engineering for corals in urban areas.

Matched MeSH terms: Japan
The first Philippine species of Loeblites Franz (Coleoptera: Staphylinidae: Scydmaeninae)

JaŁoszyŃski P

Zootaxa, 2018 Sep 04;4471(1):185-188.
PMID: 30313426 DOI: 10.11646/zootaxa.4471.1.11

Loeblites Franz, 1986 is a genus of Glandulariini with adults sharing a very similar body form and most taxonomically important structures with Syndicus Motschulsky, 1851. One of the most conspicuous differences between these genera is the antennal structure. In Syndicus, the antennomere XI is strongly reduced, much shorter than X and lacks the basal stalk, so that the two terminal antennomeres are compactly assembled. They either form one oval structure that appears as a single antennomere because the base of subconical antennomere XI is as broad as apex of X (Syndicus s. str.) or the antennomere XI forms a distinct small 'papilla' on top of X (subgen. Semisyndicus Jałoszyński, 2004) because the base of antennomere XI is much narrower than apex of X. Adults of Loeblites have unmodified antennae, with the antennomere XI strongly elongate and with a narrow basal stalk; additionally the antennae are strikingly slender, nearly filiform. Morphological structures of both genera were described and illustrated by Jałoszyński (2004, 2005). While Syndicus is species-rich, often abundant in leaf litter and under bark in subtropical forests (Jałoszyński 2004, 2006, 2008, 2009, 2011, 2014; Jałoszyński Nomura 2006; Yin Li 2015; Yin et al. 2014; Yin Zhou 2016; Zhou Yin 2017), and broadly distributed from southeastern Australia, through Southeast Asia, Yunnan (China) and Ryukyus (Japan), up to Sri Lanka, India and the Himalayas, Loeblites comprises merely four species known to occur in Malaysia, Thailand and China (Jałoszyński 2005; Zhou Li 2015). Loeblites mastigicornis Franz, 1986 is known to occur in Chiang Mai (northern Thailand), L. sabahensis Franz, 1992 and L. minor Jałoszyński, 2005 in Sabah (northern Borneo), and L. chinensis Zhou Li, 2015 in Yunnan (southwest China). Two females representing an undescribed species were also recorded from Yunnan by Zhou Li (2015). Specimens of this interesting genus are found rarely, in small numbers and they are typically sifted from leaf litter in subtropical forests.

Matched MeSH terms: Japan
New records of species of the Polyonyx sinensis group (Crustacea: Decapoda: Anomura: Porcellanidae) from Japan, the Philippines, Singapore, and Malaysia, with descriptions of two new species

Osawa M, Naruse T, Ng PKL

Zootaxa, 2018 Jun 06;4429(2):303-323.
PMID: 30313270 DOI: 10.11646/zootaxa.4429.2.6

Five species of the genus Polyonyx Stimpson, 1858 are reported from southern Japan, the Philippines, Singapore, and Peninsular Malaysia. All of them belong to the P. sinensis group, which is morphologically defined by having the dactyli of the ambulatory legs each with the dorsal claw being much smaller than the ventral claw. Two species are described as new to science, one each from Peninsular Malaysia and the Ryukyu Islands in Japan, and their affinities are discussed. Polyonyx boucheti Osawa, 2007, P. heok Osawa Ng, 2016, and P. thai Werding, 2001, are also newly reported from southern Japan, the Philippines, and Singapore. A key to the Indo-West Pacific species of the P. sinensis group is provided.

Matched MeSH terms: Japan
Fulltext Inculcating halal values in seaweed production for competitive positioning

Normawaty Mohammad Noor, Sarina Muhammad Noor, Weliyadi, Rukisah Salleh

International Medical Journal Malaysia, 2018;17(101):37-40.
MyJurnal

Seaweed industry is important in several countries including Malaysia, Japan, Indonesia, and the Philippines. The seaweed, Kappaphycus is widely used in a variety of food products as an excellent nutritional supplement. There are several stages in producing raw Kappaphycus for industry such as cultivation and harvest. Most of these steps follow a traditional way which has been practiced from one generation to another. As seaweed is part of the main ingredients in many final produce, its processing must incorporate cleanliness and quality aspect. Therefore, a focus on Halal is of utmost importance. Halal is a concept that stresses on shariah law and ensuring the utmost quality which benefits most producers especially in food and supplement products. However, the knowledge of Halal is still limited in marine production including seaweed. The seaweed process has gone through numerous stages yet none of them has been checked on its
Halalness aspect. This study is to deliberate on the aspect of Halalness for each stage involved, including cultivation and harvesting. To achieve this, observations and literature search were performed and findings showed that there is lack of hygienic practices in handling seaweed production. Therefore, conjoint initiatives among university-industry-government are needed to enhance the value proposition of the seaweed production as it complies with the concept of Halalness. This will contribute towards the development of Halal ecosystem from seed to harvest of quality seaweed production.

