MyMedR

Fulltext The importance of Good Clinical Practice guidelines and its role in clinical trials

Vijayananthan A, Nawawi O

Biomed Imaging Interv J, 2008 Jan;4(1):e5.

PMID: 21614316 MyJurnal DOI: 10.2349/biij.4.1.e5

Good Clinical Practice (GCP) is an international ethical and scientific quality standard for the design, conduct, performance, monitoring, auditing, recording, analyses and reporting of clinical trials. It also serves to protect the rights, integrity and confidentiality of trial subjects. It is very important to understand the background of the formation of the ICH-GCP guidelines as this, in itself, explains the reasons and the need for doing so. In this paper, we address the historical background and the events that led up to the formation of these guidelines. Today, the ICH-GCP guidelines are used in clinical trials throughout the globe with the main aim of protecting and preserving human rights.

Matched MeSH terms: Eye

Fulltext Intra-cranial metastatic lacrimal gland tumour

Wahab NA, Ramasamy U, George J, Madhavan M, Arif AR, Abdullah J

Med J Malaysia, 2006 Dec;61(5):641-3.

PMID: 17623971 MyJurnal

We report a case of an adult who presented with progressive swelling in the right eye with suggestive of intracranial lesion on imaging. Histopathological revealed a lacrimal gland malignant mixed tumour.

Matched MeSH terms: Eye Neoplasms/diagnosis; Eye Neoplasms/pathology; Eye Neoplasms/surgery*

Hypotensive anesthesia in the management of a posterior suprachoroidal foreign body

Hashim H, Lim KS, Choong YY, Nor NM

Retina, 2005 Jan;25(1):87-9.

PMID: 15655449

Matched MeSH terms: Eye Foreign Bodies/surgery*; Eye Injuries, Penetrating/surgery*

Fulltext Increment of Access Points in Integrated System of Wavelength Division Multiplexed Passive Optical Network Radio over Fiber

Amiri IS, Alavi SE, Soltanian MR, Fisal N, Supa'at AS, Ahmad H

Sci Rep, 2015;5:11897.

PMID: 26153536 DOI: 10.1038/srep11897

This paper describes a novel technique to increase the numbers of access points (APs) in a wavelength division multiplexed-passive optical network (WDM-PON) integrated in a 100 GHz radio-over-fiber (RoF). Eight multi-carriers separated by 25 GHz intervals were generated in the range of 193.025 to 193.200 THz using a microring resonator (MRR) system incorporating an add-drop filter system. All optically generated multi-carriers were utilized in an integrated system of WDM-PON-RoF for transmission of four 43.6 Gb/sec orthogonal frequency division multiplexing (OFDM) signals. Results showed that an acceptable BER variation for different path lengths up to 25 km was achievable for all four access points and thus the transmission of four OFDM channels is feasible for a 25 km standard single mode fiber (SSMF) path length.

Matched MeSH terms: Eye

White-eyed blowout fracture: Diagnostic pitfalls and review of literature

Yew CC, Shaari R, Rahman SA, Alam MK

Injury, 2015 Sep;46(9):1856-9.

PMID: 25986667 DOI: 10.1016/j.injury.2015.04.025

White-eyed blowout fracture was first termed by Jordan et al. in individuals sustaining a blow to the periocular area and presenting with ocular symptoms, although with minimal soft tissue signs of trauma. It is often found in pure orbital floor blowout fractures among paediatric patients, and it could manifest as a linear or hinge-like trapdoor deformity. Unlike the more common open orbital blowout fractures with distinct diagnostic clinical signs, white-eyed blowout fractures are rarer and their diagnoses can be easily missed, subsequently costing an optimal time window for surgical intervention. This is critical as better outcomes are found with earlier release of entrapments. This report describes a case of a white-eyed blowout fracture in a 10-year-old child faced with its diagnostic challenges. The current literature review discusses the types of fracture pattern, signs and symptoms, mechanism of action, as well as timing of surgery. In view of the common complication of persistent diplopia, clinical pitfalls in achieving this diagnosis are emphasized to prevent any delay of treatment. Current literature evidences are weighted towards urgent surgical intervention, as positive outcomes are found to correlate with earlier release of entrapments.

