Displaying publications 41 - 60 of 357 in total

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  1. The effectiveness of group reminiscence therapy for loneliness, anxiety and depression in older adults in long-term care: a systematic review
    Syed Elias SM, Neville C, Scott T
    Geriatr Nurs, 2015 Sep-Oct;36(5):372-80.
    PMID: 26099638 DOI: 10.1016/j.gerinurse.2015.05.004
    Loneliness, anxiety and depression are common problems for older adults in long-term care. Reminiscence therapy is a non-pharmacological intervention that may be of some benefit. In comparison to individual reminiscence therapy, group reminiscence therapy is a preferred option when dealing with the resource constraints of long-term care. The aim of this paper was to systematically review the literature in order to explore the effectiveness of group reminiscence therapy for older adults with loneliness, anxiety and depression in long-term care. Results indicated that group reminiscence therapy is an effective treatment for depression in older adults, however to date, there is limited research support for its effectiveness to treat loneliness and anxiety. Further research and an improvement in methodological quality, such as using qualitative and mixed methods approaches, is recommended to help establish an evidence base and provide better understanding of the effectiveness of group reminiscence therapy.
    Matched MeSH terms: Depressive Disorder
  2. Fulltext Association of Whole-Genome and NETRIN1 Signaling Pathway-Derived Polygenic Risk Scores for Major Depressive Disorder and White Matter Microstructure in the UK Biobank
    Barbu MC, Zeng Y, Shen X, Cox SR, Clarke TK, Gibson J, et al.
    Biol Psychiatry Cogn Neurosci Neuroimaging, 2019 01;4(1):91-100.
    PMID: 30197049 DOI: 10.1016/j.bpsc.2018.07.006
    BACKGROUND: Major depressive disorder is a clinically heterogeneous psychiatric disorder with a polygenic architecture. Genome-wide association studies have identified a number of risk-associated variants across the genome and have reported growing evidence of NETRIN1 pathway involvement. Stratifying disease risk by genetic variation within the NETRIN1 pathway may provide important routes for identification of disease mechanisms by focusing on a specific process, excluding heterogeneous risk-associated variation in other pathways. Here, we sought to investigate whether major depressive disorder polygenic risk scores derived from the NETRIN1 signaling pathway (NETRIN1-PRSs) and the whole genome, excluding NETRIN1 pathway genes (genomic-PRSs), were associated with white matter microstructure.

    METHODS: We used two diffusion tensor imaging measures, fractional anisotropy (FA) and mean diffusivity (MD), in the most up-to-date UK Biobank neuroimaging data release (FA: n = 6401; MD: n = 6390).

    RESULTS: We found significantly lower FA in the superior longitudinal fasciculus (β = -.035, pcorrected = .029) and significantly higher MD in a global measure of thalamic radiations (β = .029, pcorrected = .021), as well as higher MD in the superior (β = .034, pcorrected = .039) and inferior (β = .029, pcorrected = .043) longitudinal fasciculus and in the anterior (β = .025, pcorrected = .046) and superior (β = .027, pcorrected = .043) thalamic radiation associated with NETRIN1-PRS. Genomic-PRS was also associated with lower FA and higher MD in several tracts.

    CONCLUSIONS: Our findings indicate that variation in the NETRIN1 signaling pathway may confer risk for major depressive disorder through effects on a number of white matter tracts.