Matched MeSH terms: Japan
Fulltext Morphological descriptions and morphometric discriminant function analysis reveal an additional four groups of Scylla spp

Fazhan H, Waiho K, Quinitio E, Baylon JC, Fujaya Y, Rukminasari N, et al.

PeerJ, 2020;8:e8066.
PMID: 31915566 DOI: 10.7717/peerj.8066

There are four species of mud crabs within the genus Scylla, and most of them live sympatrically in the equatorial region. Apart from a report in Japan about the finding of a natural Scylla hybrid more than a decade ago after the division of genus Scylla into four species by Keenan, Davie & Mann (1998), no subsequent sighting was found. Thus, this study investigates the possible natural occurrence of potential hybridization among Scylla species in the wild. A total of 76,211 individuals from mud crab landing sites around the Malacca Straits, South China Sea and Sulu Sea were screened. In addition to the four-purebred species, four groups (SH 1, n = 2, 627; SH 2, n = 136; SH 3, n = 1; SH 4, n = 2) with intermediate characteristics were found, mostly at Sulu Sea. Discriminant Function Analysis revealed that all Scylla species, including SH 1 - 4, are distinguishable via their morphometric ratios. The most powerful discriminant ratios for each character and the top five discriminant ratios of males and females were suggested. The carapace width of SH 1 males and females were significantly smaller than pure species. Based on the discriminant ratios and the description of morphological characters, we hypothesize that the additional four groups of Scylla with intermediate characteristics could be presumed hybrids. Future work at the molecular level is urgently needed to validate this postulate.

Matched MeSH terms: Japan
Pan-Asian adapted ESMO Clinical Practice Guidelines for the management of patients with early breast cancer: a KSMO-ESMO initiative endorsed by CSCO, ISMPO, JSMO, MOS, SSO and TOS

Park YH, Senkus-Konefka E, Im SA, Pentheroudakis G, Saji S, Gupta S, et al.

Ann Oncol, 2020 04;31(4):451-469.
PMID: 32081575 DOI: 10.1016/j.annonc.2020.01.008

In view of the planned new edition of the most recent version of the European Society for Medical Oncology (ESMO) Clinical Practice Guidelines for the diagnosis, treatment and follow-up of primary breast cancer published in 2015, it was decided at the ESMO Asia Meeting in November 2018, by both the ESMO and the Korean Society of Medical Oncology (KSMO), to convene a special face-to-face guidelines meeting in 2019 in Seoul. The aim was to adapt the latest ESMO 2019 guidelines to take into account the ethnic and geographical differences associated with the treatment of early breast cancer in Asian patients. These guidelines represent the consensus opinions reached by experts in the treatment of patients with early breast cancer representing the oncology societies of Korea (KSMO), China (CSCO), India (ISMPO) Japan (JSMO), Malaysia (MOS), Singapore (SSO) and Taiwan (TOS). The voting was based on scientific evidence, and was independent of both the current treatment practices, and the drug availability and reimbursement situations, in the individual participating Asian countries.

Matched MeSH terms: Japan
Craniofacial Anthropometric Profile of East Asians

Raveendran M

J Craniofac Surg, 2019 Mar 19.
PMID: 30896517 DOI: 10.1097/SCS.0000000000005444

Facial anthropometric data has significant ethnic variation. East Asia, comprised of fourteen countries, represents a significant proportion of the global population. This systematic review presents the facial anthropometric data collected from these countries. The systematic review was conducted in accordance with PRISMA guidelines. An electronic search of the MEDLINE database returned 3054 articles. Twenty articles were considered eligible for inclusion. Nine studies were conducted in China, 1 in Indonesia, 2 in Japan,3 in Korea, 4 in Malaysia, and 1 was a multicentre study conducted in China, Japan, Thailand, and Vietnam. Qualitative and quantitative parameters were extracted from the20 studies. No data was found for the other East Asian countries. There is a paucity of facial anthropometric data for East Asian countries despite their high burden of craniofacial anomalies and a strong demand for cosmetic facial surgery, both of which would benefit from the collection of robust craniofacial norms. It is in the interest of both the craniofacial surgeon and the East Asian patient to collect baseline facial anthropometric data for this population.