Matched MeSH terms: Eye

Fulltext Giant cell arteritis with panocular involvement in an Indian male

Fathilah J, Jamaliah R

Med J Malaysia, 2003 Mar;58(1):111-4.

PMID: 14556335

A case of giant cell arteritis with systemic and panocular involvement is reported here. This elderly Indian male presented with symptoms of unilateral temporal headache and intermittent jaw claudication for a month followed by diplopia and blurring of vision and later loss of vision in the right eye. The right eye showed some limitation of ocular movements, presence of relative afferent pupil defect, anterior segment ischaemic changes and anterior ischaemic optic neuropathy. Visual evoked potential showed an absent P1 wave while the left eye with normal 6/6 vision sowed a prolonged P1 wave. Fundus fluoresceine angiography showed delay in choroidal perfusion. His erythrocyte sedimentation rate (ESR) was 120 mm/hr and he was started on oral prednisolone. Superficial temporal artery biopsy obtained one week after starting steroids was positive for giant cell arteritis. Steroids led to the resolution of optic disc swelling, disappearance of anterior segment signs, full recovery of right ocular movements and no further deterioration of the fellow eye. On steroids, he developed insomnia and progressive myopathy which resolved and is now symptom free at lower doses of steroids.

Matched MeSH terms: Eye Diseases/diagnosis*; Eye Diseases/etiology*; Eye Diseases/therapy

Orbital injuries in children: play-related

Shriwas SR, Kinzha AZ

Indian J Ophthalmol, 1993 Oct;41(3):129-30.

PMID: 8125546

Matched MeSH terms: Eye Foreign Bodies/etiology; Eye Injuries, Penetrating/etiology*

Fulltext Multi Beam Dielectric Lens Antenna for 5G Base Station

Ansarudin F, Abd Rahman T, Yamada Y, Rahman NHA, Kamardin K

Sensors (Basel), 2020 Oct 16;20(20).

PMID: 33081110 DOI: 10.3390/s20205849

In the 5G mobile system, new features such as millimetre wave operation, small cell size and multi beam are requested at base stations. At millimetre wave, the base station antennas become very small in size, which is about 30 cm; thus, dielectric lens antennas that have excellent multi beam radiation pattern performance are suitable candidates. For base station application, the lens antennas with small thickness and small curvature are requested for light weight and ease of installation. In this paper, a new lens shaping method for thin and small lens curvature is proposed. In order to develop the thin lens antenna, comparisons of antenna structures with conventional aperture distribution lens and Abbe's sine lens are made. Moreover, multi beam radiation pattern of three types of lenses are compared. As a result, the thin and small curvature of the proposed lens and an excellent multi beam radiation pattern are ensured.

Matched MeSH terms: Eye Abnormalities

Fulltext Spot diagram profile of uncorrected and corrected myopic model eye

Shah Farez Othman, Nizam Tamchek, Farah Diana Muhammad, Shah Farez Othman, Shah Farez Othman, Mohd Hafidz Ithnin

Journal of Optometry, Eye and Health Research, 2020;2(1):34-47.

MyJurnal

Current trend shows that the eye modelling is based on the emmetropic eye taken its ocular optical components value from the population-based studies. However, no studies have been done to study the effect of aberration of myopic refractive error by modelling the eye using the parameters from ocular biometrics and ray tracing method. The objective of the present study was to determine the spot diagram (SPD) profile of myopic refractive error using eye modelling and ray tracing technique. Three eye models had been successfully modeled in Zemax software, namely, emmetropic Liou and Brennan, myopic Liou and Brennan, corrected myopic Liou and Brennan. The optical performance of the eye models were tested using the SPD profile. The ray distribution from the analysis of SPD of myopic Liou and Brennan eye was larger compared to the emmetropic model. In comparison with the emmetropic Liou and Brennan model, for the blue wavelength, the RMS spot radius for the corrected version was increased. However, the RMS values were decreased for green and red wavelengths. For the corrected myopic version of Liou and Brennan, in comparison with its emmetropic model, the Airy disc diameter increased with the increment of wavelengths. It was found that the Airy disc diameter accuracy were higher for the blue, green and red wavelengths. Although the accuracy values were in a positive sign, for Airy disc diameter, the smaller value indicates a diffraction-limited condition.