    Matched MeSH terms: Depressive Disorder, Major/genetics*; Depressive Disorder, Major/metabolism; Depressive Disorder, Major/pathology*
  3. Fulltext Investigating Emotion in Malay, Australian and Iranian Individuals with and without Depression
    Jobson L, Mirabolfathi V, Moshirpanahi S, Parhoon H, Gillard J, Mukhtar F, et al.
    Sci Rep, 2019 12 04;9(1):18344.
    PMID: 31797979 DOI: 10.1038/s41598-019-54775-x
    This study investigated the influence of culture and depression on (1) emotion priming reactions, (2) the recall of subjective experience of emotion, and (3) emotion meaning. Members of individualistic culture (Australia, n = 42) and collectivistic culture (Iran, n = 32, Malaysia, n = 74) with and without depression completed a biological motion task, subjective experience questionnaire and emotion meaning questionnaire. Those with depression, regardless of cultural group, provided significantly fewer correct responses on the biological motion task than the control group. Second, the collectivistic control groups reported greater social engaging emotion than the Australian control group. However, the three depressed groups did not differ culturally. The Australian depressed group reported significantly greater interpersonally engaging emotion than the Australian control group. Third, the collectivistic groups reported significantly greater social worth, belief changes and sharing of emotion than the individualistic group. Depression did not influence these cultural effects. Instead we found that those with depression, when compared to controls, considered emotions as subjective phenomena, that were qualifying for relationships with others, and associated with greater agency appraisals. The applicability of the biocultural framework of emotion in depression was considered.
    Matched MeSH terms: Depressive Disorder/epidemiology; Depressive Disorder/pathology; Depressive Disorder/psychology*
  4. Fulltext Tianeptine dependence: a case report
    Syed Nabil, Ng, Chong Guan, Rusdi Abd Rashid
    Malaysian Journal of Psychiatry, 2018;27(1):0-0.
    MyJurnal
    Tianeptine is an atypical tricyclic antidepressant that is prescribed mainly for the treatment of depression and anxiety disorder. There have been scattered reported cases of tianeptine dependence and abuse in the literature. We report the case of a 32-year-old gentleman with resistant major depressive disorder that was initially successfully treated with Tianeptine. When his depression relapse due to work-related issue, he step-up his dosages without supervision. He developed tolerance and withdrawal to tianeptine making it difficult for him to stop without help. This case highlights the possibility of tianeptine abuse to its high tolerability and easy access for purchase.
    Matched MeSH terms: Depressive Disorder, Major
  5. Fulltext Screening of brain-derived neurotrophic factor (BDNF) single nucleotide polymorphisms and plasma BDNF levels among Malaysian major depressive disorder patients
    Aldoghachi AF, Tor YS, Redzun SZ, Lokman KAB, Razaq NAA, Shahbudin AF, et al.
    PLoS One, 2019;14(1):e0211241.
    PMID: 30677092 DOI: 10.1371/journal.pone.0211241
    BACKGROUND: Brain-derived neurotrophic factor (BDNF) is a neurotrophin found in abundance in brain regions such as the hippocampus, cortex, cerebellum and basal forebrain. It has been associated with the risk of susceptibility to major depressive disorder (MDD). This study aimed to determine the association of three BDNF variants (rs6265, rs1048218 and rs1048220) with Malaysian MDD patients.

    METHODS: The correlation of these variants to the plasma BDNF level among Malaysian MDD patients was assessed. A total of 300 cases and 300 matched controls recruited from four public hospitals within the Klang Valley of Selangor State, Malaysia and matched for age, sex and ethnicity were screened for BDNF rs6265, rs1048218 and rs1048220 using high resolution melting (HRM).

    FINDINGS: BDNF rs1048218 and BDNF rs1048220 were monomorphic and were excluded from further analysis. The distribution of the alleles and genotypes for BDNF rs6265 was in Hardy-Weinberg equilibrium for the controls (p = 0.13) but was in Hardy Weinberg disequilibrium for the cases (p = 0.011). Findings from this study indicated that having BDNF rs6265 in the Malaysian population increase the odds of developing MDD by 2.05 folds (95% CI = 1.48-3.65). Plasma from 206 cases and 206 controls were randomly selected to measure the BDNF level using enzyme-linked immunosorbent assay (ELISA). A significant decrease in the plasma BDNF level of the cases as compared to controls (p<0.0001) was observed. However, there was no evidence of the effect of the rs6265 genotypes on the BDNF level indicating a possible role of other factors in modulating the BDNF level that warrants further investigation.

