MyMedR

Fulltext Does glucose-6-phosphate dehydrogenase deficiency modify the course of leprosy or its treatment

Pettit JHS, Chin J

Lepr Rev, 1964 Jul;35(4):149-56.

In a survey of over 1,000 patients with leprosy, 47 cases ( 4.4 per cent) were found to have glucose-6-phosphate dehydrogenase deficiency. A controlled clinical study suggests that such a deficiency does not modify the overall response to therapy but may predispose to a greater tendency to leprosy reactions. All patients were receiving 600 to 800 mgm. of sulphone per week and none had a frank haemolytic anaemia.

Matched MeSH terms: Anemia*; Anemia, Hemolytic*

Sickle-cell anaemia in an Indian family in Malaya

VELLA F, HART PL

Med J Malaya, 1959 Dec;14:144-50.

PMID: 13841616

Matched MeSH terms: Anemia*; Anemia, Sickle Cell/epidemiology*

Susceptibility to drug-induced haemolysis in Singapore

VELLA F

Med J Malaya, 1959 Jun;13:298-308.

PMID: 13841622

Matched MeSH terms: Anemia*; Anemia, Hemolytic/etiology*

Spinal cord degenerations due to faulty diets

Pallister RA

Malayan Medical Journal, 1936;11:109-111.

Matched MeSH terms: Anemia

In silico study of missense variants of FANCA, FANCC and FANCG genes reveals high risk deleterious alleles predisposing to Fanconi anemia pathogenesis

Shahid M, Azfaralariff A, Zubair M, Abdulkareem Najm A, Khalili N, Law D, et al.

Gene, 2022 Feb 20;812:146104.

PMID: 34864095 DOI: 10.1016/j.gene.2021.146104

Among the 22 Fanconi anemia (FA) reported genes, 90% of mutational spectra were found in three genes, namely FANCA (64%), FANCC (12%) and FANCG (8%). Therefore, this study aimed to identify the high-risk deleterious variants in three selected genes (FANCA, FANCC, and FANCG) through various computational approaches. The missense variant datasets retrieved from the UCSC genome browser were analyzed for their pathogenicity, stability, and phylogenetic conservancy. A total of 23 alterations, of which 16 in FANCA, 6 in FANCC and one variant in FANCG, were found to be highly deleterious. The native and mutant structures were generated, which demonstrated a profound impact on the respective proteins. Besides, their pathway analysis predicted many other pathways in addition to the Fanconi anemia pathway, homologous recombination, and mismatch repair pathways. Hence, this is the first comprehensive study that can be useful for understanding the genetic signatures in the development of FA.

Matched MeSH terms: Fanconi Anemia/genetics*; Fanconi Anemia Complementation Group A Protein/genetics*; Fanconi Anemia Complementation Group A Protein/chemistry; Fanconi Anemia Complementation Group C Protein/genetics*; Fanconi Anemia Complementation Group C Protein/chemistry; Fanconi Anemia Complementation Group G Protein/genetics*; Fanconi Anemia Complementation Group G Protein/chemistry

Hyperthyroidism and autoimmune hemolytic anemia--a case report

Chee YC, Gill DS, Poh SC

Med J Malaysia, 1978 Dec;33(2):154-5.

PMID: 755168

Matched MeSH terms: Anemia, Hemolytic, Autoimmune/complications*

Vitamin‐B12 Deficiency in the Megaloblastic Anaemias of Malaya

Tasker PWG, Mollin DL, Berriman H

Br J Haematol, 1958;4:167-176.

DOI: 10.1111/j.1365-2141.1958.tb03847.x

Matched MeSH terms: Anemia; Anemia, Megaloblastic

Thalassaemia: an enzyme defect?

VELLA F

Med J Malaya, 1959 Dec;14:116-21.

PMID: 13841623

Matched MeSH terms: Anemia*

Studies in the nutritional anaemias of Malaya, diagnosis

TASKER PW

Med J Malaya, 1954 Dec;9(2):152-60.

PMID: 14355278

Matched MeSH terms: Anemia*

Fulltext Association between Serum Free Thyroxine and Anemia in Euthyroid Adults: A Nationwide Study (Endocrinol Metab 2020;35:106-14, Mijin Kim et al.)

Ma ZF

Endocrinol Metab (Seoul), 2020 Jun;35(2):484-485.

PMID: 32615733 DOI: 10.3803/EnM.2020.35.2.484

Matched MeSH terms: Anemia*

RET-Y and RBC-Y in the diagnosis of iron deficiency associated with anaemia of inflammation

Jayaranee S, Sthaneshwar P

Int J Lab Hematol, 2010 Oct;32(5):512-8.

