Displaying publications 81 - 100 of 284 in total

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  1. Fulltext Associations of clothing size, adiposity and weight change with risk of postmenopausal breast cancer in the UK Women's Cohort Study (UKWCS)
    Moy FM, Greenwood DC, Cade JE
    BMJ Open, 2018 Sep 28;8(9):e022599.
    PMID: 30269068 DOI: 10.1136/bmjopen-2018-022599
    OBJECTIVES: Breast cancer is associated with overweight and obesity after menopause. However, clothing size as a proxy of adiposity in predicting postmenopausal breast cancer is not widely studied. We aimed to explore the relationships between postmenopausal breast cancer risk with adipose indicators (including clothing sizes) and weight change over adulthood.

    DESIGN: Prospective cohort study.

    SETTING: England, Wales and Scotland.

    PARTICIPANTS: 17 781 postmenopausal women from the UK Women's Cohort Study.

    PRIMARY OUTCOME MEASURE: Incident cases of malignant breast cancers (International Classification of Diseases (ICD) 9 code 174 and ICD 10 code C50).

    RESULTS: From 282 277 person-years follow-up, there were 946 incident breast cancer cases with an incidence rate of 3.35 per 1000 women. Body mass index (HR: 1.04; 95% CI: 1.02 to 1.07), blouse size (HR: 1.10; 1.03 to 1.18), waist circumference (HR: 1.07; 1.01 to 1.14) and skirt size (HR: 1.14;1.06 to 1.22) had positive associations with postmenopausal breast cancer after adjustment for potential confounders. Increased weight over adulthood (HR: 1.02; 1.01 to 1.03) was also associated with increased risk for postmenopausal breast cancer.

    CONCLUSIONS: Blouse and skirt sizes can be used as adipose indicators in predicting postmenopausal breast cancer. Maintaining healthy body weight over adulthood is an effective measure in the prevention of postmenopausal breast cancer.

    Matched MeSH terms: Great Britain/epidemiology
  2. Fulltext The role of CT in case ascertainment and management of COVID-19 pneumonia in the UK: insights from high-incidence regions
    Chua F, Armstrong-James D, Desai SR, Barnett J, Kouranos V, Kon OM, et al.
    Lancet Respir Med, 2020 May;8(5):438-440.
    PMID: 32220663 DOI: 10.1016/S2213-2600(20)30132-6
    Matched MeSH terms: Great Britain/epidemiology
  3. Fulltext Combating obesity through healthy eating behavior: a call for system dynamics optimization
    Abidin NZ, Mamat M, Dangerfield B, Zulkepli JH, Baten MA, Wibowo A
    PLoS One, 2014;9(12):e114135.
    PMID: 25502170 DOI: 10.1371/journal.pone.0114135
    Poor eating behavior has been identified as one of the core contributory factors of the childhood obesity epidemic. The consequences of obesity on numerous aspects of life are thoroughly explored in the existing literature. For instance, evidence shows that obesity is linked to incidences of diseases such as heart disease, type-2 diabetes, and some cancers, as well as psychosocial problems. To respond to the increasing trends in the UK, in 2008 the government set a target to reverse the prevalence of obesity (POB) back to 2000 levels by 2020. This paper will outline the application of system dynamics (SD) optimization to simulate the effect of changes in the eating behavior of British children (aged 2 to 15 years) on weight and obesity. This study also will identify how long it will take to achieve the government's target. This paper proposed a simulation model called Intervention Childhood Obesity Dynamics (ICOD) by focusing the interrelations between various strands of knowledge in one complex human weight regulation system. The model offers distinct insights into the dynamics by capturing the complex interdependencies from the causal loop and feedback structure, with the intention to better understand how eating behaviors influence children's weight, body mass index (BMI), and POB measurement. This study proposed a set of equations that are revised from the original (baseline) equations. The new functions are constructed using a RAMP function of linear decrement in portion size and number of meal variables from 2013 until 2020 in order to achieve the 2020 desired target. Findings from the optimization analysis revealed that the 2020 target won't be achieved until 2026 at the earliest, six years late. Thus, the model suggested that a longer period may be needed to significantly reduce obesity in this population.
    Matched MeSH terms: Great Britain/epidemiology
  4. Fulltext At-admission prediction of mortality and pulmonary embolism in an international cohort of hospitalised patients with COVID-19 using statistical and machine learning methods
    Mesinovic M, Wong XC, Rajahram GS, Citarella BW, Peariasamy KM, van Someren Greve F, et al.