    CONCLUSION: The study indicated that having the BDNF rs6265 allele (A) increase the risk of developing MDD in the Malaysian population suggesting a possible role of BDNF in the etiology of the disorder.

    Matched MeSH terms: Depressive Disorder, Major/blood; Depressive Disorder, Major/etiology; Depressive Disorder, Major/genetics*
  6. Fulltext The prevalence of depression and its relationship to health related quality of life among Prostate cancer patients in tertiary centres, Kuala Lumpur
    Mohamad Rodi Isa, Moy FM, Azad Hassan Abdul Razack, Zulkifli Mohd Zainuddin, Nur Zuraida Zainal
    Journal of Clinical and Health Sciences, 2016;1:36-45.
    To determine the prevalence of depression and its relationship with health related quality of life among prostate cancer patients in tertiary medical centres, Kuala Lumpur.
    Matched MeSH terms: Depressive Disorder
  7. Positive effects of Individual Cognitive Behavior Therapy for patients with unipolar mood disorders with suicidal ideation in Malaysia: A randomised controlled trial
    Sinniah A, Oei TPS, Maniam T, Subramaniam P
    Psychiatry Res, 2017 08;254:179-189.
    PMID: 28463716 DOI: 10.1016/j.psychres.2017.04.026
    The aim of this study was to investigate the effectiveness of Individual Cognitive Behavior Therapy (ICBT) in treating patients with mood disorders with suicidal ideation. A total of 69 patients (48 females, 21 males) with the diagnoses above were randomly allocated to either the group of Treatment As Usual (TAU)+ICBT (n=33) or the TAU group (n=36). All participants completed the Beck Depression Inventory (BDI), Beck Scale for Suicide Ideation (BSS), Positive and Negative Suicide Ideation Inventory (PANSI), Beck Hopelessness Scale (BHS), and Depression Anxiety Stress Scale-21 (DASS-21). These questionnaires were administered at pre-treatment, midway through treatment (week 4), post-treatment (week 8), and at follow-ups after three months (week 20) and six months (week 32). Factorial ANOVA results showed that the TAU+ICBT patients improved significantly and at faster rate as compared to the TAU group, which showed improvement only from pre to mid treatment on DASS-D and BHS-T measures. The effect size (Cohen's d), for the TAU+ICBT group showed large effect (1.47) for depressive symptoms and suicidal ideation (1.00). These findings suggest that ICBT used in addition to the TAU, was effective in enhancing treatment outcome of patients with unipolar mood disorders as well as, reducing risk for suicide behavior.
    Matched MeSH terms: Depressive Disorder/epidemiology; Depressive Disorder/psychology*; Depressive Disorder/therapy*
  8. Fulltext Psychological distress among cancer patients on chemotherapy
    Nor Zuraida, Z., Ng, C.G.
    JUMMEC, 2010;13(1):12-18.
    MyJurnal
    Distress has become a major issue in cancer population. Patients may suffer from either physical,psychological distress or both. Cancer patients who are undergoing chemotherapy are more likely to experience psychological distress. This could be due to the negative effects of chemotherapy agents, the uncertainty of post-treatment, and the occurrence of psychosocial problems. As a result, the patient may experience a normal reaction such as sadness or may develop common psychiatric disorders such as depression and anxiety.
    Matched MeSH terms: Depressive Disorder
  9. Fulltext Hospital-based pulmonary rehabilitation program is more effective than home-based pulmonary rehabilitation in improving the quality of life of chronic obstructive pulmonary disease (COPD) patients. [Program rehabilitasi pulmonari di hospital lebih berkesan daripada program rehabilitasi pulmonari di rumah dalam meningkatkan kualiti hidup pesakit obstruksi pulmonari kronik (COPD)]