PMID: 20109166 DOI: 10.1111/j.1751-553X.2009.01215.x

We evaluated the usefulness of RET-Y and RBC-Y in distinguishing functional iron deficiency from iron-deficiency anaemia (IDA) in patients with anaemia of inflammation (AI). Sixty healthy blood donors constituted the control group. We studied RET-Y and RBC-Y in 115 patients with hypochromic/microcytic anaemia. Of these 42 patients had uncomplicated IDA and 73 had AI. The AI patients were further subdivided into AI with IDA and AI with functional IDA based on soluble transferrin receptor (sTfR) levels. The mean RBC-Y and RET-Y values in iron-deficient patients were 122.4 and 119.8, respectively, which were significantly lower than the control (P < 0.001). The mean level of RET-Y in patients with AI associated with IDA was 149.3 and this level in AI patients with functional iron deficiency was 147.4. RET-Y levels in both subgroups of AI patients were significantly lower than control but no significant difference was observed between the two subgroups. Similar findings were observed for RBC-Y. Receiver operating characteristic analysis also showed lower specificity for RBC-Y and RET-Y compared with that of sTfR and its log ferritin ratio (F-index). RET-Y and RBC-Y are useful in the diagnosis of simple IDA but have limited utility in the diagnosis of IDA with AI.

Matched MeSH terms: Anemia/diagnosis*; Anemia/etiology; Anemia, Iron-Deficiency/blood; Anemia, Iron-Deficiency/diagnosis*

Congenital dyserythropoietic anaemia: report of three cases

Ariffin WA, Karnaneedi S, Choo KE, Normah J

J Paediatr Child Health, 1996 Apr;32(2):191- 3.

PMID: 9156534

Between January 1985 and June 1992, the Paediatric Department of Hospital Universiti Sains Malaysia has diagnosed congenital dyserythropoietic anaemia in three children, two of whom were siblings. The age of onset ranged from 1 to 3 years. All of them became transfusion-dependent before the age of 4 months. One of them was successfully treated with bone marrow transplantation.

Matched MeSH terms: Anemia, Dyserythropoietic, Congenital/blood; Anemia, Dyserythropoietic, Congenital/classification; Anemia, Dyserythropoietic, Congenital/diagnosis*; Anemia, Dyserythropoietic, Congenital/genetics; Anemia, Dyserythropoietic, Congenital/therapy

IDIOPATHIC AUTO-IMMUNE HAEMOLYTIC ANAEMIA IN MALAYA

LIE-INJOLUAN EN, PILLAY RP

Acta Haematol., 1964 May;31:282-8.

PMID: 14172696

Matched MeSH terms: Anemia*; Anemia, Hemolytic*; Anemia, Hemolytic, Autoimmune*

Fulltext Prevalence of Anaemia and Iron Deficiency among Primary Schoolchildren in Malaysia

Nik Shanita S, Siti Hanisa A, Noor Afifah AR, Lee ST, Chong KH, George P, et al.

Int J Environ Res Public Health, 2018 10 23;15(11).

PMID: 30360488 DOI: 10.3390/ijerph15112332

The present study aimed to report the prevalence of anaemia and iron deficiency (ID) and to explore the associations among socio-demographic characteristics, nutritional status and inflammation status in the occurrence of anaemia and ID in a nationally representative sample of Malaysian primary schoolchildren. Using data from the South East Asian Nutrition Surveys (SEANUTS), 544 Malaysian children aged 7 to 12 years were included in this secondary analysis. Blood samples were drawn for haemoglobin and serum ferritin analysis while C-reactive protein (CRP) and α-1-acid glycoprotein (AGP) were measured to detect inflammation. Prevalence of anaemia and ID were 4.0% and 5.2%, respectively. There were significantly more anaemic indigenous bumiputra children (9.9%) than Chinese children (0.6%). Correction for inflammation did not change the prevalence of ID. More overweight/obese children than thin/normal weight children were found to have elevated acute phase protein (APP). Children with elevated inflammatory markers had significantly higher ferritin level than children without inflammation. Periodic health assessments of anaemia and ID at the population level to monitor and clarify the epidemiology of health problems are required to inform public health policies and strategies.

Matched MeSH terms: Anemia/blood; Anemia/epidemiology; Anemia, Iron-Deficiency/blood; Anemia, Iron-Deficiency/epidemiology*

Microcytic to hypochromic ratio as a discriminant index of thalassaemia trait in subjects with hypochromic anaemia

Wee SY, Muhamed Said SS, Raja Sabudin RZA, Alauddin H, Ithnin A

Malays J Pathol, 2020 Aug;42(2):195-201.

PMID: 32860371

INTRODUCTION: Differentiating between thalassaemia and iron deficiency anaemia (IDA) in hypochromic anaemia is a challenge to pathologists as it influences the choice of subsequent specialized confirmatory tests. In this study, we aimed to evaluate the performance of microcytic to hypochromic ratio (MicroR/ Hypo-He, M/H ratio) as a discriminant index in hypochromic anaemia.