Matched MeSH terms: Japan
Pan-Asian adapted ESMO Clinical Practice Guidelines for the management of patients with intermediate and advanced/relapsed hepatocellular carcinoma: a TOS-ESMO initiative endorsed by CSCO, ISMPO, JSMO, KSMO, MOS and SSO

Chen LT, Martinelli E, Cheng AL, Pentheroudakis G, Qin S, Bhattacharyya GS, et al.

Ann Oncol, 2020 03;31(3):334-351.
PMID: 32067677 DOI: 10.1016/j.annonc.2019.12.001

The most recent version of the European Society for Medical Oncology (ESMO) Clinical Practice Guidelines for the diagnosis, treatment and follow-up of hepatocellular carcinoma (HCC) was published in 2018, and covered the diagnosis, management, treatment and follow-up of early, intermediate and advanced disease. At the ESMO Asia Meeting in November 2018 it was decided by both the ESMO and the Taiwan Oncology Society (TOS) to convene a special guidelines meeting immediately after the Taiwan Joint Cancer Conference (TJCC) in May 2019 in Taipei. The aim was to adapt the ESMO 2018 guidelines to take into account both the ethnic and the geographic differences in practice associated with the treatment of HCC in Asian patients. These guidelines represent the consensus opinions reached by experts in the treatment of patients with intermediate and advanced/relapsed HCC representing the oncology societies of Taiwan (TOS), China (CSCO), India (ISMPO) Japan (JSMO), Korea (KSMO), Malaysia (MOS) and Singapore (SSO). The voting was based on scientific evidence, and was independent of the current treatment practices, the drug availability and reimbursement situations in the individual participating Asian countries.

Matched MeSH terms: Japan
Fulltext Population Genetics in Malaysia and Japanese Populations Using Power Plex Y23 System

Nakamura Y, Samejima M, Minaguchi K, Nambiar P, Hashimoto M

Bull. Tokyo Dent. Coll., 2020 Jul 04;61(2):83-94.
PMID: 32522936 DOI: 10.2209/tdcpublication.2019-0023

Population flow between Southeast Asian countries and Japan continues to gather pace. Accordingly, the number of foreigners involved in incidents in Japan has markedly increased, which means that forensic dentistry is now increasingly being faced with the need to analyze DNA from persons of non-Japanese extraction. The DNA test currently used for personal identification mainly utilizes short tandem repeats (STRs) on autosomal chromosomes and the Y-chromosome. This test was developed for use in personal identification, not for distinguishing among races; nonetheless, the standard method for personal identification is often used because the procedure has been established. To determine the degree to which racial differences can be distinguished by standard DNA analysis, 23 STRs located on the Y chromosome were investigated in 218 Malay and 426 Japanese males. The frequencies of each STR were calculated in the two populations. The difference in the power of discrimination between the Malay and Japanese populations ranged from a minimum of 0.01 to a maximum of 0.27; the difference in polymorphic information content ranged from 0.01 (minimum) to 0.23 (maximum). No major differences were noted in the polymorphisms in these two Mongoloid populations, but the distributions of the 17 STRs differed significantly. Short tandem repeat types demonstrating a likelihood of racial differences were identified in 14 of the STRs. Race-specific STR types were identified in 10 STRs. These results suggest that the likelihood of Malay or Japanese genetic background can be judged based on Y-chromosome STR test results.

Matched MeSH terms: Japan
Natural capital evaluation in the FutureCity of Shimokawa, Northern Japan, based on forest economics

Hojo A, Tsuji N, Kasuga T, Osaki M

Environ Monit Assess, 2021 Nov 12;193(12):793.
PMID: 34767121 DOI: 10.1007/s10661-021-09434-y