    Sci Rep, 2024 Jul 16;14(1):16387.
    PMID: 39013928 DOI: 10.1038/s41598-024-63212-7
    By September 2022, more than 600 million cases of SARS-CoV-2 infection have been reported globally, resulting in over 6.5 million deaths. COVID-19 mortality risk estimators are often, however, developed with small unrepresentative samples and with methodological limitations. It is highly important to develop predictive tools for pulmonary embolism (PE) in COVID-19 patients as one of the most severe preventable complications of COVID-19. Early recognition can help provide life-saving targeted anti-coagulation therapy right at admission. Using a dataset of more than 800,000 COVID-19 patients from an international cohort, we propose a cost-sensitive gradient-boosted machine learning model that predicts occurrence of PE and death at admission. Logistic regression, Cox proportional hazards models, and Shapley values were used to identify key predictors for PE and death. Our prediction model had a test AUROC of 75.9% and 74.2%, and sensitivities of 67.5% and 72.7% for PE and all-cause mortality respectively on a highly diverse and held-out test set. The PE prediction model was also evaluated on patients in UK and Spain separately with test results of 74.5% AUROC, 63.5% sensitivity and 78.9% AUROC, 95.7% sensitivity. Age, sex, region of admission, comorbidities (chronic cardiac and pulmonary disease, dementia, diabetes, hypertension, cancer, obesity, smoking), and symptoms (any, confusion, chest pain, fatigue, headache, fever, muscle or joint pain, shortness of breath) were the most important clinical predictors at admission. Age, overall presence of symptoms, shortness of breath, and hypertension were found to be key predictors for PE using our extreme gradient boosted model. This analysis based on the, until now, largest global dataset for this set of problems can inform hospital prioritisation policy and guide long term clinical research and decision-making for COVID-19 patients globally. Our machine learning model developed from an international cohort can serve to better regulate hospital risk prioritisation of at-risk patients.
    Matched MeSH terms: Great Britain/epidemiology
  5. Dentists should be at the forefront in the fight against sugar
    Masood M, Masood Y, Reidpath DD, Newton T
    Lancet, 2014 Jun 14;383(9934):2046.
    PMID: 24931691 DOI: 10.1016/S0140-6736(14)60996-X
    Matched MeSH terms: Great Britain
  6. Fulltext Changes in salivary immunoglobulin A (IgA) following match-play and training among English premiership footballers
    Fredericks S, Fitzgerald L, Shaw G, Holt DW
    Med J Malaysia, 2012 Apr;67(2):155-8.
    PMID: 22822634
    Decreased salivary immunoglobulin A (sIgA), a component of mucosal immunity, is associated with intensive physical activity: suggesting that sIgA may be used for the monitoring of mucosal immunity with footballers. We investigated changes in sIgA in elite footballers, in response to training and match-play. There was a decrease in sIgA following training, with a return to pre-training levels after 18 hours of rest. This return to resting levels was not observed following competitive match-play. Overnight rest was sufficient for mucosal IgA recovery following training but not following two successive matches, suggesting that sIgA may be used to monitor training in multi-sprint sports.
    Matched MeSH terms: Great Britain
  7. Medical misadventures
    Lewis K
    Med J Malaysia, 2003 Mar;58 Suppl A:68-71.
    PMID: 14556352
    Historical perspective of terminations of unwanted pregnancies in the UK. Moral and ethical considerations imposed by established church's teachings becoming increasingly in conflict with the wishes and expectations of a more secular society. Recognition that illegal abortion was, as a matter of fact available, at great risk to vulnerable girls and women. Eventually public demand and a radical and reforming government led to the current Statutory Framework. Statutory provisions: Offences against the Person Act 1861, Sections 58 and 59; Infant Life Preservation Act 1929 Section 1. Recognition of the limited flexibility allowed by the law in the original restrictive statutory framework. The direction to the jury in July 1938 by Macnaghten J in the case of R. v. Bourne [1939] 1 KB 687, where an eminent obstetrician was acquitted after carrying out an abortion on a young rape victim. Then the modern statutory provisions: Abortion Act 1967, amended by the Human Fertilisation and Embryology Act 1990. The statutory framework provides for healthcare professionals not to have to take part in terminations if they have a conscientious objection to doing so. While there are still fierce challenges from moral pressure groups when any changes in the detail of the law are proposed--such as reducing the maximum gestation period for a lawful termination--as a whole society seems to have accepted the current law. Issues affecting doctors who consider and provide terminations; current medico-legal problems relating to wanted pregnancies that have been lost by reason of clinical negligence, and unwanted children that have been born by reason of clinical negligence.