Matched MeSH terms: Eye

Fulltext Crystal structure of a second monoclinic polymorph of 3-meth-oxy-benzoic acid with Z' = 1

Chia TS, Kwong HC, Wong QA, Quah CK, Arafath MA

Acta Crystallogr E Crystallogr Commun, 2019 Jan 01;75(Pt 1):8-11.

PMID: 30713724 DOI: 10.1107/S2056989018016900

A new polymorphic form of the title compound, C8H8O3, is described in the centrosymmetric monoclinic space group P21/c with Z' = 1 as compared to the first polymorph, which crystallizes with two conformers (Z' = 2) in the asymmetric unit in the same space group. In the crystal of the second polymorph, inversion dimers linked by O-H⋯O hydrogen bonds occur and these are linked into zigzag chains, propagating along the b-axis direction by C-H⋯O links. The crystal structure also features a weak π-π inter-action, with a centroid-to-centroid distance of 3.8018 (6) Å. The second polymorph of the title compound is less stable than the reported first polymorph, as indicated by its smaller calculated lattice energy.

Matched MeSH terms: Eye, Artificial

Fulltext Grade IV hypertensive retinopathy as a rare first representation of hypertension: a case report

Tengku Kamalden, T.A., Choo, M.M., Fauzi, A.

JUMMEC, 2006;9(2):32-34.

MyJurnal

Malignant hypertension affects less than 1% of people with high blood pressure, and is a hypertensive emergency. It is rare for patients to present initially with this form of elevated blood pressure, which is almost always associated with acute target organ damage, which can manifest in many forms including ocular, neurological, cardiac and renal. This treatable condition is associated with a high rate of morbidity and mortality therefore, early detection and immediate management is of paramount importance.

Matched MeSH terms: Eye

Ocular conditions among the Orang Asli, the jungle aborigines of West Malaysia

Weerekoon L

Trans Ophthalmol Soc N Z, 1973;25:30-5.

PMID: 4519227

Matched MeSH terms: Eye Diseases/epidemiology*; Eye Injuries/epidemiology

Fulltext A study of factors influencing eye screening: descriptive findings

Rif'atunnailah Mat Isa, Adzura Salam, Sumaiyah @ Thandar Soe Jamaluddin

International Medical Journal Malaysia, 2017;16(11):13-13.

MyJurnal

Individuals with Diabetes Mellitus (DM) are at increased risk for developing
diabetic ocular complications. This study was carried out to determine factors
influencing eye screening among Diabetes Mellitus patients. The descriptive findings of
participants’ sociodemographic data will be discussed. (Copied from article).

Matched MeSH terms: Eye

Fulltext Bilateral optic neuritis with maculopathy: A rare manifestation of dengue fever

Boo YL, Lim SY, Chin PW, Hoo FK

Malays Fam Physician, 2017;12(1):32-34.

PMID: 28503273 MyJurnal

Dengue fever is a common mosquito-borne disease, which is endemic in tropical and subtropical countries. Bilateral optic neuropathy is a relatively unusual dengue-related ocular complication. Here, we present a case of bilateral optic neuritis with maculopathy complicating dengue infection.

Matched MeSH terms: Eye

Fulltext Review of ocular injuries in Malaysia

Thevi T, Reddy SC

Malaysian Journal of Public Health Medicine, 2017;17(1):69-77.