MATERIALS AND METHODS: A retrospective study was carried out on 318 subjects with hypochromic anaemia, which comprised 162 IDA and 156 thalassaemia trait subjects with α-thalassemia, β-thalassemia and HbE trait. Optimal cut-off value, sensitivity and specificity of M/H ratio for thalassaemia trait discrimination was determined using Receiver Operating Characteristic (ROC) analysis.

RESULTS: Subjects with thalassaemia trait showed higher MicroR compared to IDA ( p< 0.001) while subjects with IDA demonstrated higher Hypo-He than thalassaemia trait (p < 0.001). M/H ratio was significantly higher in thalassaemia trait compared to IDA, with medians of 3.77 (interquartile range: 2.57 - 6.52) and 1.73 (interquartile range: 1.27 - 2.38), respectively (p < 0.001). M/H ratio ≥ 2.25 was the optimal cut-off value for discriminating thalassaemia trait from IDA in hypochromic anaemia, with the area under ROC curve (AUC) of 0.83, sensitivity of 80.8% and specificity of 71.6%.

CONCLUSIONS: M/H ratio is a useful discriminant index to distinguish thalassaemia trait from IDA in hypochromic anaemia prior to diagnostic analysis for thalassaemia confirmation. High M/H ratio is suggestive of thalassaemia trait than of IDA. However, more studies are required to establish the role of M/H ratio as a screening tool for thalassaemia discrimination in hypochromic anaemia.

Matched MeSH terms: Anemia, Hypochromic/pathology*; Anemia, Iron-Deficiency/diagnosis; Anemia, Iron-Deficiency/pathology

Fulltext Serum soluble transferrin receptor in hypochromic microcytic anaemia

Jayaranee S, Sthaneshwar P

Singapore Med J, 2006 Feb;47(2):138-42.

PMID: 16435056

The objective of this study was to assess the clinical significance of soluble transferrin receptor (sTfR) in hypochromic microcytic anaemia.

Matched MeSH terms: Anemia/diagnosis; Anemia/etiology; Anemia, Iron-Deficiency/diagnosis*

Successful pregnancy following aplastic anaemia

Leong KW, Teh A, Bosco JJ, Lim J

Postgrad Med J, 1995 Oct;71(840):625-7.

PMID: 8545293

Pregnancy following idiopathic aplastic anaemia is rare and is difficult to manage because of life-threatening episodes of bleeding and infections. Only a handful of cases has been reported in the literature. The pregnancies were unsuccessful in the majority. The present report describes a patient with moderately severe idiopathic aplastic anaemia who was managed with intensive haematological support leading to delivery of a healthy infant by caesarean section. Despite platelet transfusion refractoriness as a result of transfusions prior to pregnancy, adequate platelet transfusions prevented excessive bleeding. The literature is reviewed and management with platelet transfusions is discussed.

Matched MeSH terms: Anemia, Aplastic/etiology; Anemia, Aplastic/therapy*

Erythrocyte transketolase activity and anaemia

Chong YH, Ho GS

Med J Malaysia, 1973 Dec;28(2):113-4.

PMID: 4276226

Matched MeSH terms: Anemia/blood; Anemia/enzymology*

Burden of anemia among indigenous populations

Khambalia AZ, Aimone AM, Zlotkin SH

Nutr Rev, 2011 Dec;69(12):693-719.

PMID: 22133195 DOI: 10.1111/j.1753-4887.2011.00437.x

An international perspective of the magnitude of anemia in indigenous peoples is currently lacking. The present systematic review was performed to characterize the global prevalence, severity, and etiology of anemia in indigenous peoples by conducting a systematic search of original research published in English from 1996 to February 2010 using PubMed, Medline, and Embase. A total of 50 studies, representing the following 13 countries, met the inclusion criteria: Australia, Brazil, Canada, Guatemala, India, Kenya, Malaysia, Mexico, New Zealand, Sri Lanka, Tanzania, the United States, and Venezuela. Results indicate major deficiencies in the coverage and quality of anemia monitoring data for indigenous populations worldwide. The burden of anemia is overwhelmingly higher among indigenous groups compared to the general population and represents a moderate (20-39.9%) to severe (≥40%) public health problem. For the most part, the etiology of anemia is preventable and includes inadequate diet, poor living conditions, and high infection rates (i.e., malaria and intestinal parasites). A concerted global effort is needed to reduce the worldwide burden of anemia in these marginalized populations.

Matched MeSH terms: Anemia/etiology; Anemia/epidemiology*

Anaemia in pregnancy in an aboriginal population

Ong HC

J Trop Med Hyg, 1974 Jan;77(1):22-6.

PMID: 4811560

Matched MeSH terms: Anemia/epidemiology*; Anemia, Hypochromic/epidemiology; Anemia, Macrocytic/epidemiology

Displaying publications 21 - 40 of 386 in total