    Ayiesah Ramli, Nor Azlin Mohd Nordin, Asfarina Zanudin, Wong, Judy
    Jurnal Sains Kesihatan Malaysia, 2009;7(2):47-58.
    MyJurnal
    This study identified the effectiveness between home-based and hospital-based pulmonary rehabilitation program on the quality of life of chronic obstructive pulmonary disease (COPD) patients. Thirty five patients who met the inclusion criteria were referred by physicians and randomized to either hospital-based pulmonary rehabilitation (PRPH) or home-based pulmonary rehabilitation (PRPR). The PRPH program was scheduled twice a week for eight weeks at the Physiotherapy Department, Universiti Kebangsaan Malaysia Medical Centre (UKMMC). Whilst, the PRPR group was required to attend sessions at the Physiotherapy Department twice to learn the exercise regimens before carrying out the exercises themselves at home. Subjects were asked to record activitites in a diary and a telephone call was made once every two weeks to ensure compliance towards the exercise regimens. The SF-36 questionnaire and Geriatric Depression Scale were outcome measures used in assessing status of patients prior to treatment and after intervention at the 8th week Seventeen (48.6%) subjects completed the PRPH and 15 (43%), the PRPR. Results indicated that in the PRPH group there were significant improvements in some of the domains of SF-36, i.e., role physical (p = 0.012) body pain (p = 0.040), general health (p = 0.008) and role emotional (p = 0.012). In the PRPR group, the Geriatric Depression Scale mean score was 1.8 ± 0.41 at baseline compared to 1.69 ± 0.48 following intervention (p > 0.05). Whilst, among the PRPH group, the mean was 1.87 ± 0.35 at baseline and 1.53 ± 0.52 after eight week (p < 0.05). In conclusion, hospital-based pulmonary rehabilitation is more effective than the home-based pulmonary rehabilitation in improving the quality of life and reducing depression among patients with COPD.
    Keywords: Home Based Pulmonary Rehabilitation Program (PRPR); Hospital based Pulmonary Rehabilitation Program (PRPH); COPD; Quality of life (QOL).
    Matched MeSH terms: Depressive Disorder
  10. Fulltext A case report of a patient involved in an alleged homicide-attempted suicide case - a theoretical discussion on the theory of homicide-suicide
    Ahmad Nabil, M.R., Suarn, S.
    Medicine & Health, 2015;10(2):141-145.
    MyJurnal
    This case report stresses the role of depression in the manifestation of a homicide-attempted suicide. We report the case of a man who allegedly murdered his partner and then attempted suicide. Previously, he had several failures and rejections in relationships in addition to work-related stress. He was diagnosed with major depressive disorder and treated with antidepressant. The scarcity of homicide-attempted suicide as exemplified in this case could give an insight to the Psychiatrist for better understading and possible prevention.
    Matched MeSH terms: Depressive Disorder, Major
  11. Fulltext The psychological impact of diabetic limb problems
    Bahari R
    International Medical Journal Malaysia, 2015;14(2):3-8.
    MyJurnal
    Limb problem is a common complication for patients with diabetes. While the impact of diabetic limb problems
    on physical health is well known, the psychological impact of the condition is still largely unknown. People with
    diabetes with or without foot ulcers frequently suffer from major depressive disorder, and this is made worse