    Matched MeSH terms: Great Britain
  8. The legal aspects of the termination of unwanted pregnancies and the risks faced by the medical doctor: a UK perspective
    Gibson C
    Med J Malaysia, 2003 Mar;58 Suppl A:36-48.
    PMID: 14556349
    Historical perspective of terminations of unwanted pregnancies in the UK. Moral and ethical considerations imposed by established church's teachings becoming increasingly in conflict with the wishes and expectations of a more secular society. Recognition that illegal abortion was, as a matter of fact available, at great risk to vulnerable girls and women. Eventually public demand and a radical and reforming government led to the current Statutory Framework. Statutory provisions: Offences against the Person Act 1861, Sections 58 and 59; Infant Life Preservation Act 1929 Section 1. Recognition of the limited flexibility allowed by the law in the original restrictive statutory framework. The direction to the jury in July 1938 by Macnaghten J in the case of R. v. Bourne [1939] 1 KB 687, where an eminent obstetrician was acquitted after carrying out an abortion on a young rape victim. Then the modern statutory provisions: Abortion Act 1967, amended by the Human Fertilisation and Embryology Act 1990. The statutory framework provides for healthcare professionals not to have to take part in terminations if they have a conscientious objection to doing so. While there are still fierce challenges from moral pressure groups when any changes in the detail of the law are proposed--such as reducing the maximum gestation period for a lawful termination--as a whole society seems to have accepted the current law. Issues affecting doctors who consider and provide terminations; current medico-legal problems relating to wanted pregnancies that have been lost by reason of clinical negligence, and unwanted children that have been born by reason of clinical negligence.
    Matched MeSH terms: Great Britain
  9. John Desmond Gimlette: "one of God's own"
    Fleming PR
    J Med Biogr, 1998 Nov;6(4):222-6.
    PMID: 11623507
    Matched MeSH terms: Great Britain
  10. Specificity of Schneider's first rank symptoms for schizophrenia in Malay patients
    Salleh MR
    Psychopathology, 1992;25(4):199-203.
    PMID: 1492143
    The frequency of Schneider's first rank symptoms (FRS) was studied in 221 Malay patients with functional psychosis. The prevalence of FRS in schizophrenia was 26.7%. The most common symptoms were voice arguing, passivity phenomena and somatic passivity. In the absence of organic brain dysfunction, the specificity of FRS for schizophrenia was 87.8%, and their positive predictive value was 90.6%. These findings indicate that although FRS is not pathognomonic of schizophrenia, their presence should be regarded as strongly suggestive of schizophrenia in the absence of organic etiology. FRS do not however occur with sufficient frequency to have potential diagnostic in schizophrenia.
    Matched MeSH terms: Great Britain
  11. Medical affairs in the Far East after V-J day. A personal view
    Girdwood RH
    Scott Med J, 1995 Jun;40(3):84-7.
    PMID: 7569872
    The invasion of Singapore and Malaya was delayed because of the reduction in the period of service in the Far East. The atom bombs were then dropped and plans for all services including medical ones had to be altered, their main aim becoming the treatment and repatriation of surviving prisoners of war. The ending of the war did not occur abruptly on V-J day; many Japanese troops had to be convinced that the war was over. Meantime the treatment of diseases in British and other service men continued; reference is made to some experiences in Rangoon. The morale of personnel who now were anxious to return to their homes was low and efforts were made to raise their spirits. In India it was accepted that the days of British rule were over.
    Matched MeSH terms: Great Britain
  12. Tropical treatment
    Tomlinson A
    Nurs Times, 1993 Sep;89(35):40-1.
    PMID: 8139959
    Matched MeSH terms: Great Britain
  13. Sir Neil Hamilton Fairley, drug resistant malaria and the myth of massive infection in Malaya 1947-63
    O'Keefe BG
    Occas Pap Med Hist Aust, 1990;4:201-19.
    PMID: 11622898
    Matched MeSH terms: Great Britain
  14. Endoscopic disinfection: practices and recommendations
    Tandon RK
    J Gastroenterol Hepatol, 1991 1 1;6(1):37-9.