MyJurnal

Ocular injuries or trauma to the eye can be caused by variety of objects resulting in a spectrum of lesions in the eye. We did a Pubmed/Google/Science Direct search to review the spectrum of ocular injuries in Malaysia. In our review, we included 28 papers providing information on ocular injuries which were published from Malaysia during the period 1991-2016 in different medical journals. Prevalence was more among males with an average age of 35 years. Among adults they were more common in the workplace but in children it occurred at home. Few wore protective glasses at work. The mode of injury was due to sharp objects hitting the eye, motor vehicle and domestic accidents, firecrackers, chemicals and rarer causes like superglue and durian fruit. Prognostic factors for outcome were the initial visual acuity, length of the wound, associated factors like hyphaema, intraocular foreign body and vitreous prolapse. Missing the diagnosis of perforation of the eyeball is possible without eliciting a proper history. Protective devices must be worn to prevent injuries. Display of health education charts showing the effect of injuries in the eye and their preventive measures in health centres, private hospitals, schools, factories and sports centres will increase the awareness of public about the ocular injuries. It is important to diagnose the tissues involved in ocular trauma by the general practitioners and primary care physicians and refer the patients to the Ophthalmologist urgently for treatment to salvage vision. Compensation mechanisms should then be put forth in terms of rehabilitation and for monetary loss.

Matched MeSH terms: Eye Foreign Bodies; Eye Injuries*; Eye Protective Devices

Fulltext Endogenous endophthalmitis as a septic complication postureteroscope candiduria

Inn FX, Md Noh UK, Jasman MH

Urol Ann, 2017 2 22;9(1):83-85.

PMID: 28216938 DOI: 10.4103/0974-7796.198902

Ureteroscopy (URS) is commonly used by urologists to treat ureteral stones. It is a relatively low-risk procedure. Both urinary tract obstruction and contamination of instrument can cause candiduria post-URS, and this infection can be treated with an antifungal medication. Candidemia is known as hematogenous dissemination, and ocular tissue is a common invasion. However, endogenous endophthalmitis, due to postureteroscope candiduria, has not been reported up to date. This is a devastating complication that may lead to visual loss. Here, we describe a case of endogenous endophthalmitis as a consequence of candiduria after URS.

Matched MeSH terms: Eye

Effectiveness of topical insulin for the treatment of surface corneal pathologies

Castro Mora MP, Palacio Varona J, Perez Riaño B, Laverde Cubides C, Rey-Rodriguez DV

Arch Soc Esp Oftalmol (Engl Ed), 2023 Apr;98(4):220-232.

PMID: 36871851 DOI: 10.1016/j.oftale.2023.03.007

The Purpose is to identify, through a systematic literature review, the current evidence regarding the effectiveness of topical insulin treatment in ocular surface pathologies. A literature search was implemented in Medline (Pubmed), Embase and Web Of Science medical indexing databases by using keywords such as "insulin" AND "cornea" OR "corneal" OR "dry eye" in published papers in English or Spanish within the last eleven years (2011-2022). Nine papers were identified with 180 participants from the United States, Spain, Ireland, Canada, Portugal and Malaysia, with persistent refractory epithelial defects and secondary to vitrectomy, whose extension of the lesion was from 3,75mm2 to 65.47mm2. The preparation was dissolved with artificial tears and the insulin concentration ranged from 1 IU/ml to 100 IU/ml. In all cases, the resolution of the clinical picture was complete with a healing time from 2.5 days to 60.9 days, the latter being a secondary case to a difficult-to-control caustic burn. Topical insulin has been effective for the treatment of persistent epithelial defects. The intermediate action and low concentrations showed a shorter resolution time in neurotrophic ulcers and induced during vitreoretinal surgery.

Matched MeSH terms: Lubricant Eye Drops

Fulltext Relationship between autonomic arousal and attention orienting in children and adolescents with ADHD, autism and co-occurring ADHD and autism

Bellato A, Arora I, Kochhar P, Ropar D, Hollis C, Groom MJ

Cortex, 2023 Sep;166:306-321.