    by the presence of limb complications. Furthermore, depression itself can have negative consequences on the
    person’s diabetes. Hence, in caring for people with diabetic foot problem, the psychological sequelae must not
    be overlooked but managed accordingly
    Matched MeSH terms: Depressive Disorder, Major
  12. Fulltext Anxiety-depression psychopathology of a patient with voyeurism, major depression and premature ejaculation
    Ismail N, Husain R, Sidi H
    ASEAN Journal of Psychiatry, 2017;18(2):278-280.
    MyJurnal
    Objective: This case report highlights a case of young male referred for psychiatric evaluation due to paraphilic disorder. This 27-year old single male working as an assistant accountant was noted to have voyeuristic behaviour and presented with depressive symptoms since his teenage age. He has poor coping whenever he experiences stress in life. He started to watch pornographic videos and subsequently get involved by peeping pre-pubescent’s undergarments. These activities are followed by a compulsive behaviour such as masturbation to gratify his sexual arousal.
    Results: The patient undergone several psychotherapy sessions, and medical report was furnished for the court's purpose. Our assessment revealed that he was suffering from a lifetime major depressive disorder,and he was prescribed with Tablet Sertraline 50mg/daily.He also has premature ejaculation, severe in nature. He regretted his voyeuristic urge and psychotherapyfocused on how to channel his sexual needs.
    Conclusion: Mood disorder is seen in paraphilic disorder and has to be dealt with in order to establish good management care.
    Matched MeSH terms: Depressive Disorder, Major
  13. Fulltext A diagnostic dilemma: catatonia, serotonin syndrome and Parkinsonism
    Mohd Miharbeim M.F., Ahmad Zafri, A.B., Suhaila, M.Z.
    Malaysian Journal of Psychiatry, 2017;26(1):0-0.
    MyJurnal
    Catatonia may concomitantly occur with other psychiatric diagnoses such as
    Major Depressive Disorder, however problem in diagnosis may arise due to
    the overlapping features with other problems such as serotonin syndromes,
    neuroleptic malignant syndromes and Parkinsonism. Despite the diagnostic
    dilemma and lack of diagnostic tools, the clinical correlation between the
    carbon monoxide poisoning and the late-onset development of the
    Parkinsonian features is the highlight of this report.
    Matched MeSH terms: Depressive Disorder, Major
  14. Fulltext Understanding trypophobia: the fear of holes
    Aminuddin, I., Lotfi, H.A.
    Malaysian Journal of Psychiatry, 2016;25(2):0-0.
    MyJurnal
    The sight of clustered holes can bring about uneasiness in people, and the disgust response towards it is called trypophobia. Reactions in humans vary from nausea to severe depression. We explore the possible causes of this unique phenomenon, such as evolutionary adaptation and spectral features. We also uncover the clinical features and its relationship to other psychological conditions for example, obsessive-compulsive disorder.
    Matched MeSH terms: Depressive Disorder, Major
  15. Cognitive dysfunction in Malaysian patients with major depressive disorder: A subgroup analysis of a multicountry, cross-sectional study
    Zainal NZ, Kalita P, Herr KJ
    Asia Pac Psychiatry, 2019 Mar;11(1):e12346.
    PMID: 30511420 DOI: 10.1111/appy.12346
    INTRODUCTION: Cognitive dysfunction has been significantly associated with functional impairment in patients with major depressive disorder (MDD).