    PMID: 1883975
    Matched MeSH terms: Great Britain
  15. Breast feeding among the Chinese in four countries
    Koh TH
    J Trop Pediatr, 1981 04;27(2):88-91.
    PMID: 7230315 DOI: 10.1093/tropej/27.2.88
    Matched MeSH terms: Great Britain
  16. Taking it apart and putting it back together again: Using Item Pool Visualisation to summarise complex data patterns in (positive) body image research
    Swami V, Furnham A, Horne G, Stieger S
    Body Image, 2020 Sep;34:155-166.
    PMID: 32593946 DOI: 10.1016/j.bodyim.2020.05.004
    Issues of construct commonality and distinguishability in body image research are typically addressed using structural equal models, but such methods can sometimes present problems of interpretation when data patterns are complex. One recent-developed tool that could help in summarising complex data patterns is Item Pool Visualisation (IPV), an illustrative method that locates item pools from within the same dataset and illustrates these in the form of single or nested radar charts. Here, we demonstrate the utility of IPV in visualising data patterns vis-à-vis positive body image. Five-hundred-and-one adults from the United Kingdom completed seven widely-used measures of positive body image and data were subjected IPV. Results demonstrated that, of the included measures, the Body Appreciation Scale-2 provided the closest and most precise measurement of a core positive body image construct. The Functionality Appreciation Scale and the Authentic Pride subscale of the Body and Appearance Self-Conscious Emotions Scale tapped more distal aspects. Our results also highlight possible limitations with the use of several other instruments as measures of positive body image. We discuss implications for research aimed at better understanding the nature of positive body image and interpreting complex data patterns in body image research more generally.
    Matched MeSH terms: Great Britain
  17. Body acceptance by others: Refinement of the construct, and development and psychometric evaluation of a revised measure - The Body Acceptance by Others Scale-2
    Swami V, Todd J, Stieger S, Furnham A, Horne G, Tylka TL
    Body Image, 2021 Mar;36:238-253.
    PMID: 33387962 DOI: 10.1016/j.bodyim.2020.11.007
    The Body Acceptance by Others Scale (BAOS) measures the degree to which individuals perceive body acceptance by others, but its factor structure is questionable. Here, we developed a revision of the BAOS (i.e., the BAOS-2) by designing novel items reflective of generalised perceptions of body acceptance by others. In three studies, we examined the psychometrics of the 13-item BAOS-2. Study 1, with United Kingdom adults (N = 601), led to the extraction of a unidimensional model of BAOS-2 scores and provided evidence of 4-week test-retest reliability. Study 2, with United Kingdom adults (N = 423), indicated that the unidimensional model of BAOS-2 scores had adequate fit and that scores were invariant across gender. Study 2 also provided evidence of convergent, construct, criterion, discriminant, and incremental validity. Study 3 cross-validated the fit of the unidimensional model in adults from the United State (N = 503) and provided evidence of invariance across gender and national group. Internal consistency coefficients of BAOS-2 scores were adequate across all three studies. There were no significant gender differences in BAOS-2 scores and a significant national difference had a negligible effect size. Thus, the BAOS-2 is a psychometrically-sound measure that can be utilised in future research.
    Matched MeSH terms: Great Britain
  18. Engaging with Lyell: Alfred Russel Wallace's Sarawak Law and Ternate papers as reactions to Charles Lyell's Principles of Geology
    Costa JT
    Theory Biosci, 2013 Dec;132(4):225-37.
    PMID: 24014172 DOI: 10.1007/s12064-013-0188-1
    Alfred Russel Wallace (1823-1913) and Charles Darwin (1809-1882) are honored as the founders of modern evolutionary biology. Accordingly, much attention has focused on their relationship, from their independent development of the principle of natural selection to the receipt by Darwin of Wallace's essay from Ternate in the spring of 1858, and the subsequent reading of the Wallace and Darwin papers at the Linnean Society on 1 July 1858. In the events of 1858 Wallace and Darwin are typically seen as central players, with Darwin's friends Charles Lyell (1797-1875) and Joseph Dalton Hooker (1817-1911) playing supporting roles. This narrative has resulted in an under-appreciation of a more central role for Charles Lyell as both Wallace's inspiration and foil. The extensive anti-transmutation arguments in Lyell's landmark Principles of Geology were taken as the definitive statement on the subject. Wallace, in his quest to solve the mystery of species origins, engaged with Lyell's arguments in his private field notebooks in a way that is concordant with his engagement with Lyell in the 1855 and 1858 papers. I show that Lyell was the object of Wallace's Sarawak Law and Ternate papers through a consideration of the circumstances that led Wallace to send his Ternate paper to Darwin, together with an analysis of the material that Wallace drew upon from the Principles. In this view Darwin was, ironically, intended for a supporting role in mediating Wallace's attempted dialog with Lyell.