We have pragmatically but accurately evaluated the natural capital of a small northern town, Shimokawa, Hokkaido, Japan. The key industries are forestry, wood manufacturing, and agriculture. From an environmental perspective, Shimokawa was nominated as a Japanese FutureCity. Consequently, the total natural capital value (NCV) of the forest and agricultural lands was calculated to be 1.326 billion USD/year (or 24,161 USD/ha/year) and 44 million USD/year (or 19,692 USD/ha/year), respectively, in 2012. The sum of these NCVs was more than 7 times greater than the yearly gross production of the town, although the forest had a higher NCV because of the larger area (54,862 ha for forest area), compared with 2953 ha for agricultural area. This substantial NCV is mainly generated by sustainable forest management. The timber account showed that the annual tree growth was greater than the annual harvest of trees. The CO2 account derived from a one-year calculation showed that the town served as a CO2 sink at 107,249 t-CO2/year due to the large amount of annual tree growth and CO2 storage in the harvested wood products even if CO2 was emitted from industries and households. The forestry and wood manufacturing industries, as well as agriculture, created socioeconomic effects for the townspeople, ranging from job creation, study tours, and social welfare. This NCV accounting for Shimokawa town ensures the sustainable use of valuable environmental assets and will help other communities recognize their own NCV accounts.

Matched MeSH terms: Japan
Fulltext Seasonal and year-round use of the Kushiro Wetland, Hokkaido, Japan by sika deer (Cervus nippon yesoensis)

Takafumi H, Kamii T, Murai T, Yoshida R, Sato A, Tachiki Y, et al.

PeerJ, 2017;5:e3869.
PMID: 29038752 DOI: 10.7717/peerj.3869

The sika deer (Cervus nippon yesoensis) population in the Ramsar-listed Kushiro Wetland has increased in recent years, and the Ministry of the Environment of Japan has decided to take measures to reduce the impact of deer on the ecosystem. However, seasonal movement patterns of the deer (i.e., when and where the deer inhabit the wetland) remain unclear. We examined the seasonal movement patterns of sika deer in the Kushiro Wetland from 2013 to 2015 by analyzing GPS location data for 28 hinds captured at three sites in the wetland. Seasonal movement patterns were quantitatively classified as seasonal migration, mixed, dispersal, nomadic, resident, or atypical, and the degree of wetland utilization for each individual was estimated. The area of overlap for each individual among intra-capture sites and inter-capture sites was calculated for the entire year and for each season. Our results showed that the movement patterns of these deer were classified not only as resident but also as seasonal migration, dispersal, and atypical. Approximately one-third of the individuals moved into and out of the wetland during the year as either seasonal migrants or individuals with atypical movement. Some of the individuals migrated to farmland areas outside the wetland (the farthest being 69.9 km away). Half of the individuals inhabited the wetland all or most of the year, i.e., 81-100% of their annual home range was within the wetland area. Even among individuals captured at the same site, different seasonal movement patterns were identified. The overlap areas of the home ranges of individuals from the same capture sites were larger than those for individuals from different capture sites (e.g., mean of annual home range overlap with intra-capture sites: 47.7% vs. inter-sites: 1.3%). To achieve more effective ecosystem management including deer management in the wetland, management plans should cover inside and outside of the wetland and separate the population into multiple management units to address the different movement patterns and wetland utilization of the population.

Matched MeSH terms: Japan
Domain-Specific Sedentary Behaviour and Health-Related Quality of Life by Age among Japanese Living in Malaysia

Izawa KP, Oka K

Rev Recent Clin Trials, 2022;17(2):120-125.
PMID: 35289254 DOI: 10.2174/1574887117666220314112244

BACKGROUND: Recently, the number of Japanese people living in Asia has increased. A previous study suggested that obesity and overweight are growing health problems both in Malaysia and worldwide that result from lifestyle changes such as a decrease in physical activity, an increase in sedentary behaviour, and poor eating habits.
OBJECTIVE: The purpose of the present study was to investigate the effects of differences in social demographic factors and domain-specific sedentary behaviour and health-related quality of life by age in Japanese living overseas.
METHODS: We surveyed 109 participants by self-entry questionnaire for social demographic factors and domain-specific sedentary behaviour by life scenario and by Short Form-36 (SF-36) for healthrelated quality of life. The subjects were divided into the ≥65 years group and <65 years group.
RESULTS: Significant differences were noted in age, employment, alcohol intake, and marital status between the groups, whereas none were noted for transportation, driving, television viewing, and smartphone/personal computer use. Work time and total sitting time of sedentary behaviour were higher, and leisure-time activity and SF-36 Mental Component Score for health-related quality of life were lower in the <65 years group.
CONCLUSION: By assessing differences in social demographic factors and discouraging sedentary behaviour, sitting time in overseas-dwelling Japanese residents may be reduced, and effective strategies to improve health-related quality of life can be developed to combat such behaviour.

Matched MeSH terms: Japan

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