    METHODS: This is a subgroup analysis of 211 Malaysian patients recruited from the multicountry, multicenter, cross-sectional Cognitive Dysfunction in Asian patients with Depression (CogDAD) study. Depression severity, cognitive dysfunction, and functional disability were assessed and compared with the overall CogDAD study population. Factors associated with functional disability were also evaluated in this Malaysian patient population.

    RESULTS: Approximately half of the Malaysian patients were in their first depressive episode, with the majority being treated for mild-to-moderate depression. Furthermore, Malaysian patients experienced cognitive dysfunction, with self-reported Perceived Deficits Questionnaire (PDQ-D) scores falling within the third quartile of PDQ-D severity. Malaysian patients also reported functional disability evidenced by a mean total Sheehan Disability Scale (SDS) score of 11.47 ± 6.68, with the highest SDS score reported in the "Social Life/Leisure Activities" domain. Compared with the overall CogDAD study population, the Malaysian patient population had comparable patient demographics in terms of marital and working status; outcome scores for PHQ-9 (9-item Patient Health Questionnaire for self-reported depression severity), PDQ-D and SDS; and worst perceived cognitive dysfunction reported in the "Attention/Concentration" domain. Factors found to be significantly associated with functional disability were PDQ-D score, sick leave taken, and antidepressant treatment (P 
    Matched MeSH terms: Depressive Disorder, Major/complications*; Depressive Disorder, Major/epidemiology; Depressive Disorder, Major/physiopathology
  16. Fulltext Depression and its relationship to loneliness and life events among urban poor in the federal territory, Kuala Lumpur, Malaysia
    Siti Nor Radhiah Muhammad Y, Nor Ba’yah Abdul K
    Jurnal Psikologi Malaysia, 2016;30:133-141.
    This study examines the relationship between loneliness, life events and depression among 178 adults in the disadvantage community of Malaysia and to determine predictors of depression. A set of standardized questionnaires was used to measure depression, loneliness and stressful life events. The results showed that loneliness and stressful life events were related to depression. Results also showed that loneliness was a predictor of depression. Implications of the study in terms of theory and practice are also discussed.
    Matched MeSH terms: Depressive Disorder
  17. Manic-Depressive Psychosis (MDP): Western and Islamic approach
    Alias J, Mat N
    Jurnal Psikologi Malaysia, 2011;olume 25:22-25.
    Personal ups and downs are appropriate responses to the ups and downs of life. However, some experiences emotional extremes in moods and disturbed their normal life. Individuals who have depression at times and mania or hypomania at others are called manic-depressive; and the combination is known as manic-depressive psychosis (MDP). This paper attempts to look at manic-depressive psychosis (MDP) from the western approaches as well as from the Islamic point of view. The treatments proposed by both streams are also provided.
    Matched MeSH terms: Depressive Disorder
  18. Fulltext Preliminary study: effects of social instability stress on depressive behaviours in ovariectomised rats
    Al-Rahbi B, Zakaria R, Muthuraju S, Othman Z, Hassan A
    Malays J Med Sci, 2013 Mar;20(2):35-40.
    PMID: 23983575 MyJurnal
    Depression is one of the common post-menopausal symptoms. In addition to estrogen deficiency, social instability stress may contribute as an additional underlying factor in the development of depressive behaviour in females. Therefore, this study was aimed at examining the influence of social instability stress on depressive behaviour in ovariectomized rats.
    Matched MeSH terms: Depressive Disorder
  19. Anhedonia among patients with Major Depressive Disorder: A comparison between patients on escitalopram and healthy controls
    Ng CG, Wong SK, Loh HS, Yee A
    Clin Ter, 2014;165(6):e384-90.
    PMID: 25524191 DOI: 10.7417/CT.2014.1778
    BACKGROUND AND AIMS: Escitalopram has widely been recognized as one of the most frequently used antidepressants, with superior tolerability and great efficacy in preventing major depressive disorder (MDD) relapse and recurrence. However, anhedonia, which is a core symptom of MDD, remains difficult to treat. This study investigates the hedonic levels of MDD patients treated with Escitalopram.

    MATERIALS AND METHODS: A total of 108 participants, 26 of whom with MDD on Escitalopram, were recruited in this cross sectional study. They were evaluated using the Snaith-Hamilton Pleasure Scale (SHAPS) and Beck Depression Inventory (BDI) questionnaires to assess their hedonic state, general mental health condition and level of depression.

    RESULTS: Our study shows that most items in the SHAPS scores are significantly different between MDD patients on Escitalopram and the controls.

    CONCLUSIONS: The hedonic capacity remains different between the two groups despite patients with MDD are put on Escitalopram treatment. Escitalopram fails to alleviate the hedonic state of MDD patients. Antidepressants that improve both depressive symptoms and hedonic states should be considered when treating MDD patients in clinical settings.
    Matched MeSH terms: Depressive Disorder, Major/drug therapy*; Depressive Disorder, Major/psychology*
  20. Depression and psychosocial correlates of liver transplant candidates: a systematic review
    Mohamed S, Sabki ZA, Zainal NZ
    Asia Pac Psychiatry, 2014 Dec;6(4):447-53.
    PMID: 25132651 DOI: 10.1111/appy.12145
    Liver transplant candidates are vulnerable to develop depression. This paper aims to ascertain the prevalence of depression in liver transplant candidates and its psychosocial factors in a systematic review.
    Matched MeSH terms: Depressive Disorder/etiology*; Depressive Disorder/epidemiology
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