    Matched MeSH terms: Great Britain
  19. The Body Acceptance by Others Scale-2 (BAOS-2): Psychometric properties of a Bahasa Malaysia (Malay) translation and an assessment of invariance across Malaysia, the United Kingdom, and the United States
    Swami V, Todd J, Barron D, Wong KY, Zahari HS, Tylka TL
    Body Image, 2021 Sep;38:346-357.
    PMID: 34091281 DOI: 10.1016/j.bodyim.2021.05.009
    The Body Acceptance by Others Scale-2 (BAOS-2) is a 13-item instrument measuring generalised perceptions of body acceptance by others. Here, we first demonstrate that a Bahasa Malaysia (Malay) translation of the BAOS-2 is psychometrically valid in a sample of 1,049 Malaysian adults (Study 1). Using exploratory and confirmatory factor analysis, we extracted a unidimensional model of BAOS-2 scores that retained all 13 items. BAOS-2 scores had adequate internal consistency and indices of validity (convergent, construct, concurrent, and incremental), and were scalar invariant across gender and ethnicity (Malaysian Malays vs. Chinese). Next, we assessed invariance of BAOS-2 scores across samples from Malaysia, the United Kingdom, and the United States (total N = 2,575; Study 2). Multi-group confirmatory factor analysis showed that partial scalar invariance was achieved. Participants in the interdependent cultural context of Malaysia had significantly higher scores - with small effect sizes - than their counterparts in the independent contexts of the United Kingdom and United States. In addition, women had significantly higher scores than men, but the effect size was negligible. The present study indicates that the Malay BAOS-2 is a psychometrically valid instrument and presents the first comparison of BAOS-2 scores across interdependent and independent contexts.
    Matched MeSH terms: Great Britain
  20. Fulltext Spectral sensitivity in eyes with macular holes and their fellow eyes
    Sharanjeet-Kaur, O'Donaghue E, Murray IJ
    Clin Exp Optom, 2003 Nov;86(6):385-9.
    PMID: 14632615 DOI: 10.1111/j.1444-0938.2003.tb03083.x
    BACKGROUND: This prospective study was undertaken to investigate whether spectral sensitivity can be useful in determining the prognosis of fellow eyes of eyes with macular holes.
    METHODS: Spectral sensitivity measurements using a one degree test spot presented at a rate of 1 Hz and 25 Hz on a bright (1000 td) white background were carried out on 10 patients aged between 67 and 74 years (mean age 70.3 +/- 2.6 years). Each patient had a full thickness macular hole in one eye and a normal contralateral fellow eye. The spectral sensitivity measurements were made with eccentric fixation in the eyes with macular holes and with central fixation in the normal fellow eye. A year later, the patient files were reviewed to look at the patient's ocular condition. Another 10 subjects between the ages of 50 and 80 years (mean age 69.5 +/- 4.2 years) were also seen. These control group subjects had visual acuities of 6/9 or better with minimal ocular media changes and no ocular or systemic pathology that could affect colour vision.
    RESULTS: The 1 Hz and 25 Hz spectral sensitivities of all patients were reduced for both eyes. Despite the good eye without a macular hole having a VA of 6/6, the spectral sensitivity was similar to that of the eye with the macular hole and markedly reduced visual acuity.
    CONCLUSION: The present investigation enabled us to examine the chromatic and achromatic mechanisms by testing spectral sensitivity at 1 Hz and 25 Hz, respectively. The data revealed that both chromatic and achromatic processing could be damaged in the eye with a macular hole. Surprisingly, the spectral sensitivities of both 1 Hz and 25 Hz are equally reduced in the good fellow eye with no macular hole. A one-year follow-up showed that two of the 10 patients (20 per cent) did eventually develop a macular hole in the normal fellow eye. This indicates that there is some subclinical foveal dysfunction in the normal fellow eye, the nature of which is unclear.
    Study site: Manchester Royal Eye Hospital (MREH), United Kingdom
    Matched MeSH terms: Great Britain
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