PMID: 37459680 DOI: 10.1016/j.cortex.2023.06.002

INTRODUCTION: Attention-Deficit/Hyperactivity Disorder (ADHD) and Autism Spectrum Disorder (ASD) may be characterized by different profiles of visual attention orienting. However, there are also many inconsistent findings emerging from the literature, probably due to the fact that the potential effect of autonomic arousal (which has been proposed to be dysregulated in these conditions) on oculomotor performance has not been investigated before. Moreover, it is not known how visual attention orienting is affected by the co-occurrence of ADHD and autism in people with a double diagnosis.

METHODS: 99 children/adolescents with or without ADHD and/or autism (age 10.79 ± 2.05 years, 65% boys) completed an adapted version of the gap-overlap task (with baseline and overlap trials only). The social salience and modality of stimuli were manipulated between trials. Eye movements and pupil size were recorded. We compared saccadic reaction times (SRTs) between diagnostic groups and investigated if a trial-by-trial association existed between pre-saccadic pupil size and SRTs.

RESULTS: Faster orienting (shorter SRT) was found for baseline compared to overlap trials, faces compared to non-face stimuli and-more evidently in children without ADHD and/or autism-for multi-modal compared to uni-modal stimuli. We also found a linear negative association between pre-saccadic pupil size and SRTs, in autistic participants (without ADHD), and a quadratic association in children with ADHD (without autism), for which SRTs were slower when intra-individual pre-saccadic pupil size was smallest or largest.

CONCLUSION: Our findings are in line with previous literature and indicate a possible effect of dysregulated autonomic arousal on oculomotor mechanisms in autism and ADHD, which should be further investigated in future research studies with larger samples, to reliably investigate possible differences between children with single and dual diagnoses.

Matched MeSH terms: Eye Movements

Fulltext Case Report: Spectrum of interesting ocular manifestations following COVID-19 vaccination: a case series of real-world presentations

Tajunisah I, Tan SS, Effendi-Tenang I, Samsudin A, Ling KP, Tan WY, et al.

Front Cell Infect Microbiol, 2023;13:1243055.

PMID: 37790912 DOI: 10.3389/fcimb.2023.1243055

PURPOSE: We report the ocular findings that patients experienced after receiving the coronavirus disease 2019 (COVID-19) vaccination in three different eye centers in Malaysia.

OBSERVATIONS: A total of four cases were reported. Three patients received the Pfizer-BioNTech vaccine, while the other received the Oxford AstraZeneca type. Ocular symptoms occurred after the first vaccine dose in two patients and after the second vaccine dose in the other two. Three out of four patients required active treatment for their vision complications postvaccination. The first patient had acute-onset retinal pigment epitheliitis within 3 h of vaccination and was treated conservatively. The second patient developed unilateral choroidal neovascularization 3 days after vaccination and required intravitreal antivascular endothelial growth factor injection. The third patient presented with bilateral acute multifocal placoid pigment epitheliopathy a week after vaccination and responded to intravenous methylprednisolone. The fourth patient presented with herpes zoster infection and unilateral anterior nongranulomatous uveitis 2 weeks after vaccination and was treated with oral acyclovir and topical corticosteroids. All patients reported some amount of visual recovery.

CONCLUSIONS AND IMPORTANCE: Visual symptoms and various ocular adverse events can occur following COVID-19 vaccination, which warrants further investigation and urgent intervention if necessary. We would suggest patients receiving the COVID-19 vaccination be aware of possible ocular complications and report any symptoms, regardless of severity.

Matched MeSH terms: Eye

Fulltext HIV- and AIDS-related Ocular Manifestations in Tanzanian Patients

Sahoo S

Malays J Med Sci, 2010 Jan;17(1):12-6.

PMID: 22135520 MyJurnal

Although around 70% of HIV+ cases used to have ocular manifestations, the late reporting of cases often results in severe forms of ocular morbidity that would otherwise have been prevented. The objective of this study was to describe the ocular manifestations of HIV and AIDS-related patients who had been admitted to TM Jafferji Hospital, Dar-es-Salaam, Tanzania.

Matched MeSH terms: Eye

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